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Review

T-cell receptor- and anti-inflammatory gene-modulated T cells as therapy for autoimmune disease

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Pages 883-890 | Published online: 10 Jan 2014

References

  • Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin. Immunol. Immunopathol.84(3), 223–243 (1997).
  • Vanderlugt CL, Miller SD. Epitope spreading in immune-mediated diseses: implications for immunotherapy. Nat. Rev. Immunol.2(2), 85–95 (2002).
  • Yamamoto K, Masuko-Hongo K, Tanaka A et al. Establishment and application of a novel T cell clonality analysis using single-strand conformation polymorphism of T cell receptor messenger signals. Human Immunol.48(1–2), 23–31 (1996).
  • Yamamoto K, Okamoto A, Fujio K. Antigen-specific immunotherapy for autoimmune diseases. Expert Opin. Biol. Ther.7(3), 359–67 (2007).
  • Yamamoto K, Sakoda H, Nakajima T et al. Accumulation of multiple T cell clonotypes in the synovial lesions of patients with rheumatoid arthritis revealed by a novel clonality analysis. Int. Immunol.4(11), 1219–1223 (1992).
  • Komagata Y, Masuko K, Tashiro F et al. Clonal prevalence of T cells infiltrating into the pancreas of prediabetic non-obese diabetic mice. Int. Immunol.8(6), 807–814 (1996).
  • Zhou G, Fujio K, Sadakata A et al. Identification of systemically expanded activated T cell clones in MRL/lpr and NZB/W F1 lupus model mice. Clin. Exp. Immunol.136(3), 448–455 (2004).
  • Kent SC, Chen Y, Bregoli L et al. Expanded T cells from pancreatic lymph nodes of Type 1 diabetic subjects recognize an insulin epitope. Nature435(7039), 224–228 (2005).
  • Van den Elzen P, Menezes JS, Ametani A et al. Limited clonality in autoimmunity: drivers and regulators. Autoimmun. Rev.3(7–8), 524–529 (2004).
  • Huang JC, Ober RJ, Ward ES. The central residues of a T cell receptor sequence motif are key determinants of autoantigen recognition in murine experimental autoimmune encephalomyelitis. Eur. J. Immunol.35(1), 299–304 (2005).
  • Hofbauer M, Wiesener S, Babbe H et al. Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis. Proc. Natl Acad. Sci. USA100(7), 4090–4095 (2003).
  • Amrani A, Verdguer J, Serra S, Tafuro S, Tan R, Santamaria P. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature406(6797), 739–742 (2000).
  • Graca L, Chen TC, Le Moine A et al. Dominant tolerance: activation thresholds for peripheral generation of regulatory T cells. Trends Immunol.26(3), 130–135 (2005).
  • Schwartz RH. Natural regulatory T cells and self-tolerance. Nat. Immunol.6(4), 327–330 (2005).
  • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science299(5609), 1057–1061 (2003).
  • Nakajima A, Seroogy CM, Sandora MR et al. Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. J. Clin. Invest.107(10), 1293–1301 (2001).
  • Chernajovsky Y, Gould DJ, Podhajcer OL. Gene therapy for autoimmune diseases: quo vadis? Nat. Rev. Immunol.4(10), 800–811 (2004).
  • Vandenbark AA, Hashim G, Offner H. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature.341(6242), 541–544 (1989).
  • Cohen IR, Young DB. Autoimmunity, microbial immunity and the immunological homunculus. Immunol. Today12(4), 105–110 (1991).
  • Matsumoto Y. New approach to immunotherapy against organ-specific autoimmune diseases with T cell receptor and chemokine receptor DNA vaccines. Curr. Drug Targets Immune Endocr. Metabol. Disord.5(1), 73–77 (2005).
  • Vandenbark AA, Morgan E, Bartholomew R et al. TCR peptide therapy in human autoimmune diseases. Neurochem. Res.26(6), 713–730 (2001).
  • Tarner IH, Nakajima A, Seroogy CM et al. Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4. Clin. Immunol.105(3), 304–314 (2002).
  • Smith R, Tarner IH, Hollenhorst M et al. Localized expression of an anti-TNF single-chain antibody prevents development of collagen-induced arthritis. Gene Ther.10(15), 1248–1257 (2003).
  • Tahara H, Fujio K, Araki Y et al. Reconstitution of CD8+ T cells by retroviral transfer of the TCR α β-chain genes isolated from a clonally expanded P815-infiltrating lymphocyte. J. Immunol.171(4), 2154–2160 (2003).
  • Fujio K, Misaki Y, Setoguchi K et al. Functional reconstitution of class II MHC-restricted T cell immunity mediated by retroviral transfer of the α β TCR complex. J. Immunol.165(1), 528–532 (2000).
  • Mohan C, Adem S, Stanik V, Datta SK. Nucleosome: a major immunogen for pathogenic autoantigen-inducing T cells of lupus. J. Exp. Med.177(5), 1367–1381 (1993).
  • Kaliyaperulal A, Mohan C, Wu W, Datta SK. Nucleomosomal peptide epitope for nephritis-inducing T helper cells of murine lupus. J. Exp. Med.183(6), 2459–2469 (1996).
  • Fujio K, Okamoto A, Tahara H et al. Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease. J. Immunol.173(3), 2118–2125 (2004).
  • Fujio K, Okamoto A, Araki Y et al. Gene therapy of arthritis with TCR isolated from the inflamed paw. J. Immunol.177(11), 8140–8147 (2006).
  • van Amelsfort JM, Jacobs KM, Bijlsma JW, Lafeber FP, Taams LS. CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum.50(9), 2775–2785 (2004).
  • de Kleer IM, Wedderburn LR, Taams LS et al. CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J. Immunol.172(10), 6435–6443 (2004).
  • Ehrenstein MR, Evans JG, Singh A et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J. Exp. Med.200(3), 277–285 (2004).
  • Salomon B, Lenschow DJ, Rhee L et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity12(4), 431–440 (2000).
  • Tang Q, Henriksen KJ, Bi M et al.In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med.199(11), 1455–1465 (2004).
  • Bluestone JA, Tang Q. Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc. Natl Acad. Sci. USA101(Suppl. 2), 14622–14626 (2004).
  • Yu P, Gregg RK, Bell JJ et al. Specific T regulatory cells display broad suppressive functions against experimental allergic encephalomyelitis upon activation with cognate antigen. J. Immunol.174(11), 6772–6780 (2005).
  • Tarbell KV, Yamazaki S, Olson K, Toy P, Steinman RM. CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med.199(11), 1467–1477 (2004).
  • Morgan ME, Flierman R, van Duivenvoorde LM et al. Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells. Arthritis Rheum.52(7), 2212–2221 (2005).
  • Kessels HW, Wolkers MC, van den Boom MD, van der Valk MA, Schumacher TN. Immunotherapy through TCR gene transfer. Nat. Immunol.2(10), 957–961 (2001).
  • Coulie PG, Karanikas V, Colau D et al. A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-3. Proc. Natl Acad. Sci. USA98(18), 10290–10295 (2001).
  • Morgan RA, Dudley ME, Wunderlich JR et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science314(5796), 126–129 (2006).
  • McCormack MP, Rabbitts TH. Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency. N. Engl. J. Med.350(9), 913–922 (2004)
  • Bobisse S, Zanovello P, Rosato A. T-cell receptor gene transfer by lentiviral vectors in adoptive cell therapy. Expert Opin. Biol. Ther.7(6), 893–906 (2007).

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