Autophagy in ethanol-exposed liver disease

References

• Stahre M, Roeber J, Kanny D, et al. Contribution of excessive alcohol consumption to deaths and years of potential life lost in the United States. Prev Chronic Dis 2014;11:E109
   PubMed Web of Science ®Google Scholar
• Li Y, Wang S, Ni HM, et al. Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets. BioMed Res Int 2014;2014:498491
   PubMed Web of Science ®Google Scholar
• Czaja MJ. Functions of autophagy in hepatic and pancreatic physiology and disease. Gastroenterology 2011;140(7):1895-908
   PubMed Web of Science ®Google Scholar
• Aki T, Funakoshi T, Unuma K, Uemura K. Impairment of autophagy: from hereditary disorder to drug intoxication. Toxicology 2013;311(3):205-15
   PubMed Web of Science ®Google Scholar
• Albano E. Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med 2008;29(1-2):9-16
   PubMed Web of Science ®Google Scholar
• You M, Fischer M, Deeg MA, Crabb DW. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem 2002;277(32):29342-7
   PubMed Web of Science ®Google Scholar
• Wu D, Cederbaum AI. Oxidative stress and alcoholic liver disease. Semin Liver Dis 2009;29(2):141-54
   PubMed Web of Science ®Google Scholar
• Das S, Hajnoczky N, Antony AN, et al. Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats. Pflugers Arch 2012;464(1):101-9
   PubMed Web of Science ®Google Scholar
• Ni HM, Woolbright BL, Williams J, et al. Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy. J Hepatol 2014;61(3):617-25
   PubMed Web of Science ®Google Scholar
• Cho HI, Choi JW, Lee SM. Impairment of autophagosome-lysosome fusion contributes to chronic ethanol-induced liver injury. Alcohol 2014;48(7):717-25
   PubMed Web of Science ®Google Scholar
• Kroemer G, Marino G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010;40(2):280-93
   PubMed Web of Science ®Google Scholar
• Harada M. [Autophagy in liver diseases]. J UOEH 2011;33(4):337-44
   PubMedGoogle Scholar
• Ding WX, Li M, Chen X, et al. Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology 2010;139(5):1740-52
   PubMed Web of Science ®Google Scholar
• Nepal S, Park PH. Activation of autophagy by globular adiponectin attenuates ethanol-induced apoptosis in HepG2 cells: Involvement of AMPK/FoxO3A axis. Biochim Biophys Acta 2013;1833(10):2111-25
   PubMed Web of Science ®Google Scholar
• Walls KC, Ghosh AP, Franklin AV, et al. Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem 2010;285(14):10497-507
   PubMed Web of Science ®Google Scholar
• Donohue TMJr. Autophagy and ethanol-induced liver injury. World J Gastroenterol 2009;15(10):1178-85
   PubMed Web of Science ®Google Scholar
• Levine B, Sinha S, Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 2008;4(5):600-6
   PubMed Web of Science ®Google Scholar
• Beier JI, McClain CJ. Mechanisms and cell signaling in alcoholic liver disease. Biol Chem 2010;391(11):1249-64
   PubMed Web of Science ®Google Scholar
• Ding WX, Manley S, Ni HM. The emerging role of autophagy in alcoholic liver disease. Exp Biol Med (Maywood) 2011;236(5):546-56
   PubMed Web of Science ®Google Scholar
• Wu D, Wang X, Zhou R, Cederbaum A. CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells. Biochem Biophys Res Commun 2010;402(1):116-22
   PubMed Web of Science ®Google Scholar
• Thomes PG, Trambly CS, Thiele GM, et al. Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment. Biochem Biophys Res Commun 2012;417(1):262-7
   PubMed Web of Science ®Google Scholar
• Yang L, Rozenfeld R, Wu D, et al. Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free radical biology & medicine 2014;68:260-7
   PubMed Web of Science ®Google Scholar
• Cederbaum AI, Yang L, Wang X, Wu D. CYP2E1 Sensitizes the liver to LPS- and TNF alpha-induced toxicity via elevated oxidative and nitrosative stress and activation of ASK-1 and JNK mitogen-activated kinases. Int J Hepatol 2012;2012:582790
   PubMedGoogle Scholar
• Lu H, Zhang XY, Wang YQ, et al. Andrographolide sodium bisulfate-induced apoptosis and autophagy in human proximal tubular endothelial cells is a ROS-mediated pathway. Environ Toxicol Pharmacol 2014;37(2):718-28
   PubMed Web of Science ®Google Scholar
• Yang L, Wu D, Wang X, Cederbaum AI. Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver. Free Radic Biol Med 2012;53(5):1170-80
   PubMed Web of Science ®Google Scholar
• Howarth DL, Vacaru AM, Tsedensodnom O, et al. Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes. Alcohol Clin Exp Res 2012;36(1):14-23
   PubMed Web of Science ®Google Scholar
• Kalvakolanu DV, Gade P. IFNG and autophagy: A critical role for the ER-stress mediator ATF6 in controlling bacterial infections. Autophagy 8(11):1673-4
   PubMed Web of Science ®Google Scholar
• Younce C, Kolattukudy P. MCP-1 induced protein promotes adipogenesis via oxidative stress, endoplasmic reticulum stress and autophagy. Cell Physiol Biochem 2012;30(2):307-20
   PubMedGoogle Scholar
• Yorimitsu T, Nair U, Yang Z, Klionsky DJ. Endoplasmic reticulum stress triggers autophagy. J Biol Chem 2006;281(40):30299-304
   PubMed Web of Science ®Google Scholar
• Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011;13(2):132-41
   PubMed Web of Science ®Google Scholar
• Shaw RJ. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol (Oxf) 2009;196(1):65-80
   PubMed Web of Science ®Google Scholar
• Zeng T, Zhang C-L, Song F-Y, et al. PI3K/Akt pathway activation was involved in acute ethanol-induced fatty liver in mice. Toxicology 2012;296(1):56-66
   PubMed Web of Science ®Google Scholar
• Osna NA, Thomes PG, Donohue TMJr. Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis. World J Gastroenterol 2011;17(20):2507-14
   PubMed Web of Science ®Google Scholar
• Singh R, Kaushik S, Wang Y, et al. Autophagy regulates lipid metabolism. Nature 2009;458(7242):1131-5
   PubMed Web of Science ®Google Scholar
• Wang H, Gilham D, Lehner R. Proteomic and lipid characterization of apolipoprotein B-free luminal lipid droplets from mouse liver microsomes: implications for very low density lipoprotein assembly. J Biol Chem 2007;282(45):33218-26
   PubMed Web of Science ®Google Scholar
• Nepal S, Kim MJ, Lee ES, et al. Modulation of Atg5 expression by globular adiponectin contributes to autophagy flux and suppression of ethanol-induced cell death in liver cells. Food Chem Toxicol 2014;68:11-22
   PubMed Web of Science ®Google Scholar
• Eid N, Ito Y, Maemura K, Otsuki Y. Elevated autophagic sequestration of mitochondria and lipid droplets in steatotic hepatocytes of chronic ethanol-treated rats: an immunohistochemical and electron microscopic study. J Mol Histol 2013;44(3):311-26
   PubMed Web of Science ®Google Scholar
• Lemasters JJ. Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J Gastroenterol Hepatol 2007;22(Suppl 1):S31-7
   Google Scholar
• Rodriguez-Enriquez S, Kai Y, Maldonado E, et al. Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. Autophagy 2009;5(8):1099-106
   PubMed Web of Science ®Google Scholar
• Bonet-Ponce L, Saez-Atienzar S, da Casa C, et al. On the mechanism underlying ethanol-induced mitochondrial dynamic disruption and autophagy response. Biochim Biophys Acta 2015;1852(7):1400-9
   PubMed Web of Science ®Google Scholar
• Wu D, Cederbaum AI. Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK. Redox Biol 2013;1:552-65
   PubMed Web of Science ®Google Scholar
• Scherz-Shouval R, Elazar Z. Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci 2011;36(1):30-8
   PubMed Web of Science ®Google Scholar
• Overbye A, Fengsrud M, Seglen PO. Proteomic analysis of membrane-associated proteins from rat liver autophagosomes. Autophagy 2007;3(4):300-22
   PubMed Web of Science ®Google Scholar
• Kawaguchi Y, Kovacs JJ, McLaurin A, et al. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 2003;115(6):727-38
   PubMed Web of Science ®Google Scholar
• Bjorkoy G, Lamark T, Brech A, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005;171(4):603-14
   PubMed Web of Science ®Google Scholar
• Cuervo AM, Dice JF. Age-related decline in chaperone-mediated autophagy. J Biol Chem 2000;275(40):31505-13
   PubMed Web of Science ®Google Scholar
• Harada M, Hanada S, Toivola DM, et al. Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation. Hepatology 2008;47(6):2026-35
   PubMed Web of Science ®Google Scholar
• Lin CW, Zhang H, Li M, et al. Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. J Hepatol 2013;58(5):993-9
   PubMed Web of Science ®Google Scholar
• Poso AR, Hirsimaki P. Inhibition of proteolysis in the liver by chronic ethanol feeding. Biochem J 1991;273:149-152
   PubMed Web of Science ®Google Scholar
• Tan TC, Crawford DH, Jaskowski LA, et al. Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury. Lab Invest 2013;93(12):1295-312
   PubMed Web of Science ®Google Scholar
• Zhang Q, Li Y, Liang T, et al. ER stress and autophagy dysfunction contribute to fatty liver in diabetic mice. Int J Biol Sci 2015;11(5):559-68
   PubMed Web of Science ®Google Scholar
• Smith SL, Jennett RB, Sorrell MF, Tuma DJ. Acetaldehyde substoichiometrically inhibits bovine neurotubulin polymerization. J Clin Invest 1989;84(1):337-41
   PubMed Web of Science ®Google Scholar
• You M, Matsumoto M, Pacold CM, et al. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 2004;127(6):1798-808
   PubMed Web of Science ®Google Scholar
• Casey CA, Volentine GD, Jankovich CJ, et al. Effect of chronic ethanol administration on the uptake and degradation of asialoglycoproteins by the perfused rat liver. Biochem Pharmacol 1990;40(5):1117-23
   PubMed Web of Science ®Google Scholar
• Kharbanda KK, McVicker DL, Zetterman RK, Donohue TMJr. Ethanol consumption reduces the proteolytic capacity and protease activities of hepatic lysosomes. Biochim Biophys Acta 1995;1245(3):421-9
   PubMed Web of Science ®Google Scholar
• Donohue TMJr, Thomes PG. Ethanol-induced oxidant stress modulates hepatic autophagy and proteasome activity. Redox Biology 2014;3:29-39
   PubMed Web of Science ®Google Scholar