Advanced search
Publication Cover
Expert Review of Obstetrics & Gynecology Volume 8, 2013 - Issue 6
Journal homepage
8
Views
6
CrossRef citations to date
0
Altmetric
Reviews

Lifestyle factors and oxidative stress in female infertility: is there an evidence base to support the linkage?

Sajal GuptaCenter for Reproductive Medicine Cleveland Clinic, 9500 Euclid Avenue, Desk A19, Cleveland, OH 44195, USACorrespondence[email protected]
,
Jennifer FedorCenter for Reproductive Medicine Cleveland Clinic, 9500 Euclid Avenue, Desk A19, Cleveland, OH 44195, USA
,
Kelly BiedenharnCenter for Reproductive Medicine Cleveland Clinic, 9500 Euclid Avenue, Desk A19, Cleveland, OH 44195, USA
&
Ashok AgarwalCenter for Reproductive Medicine Cleveland Clinic, 9500 Euclid Avenue, Desk A19, Cleveland, OH 44195, USA
Pages 607-624 | Published online: 10 Jan 2014

References

  • Hull MG, Glazener CM, Kelly NJ et al. Population study of causes, treatment, and outcome of infertility. Br. Med. J. (Clin Res Ed) 291, 6510 1693–1697 (1985).
  • Evers JL. Female subfertility. Lancet 360, 9327 151–159 (2002).
  • Duckitt K. Infertility and subfertility. Clin. Evid. (9), 2044–2073 (2003).
  • Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod. Biol. Endocrinol. 3, 28 (2005).
  • Behrman HR, Kodaman PH, Preston SL, Gao S. Oxidative stress and the ovary. J. Soc. Gynecol. Investig. 8(1 Suppl. Proceedings), S40–S42 ().
  • Shkolnik K, Tadmor A, Ben-Dor S, Nevo N, Galiani D, Dekel N. Reactive oxygen species are indispensable in ovulation. Proceedings of the National Academy of Sciences of the United States of America 108, 4 1462–1467 (2011).
  • Myatt L, Cui X. Oxidative stress in the placenta. Histochem. Cell Biol. 122, 4 369–382 (2004).
  • Wang YP, Walsh SW, Guo JD, Zhang JY. Maternal levels of prostacyclin, thromboxane, vitamin E, and lipid peroxides throughout normal pregnancy. Am. J. Obstet. Gynecol. 165(6 Pt 1), 1690–1694 (1991).
  • Liu L, Trimarchi JR, Keefe DL. Involvement of mitochondria in oxidative stress-induced cell death in mouse zygotes. Biol. Reprod. 62, 6 1745–1753 (2000).
  • Ornoy A. Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy. Reprod. Toxicol. 24, 1 31–41 (2007).
  • Berker B, Kaya C, Aytac R, Satiroglu H. Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction. Hum. Reprod. 24, 9 2293–2302 (2009).
  • Laanpere M, Altmae S, Stavreus-Evers A, Nilsson TK, Yngve A, Salumets A. Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability. Nutr. Rev. 68, 2 99–113 (2010).
  • Burton GJ, Hempstock J, Jauniaux E. Oxygen, early embryonic metabolism and free radical-mediated embryopathies. Reprod. Biomed. Online 6, 1 84–96 (2003).
  • Guerin P, El Mouatassim S, Menezo Y. Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings. Hum. Reprod. Update 7(2), 175–189 (2001).
  • Angelucci S, Ciavardelli D, Di Giuseppe F et al. Proteome analysis of human follicular fluid. Biochim. Biophys. Acta 1764(11), 1775–1785 (2006).
  • Tamura H, Takasaki A, Taketani Tet al. The role of melatonin as an antioxidant in the follicle. J. Ovarian Res. 5(5 (2012).
  • Bain NT, Madan P, Betts DH. The early embryo response to intracellular reactive oxygen species is developmentally regulated. Reprod. Fertil. Dev. 23(4), 561–575 (2011).
  • Giudice LC, Kao LC. Endometriosis. Lancet 364(9447), 1789–1799 (2004).
  • Augoulea A, Alexandrou A, Creatsa M, Vrachnis N, Lambrinoudaki I. Pathogenesis of endometriosis: the role of genetics, inflammation and oxidative stress. Arch. Gynecol. Obstet. 286(1), 99–103 (2012).
  • Szczepanska M, Kozlik J, Skrzypczak J, Mikolajczyk M. Oxidative stress may be a piece in the endometriosis puzzle. Fertil. Steril. 79(6), 1288–1293 (2003).
  • Ngo C, Chereau C, Nicco C, Weill B, Chapron C, Batteux F. Reactive oxygen species controls endometriosis progression. Am. J. Pathol. 175(1), 225–234 (2009).
  • Lambrinoudaki IV, Augoulea A, Christodoulakos GE et al. Measurable serum markers of oxidative stress response in women with endometriosis. Fertil. Steril. 91(1), 46–50 (2009).
  • Garrido N, Navarro J, Garcia-Velasco J, Remoh J, Pellice A, Simon C. The endometrium versus embryonic quality in endometriosis-related infertility. Hum. Reprod. Update 8(1), 95–103 (2002).
  • Matsuzaki S, Schubert B. Oxidative stress status in normal ovarian cortex surrounding ovarian endometriosis. Fertil. Steril. 93(7), 2431–2432 (2010).
  • Prieto L, Quesada JF. Cambero O et al. Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis. Fertil. Steril. 98(1), 126–130 (2012).
  • Ota H, Igarashi S, Kato N, Tanaka T. Aberrant expression of glutathione peroxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis. Fertil. Steril. 74(2), 313–318 (2000).
  • Ota H, Igarashi S, Sato N, Tanaka H, Tanaka T. Involvement of catalase in the endometrium of patients with endometriosis and adenomyosis. Fertil. Steril. 78(4), 804–809 (2002).
  • Shah DK, Correia KF, Vitonis AF, Missmer SA. Body size and endometriosis: results from 20 years of follow-up within the Nurses' Health Study II prospective cohort. Hum. Reprod. 28(7), 1783–1792 (2013).
  • Knochenhauer ES, Key TJ. Kahsar-Miller M, Waggoner W, Boots LR, Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J. Clin. Endocrinol. Metab. 83(9), 3078–3082 (1998).
  • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum. Reprod. 19(1), 41–47 (2004).
  • Shang K, Jia X, Qiao J, Kang J, Guan Y. Endometrial abnormality in women with polycystic ovary syndrome. Reprod. Sci. 19(7), 674–683 (2012).
  • Palacio JR, Iborra A, Ulcova-Gallova Z, Badia R, Martinez P. The presence of antibodies to oxidative modified proteins in serum from polycystic ovary syndrome patients. Clin. Exp. Immunol. 144(2), 217–222 (2006).
  • Kuscu NK, Var A. Oxidative stress but not endothelial dysfunction exists in non-obese, young group of patients with polycystic ovary syndrome. Acta Obstet. Gynecol. Scand. 88(5), 612–617 (2009).
  • Victor VM, Rocha M, Banuls C et al. Induction of oxidative stress and human leukocyte/endothelial cell interactions in polycystic ovary syndrome patients with insulin resistance. J. Clin. Endocrinol. Metab. 96(10), 3115–3122 (2011).
  • Gonzalez F, Rote NS, Minium J, Kirwan JP. Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 91(1), 336–340 (2006).
  • Sabuncu T, Vural H, Harma M, Harma M. Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease. Clin. Biochem. 34(5), 407–413 (2001).
  • Fenkci IV, Serteser M, Fenkci S, Kose S. Paraoxonase levels in women with polycystic ovary syndrome. J. Reprod. Med. 52(10), 879–883 (2007).
  • Polak G, Koziol-Montewka M, Gogacz M, Blaszkowska I, Kotarski J. Total antioxidant status of peritoneal fluid in infertile women. Eur. J. Obstet. Gynecol. Reprod. Biol. 94(2), 261–263 (2001).
  • Agarwal A. Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S. The effects of oxidative stress on female reproduction: a review. Reprod. Biol. Endocrinol. 10(1),49 (2012).
  • Badawy A. BakerElNasharA, El TotongyM. Clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for augmenting ovulation in the management of unexplained infertility: a randomized double-blind controlled trial. Fertil. Steril. 86(3), 647–650 (2006).
  • El-Far M, El-Sayed IH, El-Motwally Ael G, Hashem IA, Bakry N. Tumor necrosis factor-alpha and oxidant status are essential participating factors in unexplained recurrent spontaneous abortions. Clin. Chem. Lab. Med. 45(7), 879–883 (2007).
  • Simsek M, Naziroglu M, Simsek H, Cay M, Aksakal M, Kumru S. Blood plasma levels of lipoperoxides, glutathione peroxidase, beta carotene, vitamin A and E in women with habitual abortion. Cell Biochem. Funct. 16(4), 227–231 (1998).
  • Sane AS, Chokshi SA, Mishra VV, Barad DP, Shah VC, Nagpal S. Serum lipoperoxides in induced and spontaneous abortions. Gynecol. Obstet. Invest. 31(3), 172–175 (1991).
  • Xu DX, Chen YH, Wang H, Zhao L, Wang JP, Wei W. Effect of N-acetylcysteine on lipopolysaccharide-induced intra-uterine fetal death and intra-uterine growth retardation in mice. Toxicol. Sci. 88(2), 525–533 (2005).
  • Tsai IH, Chen CP, Sun FJ, Wu CH, Yeh SL. Associations of the pre-pregnancy body mass index and gestational weight gain with pregnancy outcomes in Taiwanese women. Asia Pac. J. Clin. Nutr. 21(1), 82–87 (2012).
  • Rich-Edwards JW, Spiegelman D. Garland M et al. Physical activity, body mass index, and ovulatory disorder infertility. Epidemiology 13(2), 184–190 (2002).
  • Rachon D, Teede H. Ovarian function and obesity--interrelationship, impact on women's reproductive lifespan and treatment options. Mol. Cell. Endocrinol. 316(2), 172–179 (2010).
  • Robker RL, Akison LK. Bennett BD et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J. Clin. Endocrinol. Metab. 94(5), 1533–1540 (2009).
  • Van DerSteeg JW, Steures P, Eijkemans MJ et al. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum. Reprod. 23(2), 324–328 (2008).
  • Boots C, Stephenson MD. Does obesity increase the risk of miscarriage in spontaneous conception: a systematic review. Semin. Reprod. Med. 29(6), 507–513 (2011).
  • Landres IV, Milki AA, Lathi RB. Karyotype of miscarriages in relation to maternal weight. Hum. Reprod. 25(5), 1123–1126 (2010).
  • Bloomer RJ. Fisher-Wellman KH. Systemic oxidative stress is increased to a greater degree in young, obese women following consumption of a high fat meal. Oxid. Med. Cell. Longev. 2(1), 19–25 (2009).
  • Mittal PC, Kant R. Correlation of increased oxidative stress to body weight in disease-free post menopausal women. Clin. Biochem. 42(10–11), 1007–1011 (2009).
  • Keaney JF Jr, Larson MG. Vasan RS et al. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler. Thromb. Vasc. Biol. 23(3), 434–439 (2003).
  • Wu B, Fukuo K, Suzuki K, Yoshino G, Kazumi T. Relationships of systemic oxidative stress to body fat distribution, adipokines and inflammatory markers in healthy middle-aged women. Endocr. J. 56(6), 773–782 (2009).
  • Igosheva N, Abramov AY. Poston L et al. Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS ONE 5(4), e10074 (2010).
  • Hudson JI, Hiripi E, Pope HG, Jr., Kessler RC. The prevalence and correlates of eating disorders in the national comorbidity survey replication. Biol. Psychiatry 61(3), 348–358 (2007).
  • Easter A, Treasure J, Micali N. Fertility and prenatal attitudes towards pregnancy in women with eating disorders: results from the avon longitudinal study of parents and children. BJOG 118(12), 1491–1498 (2011).
  • Helgstrand S, Andersen AM. Maternal underweight and the risk of spontaneous abortion. Acta Obstet. Gynecol. Scand. 84(12), 1197–1201 (2005).
  • Freizinger M, Franko DL, Dacey M, Okun B, Domar AD. The prevalence of eating disorders in infertile women. Fertil. Steril. 93(1), 72–78 (2010).
  • Stewart DE, Robinson E, Goldbloom DS, Wright C. Infertility and eating disorders. Am. J. Obstet. Gynecol. 163(4 Pt 1), 1196–1199 (1990).
  • Yen SS. Effects of lifestyle and body composition on the ovary. Endocrinol. Metab. Clin. North Am. 27(4), 915–926, ix (1998).
  • Van Binsbergen CJ, Coelingh Bennink HJ, Odink J, Haspels AA, Koppeschaar HP. A comparative and longitudinal study on endocrine changes related to ovarian function in patients with anorexia nervosa. J. Clin. Endocrinol. Metab. 71(3), 705–711 (1990).
  • Kirchengast S, Huber J. Body composition characteristics and fat distribution patterns in young infertile women. Fertil. Steril. 81(3), 539–544 (2004).
  • Treasure JL, Wheeler M, King EA, Gordon PA, Russell GF. Weight gain and reproductive function: ultrasonographic and endocrine features in anorexia nervosa. Clin. Endocrinol. 29(6), 607–616 (1988).
  • Hauger MS, Gibbons L, Vik T, Belizan JM. Prepregnancy weight status and the risk of adverse pregnancy outcome. Acta Obstet. Gynecol. Scand. 87(9), 953–959 (2008).
  • Han Z, Mulla S, Beyene J, Liao G, Mcdonald SD. Maternal underweight and the risk of preterm birth and low birth weight: a systematic review and meta-analyses. Inter. J. Epidemiol. 40(1), 65–101 (2011).
  • Pasternak Y, Weintraub AY. Shoham-Vardi I et al. Obstetric and perinatal outcomes in women with eating disorders. J. Womens Health (Larchmt) 21(1), 61–65 (2012).
  • Higashi Y, Sasaki S, Nakagawa K et al. Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress. J. Am. Coll. Cardiol. 42(2), 256–263 (2003).
  • Moyano D, Sierra C, Brandi N et al. Antioxidant status in anorexia nervosa. Inter. J. Eating Dis. 25(1), 99–103 (1999).
  • Nattiv A, Loucks AB, Manore MM, Sanborn CF, Sundgot-Borgen J, Warren MP. American College of Sports Medicine position stand. The female athlete triad. Med. Sci. Sports Exerc. 39(10), 1867–1882 (2007).
  • Gibbs JC, Williams NI, Scheid JL, Toombs RJ, De Souza MJ. The association of a high drive for thinness with energy deficiency and severe menstrual disturbances: confirmation in a large population of exercising women. Inter. J. Sport Nutr. Exerc. Metab. 21(4), 280–290 (2011).
  • Russell JB, Mitchell D, Musey PI, Collins DC. The relationship of exercise to anovulatory cycles in female athletes: hormonal and physical characteristics. Obstet. Gynecol. 63(4), 452–456 (1984).
  • Olive DL. Exercise and fertility: an update. Curr. Opin. Obstet. Gynecol. 22(4), 259–263 (2010).
  • Gudmundsdottir SL, Flanders WD, Augestad LB. Physical activity and fertility in women: the North-Trondelag Health Study. Hum. Reprod. 24(12), 3196–3204 (2009).
  • Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Diet and lifestyle in the prevention of ovulatory disorder infertility. Obstet. Gynecol. 110(5), 1050–1058 (2007).
  • Ji LL. Antioxidants and oxidative stress in exercise. Proc. Soc. Exp. Biol. Med. 222(3), 283–292 (1999).
  • Alessio HM, Hagerman AE, Fulkerson BK, Ambrose J, Rice RE, Wiley RL. Generation of reactive oxygen species after exhaustive aerobic and isometric exercise. Med. Sci. Sports Exerc. 32(9), 1576–1581 (2000).
  • Quindry J, Miller L, Mcginnis G et al. Environmental Temperature and Exercise Induced Blood Oxidative Stress. Inter. J. Sport Nutr. Exerc. Metab. (2012).
  • Popovic LM, Mitic NR. Radic I et al. The effect of exhaustive exercise on oxidative stress generation and antioxidant defense in guinea pigs. Adv. Clin. Exp. Med. 21(3), 313–320 (2012).
  • Siktar E, Ekinci D, Siktar E, Beydemir S, Gulcin I, Gunay M. Protective role of L-carnitine supplementation against exhaustive exercise induced oxidative stress in rats. Eur. J. Pharmacol. 668(3), 407–413 (2011).
  • Okudan N, Revan S, Balci SS, Belviranli M, Pepe H, Gokbel H. Effects of CoQ10 supplementation and swimming training on exhaustive exercise-induced oxidative stress in rat heart. Bratisl. Lek. listy 113(7), 393–399 (2012).
  • Allgrove J, Farrell E, Gleeson M, Williamson G, Cooper K. Regular dark chocolate consumption's reduction of oxidative stress and increase of free-fatty-acid mobilization in response to prolonged cycling. Inter. J. Sport Nutr. Exerc. Metab. 21(2), 113–123 (2011).
  • Practice Committee of American Society for Reproductive Medicine. Smoking and infertility. Fertil. Steril. 90(5 Suppl.), S254–S259 (2008).
  • Augood C, Duckitt K, Templeton AA. Smoking and female infertility: a systematic review and meta-analysis. Hum. Reprod. 13(6), 1532–1539 (1998).
  • Soares SR, Melo MA. Cigarette smoking and reproductive function. Curr. Opin. Obstet. Gynecol. 20(3), 281–291 (2008).
  • Sobinoff AP, Pye V, Nixon B, Roman SD, Mclaughlin EA. Jumping the gun: smoking constituent BaP causes premature primordial follicle activation and impairs oocyte fusibility through oxidative stress. Toxicol. Appl. Pharmacol. 260(1), 70–80 (2012).
  • Sharara FI, Beatse SN, Leonardi MR, Navot D, Scott RT, Jr. Cigarette smoking accelerates the development of diminished ovarian reserve as evidenced by the clomiphene citrate challenge test. Fertil. Steril. 62(2), 257–262 (1994).
  • Huang J, Okuka M, Mclean M, Keefe DL, Liu L. Effects of cigarette smoke on fertilization and embryo development in vivo. Fertil. Steril. 92(4), 1456–1465 (2009).
  • Soares SR, Simon C, Remohi J, Pellicer A. Cigarette smoking affects uterine receptiveness. Hum. Reprod. 22(2), 543–547 (2007).
  • Talbot P, Riveles K. Smoking and reproduction: the oviduct as a target of cigarette smoke. Reprod. Biol. Endocrinol. 3, 52 (2005).
  • Dicarlantonio G, Talbot P. Inhalation of mainstream and sidestream cigarette smoke retards embryo transport and slows muscle contraction in oviducts of hamsters (Mesocricetus auratus). Biol. Reprod. 61(3), 651–656 (1999).
  • Asano H, Horinouchi T, Mai Y et al. Nicotine- and tar-free cigarette smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase. J. Pharmacol. Sci. 118(2), 275–287 (2012).
  • Northrop-Clewes CA, Thurnham DI. Monitoring micronutrients in cigarette smokers. Clin. Chim. Acta 377(1-2), 14–38 (2007).
  • Paszkowski T, Clarke RN, Hornstein MD. Smoking induces oxidative stress inside the Graafian follicle. Hum. Reprod. 17(4), 921–925 (2002).
  • Zenzes MT. Smoking and reproduction: gene damage to human gametes and embryos. Hum. Reprod. Update 6(2), 122–131 (2000).
  • Revonta M, Raitanen J, Sihvo S et al. Health and life style among infertile men and women. Sex. Reprod. Healthc. 1(3), 91–98 (2010).
  • Tolstrup JS, Kjaer SK. Holst C et al. Alcohol use as predictor for infertility in a representative population of Danish women. Acta Obstet. Gynecol. Scand. 82(8), 744–749 (2003).
  • Jensen TK, Hjollund NH. Henriksen TB et al. Does moderate alcohol consumption affect fertility? Follow up study among couples planning first pregnancy. BMJ 317(7157), 505–510 (1998).
  • Grodstein F, Goldman MB, Cramer DW. Infertility in women and moderate alcohol use. Am. J. Public Health 84(9), 1429–1432 (1994).
  • Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Caffeinated and alcoholic beverage intake in relation to ovulatory disorder infertility. Epidemiology 20(3), 374–381 (2009).
  • Rasch V. Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion. Acta Obstet. Gynecol. Scand. 82(2), 182–188 (2003).
  • Tolstrup JS, Kjaer SK, Munk C et al. Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion? Hum. Reprod. 18(12), 2704–2710 (2003).
  • Juhl M. Nyboe Andersen AM, Gronbaek M, Olsen J. Moderate alcohol consumption and waiting time to pregnancy. Hum. Reprod. 16(12), 2705–2709 (2001).
  • Hirano T. Alcohol consumption and oxidative DNA damage. Inter. J. Environ. Res. Public Health 8(7), 2895–2906 (2011).
  • Schrieks IC, Van Den Berg R, Sierksma A, Beulens JW, Vaes WH, Hendriks HF. Effect of red wine consumption on biomarkers of oxidative stress. Alcohol Alcohol. 48(2), 153–159 (2012).
  • Gauthier TW, Kable JA, Burwell L, Coles CD, Brown LA. Maternal alcohol use during pregnancy causes systemic oxidation of the glutathione redox system. Alcohol. Clin. Exp. Res. 34(1), 123–130 (2010).
  • Wilcox A, Weinberg C, Baird D. Caffeinated beverages and decreased fertility. Lancet 2(8626–8627), 1453–1456 (1988).
  • Bolumar F, Olsen J, Rebagliato M, Bisanti L. Caffeine intake and delayed conception: a European multicenter study on infertility and subfecundity. European study group on infertility subfecundity. Am. J. Epidemiol. 145(4), 324–334 (1997).
  • Cnattingius S, Signorello LB, Anneren G et al. Caffeine intake and the risk of first-trimester spontaneous abortion. New Engl. J. Med. 343(25), 1839–1845 (2000).
  • Greenwood DC, Alwan N, Boylan S et al. Caffeine intake during pregnancy, late miscarriage and stillbirth. Eur. J. Epidemiol. 25(4), 275–280 (2010).
  • Wisborg K, Kesmodel U, Bech BH, Hedegaard M, Henriksen TB. Maternal consumption of coffee during pregnancy and stillbirth and infant death in first year of life: prospective study. BMJ 326(7386), 420 ().
  • Signorello LB, Mclaughlin JK. Maternal caffeine consumption and spontaneous abortion: a review of the epidemiologic evidence. Epidemiology 15(2), 229–239 (2004).
  • Peck JD, Leviton A, Cowan LD. A review of the epidemiologic evidence concerning the reproductive health effects of caffeine consumption: a 2000-2009 update. Food Chem. Toxicol. 48(10), 2549–2576 (2010).
  • Lv X, Chen Z, Li J et al. Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress. Inflamm. Res. 59(8), 635–645 (2010).
  • Varma SD, Kovtun S, Hegde K. Effectiveness of topical caffeine in cataract prevention: studies with galactose cataract. Mol. Vis. 16, 2626–2633 (2010).
  • Chu YF, Chang WH, Black RM et al. Crude caffeine reduces memory impairment and amyloid beta(1-42) levels in an Alzheimer's mouse model. Food Chem. 135(3), 2095–2102 (2012).
  • Azam S, Hadi N, Khan NU, Hadi SM. Antioxidant and prooxidant properties of caffeine, theobromine and xanthine. Med. Sci. Monit. 9(9), BR325–BR330 (2003).
  • Park B, Mcpartland JM, Glass M. Cannabis, cannabinoids and reproduction. rostaglandins, leukotrienes, and essential fatty acids. 70(2), 189–197 (2004).
  • Sauer MA, Rifka SM, Hawks RL, Cutler GB Jr, Loriaux DL. Marijuana: interaction with the estrogen receptor. J. Pharmacol. Exp. Ther. 224(2), 404–407 (1983).
  • Mueller BA, Daling JR, Weiss NS, Moore DE. Recreational drug use and the risk of primary infertility. Epidemiology 1(3), 195–200 (1990).
  • El Marroun H, Tiemeier H, Steegers EA et al. Intrauterine cannabis exposure affects fetal growth trajectories: the Generation R Study. J. Am. Acad. Child Adolesc. Psychiatry 48(12), 1173–1181 (2009).
  • Sarafian TA, Magallanes JA, Shau H, Tashkin D, Roth MD. Oxidative stress produced by marijuana smoke. An adverse effect enhanced by cannabinoids. Am. J. Respir. Cell Mol. Biol. 20(6), 1286–1293 (1999).
  • Parrott AC, Milani RM. Gouzoulis-Mayfrank E, Daumann J. Cannabis and Ecstasy/MDMA (3,4-methylenedioxymethamphetamine): an analysis of their neuropsychobiological interactions in recreational users. J. Neural. Transm. 114(8), 959–968 (2007).
  • Thyer AC, King TS, Moreno AC et al. Cocaine impairs ovarian response to exogenous gonadotropins in nonhuman primates. J. Soc. Gynecol. Invest. 8(6), 358–362 (2001).
  • Dietrich JB, Mangeol A, Revel MO, Burgun C, Aunis D, Zwiller J. Acute or repeated cocaine administration generates reactive oxygen species and induces antioxidant enzyme activity in dopaminergic rat brain structures. Neuropharmacology 48(7), 965–974 (2005).
  • Valente MJ, Carvalho F, Bastos MD, De Pinho PG, Carvalho M. Contribution of oxidative metabolism to cocaine-induced liver and kidney damage. Curr. Med. Chem. 19(33), 5601–5606 (2012).
  • Cerretani D, Fineschi V, Bello S, Riezzo I, Turillazzi E, Neri M. Role of oxidative stress in cocaine-induced cardiotoxicity and cocaine-related death. Curr. Med. Chem. 19(33), 5619–5623 (2012).
  • Schmidt L, Holstein BE, Boivin J et al. Patients' attitudes to medical and psychosocial aspects of care in fertility clinics: findings from the Copenhagen Multi-centre Psychosocial Infertility (COMPI) Research Programme. Hum. Reprod. 18(3), 628–637 (2003).
  • Domar AD, Broome A, Zuttermeister PC, Seibel M, Friedman R. The prevalence and predictability of depression in infertile women. Fertil. Steril. 58(6), 1158–1163 (1992).
  • Daley CA, Macfarlane MS, Sakurai H, Adams TE. Effect of stress-like concentrations of cortisol on follicular development and the preovulatory surge of LH in sheep. J. Reprod. Fertil. 117(1), 11–16 (1999).
  • Louis GM, Lum KJ, Sundaram R et al. Stress reduces conception probabilities across the fertile window: evidence in support of relaxation. Fertil. Steril. 95(7), 2184–2189 (2011).
  • Monti C, Ciarrocca M, Cardella C et al. Exposure to urban stressor and effects on luteinizing hormone (LH) in female outdoor workers. J. Environ. Sci. Health A Tox. Hazard. Subst. Environ. Eng. 41(8), 1437–1448 (2006).
  • Mutsaerts MA, Groen H, Huiting HG et al. The influence of maternal and paternal factors on time to pregnancy--a Dutch population-based birth-cohort study: the GECKO Drenthe study. Hum. Reprod. 27(2), 583–593 (2012).
  • Eskiocak S, Gozen AS, Kilic AS, Molla S. Association between mental stress & some antioxidant enzymes of seminal plasma. Indian J. Med. Res. 122(6), 491–496 (2005).
  • Adachi S, Kawamura K, Takemoto K. Oxidative damage of nuclear DNA in liver of rats exposed to psychological stress. Cancer Res. 53(18), 4153–4155 (1993).
  • Toft G, Hagmar L, Giwercman A, Bonde JP. Epidemiological evidence on reproductive effects of persistent organochlorines in humans. Reprod. Tox. 19(1), 5–26 (2004).
  • Herrero-Mercado M, Waliszewski SM, Caba M et al. Organochlorine pesticide gradient levels among maternal adipose tissue, maternal blood serum and umbilical blood serum. Bull. Environ. Contam. Toxicol. 86(3), 289–293 (2011).
  • Lopez-Espinosa MJ, Murcia M, Iniguez C et al. Prenatal exposure to organochlorine compounds and birth size. Pediatrics 128(1), e127–e134 (2011).
  • Parlett LE, Calafat AM, Swan SH. Women's exposure to phthalates in relation to use of personal care products. J. Exp. Sci. Environ. Epidemiol. 23(2), 197–206 (2013).
  • Tranfo G, Caporossi L, Paci E et al. Urinary phthalate monoesters concentration in couples with infertility problems. Toxicol. Lett. 213(1), 15–20 (2012).
  • Toft G, Thulstrup AM, Jonsson BA et al. Fetal loss and maternal serum levels of 2,2',4,4',5,5'-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure: a cohort study in Greenland and two European populations. Environm. Health 9, 22 (2010).
  • Wen S, Yang FX, Gong Y et al. Elevated levels of urinary 8-hydroxy-2'-deoxyguanosine in male electrical and electronic equipment dismantling workers exposed to high concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans, polybrominated diphenyl ethers, and polychlorinated biphenyls. Environm. Sci. Technol. 42(11), 4202–4207 (2008).
  • Zhu Y, Kalen AL, Li L et al. Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure. Free Radic. Biol. Med. 47(12), 1762–1771 (2009).
  • Pathak R, Suke SG, Ahmed T et al. Organochlorine pesticide residue levels and oxidative stress in preterm delivery cases. Human Exp. Toxicol. 29(5), 351–358 (2010).
  • Lopez O, Hernandez AF, Rodrigo L et al. Changes in antioxidant enzymes in humans with long-term exposure to pesticides. Toxicol. Lett 171(3), 146–153 (2007).
  • Patel MM, Chillrud SN, Deepti KC, Ross JM, Kinney PL. Traffic-related air pollutants and exhaled markers of airway inflammation and oxidative stress in New York City adolescents. Environ. Res. 121, 71–78 (2012).
  • Gong J, Zhu T, Kipen H et al. Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress. J. Expo. Sci. Environ. Epidemiol. 23(3), 322–327 (2013).
  • Smith KW, Souter I, Dimitriadis I et al. Urinary paraben concentrations and ovarian aging among women from a fertility center. Environ. Health Perspect. (2013) (Epub ahead of print).
  • Orvieto R, Meltcer S, Nahum R, Rabinson J, Anteby EY, Ashkenazi J. The influence of body mass index on in vitro fertilization outcome. Inter. J. Gynaecol. Obstet. 104(1), 53–55 (2009).
  • Bellver J, Ayllon Y, Ferrando M et al. Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertil. Steril. 93(2), 447–454 (2010).
  • Koning AM, Kuchenbecker WK, Groen H et al. Economic consequences of overweight and obesity in infertility: a framework for evaluating the costs and outcomes of fertility care. Hum. Reprod. Update 16(3), 246–254 (2010).
  • Fedorcsak P, Dale PO, Storeng R et al. Impact of overweight and underweight on assisted reproduction treatment. Hum. Reprod. 19(11), 2523–2528 (2004).
  • Dickey RP, Xiong X, Gee RE, Pridjian G. Effect of maternal height and weight on risk of preterm birth in singleton and twin births resulting from in vitro fertilization: a retrospective cohort study using the society for assisted reproductive technology clinic outcome reporting system. Fertil. Steril. 97(2), 349–354 (2012).
  • Luke B, Brown MB, Stern JE, Missmer SA, Fujimoto VY, Leach R. Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates. Hum. Reprod. 26(1), 245–252 (2011).
  • Styne-Gross A, Elkind-Hirsch K, Scott RT Jr. Obesity does not impact implantation rates or pregnancy outcome in women attempting conception through oocyte donation. Fertil. Steril. 83(6), 1629–1634 (2005).
  • Shah DK, Missmer SA, Berry KF, Racowsky C, Ginsburg ES. Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization. Obstet. Gynecol. 118(1), 63–70 (2011).
  • Chavarro JE, Ehrlich S, Colaci DS et al. Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction. Fertil. Steril. 98(1), 109–116 (2012).
  • Li Y, Yang D, Zhang Q. Impact of overweight and underweight on IVF treatment in Chinese women. Gynecol. Endocrinol. 26(6), 416–422 (2010).
  • Veleva Z, Tiitinen A, Vilska S et al. High and low BMI increase the risk of miscarriage after IVF/ICSI and FET. Hum. Reprod. 23(4), 878–884 (2008).
  • Pinborg A, Gaarslev C, Hougaard CO et al. Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples. Reprod. Biomed. Online 23(4), 490–499 (2011).
  • Morris SN, Missmer SA, Cramer DW, Powers RD, Mcshane PM, Hornstein MD. Effects of lifetime exercise on the outcome of in vitro fertilization. Obstet. Gynecol. 108(4), 938–945 (2006).
  • Waylen AL, Metwally M, Jones GL, Wilkinson AJ, Ledger WL. Effects of cigarette smoking upon clinical outcomes of assisted reproduction: a meta-analysis. Hum. Reprod. Update 15(1), 31–44 (2009).
  • Rossi BV, Berry KF, Hornstein MD, Cramer DW, Ehrlich S, Missmer SA. Effect of alcohol consumption on in vitro fertilization. Obstet. Gynecol. 117(1), 136–142 (2011).
  • Klonoff-Cohen HS, Natarajan L, Chen RV. A prospective study of the effects of female and male marijuana use on in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT) outcomes. Am. J. Obstet. Gynecol. 194(2), 369–376 (2006).
  • Al-Saleh I, El-Doush I, Grisellhi B, Coskun S. The effect of caffeine consumption on the success rate of pregnancy as well various performance parameters of in-vitro fertilization treatment. Med. Sci. Monit. 16(12), CR598–CR605 (2010).
  • Chiaffarino F, Baldini MP, Scarduelli C et al. Prevalence and incidence of depressive and anxious symptoms in couples undergoing assisted reproductive treatment in an Italian infertility department. Eur. J. Obstet. Gynecol. Reprod. Biol. 158(2), 235–241 (2011).
  • Li XH, Ma YG, Geng LH, Qin L, Hu H, Li SW. Baseline psychological stress and ovarian norepinephrine levels negatively affect the outcome of in vitro fertilisation. Gynecol. Endocrinol. 27(3), 139–143 (2011).
  • Gourounti K, Anagnostopoulos F, Vaslamatzis G. The relation of psychological stress to pregnancy outcome among women undergoing in-vitro fertilization and intracytoplasmic sperm injection. Women Health 51(4), 321–339 (2011).
  • An Y, Wang Z, Ji H, Zhang Y, Wu K. Pituitary-adrenal and sympathetic nervous system responses to psychiatric disorders in women undergoing in vitro fertilization treatment. Fertil. Steril. 96(2), 404–408 (2011).
  • Matthiesen SM, Frederiksen Y, Ingerslev HJ, Zachariae R. Stress, distress and outcome of assisted reproductive technology (ART): a meta-analysis. Hum. Reprod. 26(10), 2763–2776 (2011).
  • Younglai EV, Foster WG, Hughes EG, Trim K, Jarrell JF. Levels of environmental contaminants in human follicular fluid, serum, and seminal plasma of couples undergoing in vitro fertilization. Arch. Environ. Cont. Toxicol. 43(1), 121–126 (2002).
  • Meeker JD, Maity A, Missmer SA et al. Serum concentrations of polychlorinated biphenyls in relation to in vitro fertilization outcomes. Environ. Health Persp. 119(7), 1010–1016 (2011).
  • Mahalingaiah S, Missmer SA, Maity A et al. Association of hexachlorobenzene (HCB), dichlorodiphenyltrichloroethane (DDT), and dichlorodiphenyldichloroethylene (DDE) with in vitro fertilization (IVF) outcomes. Environ. Health Persp. 120(2), 316–320 (2012).
  • Dei M, Seravalli V, Bruni V, Balzi D, Pasqua A. Predictors of recovery of ovarian function after weight gain in subjects with amenorrhea related to restrictive eating disorders. Gynecol. Endocrinol. 24(8), 459–464 (2008).
  • Clark AM, Ledger W, Galletly C et al. Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women. Hum. Reprod. 10(10), 2705–2712 (1995).
  • Tan O, Carr BR. The impact of bariatric surgery on obesity-related infertility and in vitro fertilization outcomes. Semin. Reprod. Med. 30(6), 517–528 (2012).
  • Comhaire F. The role of food supplementation in the treatment of the infertile couple and for assisted reproduction. Andrologia 42(5), 331–340 (2010).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.