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Expert Review of Respiratory Medicine Volume 7, 2013 - Issue 6
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The usefulness of the mannitol challenge test for asthma

Celeste PorsbjergDepartment of Respiratory Medicine, Respiratory Research Unit, Bispebjerg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, DenmarkCorrespondence[email protected]
,
Asger SverrildDepartment of Respiratory Medicine, Respiratory Research Unit, Bispebjerg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
&
Vibeke BackerDepartment of Respiratory Medicine, Respiratory Research Unit, Bispebjerg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
Pages 655-663 | Published online: 09 Jan 2014

References

  • Asher MI, Montefort S, Bjorksten B et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: Isaac Phases One and Three repeat multicountry cross-sectional surveys. Lancet 368(9537), 733–743 (2006).
  • Accordini S, Corsico AG, Braggion M, Gerbase MW et al. The cost of persistent asthma in Europe: an international population-based study in adults. Int. Arch. Allergy Immunol. 160(1), 93–101 (2013).
  • Herland K, Akselsen JP, Skjønsberg OH, Bjermer L. How representative are clinical study patients with asthma or COPD for a larger “real life” population of patients with obstructive lung disease? Respir. Med. 99(1), 11–19 (2005).
  • Crapo RO, Casaburi R, Coates AL et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am. J. Respir. Crit. Care Med. 161(1), 309–329 (2000).
  • Anderson SD, Brannan J, Spring J et al. A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol. Am. J. Respir. Crit. Care Med. 156(3 Pt 1), 758–765 (1997).
  • Koskela HO, Hyvarinen L, Brannan JD et al. Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma. Chest (2003) 124(4), 1341–1349 (2003).
  • Subbarao P, Brannan JD, Ho B et al. Inhaled mannitol identifies methacholine-responsive children with active asthma. Pediatr. Pulmonol. 29(4), 291–298 (2000).
  • Brannan JD, Anderson SD, Perry CP et al. The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline. Respir. Res. 6(144) (2005)
  • Anderson SD, Charlton B, Weiler JM et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir. Res. 10(1), 4 (2009).
  • Andregnette-Roscigno V, Fernandez-Nieto M, Del Potro MG et al. Methacholine is more sensitive than mannitol for evaluation of bronchial hyperresponsiveness in children with asthma. J. Allergy Clin. Immunol. 126(4), 869–871 (2010).
  • Sverrild A, Porsbjerg C, Thomsen SF, Backer V. Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: a random-sample population study. J. Allergy Clin. Immunol. 126(5), 952–958 (2010).
  • Barben J, Kuehni CE, Strippoli MP et al. Mannitol dry powder challenge in comparison with exercise testing in children. Pediatr. Pulmonol. 46(9), 842–848 (2011).
  • Kersten ET, Driessen JM, van der Berg JD et al. Mannitol and exercise challenge tests in asthmatic children. Pediatr. Pulmonol. 44(7), 655–661 (2009).
  • Porsbjerg C, Brannan JD, Anderson SD et al. Relationship between airway responsiveness to mannitol and to methacholine and markers of airway inflammation, peak flow variability and quality of life in asthma patients. Clin. Exp. Allergy 38(1), 43–50 (2008).
  • Anderson SD. Indirect challenge tests: Airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 138( 2 Suppl.), S25–S30 (2010).
  • Eggleston PA, Kagey-Sobotka A, Lichtenstein LM. A comparison of the osmotic activation of basophils and human lung mast cells. Am. Rev. Respir. Dis. 135(5), 1043–1048 (1987).
  • Brannan JD, Gulliksson M, Anderson SD et al. Evidence of mast cell activation and leukotriene release after mannitol inhalation. Eur. Respir. J. 22(3), 491–496 (2003).
  • Brannan JD, Anderson SD, Freed R et al. Nedocromil sodium inhibits responsiveness to inhaled mannitol in asthmatic subjects. Am. J. Respir. Crit. Care Med. 161(6), 2096–2099 (2000).
  • Brannan JD, Gulliksson M, Anderson SD et al. Inhibition of mast cell pgd2 release protects against mannitol-induced airway narrowing. Eur. Respir. J. 27(5), 944–950 (2006).
  • Brannan JD, Koskela H, Anderson SD et al. Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects. Respirology 7(1), 37–44 (2002).
  • Brannan JD, Anderson SD, Gomes K et al. Fexofenadine decreases sensitivity to and montelukast improves recovery from inhaled mannitol. Am. J. Respir. Crit. Care Med. 163(6), 1420–1425 (2001).
  • Currie GP, Haggart K, Lee DK et al. Effects of mediator antagonism on mannitol and adenosine monophosphate challenges. Clin. Exp. Allergy 33(6), 783–788 (2003).
  • Anderson SD, Brannan JD, Perry CP et al. Sodium cromoglycate alone and in combination with montelukast on the airway response to mannitol in asthmatic subjects. J. Asthma 47(4), 429–433 (2010).
  • Singapuri A, McKenna S, Brightling CE. The utility of the mannitol challenge in the assessment of chronic cough: a pilot study. Cough 4, 10 (2008).
  • Stolz D, Anderson SD, Gysin C et al. Airway reactivity to inhaled mannitol in cigarette smokers: a longitudinal study. Respir. Med. 101(7), 1470–1476 (2007).
  • Backer V, Nolte H, Pedersen L, Dam N, Harving H. Unawareness and undertreatment of asthma: follow-up in a different geographic area in Denmark. Allergy 64(8), 1179–1184 (2009).
  • Leuppi JD, Salome CM, Jenkins CR et al. Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids. Am. J. Respir. Crit. Care Med. 163(2), 406–412 (2001).
  • Brannan JD, Perry C, Anderson SD. Mannitol test results in asthmatics receiving inhaled corticosteroids. J. Allergy Clin. Immunol. 131(6), 906–907 (2013)
  • Porsbjerg C, Rasmussen L, Thomsen SF et al. Response to mannitol in asymptomatic subjects with airway hyper-responsiveness to methacholine. Clin. Exp. Allergy 37(1), 22–28 (2007).
  • Backer V, Groth S, Dirksen A et al. Sensitivity and specificity of the histamine challenge test for the diagnosis of asthma in an unselected sample of children and adolescents. Eur. Respir. J. 4(9), 1093–1100 (1991).
  • Kolnaar BG, Folgering H, van den Hoogen HJ, van Weel C. Asymptomatic bronchial hyperresponsiveness in adolescents and young adults. Eur. Respir. J. 10(1), 44–50 (1997).
  • Stevens WJ, Vermeire PA. Bronchial responsiveness to histamine and allergen in patients with asthma, rhinitis, cough. Eur. J. Respir. Dis. 61(4), 203–212 (1980).
  • Scherr A, Schafroth Török S, Jochmann A et al. Response to add-on inhaled corticosteroids in COPD based on airway hyperresponsiveness to mannitol. Chest 142(4), 919–926 (2012).
  • Kippelen P, Anderson SD. Airway injury during high-level exercise. Br. J. Sports Med. 46(6), 385–390 (2012).
  • Holzer K, Anderson SD, Chan HK et al. Mannitol as a challenge test to identify exercise-induced bronchoconstriction in elite athletes. Am. J. Respir. Crit. Care Med. 167(4), 534–537 (2003).
  • Porsbjerg C, Brannan JD. Alternatives to exercise challenge for the objective assessment of exercise-induced bronchospasm: eucapnic vountary hypernoea and the osmotic challlenge tests. Breathe 7(1), 53–63 (2010).
  • Brannan JD, Koskela H, Anderson SD et al. Responsiveness to mannitol in asthmatic subjects with exercise- and hyperventilation-induced asthma. Am. J. Respir. Crit. Care Med. 158(4), 1120–1126 (1998).
  • Miedinger D, Chhajed PN, Tamm M et al. Diagnostic tests for asthma in firefighters. Chest 131(6), 1760–1767 (2007).
  • Miedinger D, Mosimann N, Meier R et al. Asthma tests in the assessment of military conscripts. Clin. Exp. Allergy 40(2), 224–231 (2010).
  • Anderson WJ, Lipworth BJ. Relationship of mannitol challenge to methacholine challenge and inflammatory markers in persistent asthmatics receiving inhaled corticosteroids. Lung 190(5), 513–521 (2012).
  • Leuppi JD, Salome CM, Jenkins CR et al. Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma. Eur. Respir. J. 18(3), 444–450 (2001).
  • Lipworth BJ, Short PM, Williamson PA, Clearie KL, Fardon TC, Jackson CM. A randomized primary care trial of steroid titration against mannitol in persistent asthma: STAMINA trial. Chest 141(3), 607–615 (2012).
  • Baraket M, Oliver BG, Burgess JK, Lim S, King GG, Black JL. Is low dose inhaled corticosteroid therapy as effective for inflammation and remodeling in asthma? A randomized, parallel group study. Respir. Res. 13, 11 (2012).

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