Hydroxyurea therapy contributes to infertility in adult men with sickle cell disease: a review

References

• Therrell BL, Hannon WH. National evaluation of US newborn screening system components. Ment Retard Dev Disabil Res Rev 2006;12(4):236-45
   PubMedGoogle Scholar
• Quinn CT, Rogers ZR, Buchanan GR. Survival of children with sickle cell disease. Blood 2004;103(11):4023-7
   PubMed Web of Science ®Google Scholar
• Telfer P, Coen P, Chakravorty S, et al. Clinical outcomes in children with sickle cell disease living in England: a neonatal cohort in East London. Haematologica 2007;92(7):905-12
   PubMed Web of Science ®Google Scholar
• Voskaridou E, Christoulas D, Bilalis A, et al. The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS). Blood 2010;115(12):2354-63
   PubMed Web of Science ®Google Scholar
• Elmariah H, Garrett ME, De Castro LM, et al. Factors associated with survival in a contemporary adult sickle cell disease cohort. Am J Hematol 2014;89(5):530-5
   PubMed Web of Science ®Google Scholar
• Brawley OW, Cornelius LJ, Edwards LR, et al. National Institutes of Health Consensus Development Conference statement: hydroxyurea treatment for sickle cell disease. Ann Intern Med 2008;148(12):932-8
   PubMed Web of Science ®Google Scholar
• Which database should I use? Available from: www.adelaide.edu.au/library/guide/med/wd.html
   Google Scholar
• Koc A, Wheeler LJ, Mathews CK, Merrill GF. Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools. J Biol chem 2004;279(1):223-30
   PubMed Web of Science ®Google Scholar
• Gwilt PR, Tracewell WG. Pharmacokinetics and pharmacodynamics of hydroxyurea. Clin Pharmacokinet 1998;34(5):347-58
   PubMed Web of Science ®Google Scholar
• Charache S, Terrin ML, Moore RD, et al. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the multicenter study of hydroxyurea in sickle cell anemia. N Engl J Med 1995;332(20):1317-22
   PubMed Web of Science ®Google Scholar
• Wang WC, Ware RE, Miller ST, et al. Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG). Lancet 2011;377(9778):1663-72
   PubMed Web of Science ®Google Scholar
• Kassim AA, DeBaun MR. The case for and against initiating either hydroxyurea therapy, blood transfusion therapy or hematopoietic stem cell transplant in asymptomatic children with sickle cell disease. Expert Opin Pharmacother 2014;15(3):325-36
   PubMed Web of Science ®Google Scholar
• Practice Committee of American Society for Reproductive M. Definitions of infertility and recurrent pregnancy loss. Fertil Steril 2008;90(5(Suppl):S60
   PubMedGoogle Scholar
• Adediran A, Wright K, Akinbami A, et al. Prevalence of priapism and its awareness amongst male homozygous sickle cell patients in Lagos, Nigeria. Adv Urol 2013;2013:890328
   PubMedGoogle Scholar
• Emond AM, Holman R, Hayes RJ, Serjeant GR. Priapism and impotence in homozygous sickle cell disease. Arch Intern Med 1980;140(11):1434-7
   PubMedGoogle Scholar
• Abbasi AA, Prasad AS, Ortega J, et al. Gonadal function abnormalities in sickle cell anemia. Studies in adult male patients. Ann Intern Med 1976;85(5):601-5
   PubMedGoogle Scholar
• Osegbe DN, Akinyanju OO. Testicular dysfunction in men with sickle cell disease. Postgrad Med J 1987;63(736):95-8
   PubMedGoogle Scholar
• Jouannet P, Ducot B, Feneux D, Spira A. Male factors and the likelihood of pregnancy in infertile couples. I. Study of sperm characteristics. Int J Androl 1988;11(5):379-94
   PubMedGoogle Scholar
• Osegbe DN, Akinyanju O, Amaku EO. Fertility in males with sickle cell disease. Lancet 1981;2(8241):275-6
   PubMed Web of Science ®Google Scholar
• Berthaut I, Guignedoux G, Kirsch-Noir F, et al. Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males. Haematologica 2008;93(7):988-93
   PubMed Web of Science ®Google Scholar
• Organization WH. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. Cambridge University Press; Cambridge University Press: 1999
   Google Scholar
• deBeck C, Ghasemian R. Acute segmental testicular infarction. Int J Urol 2006;13(5):651-2
   PubMedGoogle Scholar
• Gofrit ON, Rund D, Shapiro A, et al. Segmental testicular infarction due to sickle cell disease. J Urol 1998;160(3 Pt 1):835-6
   PubMedGoogle Scholar
• Holmes NM, Kane CJ. Testicular infarction associated with sickle cell disease. J Urol 1998;160(1):130
   PubMedGoogle Scholar
• Li M, Fogarty J, Whitney KD, Stone P. Repeated testicular infarction in a patient with sickle cell disease: a possible mechanism for testicular failure. Urology 2003;62(3):551
   PubMed Web of Science ®Google Scholar
• Anderson MJ, Dunn JK, Lipshultz LI, Coburn M. Semen quality and endocrine parameters after acute testicular torsion. J Urol 1992;147(6):1545-50
   PubMedGoogle Scholar
• Lin WW, Kim ED, Quesada ET, et al. Unilateral testicular injury from external trauma: evaluation of semen quality and endocrine parameters. J Urol 1998;159(3):841-3
   PubMedGoogle Scholar
• Quinn CT, McKinstry RC, Dowling MM, et al. Acute silent cerebral ischemic events in children with sickle cell anemia. JAMA Neurol 2013;70(1):58-65
   PubMedGoogle Scholar
• Nahoum CR, Fontes EA, Freire FR. Semen analysis in sickle cell disease. Andrologia 1980;12(6):542-5
   PubMedGoogle Scholar
• Farias JG, Bustos-Obregon E, Orellana R, et al. Effects of chronic hypobaric hypoxia on testis histology and round spermatid oxidative metabolism. Andrologia 2005;37(1):47-52
   PubMedGoogle Scholar
• Gasco M, Rubio J, Chung A, et al. Effect of high altitude exposure on spermatogenesis and epididymal sperm count in male rats. Andrologia 2003;35(6):368-74
   PubMedGoogle Scholar
• Okumura A, Fuse H, Kawauchi Y, et al. Changes in male reproductive function after high altitude mountaineering. High Alt Med Biol 2003;4(3):349-53
   PubMedGoogle Scholar
• Donayre J, Guerra-Garcia R, Moncloa F, Sobrevilla LA. Endocrine studies at high altitude. IV. Changes in the semen of men. J Reprod Fertil 1968;16(1):55-8
   PubMedGoogle Scholar
• Ficsor G, Ginsberg LC. The effect of hydroxyurea and mitomycin C on sperm motility in mice. Mutat Res 1980;70(3):383-7
   PubMedGoogle Scholar
• Wiger R, Hongslo JK, Evenson DP, et al. Effects of acetaminophen and hydroxyurea on spermatogenesis and sperm chromatin structure in laboratory mice. Reprod Toxicol 1995;9(1):21-33
   PubMed Web of Science ®Google Scholar
• Wyrobek AJ, Bruce WR. Chemical induction of sperm abnormalities in mice. Proc Natl Acad Sci USA 1975;72(11):4425-9
   PubMed Web of Science ®Google Scholar
• Jones KM, Niaz MS, Brooks CM, et al. Adverse effects of a clinically relevant dose of hydroxyurea used for the treatment of sickle cell disease on male fertility endpoints. Int J Environ Res Public Health 2009;6(3):1124-44
   PubMed Web of Science ®Google Scholar
• Grigg A. Effect of hydroxyurea on sperm count, motility and morphology in adult men with sickle cell or myeloproliferative disease. Intern Med J 2007;37(3):190-2
   PubMed Web of Science ®Google Scholar