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Expert Review of Gastroenterology & Hepatology Volume 7, 2013 - Issue 8
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Editorials

Thiopurines during pregnancy in inflammatory bowel disease: is there a risk for the (unborn) child?

Nanne KH de BoerDepartment of Gastroenterology and Hepatology, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The [email protected]
,
Tim de MeijDepartment of Paediatric Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands
&
Adriaan A van BodegravenDepartment of Gastroenterology and Hepatology, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The [email protected]
Pages 669-671 | Published online: 10 Jan 2014

References

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  • Peyrin-Biroulet L, Oussalah A, Roblin X, Sparrow MP. The use of azathioprine in Crohn's disease during pregnancy and in the post-operative setting: a worldwide survey of experts. Aliment. Pharmacol. Ther. 33(6), 707–713 (2011).
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  • Jharap B, de Boer NK, Stokkers P et al. Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease. Gut doi:10.1136/gutjnl-2012-303615 (2013) ( Epub ahead of print).
  • Connell WR, Kamm MA, Ritchie JK, Lennard-Jones JE. Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience. Gut 34(8), 1081–1085 (1993).
  • de Meij TG, Jharap B, Kneepkens CM, van Bodegraven AA, de Boer NK; Dutch Initiative on Crohn and Colitis. Long-term follow-up of children exposed intrauterine to maternal thiopurine therapy during pregnancy in females with inflammatory bowel disease. Aliment. Pharmacol. Ther 38(1), 38–43 (2013).
  • Casanova MJ, Chaparro M, Domenech E et al. Safety of thiopurines and anti-TNF-α drugs during pregnancy in patients with inflammatory bowel disease. Am. J. Gastroenterol. 108(3), 433–440 (2013).

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