29
Views
5
CrossRef citations to date
0
Altmetric
Review

Death of memory T-cell subsets in humans: changes during aging

&
Pages 637-645 | Published online: 10 Jan 2014

References

  • Hengartner MO. The biochemistry of apoptosis. Nature407, 770–776 (2002).
  • Gupta S. Decision between life and death during TNF-induced signaling. J. Clin. Immunol.22, 270–278 (2002).
  • Lorenzo HK, Susin SA, Penninger J, Kroemer G. Apoptosis inducing factor (AIF): a physiologically old, caspases-independent effector of cell death. Cell Death Differ.6, 516–524 (1999).
  • Gupta S. Death of lymphocytes: a clue to immune deficiency in human aging. Discovery Med.5, 298–302 (2005).
  • Song LJ, Nagel JE, Chrest FJ, Collins GD, Adler WH. Comparison of CD3 and CD2 activation pathways in T cells from young and elderly adults. Aging4, 307–315 (1993).
  • Miller RA. The aging immune system. Primers and prospectus. Science273, 70–74 (1996).
  • Gupta S. Membrane signal transduction in T cell in aging humans. Ann. NY Acad. Sci.568, 277–282 (1989).
  • Ershler WB. Interleukin-6: a cytokine for gerontologists. J. Am. Geriatric Soc.41, 176–181 (1993).
  • Powelec G, Barnett Y, Effros R et al. T cells and aging. Front. Biosci.7, D1058–D1183 (2002).
  • Fagiola U, Cossarizza A, Scala E et al. Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine. J. Infect. Dis.167, 584–592 (1993).
  • Fagnoni FF, Vescovini R, Paserri G et al. Shortage of circulating naïve CD8+ T cells provides new insights on immunodeficiency in aging. Blood95, 2860–2868 (2002).
  • Nociari MM, Telford W, Russo C. Postthymic development of CD28-CD8+ T cell subsets: age-associated expansion and shift from naïve to memory phenotype. J. Immunol.162, 3327–3335 (1999).
  • Romanyukha AA, Yashin AI. Age-related changes in population of peripheral T cells: towards a model of immunosenescence. Mech. Ageing Dev.124, 433–443 (2003).
  • Effros RB, Boucher N, Porter V et al. Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause of both in vivo and in vitro immunosenescence. Exp. Gerontol.29, 601–609 (1994).
  • Posnett DN, Sinha R, Kabak S, Russo C. Clonal populations of T cells in normal elderly humans: the cell equivalent to “benign monoclonal gammopathy”. J. Exp. Med.179, 609–618 (1994).
  • Krammer PH. CD95’s deadly mission in the immune system. Nature407, 789–795 (2000).
  • Ashkanazi A, Dixit VM. Death receptors: signaling and modulation. Science281, 1305–1308 (1998).
  • Gupta S. Molecular steps of death receptor and mitochondrial pathways of apoptosis. Life Sci.69, 2957–2964 (2000).
  • Gupta S. Molecular steps of TNF receptor-mediated apoptosis. Curr. Mol. Med.1, 299–306 (2001).
  • Hsu H, Shu HB, Pan MG, Goeddel DV. TRADD–TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell84, 299–308 (1996).
  • Screaton G, Xu X-N. T cell life and death signaling via TNF-receptor family members. Curr. Opin. Immunol.12, 316–322 (2000).
  • Thomas B, Grell M, Pfizenmaier K, Scheurich P. Identification of a 60-kDa tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses. J. Exp. Med.172, 1019–1023 (1990).
  • Locksley RM, Kileen N, Lenardo MJ. The TNF and TNF receptor superfamilies: interating mammalian biology. Cell104, 487–501 (2001).
  • Weiss T, Grell M, Siekienski K et al. TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60. J. Immunol.161, 3136–3142 (1998).
  • Declercz W, Denecker G, Fiers W, Vandenabeele P. Cooperation of both TNF receptors in inducing apoptosis: involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75. J. Immunol.161, 390–399 (1998).
  • Haridas V, Darnay BG, Natrajan K, Helle R, Aggarwal BB. Overexpression of the p80 TNFR leads to TNF-dependent apoptosis, nuclear factor-κB activation. J. Immunol.160, 3152–3162 (1998).
  • Vandenabeele P, Declercq W, Vanhaesebroeck B, Grooten J, Fiers W. Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells. J. Immunol.154, 2904–2913 (1995).
  • Tartaglia L, Pennica D, Goddel DV. Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the p55-kDa TNF receptor. J. Biol. Chem.268, 18542–18548 (1993).
  • Pimentel-Muinos FX, Seed B. Regulated commitment of TNF receptor signaling: a molecular switch for death or activation. Immunity11, 783–793 (1999).
  • Karin M, Lin A. NF-κB at the crossroads of life and death. Nat. Immunol.3, 221–227 (2002).
  • Ghosh S, Karin M. Missing pieces in the NF-κB puzzle. Cell109, S81–S96 (2002).
  • Natoli G, Costanzo A, Ianni A et al. Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF-2-dependent pathway. Science275, 200–203 (1997).
  • Ichijo N, Nishida E, Irie K et al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science275, 90–94 (1997).
  • De Smaele E, Zazzeroni F, Papa S et al. Induction of gadd45β by NF-κB downregulates proapoptotic JNK signaling. Nature414, 308–313 (2001).
  • Chen C, Edelstein LC, Gelinas C. The Rel/ NF-κB family directly activates expression of the apoptotic inhibitor Bcl-x (L). Mol. Cell. Biol.20, 2687–2695 (2000).
  • Tang G, Minemoto Y, Dibling B et al. Inhibition of JNK activation through NF-κB target genes. Nature414, 313–317 (2001).
  • Green DR, Evan GI. A matter of life and death. Cancer Cell1, 19–30 (2002).
  • Kroemer G, Reed JC. Mitochondrial control of cell death. Nat. Med.6, 513–519 (2000).
  • Martinou J-C, Green DR. Breaking the mitochondrial barrier. Nat. Rev. Mol. Cell Biol.2, 63–67 (2001).
  • Zamzami N, Kroemer G. The mitochondrion in apoptosis: how Pandora’s box opens. Nat. Rev. Mol. Cell. Biol.2, 67–71 (2001).
  • Gupta S. Molecular signaling in death receptor and mitochondrial pathways of apoptosis. Int. J. Oncol.22, 15–20 (2003).
  • Li LY, Luo X, Wang X. Endonuclease G is an apoptotic DNAase when released from mitochondria. Nature412, 95–99 (2001).
  • Kaufman RJ. Orchestrating the unfolded protein response in health and disease. J. Clin. Invest.110, 1389–1398 (2002).
  • Ferri KF, Kroemer G. Organelle-specific initiation of cell death pathways. Nat. Cell. Biol.3, E255–E266 (2001).
  • Orrenius S, Zhivotovsky B, Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat. Rev. Mol. Cell Biol.4, 552–564 (2003).
  • Hacki J, Egger L, Monney L et al. Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2. Oncogene19, 2286–2295 (2000).
  • Gupta S. Molecular mechanisms of apoptosis in the cells of the immune system in human aging. Immunol. Rev.205, 114–129 (2005).
  • Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decision. J. Clin. Invest.115, 2656–2664 (2005).
  • Irmler M, Thome M, Hahne M et al. Inhibition of death receptor signals by cellular FLIP. Nature388, 190–195 (1997).
  • Thome M, Schneider P, Hofmann C et al. Viral Flice-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature386, 517–521 (1997).
  • Kataoka T, Budd RC, Holler N et al. The caspases-8 inhibitor FLIP promotes activation of NF-κB and ERK signaling pathways. Curr. Biol.10, 640–648, (1997).
  • Kataoka T,Tschopp J. N-terminal fragment of cFLIP (L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-κB activation. Mol. Cell Biol.24, 2627–2636 (2004).
  • Golks A, Brenner D, Krammer PH, Lavrik IN. The c-FLIP-NH2 terminus (p22-FLIP) induces NF-κB activation. J. Exp. Med.203, 1295–1305 (2006).
  • Opipari AW Jr, Hu HM, Yabkowitz R, Dixit VM. The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J. Biol. Chem.267, 12424–12427 (1992).
  • Heyninck K. Beyaert R. A20 inhibits NF-κB activation by dual ubiquitin-editing functions. Trends Biochem. Sci.30, 1–4 (2005).
  • Salvesen GS, Duckett CS. IAP proteins: blocking the road to death’s door. Nat. Rev. Mol. Cell Biol.3, 401–410 (2004).
  • Reed JC. Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities. Cell Death Diff.13, 1378–1386 (2006).
  • Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Ann. Rev. Immunol.22, 745–763 (2004).
  • Kataoka T, Budd RC, Holler N et al. Preferential localization of effector memory cells in nonlymphoid tissue. Science291, 2413–2417 (2001).
  • Weninger W, Crowley MA, Manjunath N, von Andriane UH. Migratory properties of naïve, effector, and memory CD8 (+) T cells. J. Exp. Med.194, 953–966 (2001).
  • Tomiyama H, Matsuda T, Takiguchi M. Differentiation of CD8+ T cells from a memory to memory/effector phenotype. J. Immunol.168, 5538–5550 (2002).
  • Gupta S, Bi R, Su K, Yel L, Chiplunkar S, Gollapudi S. Characterization of naïve, memory, and effector CD8+ T cells: effect of age. Exp. Gerontol.39, 545–550 (2004).
  • Gupta S, Gollapudi S. Molecular mechanisms of TNF-α-induced apoptosis in naïve and memory T cell subsets. Autoimmun. Rev.5, 264–268 (2006).
  • Gupta S, Bi R, Gollapudi S. Differential sensitivity of naïve and memory subsets of human CD8+ T cells to TNF-α-induced apoptosis. J. Clin. Immunol.26, 193–203 (2006).
  • Gupta S. Tumor necrosis factor-α-induced apoptosis in T cells from aged humans: a role of TNFR-I and downstream signaling molecules. Exp. Gerontol.37, 293–299 (2002).
  • Aggarwal S, Gupta S. Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. J. Immunol.160, 1627–1637 (1998).
  • Aggarwal S, Gollapudi S, Gupta S. Increased TNF-α-induced apoptosis in lymphocytes from aged humans: changes in TNF-α receptor expression and activation of caspases. J. Immunol.162, 2154–2161 (1999).
  • Gupta S. Tumor necrosis factor-α-induced apoptosis in T cell subsets from aged humans. Receptor expression and downstream signaling events. Exp. Gerontol.37, 293–299 (2002).
  • Gupta S, Chiplunkar S, Kim C, Yel L, Gollapudi S. Effect of age on molecular signaling of TNF-α-induced apoptosis in human lymphocytes. Mech. Ageing Dev.124, 503–509 (2003).
  • Gupta S. Molecular and biochemical pathways of apoptosis in lymphocytes from aged humans. Vaccine18, 1596–1601 (2000).
  • Phelouzat MA, Arbogast A, Laforge T, Quadri RA, Proust JJ. Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence. Mech. Ageing Dev.88, 25–38 (1996).
  • Phelouzat MA, Laforge T, Abrogast A, Quadri RA, Boutet S, Proust JJ. Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional fas receptors. Mech. Ageing Dev.96, 35–46 (1997).
  • Lechner H, Amort M, Steger MM, Maczek C, Grubeck-Lobenstein B. Regulation of CD95 (Apo-1) expression and the induction of apoptosis of human T cells: changes in old age. Int. Arch. Allergy Immunol.110, 238–243 (1996).
  • Aggarwal S, Gupta S. Increased activity of caspase-3 and caspase-8 during Fas-mediated apoptosis in lymphocytes from aging humans. Clin. Exp. Immunol.117, 285–290 (1999).
  • Miyawaki T, Uehara T, Nabu R et al. Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J. Immunol.49, 3753–3758 (1992).
  • Shinohara S, Sawada T, Nishioka Y et al. Differential expression of Fas and Bcl-2 protein on CD4+ T cells, CD8+ T cells and monocytes. Cell. Immunol.163, 303–308 (1995).
  • Iwai K, Miyawaki T, Takizawa T et al. Differential expression of bcl-2 and susceptibility to anti-Fas-mediated death in peripheral blood lymphocytes, monocytes and neutrophils. Blood84, 1201–1208 (1994).
  • Gupta S, Kim C, Yel L, Gollapudi S. A role of Fas-associated death domain (FADD) in increased apoptosis in aged humans. J. Clin. Immunol.24, 24–29 (2004).
  • Gupta S. and Gollapudi S. TNF-α-induced apoptosis in human naïve and memory CD8+ T cells in aged humans. Exp. Gerontol.41, 69–77 (2006).
  • Pahlavani M, Harris MD. The age-related changes in DNA binding activity of AP-1, NF-κB, and Oct-1 transcription factors in lymphocytes from rats. Age19, 45–54 (1996).
  • Whisler RL, Beiqing L, Chen M. Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT. Cell. Immunol.169, 185–195 (1996).
  • Trebilcock GU, Ponnappan U. Evidence for lowered induction of nuclear factor κB in activated human T lymphocytes during aging. Gerontology42, 137–146 (1996).
  • Ponnappan U, Zhong M, Trebilcock GU. Decreased proteosome-mediated degradation in T cells from the elderly: a role in immune senescence. Cell. Immunol.192, 167–174 (1999).
  • Gupta S, Bi R, Kim C, Yel L, Chiplunkar S, Gollapudi S. A role of NF-κB signaling pathway in increased tumor necrosis factor-α-induced apoptosis of lymphocytes in aged humans. Cell Death Diff.12, 177–183 (2005).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.