Potential pharmacological interventions against hematotoxicity: an overview

References

• Bloom JC, Brandt JT. Toxic responses of blood. Casarett’s and Doull’s toxicology: The basic science of poisons. The McGraw-Hill Companies; USA: 2008p. 455-84
   Google Scholar
• Smith EP. Hematologic disorders after solid organ transplantation. Hematology Am Soc Hematol Educ Program 2010;1:281-6
   Google Scholar
• Verrotti A, Scaparrotta A, Grosso S, et al. Anticonvulsant drugs and hematological disease. Neurol Sci 2014;35(7):983-93
   PubMed Web of Science ®Google Scholar
• Berger I, Seqal I, Shmueli D, et al. The effect of antiepileptic drugs on mitochondrial activity: a pilot study. J Child Neurol 2010;25(5):541-5
   PubMed Web of Science ®Google Scholar
• Orasan O, Cozma A, Rednic N, et al. Anemia – a complication of antiviral treatment in chronic viral hepatitis C. Rom J Intern Med 2009;47(3):217-25
   PubMedGoogle Scholar
• Gribaldo L, Malerba I, Collotta A, et al. Inhibition of CFU-E/BFU-E by 3′-azido-3′-deoxythymidine, chlorpropamide, and protoporphirin IX zinc (II): a comparison between direct exposure of progenitor cells and long-term exposure of bone marrow cultures. Toxicol Sci 2000;58(1):96-101
   PubMed Web of Science ®Google Scholar
• de Vocht F, Vlaanderen J, Povey AC, et al. Environmental and occupational toxicants. IARC Sci Publ 2011;163-163:74
   Google Scholar
• Umarani V, Muvvala S, Ramesh A, et al. Rutin potentially attenuates fluoride induced oxidative stress mediated cardiotoxicity, blood toxicity and dyslipidemia in rats. Toxicol Mech Methods 2015. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Van Den Heuvel RL, Leppens H, Schoeters GE. Use of in vitro assays to assess hematotoxic effects of environmental compounds. Cell Biol Toxicol 2001;17(2):107-16
   PubMed Web of Science ®Google Scholar
• Graeme KA, Pollack CV. Heavy metal toxicity, Part I: arsenic and mercury. J Emerg Med 1998;16(1):45-56
   PubMedGoogle Scholar
• Ramadhas M, Palanisamy K, Sudhagar M, et al. Ameliorating effect of Phoenix dactylifera on lambda cyhalothrin induced biochemical, hematological and hepatopathological alterations in male wistar rats. Biomed Aging Pathol 2014;4(3):273-9
   Google Scholar
• Chatterjee S, Basak P, Chaklader M, et al. Pesticide induced alterations in marrow physiology and depletion of stem and stromal progenitor population: an experimental model to study the toxic effects of pesticide. Environ Toxicol 2014;29(1):84-97
   PubMed Web of Science ®Google Scholar
• Halfdanarson TR, Litzow MR, Murray JA. Hematologic manifestations of celiac disease. Blood 2007;109(2):412-21
   PubMed Web of Science ®Google Scholar
• Albella B, Faircloth G, López-Lázaro L, et al. In vitro toxicity of ET-743 and aplidine, two marine-derived antineoplastics, on human bone marrow haematopoietic progenitors. comparison with the clinical results. Eur J Cancer 2002;38(10):1395-404
   PubMed Web of Science ®Google Scholar
• Ziepert M, Schmits R, Trümper L, et al. Prognostic factors for hematotoxicity of chemotherapy in aggressive non-Hodgkin’s lymphoma. Ann Oncol 2008;19(4):752-62
   PubMed Web of Science ®Google Scholar
• Moiseeva I, Zinov’ev AI, Ionicheva LV, et al. Comparative study of the hemato-protective effect of Dicarbamine and Leykostime in experimental radiation damage to the blood system. Vopr Onkol 2013;59(2):71-4
   PubMedGoogle Scholar
• Tannehill SP, Mehta MP. Amifostine and radiation therapy: past, present, and future. Semin Oncol 1996;23(4 Suppl 8):69-77
   PubMed Web of Science ®Google Scholar
• Kurbacher CM, Mallmann PK. Chemoprotection in anticancer therapy: the emerging role of amifostine (WR-2721). Anticancer Res 1998;18(3C):2203-10
   PubMed Web of Science ®Google Scholar
• Lv W, Zhang M, Zhang Z, et al. Amifostine acts upon mitochondria to stimulate growth of bone marrow and regulate cytokines. Adv Exp Med Biol 2013;789:195-201
   PubMed Web of Science ®Google Scholar
• Dobrenis K, Gauthier LR, Barroca V, et al. G-CSF off-target effect on nerve outgrowth promotes prostate cancer development. Int J Cancer 2015;136(4):982-8
   PubMed Web of Science ®Google Scholar
• Makita K, Ohta K, Mugitani A, et al. Acute myelogenous leukemia in a donor after granulocyte colony-stimulating factor-primed peripheral blood stem cell harvest. Bone Marrow Transplant 2004;33(6):661-5
   PubMed Web of Science ®Google Scholar
• Pentz RD. Healthy sibling donation of G-CSF primed stem cells: a call for research. Pediatr Blood Cancer 2006;46(4):407-8
   PubMed Web of Science ®Google Scholar
• Donadieu J. Is G-CSF-mobilized peripheral stem cell harvest harmful? Pediatr Blood Cancer 2007;48(5):594-5
   PubMed Web of Science ®Google Scholar
• Sytkowski AJ. Does erythropoietin have a dark side? Epo signaling and cancer cells. Sci STKE 2007;395:38
   Google Scholar
• Lapierre A, Souquet PJ. Use of erythropoiesis stimulating agents. Rev Mal Respir 2014;31(2):162-72
   PubMed Web of Science ®Google Scholar
• Pratheeshkumar P, Budhraja A, Son YO, et al. Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One 2012;7(10):e47516
   PubMed Web of Science ®Google Scholar
• Larocca LM, Teofili L, Leone G, et al. Antiproliferative activity of quercetin on normal bone marrow and leukaemic progenitors. Br J Haematol 1991;79(4):562-6
   PubMed Web of Science ®Google Scholar
• Kim H, Moon JY, Ahn KS, et al. Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells. Oxid Med Cell Longev 2013;2013:596496
   PubMed Web of Science ®Google Scholar
• Youn H, Jeong JC, Jeong YS, et al. Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull 2013;36(6):944-51
   PubMed Web of Science ®Google Scholar
• Wang H, Yuan Z, Chen Z, et al. Effect of quercetin on glioma cell U87 apoptosis and feedback regulation of MDM2-p53. Nan Fang Yi Ke Da Xue Xue Bao 2014;34(5):686-9
   PubMedGoogle Scholar
• Nabavi SM, Nabavi SF, Eslami S, et al. In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue. Food Chem 2012;132(2):931-5
   Web of Science ®Google Scholar
• Tabaczar S, Pieniążek A, Czepas J, et al. Quercetin attenuates oxidative stress in the blood plasma of rats bearing DMBA-induced mammary cancer and treated with a combination of doxorubicin and docetaxel. Gen Physiol Biophys 2013;32(4):535-43
   PubMed Web of Science ®Google Scholar
• Orsolic N, Car N. Quercetin and hyperthermia modulate cisplatin-induced DNA damage in tumor and normal tissues in vivo. Tumour Biol 2014;35(7):6445-54
   PubMed Web of Science ®Google Scholar
• Carl H, Chandni A, Neha K, et al. Curcumin as a modulator of oxidative stress during storage: a study on plasma. Transfus Apher Sci 2014;50(2):288-93
   PubMed Web of Science ®Google Scholar
• El-Bahr SM. Curcumin regulates gene expression of insulin like growth factor, B-cell CLL/lymphoma 2 and antioxidant enzymes in streptozotocin induced diabetic rats. BMC Complement Altern Med 2013;13:368
   PubMed Web of Science ®Google Scholar
• Gao S, Duan X, Wang X, et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol 2013;59:739-47
   PubMed Web of Science ®Google Scholar
• Nabavi SF, Daglia M, Moghaddam AH, et al. Curcumin and liver disease: from chemistry to medicine. Comprehensive Rev Food Sci Food Safety 2014;13(1):62-77
   PubMed Web of Science ®Google Scholar
• Anitha A, Sreeranganathan M, Chennazhi KP, et al. In vitro combinatorial anticancer effects of 5-fluorouracil and curcumin loaded N,O-carboxymethyl chitosan nanoparticles toward colon cancer and in vivo pharmacokinetic studies. Eur J Pharm Biopharm 2014;88(1):238-51
   PubMed Web of Science ®Google Scholar
• Palange AL, Di Mascolo D, Carallo C, et al. Lipid-polymer nanoparticles encapsulating curcumin for modulating the vascular deposition of breast cancer cells. Nanomedicine 2014;10(5):991-1002
   PubMed Web of Science ®Google Scholar
• Garufi A, Trisciuoglio D, Porru M, et al. A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells. J Exp Clin Cancer Res 2013;32(1):72
   PubMed Web of Science ®Google Scholar
• Storka A, Vcelar B, Klickovic U, et al. Effect of liposomal curcumin on red blood cells in vitro. Anticancer Res 2013;33(9):3629-34
   PubMed Web of Science ®Google Scholar
• Deng SL, Chen WF, Zhou B, et al. Protective effects of curcumin and its analogues against free radical-induced oxidative haemolysis of human red blood cells. Food Chem 2006;98(1):112-19
   Web of Science ®Google Scholar
• Yunos NM, Beale P, Yu JQ, et al. Synergism from sequenced combinations of curcumin and epigallocatechin-3-gallate with cisplatin in the killing of human ovarian cancer cells. Anticancer Res 2011;31(4):1131-40
   PubMed Web of Science ®Google Scholar
• Day RM, Davis TA, Barshishat-Kupper M, et al. Enhanced hematopoietic protection from radiation by the combination of genistein and captopril. Int Immunopharmacol 2013;15(2):348-56
   PubMed Web of Science ®Google Scholar
• Singh VK, Grace MB, Parekh VI, et al. Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice. Int Immunopharmacol 2009;9(12):1401-10
   PubMed Web of Science ®Google Scholar
• Colado Simao AN, Suzukawa AA, Casado MF, et al. Genistein abrogates pre-hemolytic and oxidative stress damage induced by 2,2′-Azobis (amidinopropane). Life Sci 2006;78(11):1202-10
   PubMed Web of Science ®Google Scholar
• Zhou Y, Mi MT. Genistein stimulates hematopoiesis and increases survival in irradiated mice. J Radiat Res 2005;46(4):425-33
   PubMed Web of Science ®Google Scholar
• Ishimi Y, Yoshida M, Wakimoto S, et al. Genistein, a soybean isoflavone, affects bone marrow lymphopoiesis and prevents bone loss in castrated male mice. Bone 2002;31(1):180-5
   PubMed Web of Science ®Google Scholar
• Aufderklamm S, Miller F, Galasso A, et al. Chemoprevention of prostate cancer by isoflavonoids. Recent Results Cancer Res 2014;202:101-8
   PubMedGoogle Scholar
• Damle AA, Pawar YP, Narkar AA. Anticancer activity of betulinic acid on MCF-7 tumors in nude mice. Indian J Exp Biol 2013;51(7):485-91
   PubMed Web of Science ®Google Scholar
• Li Q, Li Y, Wang X, et al. Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release. Mol Carcinog 2011;50(10):760-9
   PubMed Web of Science ®Google Scholar
• Liu Y, Luo W. Betulinic acid induces Bax/Bak-independent cytochrome c release in human nasopharyngeal carcinoma cells. Mol Cells 2012;33(5):517-24
   PubMed Web of Science ®Google Scholar
• Emmerich D, Vanchanagiri K, Baratto LC, et al. Synthesis and studies of anticancer properties of lupane-type triterpenoid derivatives containing a cisplatin fragment. Eur J Med Chem 2014;75:460-6
   PubMed Web of Science ®Google Scholar
• Park SY, Kim HJ, Kim KR, et al. Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment. Toxicol Appl Pharmacol 2014;275(2):152-62
   PubMed Web of Science ®Google Scholar
• Kumar S, Gautam S, Sharma A. Antimutagenic and antioxidant properties of plumbagin and other naphthoquinones. Mutat Res 2013;755(1):30-41
   PubMed Web of Science ®Google Scholar
• Luo P, Wong YF, Ge L, et al. Anti-inflammatory and analgesic effect of plumbagin through inhibition of nuclear factor-kappaB activation. J Pharmacol Exp Ther 2010;335(3):735-42
   PubMed Web of Science ®Google Scholar
• Li YC, He SM, He ZX, et al. Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells. Cancer Lett 2014;344(2):239-59
   PubMed Web of Science ®Google Scholar
• Tian L, Yin D, Ren Y, et al. Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. Mol Med Rep 2012;5(1):126-32
   PubMed Web of Science ®Google Scholar
• Sinha S, Pal K, Elkhanany A, et al. Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivo. Int J Cancer 2013;132(5):1201-12
   PubMed Web of Science ®Google Scholar
• Kawiak A, Zawacka-Pankau J, Lojkowska E. Plumbagin induces apoptosis in Her2-overexpressing breast cancer cells through the mitochondrial-mediated pathway. J Nat Prod 2012;75(4):747-51
   PubMed Web of Science ®Google Scholar
• Qiu JX, He YQ, Wang Y, et al. Plumbagin induces the apoptosis of human tongue carcinoma cells through the mitochondria-mediated pathway. Med Sci Monit Basic Res 2013;19:228-36
   PubMedGoogle Scholar
• Son TG, Camandola S, Arumugam TV, et al. Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia. J Neurochem 2010;112(5):1316-26
   PubMed Web of Science ®Google Scholar
• Babaei A, Arshami J, Haqhparast A, et al. Effects of saffron (Crocus sativus) petal ethanolic extract on hematology, antibody response, and spleen histology in rats. Avicenna J Phytomed 2014;4(2):103-9
   PubMedGoogle Scholar
• Del Bo C, Martini D, Vendrame S, et al. Improvement of lymphocyte resistance against H(2)O(2)-induced DNA damage in Sprague–Dawley rats after eight weeks of a wild blueberry (Vaccinium angustifolium)-enriched diet. Mutat Res 2010;703(2):158-62
   PubMed Web of Science ®Google Scholar
• Bonarska-Kujawa D, Pruchnik H, Cyboran S, et al. Biophysical mechanism of the protective effect of blue honeysuckle (Lonicera caerulea L. var. kamtschatica Sevast.) polyphenols extracts against lipid peroxidation of erythrocyte and lipid membranes. J Membr Biol 2014;247(7):611-25
   PubMed Web of Science ®Google Scholar
• Nabavi SM, Nabavi SF, Setzer WN, et al. Interaction of different extracts of Primula heterochroma Stapf. with red blood cell membrane lipids and proteins: antioxidant and antihemolytic effects. J Diet Suppl 2012;9(4):285-92
   PubMedGoogle Scholar
• Kropat C, Mueller D, Boettler U, et al. Modulation of Nrf2-dependent gene transcription by bilberry anthocyanins in vivo. Mol Nutr Food Res 2013;57(3):545-50
   PubMed Web of Science ®Google Scholar
• Mackenroth J, Hölig K, Kuhlisch E, et al. Influence of packed red cell transfusions on blood selenium concentration in pediatric hemato-oncology. Klin Padiatr 2008;220(3):153-8
   PubMed Web of Science ®Google Scholar
• Rahmanto AS, Davies MJ. Selenium-containing amino acids as direct and indirect antioxidants. IUBMB Life 2012;64(11):863-71
   PubMed Web of Science ®Google Scholar
• Richie JP, Das A, Calcagnotto AM, et al. Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial. Cancer Prev Res (Phila) 2014;7(8):796-804
   PubMed Web of Science ®Google Scholar
• Hu YJ, Chen Y, Zhang YQ, et al. The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients. Biol Trace Elem Res 1997;56(3):331-41
   PubMed Web of Science ®Google Scholar
• Panchuk R, Skorokhyd N, Chumak V, et al. Specific antioxidant compounds differentially modulate cytotoxic activity of doxorubicin and cisplatin: in vitro and in vivo study. Croat Med J 2014;55(3):206-17
   PubMed Web of Science ®Google Scholar
• Sieja K, Talerczyk M. Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy. Gynecol Oncol 2004;93(2):320-7
   PubMed Web of Science ®Google Scholar
• Sharma S, Raghuvanshi BP, Shukla S. Toxic effects of lead exposure in rats: involvement of oxidative stress, genotoxic effect, and the beneficial role of N-acetylcysteine supplemented with selenium. J Environ Pathol Toxicol Oncol 2014;33(1):19-32
   PubMed Web of Science ®Google Scholar
• Sonaa E, Usha S, Ja In J. An ex vivo study of selenium, genistein on the morphological and nuclear changes in anticancer drug-induced apoptosis in human peripheral blood lymphocytes. Biofactors 2013;39(3):279-93
   PubMed Web of Science ®Google Scholar
• Mohamed J, Wei WL, Husin NN, et al. Selenium supplementation reduced oxidative stress in diethylnitrosamine-induced hepatocellular carcinoma in rats. Pak J Biol Sci 2011;14(23):1055-60
   PubMedGoogle Scholar
• Hu Y, Spengler ML, Kuropatwinski KK, et al. Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1. Oncotarget 2011;2(12):1279-90
   PubMedGoogle Scholar
• Taskin E, Dursun N. The protection of selenium on adriamycin-induced mitochondrial damage in rat. Biol Trace Elem Res 2012;147(1-3):165-71
   PubMed Web of Science ®Google Scholar
• de Rosa V, Erkekoğlu P, Forestier A, et al. Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells. Free Radic Res 2012;46(2):105-16
   PubMed Web of Science ®Google Scholar
• Bhattacharjee A, Basu A, Ghosh P, et al. Protective effect of Selenium nanoparticle against cyclophosphamide induced hepatotoxicity and genotoxicity in Swiss albino mice. J Biomater Appl 2014;29(2):303-17
   PubMed Web of Science ®Google Scholar