Control of normal and abnormal proliferation in the epidermis: EGF receptor function and epidermal hyperplasia

References

• Pellegrini G, Dellambra E, Golisano O, Martinelli E, McKeon F, De Luca M. p63 identifies keratinocyte stem cells. Proc. Natl Acad. Sci. 98, 3156–3161 (2001).
   PubMed Web of Science ®Google Scholar
• Webb A, Li Am Kaur P. Location and phenotype of human adult keratinocyte stem cells of the skin. Differentiation 72, 387–395 (2004).
   PubMed Web of Science ®Google Scholar
• Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 6, 331–343 (1975).
   PubMed Web of Science ®Google Scholar
• Boelsma E, Gibbs S, Faller C, Ponec M. Characterization and comparison of reconstructed skin models: morphological and immuno-histochemical evaluation. Acta Dermato. Venereol. 80, 82–88 (2000).
   PubMed Web of Science ®Google Scholar
• Botham PA, Earl LK, Fentem JH, Rouguet R, Van De Sandt JJM. Alternative methods for skin irritation testing. ATLA 26, 195–211 (1998).
   Google Scholar
• Ponec M, Boelsma E, Gibbs S, Mommaas M. Characterization of reconstructed skin models. Skin Pharmacol. Appl. Skin Physiol. 15, 4–17 (2002).
   PubMedGoogle Scholar
• Bernhofer LP, Barkovic S, Appa Y, Martin KM. IL-1α and IL-1 receptor antagonist secretion from epidermal equivalents and the prediction of the irritation potential of mild soaps and surfactant-based consumer products. Toxicol. In Vitro 13, 231–239 (1999).
   PubMed Web of Science ®Google Scholar
• Boelsma E, Gibbs S, Faller C, Ponec M. Characterization and comparison of reconstructed skin models: morphological and immuno-histochemical evaluation. Acta Dermato. Venereol. 80, 82–88 (2000).
   PubMed Web of Science ®Google Scholar
• Jacobs JJL, Lehe C, Cammans KDA, Das PK, Elliott GR. An in vitro model for detecting skin irritants: methyl green-pyronine staining of human skin explant cultures. Toxicol. In Vitro 16, 581–588 (2002).
   PubMed Web of Science ®Google Scholar
• Coquette A, Berna N, Vandenbosch A, Rosdy M, De Wever B, Poumay Y. Analysis of interleukin-1α (IL-1α) and interleukin-8 (IL-8) expression and release in in vitro reconstructed human epidermis for the prediction of in vivo skin irritation and/or sensitization. Toxicol. In Vitro 17, 311–321 (2003).
   PubMed Web of Science ®Google Scholar
• Lehe CL, Jacobs JJL, Elliott GR, Das PK. A two-centre evaluation of the human organotypic skin explant culture model for screening contact allergens. ATLA 31, 553–561 (2003).
   Google Scholar
• Ponec M, Kempenaar J. Use of human skin recombinants as an in vitro model for testing the irritation potential of cutaneous irritants. Skin Pharmacol. 8, 49–59 (1995).
   PubMedGoogle Scholar
• Botham PA. The validation of in vitro methods for skin irritation. Toxicol. Lett. 149, 387–390 (2004).
   PubMed Web of Science ®Google Scholar
• Jacobs JJL, Lehe CL, Cammans KDA, Das PK, Elliott GR. Assessment of contact allergens by dissociation of irritant and sensitizing properties. Toxicol. In Vitro 18, 681–690 (2004).
   PubMed Web of Science ®Google Scholar
• Ponec M, Boelsma E, Gibbs S, Mommaas M. Characterization of reconstructed skin models. Skin Pharmacol. Appl. Skin Physiol. 15, 4–17 (2002).
   PubMedGoogle Scholar
• Welss T, Basketter DA, Schroder KR. In vitro skin irritation: facts and future. State of the art review of mechanisms and models. Toxicol. In Vitro 18, 231–243 (2004).
   PubMed Web of Science ®Google Scholar
• Poumay Y, Dupont F, Marcoux S, Leclercq-Smekens M, Herin M, Coquette A. A simple reconstructed human epidermis: preparation of a culture model and utilization in in vitro studies. Arch. Dermatol. Res. 296, 203–211 (2004).
   PubMed Web of Science ®Google Scholar
• Varani J, Fligiel SE, Schuger L et al. Effects of all trans-retinoic acid and Ca2+ on human skin in organ culture. Am. J. Pathol. 142, 189–198 (1993).
   PubMed Web of Science ®Google Scholar
• Varani J, Larson BK, Perone P, Inman DR, Fligiel SEG, Voorhees JJ. All trans-retinoic acid and extracellular Ca2+ differentially influence extracellular matrix production by human skin in organ culture. Am. J. Pathol. 142, 1813–1822 (1993).
   PubMed Web of Science ®Google Scholar
• Varani J, Perone P, Griffiths CEM, Inman DR, Fligiel SEG, Voorhees JJ. All-trans retinoic acid (RA) stimulates events in organ-cultured human skin that underlie repair. Adult skin from sun-protected and sun-exposed sites responds in an identical manner to RA while neonatal foreskin responds differently. J. Clin. Invest. 94, 1747–1756 (1994).
   PubMed Web of Science ®Google Scholar
• Lateef H, Sevens M, Varani J. All-trans retinoic acid suppresses matrix metalloproteinase production/activation and increases collagen synthesis in diabetic skin in organ culture. Am. J. Pathol. 165, 167–174 (2004).
   PubMed Web of Science ®Google Scholar
• Nickoloff BJ, Kunkel SL, Burdick M, Strieter RM. Severe combined immunodeficiency mouse and human psoriatic skin chimeras. Validation of a new animal model. Am. J. Pathol. l46, 580–588 (1995).
   Google Scholar
• Wrone-Smith T, Nickoloff BJ. Dermal injection of immunocytes induces psoriasis. J. Clin. Invest. 98, 1878–1887 (1996).
   PubMed Web of Science ®Google Scholar
• Gilhar A, David M, Ullmann Y, Berkutski T, Kalish RS. T-lymphocyte dependence of psoriatic pathology in human psoriatic skin grafted to SCID mice. J. Invest. Dermatol. 109, 283–288 (1997).
   PubMed Web of Science ®Google Scholar
• Zeigler M, Chi Y, Tumas DB, Bodary S, Tang H, Varani J. Anti-CD11a ameliorates disease in the human psoriatic skin-SCID mouse transplant model: comparison of antibody to CD11a with Cyclosporin A and clobetasol propionate. Lab. Invest. 81, 1253–1261 (2001).
   PubMed Web of Science ®Google Scholar
• Ellis CN, Varani J, Fisher GJ, Pershadsingh HA, Benson SC, Kurtz TW. Troglitazone improves psoriasis and normalizes models of proliferative skin disease. Arch. Dermatol. 136, 609–615 (2000).
   PubMed Web of Science ®Google Scholar
• Bhagavathula N, Nerusu KC, Fisher GJ et al. Amphiregulin and epidermal hyperplasia: amphiregulin is required to maintain the psoriatic phenotype of human skin grafts on SCID mice. Am. J. Pathol. 166, 1009–1016 (2005).
   PubMed Web of Science ®Google Scholar
• Bhagavathula N, Nerusu K, Reddy M et al. BP-1007: A novel synthetic thiazoladinedione that inhibits epidermal hyperplasia in psoriatic skin – SCID mouse transplants following topical application. J. Pharmacol. Exp. Therapeut. 315, 996–1004 (2005).
   PubMed Web of Science ®Google Scholar
• Villadsen LS, Schuurman J, Beurskens F et al. Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model. J. Clin. Invest. 112, 1571–1580 (2003).
   PubMed Web of Science ®Google Scholar
• Zollner TM, Podda M, Pien C, Elliott PJ, Kaufmann R, Boehncke WH. Proteasome inhibition reduces T cell activation and severity of psoriasis in a SCID-hu model. J. Clin. Invest. 109, 671–679 (2002).
   PubMed Web of Science ®Google Scholar
• Griffiths CE, Kang S, Ellis CN et al. Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation. A double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin cream. Arch. Dermatol. 131, 1037–1044 (1995).
   PubMedGoogle Scholar
• Kang S, Duell EA, Fisher GJ et al. Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid-binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J. Invest. Dermatol. 105, 549–556 (1995).
   PubMed Web of Science ®Google Scholar
• Tavakkol A, Varani J, Elder JT, Zouboulis CC. Maintenance of human skin in organ culture: role for insulin-like growth factor-1 receptor and epidermal growth factor receptor. Arch. Dermatol. Res. 291, 643–651 (1999).
   PubMed Web of Science ®Google Scholar
• Zeigler ME, Krause S, Karmiol S, Varani J. Growth factor-induced epidermal invasion of the dermis in human skin organ culture: dermal invasion correlated with epithelial cell motility. Invasion Metastasis 16, 3–10 (1996).
   PubMedGoogle Scholar
• Zeigler ME, Chi Y, Schmidt T, Varani J. Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes. J. Cell. Physiol. 180, 271–284 (1999).
   PubMed Web of Science ®Google Scholar
• Sander HM, Morris LF, Phillips CM, Harrison PE, Menter A. The annual cost of psoriasis. J. Am. Acad. Dematol. 128, 422–425 (1993).
   Web of Science ®Google Scholar
• Weiss SC, Kimball AB, Liewehr DJ, Blauvelt A, Turner ML, Emanuel EJ. Quantifying the harmful effect of psoriasis on health-related quality of life. J. Am. Acad. Dermatol. 47, 512–518 (2002).
   PubMed Web of Science ®Google Scholar
• Krueger GC, Bergstresser PR, Lowe NJ, Voorhees JJ, Weinstein GD. Psoriasis. J. Am. Acad. Dermatol. 11, 937–947 (1984).
   PubMed Web of Science ®Google Scholar
• Fry L. Psoriasis. Br. J. Dermatol. 119, 445–461 (1988).
   PubMed Web of Science ®Google Scholar
• Nickoloff BJ, Mitra RS, Riser BL, Dixit VM, Varani J. Modulation of keratinocyte motility; correlation with production of extracellular matrix molecules in response to growth promoting and anti-proliferative factors. Am. J. Path. 132, 543–551 (1988).
   PubMed Web of Science ®Google Scholar
• Gottlieb AB, Chang CK, Posnett DN, Fanelli B, Tam JP. Detection of transforming growth factor-α in normal, malignant and hyperproliferative human keratinocytes. J. Exp. Med. 167, 670–675 (1988).
   PubMed Web of Science ®Google Scholar
• Elder JT, Fisher GJ, Lindquist PB et al. Overexpression of transforming growth factor-α in psoriatic epidermis. Science 243, 811–814 (1989).
   PubMed Web of Science ®Google Scholar
• Piepkorn M, Predd H, Underwood R, Cook P. Proliferation-differentiation relationships in the expression of heparin-binding epidermal growth factor-related factors and erbB receptors by normal and psoriatic human keratinocytes. Arch. Dermatol. Res. 27, 27 (2003).
   Google Scholar
• Cook PW, Pittelkow MR, Keeble WW, Graves-Deal R, Coffey RJ, Shipley GD Jr. Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. Cancer Res. 52, 3224–3227 (1992).
   PubMed Web of Science ®Google Scholar
• Cook PW, Piepkorn M, Clegg CH et al. Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. J. Clin. Invest. 100, 2286–2294 (1997).
   PubMed Web of Science ®Google Scholar
• Cook PW, Brown JR, Cornell KA, Pittelkow MR. Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis. Exp. Dermatol. 13, 347–356 (2004).
   PubMed Web of Science ®Google Scholar
• Varani J, Kang S, Stoll S, Elder JT. Human psoriatic skin in organ culture: comparison with normal skin exposed to exogenous growth factors and effects of an antibody to the EGF receptor. Pathobiology 66, 253–259 (1998).
   PubMed Web of Science ®Google Scholar
• Varani J, Lateef H, Fay K, Elder JT. Antagonism of epidermal growth factor receptor tyrosine kinase ameliorates the psoriatic phenotype in organ-culture skin. Skin Pharm. Physiol. 18, 123–131 (2005).
   PubMed Web of Science ®Google Scholar
• Kligman AM, Grove GL, Hirose H, Leyden JJ. Topical tretinoin for photoaged skin. J. Am. Acad. Dermatol. 15, 836–859 (1986).
   PubMed Web of Science ®Google Scholar
• Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, Voorhees JJ. Topical tretinoin improves photoaged skin: a double-blind, vehicle-controlled study. JAMA 259, 527–232 (1988).
   PubMed Web of Science ®Google Scholar
• Griffiths CEM, Russman G, Majmudar G, Singer RS, Hamilton TA, Voorhees JJ. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N. Eng. J. Med. 329, 530–534 (1993).
   PubMed Web of Science ®Google Scholar
• Chapellier B, Mark M, Messaddeq N et al. Physiological and retinoid-induced proliferations of epidermal basal keratinocytes are differently controlled. EMBO J. 21, 3402–3413 (2002).
   PubMed Web of Science ®Google Scholar
• Stoll SW, Elder JT. Retinoid regulation of heparin-binding EGF-like growth factor gene expression in human keratinocytes and skin. Exp. Dermatol. 7, 391–397 (1998).
   PubMed Web of Science ®Google Scholar
• Varani J, Zeigler M, Dame MK et al. Heparin-binding epidermal growth factor activation of keratinocyte ErbB receptors mediates epidermal hyperplasia, a prominent side-effect of retinoid therapy. J. Invest. Dermatol. 117, 1335–1341 (2001).
   PubMed Web of Science ®Google Scholar
• Rittié L, Varani J, Kang S, Fisher GJ, Voorhees JJ. Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin binding-EGF and amphiregulin in human skin in vivo. J. Invest. Dermatol. 126, 732–739 (2006).
   PubMed Web of Science ®Google Scholar
• Varani J, Fligiel H, Zhang J et al. Separation of retinoid-induced epidermal and dermal thickening from skin irritation. Arch. Dermatol. Res. 295, 255–262 (2003).
   PubMed Web of Science ®Google Scholar
• Meeks RG, Zaharevitz D, Chen RF. Membrane effects of retinoids: possible correlation with toxicity. Arch. Biochem. Biophys. 20, 141–147 (1981).
   Google Scholar
• Bloom E, Sznitowska M, Polansky J, Ma ZD, Maibach HI. Increased proliferation of skin cells by sublethal doses of sodium lauryl sulfate. Dermatology 188, 263–268 (1994).
   PubMed Web of Science ®Google Scholar
• Le M, Schalkwijk J, Siegenthaler G, van de Kerkhof PC, Veerkamp JH, van der Valk PG. Changes in keratinocyte differentiation following mild irritation by sodium dodecyl sulphate. Arch. Dermatol. Res. 288, 684–690 (1996).
   PubMed Web of Science ®Google Scholar
• Muhammad F, Monteiro-Riviere A, Riviere JE. Comparative in vivo toxicity of topical JP-8 jet fuel and its individual hydrocarbon components: identification of tridecane and tetradecane as key constituents responsible for dermal irritation. Toxicol. Path. 33, 258–266 (2005).
   PubMed Web of Science ®Google Scholar
• Ashcroft G, Mills SJ, Ashworth JJ. Ageing and wound healing. Biogerentology 3, 337–345 (2002).
   PubMed Web of Science ®Google Scholar
• Stadelmann WK, Digenis AG, Tobin GR. Physiology and healing dynamics of chronic cutaneous wounds. Am. J. Surg. 176, S26–S38 (1998).
   PubMed Web of Science ®Google Scholar
• Pilcher BK, Dumin JA, Schwartz MJ et al. Keratinocyte collagenase-1 expression requires an epidermal growth factor autocrine mechanism J. Biol. Chem. 274, 10372–10381 (1999).
   PubMed Web of Science ®Google Scholar
• Segaert S, Van Cutsem E. Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors. Ann. Oncology 16, 1425–1433 (2005).
   PubMed Web of Science ®Google Scholar
• Laffitte E and Saurat J-H. Kinase inhibitors-induced pustules. Dermatology 211, 305–306 (2005).
   PubMed Web of Science ®Google Scholar
• Busan KJ, Capodieci P, Motzer R, Kiehn T, Phelan D, Halpern AC. Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225. Br. J. Dermatol. 144, 1169–1176 (2001).
   PubMed Web of Science ®Google Scholar
• Ranson M, Epidermal growth factor receptor tyrosine kinase inhibitors Br. J. Cancer 90; 2250–2255 (2004).
   PubMed Web of Science ®Google Scholar
• Kaftan H, Vogelgesang S, Lempas K, Hosemann W, Herzog M. Inhibition of epidermal growth factor receptor by erlotinib: wound healing of experimental tympanic membrane perforations. Oncol. Neurol. 28, 245–249 (2007).
   Google Scholar
• Maas-Szabowski N, Stark HJ, Fusenig NE. Keratinocyte growth regulation in defined organotypic cultures through IL-1-induced keratinocyte growth factor expression in fibroblasts. J. Invest. Dermatol. 114, 1075–1084 (2000).
   PubMed Web of Science ®Google Scholar
• Bomford RHH, Henderson B. Interleukin 1, Inflammation and Disease. Elsevier, Amsterdam, The Netherlands (1989).
   Google Scholar
• Wood LC, Elias PM, Calhoun C, Tsai JC, Grunfeld C, Feingold KR. Barrier disruption stimulates interleukin-1α expression and release from a pre-formed pool in murine epidermis. J. Invest. Dermatol. 106, 397–403 (1996).
   PubMed Web of Science ®Google Scholar
• Bhagavathula N, Nerusu K, Ellis CN et al. Rosiglitzone inhibits biological responses in keratinocytes and signaling events that underlie responsiveness. J. Invest. Dermatol.122, 130–139 (2004).
   PubMed Web of Science ®Google Scholar
• Korinek EK, Barker N, Morin PJ et al. Constitutive transcriptional activation by a β-catenin–Tcf complex in APC-/- colon carcinoma. Science 275, 1784–1787 (1997).
   PubMed Web of Science ®Google Scholar
• Van Aken E, De Wever O, Corriega DA, Rocha AS, Mareel M. Defective E-cadherin/catenin complexes in human cancer. Virchows Arch. 439, 725–751 (2001).
   PubMed Web of Science ®Google Scholar
• Sharma C, Pradeep A, Wong L, Rana A, Rani B. Peroxisome proliferators-activated receptor γ activation can regulate β-catenin levels via a proteosome-mediated and adenomatous polyposis coli-independent pathway. J. Biol. Chem. 279, 35583–35594 (2004).
   PubMed Web of Science ®Google Scholar
• Trivin F, Boucher E, Raoul JL. Complete sustained regression of extensive psoriasis with cetuximab combination chemotherapy. Acta Oncol. 43, 592–593 (2004).
   PubMed Web of Science ®Google Scholar
• Wierzbicka E, Tourani JM, Guillet G. Improvement of psoriasis and cutaneous side-effects during tyrosine kinase inhibitor therapy for renal metastatic adenocarcinoma. A role for epidermal growth factor receptor (EGFR) inhibitors in psoriasis? Br. J. Dermatol. 155, 213–214 (2006).
   PubMed Web of Science ®Google Scholar