Advances in the diagnosis of exercise-induced bronchoconstriction

References

• Adams F. The extant works of aretaeus: the cappadocian. Sydenham Society; London, UK: 1856
   Google Scholar
• Ansley L, Kippelen P, Dickinson J, Hull J. Misdiagnosis of exercise-induced bronchoconstriction in professional soccer players. Allergy 2012;67(3):390-5
   PubMed Web of Science ®Google Scholar
• Ansley L, Rae G, Hull JH. Practical approach to exercise-induced bronchoconstriction in athletes. Prim Care Respir J 2013;22(1):122-5
   Google Scholar
• Fitch KD. An overview of asthma and airway hyper-responsiveness in Olympic athletes. Br J Sports Med 2012;46(6):413-16
   PubMed Web of Science ®Google Scholar
• Hull J, Ansley L, Garrod R, Dickinson JW. Exercise-induced bronchoconstriction in athletes-should we screen? Med Sci Sports Exerc 2007;39(12):2117-24
   PubMed Web of Science ®Google Scholar
• Parsons JP, Mastronarde JG. Exercise-induced bronchoconstriction in athletes. Chest 2005;128(6):3966
   PubMed Web of Science ®Google Scholar
• Price OJ, Ansley L, Menzies-Gow A, et al. Airway dysfunction in elite athletes – an occupational lung disease? Allergy 2013;68(11):1343-52
   PubMed Web of Science ®Google Scholar
• Molphy J, Dickinson J, Hu J, et al. Prevalence of bronchoconstriction induced by eucapnic voluntary hyperpnoea in recreationally active individuals. J Asthma 2014;51(1):44-50
   Web of Science ®Google Scholar
• Weiler JM, Bonini S, Coifman R, et al. Ad Hoc Committee of Sports Medicine Committee of American Academy of Allergy, Asthma & Immunology. American Academy of Allergy, Asthma & Immunology Work Group Report: exercise-induced asthma. J Allergy Clin Immunol 2007;119(6):1349-58
   PubMed Web of Science ®Google Scholar
• Parsons JP, Hallstrand TS, Mastronarde JG, et al. An Official American Thoracic Society Clinical Practice Guideline: exercise-induced bronchoconstriction. Am J Respir Crit Care Med 2013;187(9):1016-27
   PubMed Web of Science ®Google Scholar
• Bonini M, Lapucci G, Petrelli G, et al. Predictive value of allergy and pulmonary function tests for the diagnosis of asthma in elite athletes. Allergy 2007;62(10):1166-70
   PubMed Web of Science ®Google Scholar
• Rundell KW, Im J, Mayers LB, et al. Self-reported symptoms and exercise-induced asthma in the elite athlete. Med Sci Sports Exerc 2001;33(2):208
   PubMed Web of Science ®Google Scholar
• Fitch KD, Sue-Chu M, Anderson SD, et al. Asthma and the elite athlete: summary of the International Olympic Committee's consensus conference, Lausanne, Switzerland, January 22-24, 2008. J Allergy Clin Immunol 2008;122(2):254-60. e257
   PubMed Web of Science ®Google Scholar
• Godfrey S, Fitch KD. Exercise-induced bronchoconstriction: celebrating 50 years. Immunol Allergy Clin North Am 2013;33(3):283-97
   Google Scholar
• Anderson SD, Daviskas E. The mechanism of exercise-induced asthma is. J Allergy Clin Immunol 2000;106(3):453-9
   PubMed Web of Science ®Google Scholar
• Anderson SD, Kippelen P. Airway injury as a mechanism for exercise-induced bronchoconstriction in elite athletes. J Allergy Clin Immunol 2008;122(2):225-35
   PubMed Web of Science ®Google Scholar
• Anderson S, Kippelen P. Exercise-induced bronchoconstriction: pathogenesis. Curr Allergy Asthma Rep 2005;5(2):116-22
   PubMed Web of Science ®Google Scholar
• Hallstrand TS, Altemeier WA, Aitken ML, Henderson WR. Role of cells and mediators in exercise-induced bronchoconstriction. Immunol Allergy Clin North Am 2013;33(3):313-28
   PubMedGoogle Scholar
• Niinimaa V, Cole P, Mintz S, Shephard R. The switching point from nasal to oronasal breathing. Respir Physiol 1980;42(1):61-71
   PubMedGoogle Scholar
• Helenius IJ, Tikkanen HO, Haahtela T. Occurrence of exercise induced bronchospasm in elite runners: dependence on atopy and exposure to cold air and pollen. Br J Sports Med 1998;32(2):125-9
   PubMedGoogle Scholar
• Helenius IJ, Tikkanen HO, Sarna S, Haahtela T. Asthma and increased bronchial responsiveness in elite athletes: atopy and sport event as risk factors. J Allergy Clin Immunol 1998;101(5):646-52
   PubMed Web of Science ®Google Scholar
• Hallstrand TS. New Insights into to Pathogenesis of Exercise-induced Bronchoconstriction. Curr Opin Allergy Clin Immunol 2012;12(1):42
   Web of Science ®Google Scholar
• Hallstrand TS, Moody MW, Wurfel MM, et al. Inflammatory basis of exercise-induced bronchoconstriction. Am J Respir Crit Care Med 2005;172(6):679
   PubMed Web of Science ®Google Scholar
• Mickleborough TD, Lindley MR, Ray S. Dietary salt, airway inflammation, and diffusion capacity in exercise-induced asthma. Med Sci Sports Exerc 2005;37(6):904-14
   PubMed Web of Science ®Google Scholar
• Mickleborough TD, Murray RL, Ionescu AA, Lindley MR. Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. Am J Respir Crit Care Med 2003;168(10):1181
   PubMed Web of Science ®Google Scholar
• Hallstrand TS, Debley JS, Farin FM, Henderson WR Jr. Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction. J Allergy Clin Immunol 2007;119(5):1092-8
   PubMed Web of Science ®Google Scholar
• Bolger C, Tufvesson E, Anderson SD, et al. Effect of inspired air conditions on exercise-induced bronchoconstriction and urinary CC16 levels in athletes. J Appl Physiol 2011;111(4):1059-65
   PubMed Web of Science ®Google Scholar
• Karjalainen E, Laitinen A, Sue-Chu M, et al. Evidence of airway inflammation and remodeling in ski athletes with and without bronchial hyperresponsiveness to methacholine. Am J Respir Crit Care Med 2000;161(6):2086
   PubMed Web of Science ®Google Scholar
• Kippelen P, Anderson SD. Airway injury during high-level exercise. Br J Sports Med 2012;46(6):385-90
   PubMed Web of Science ®Google Scholar
• Hull J, Hull P, Parsons J, et al. Approach to the diagnosis and management of suspected exercise-induced bronchoconstriction by primary care physicians. BMC Pulm Med 2009;9(1):29
   PubMedGoogle Scholar
• Turcotte H, Langdeau J-B, Thibault G, Boulet L-P. Prevalence of respiratory symptoms in an athlete population. Respir Med 2003;97(8):955-63
   PubMed Web of Science ®Google Scholar
• Langdeau J-B, Boulet L-P. Is asthma over-or under-diagnosed in athletes? Respir Med 2003;97(2):109-14
   Google Scholar
• Dickinson J, McConnell A, Whyte G. Diagnosis of exercise-induced bronchoconstriction: eucapnic voluntary hyperpnoea challenges identify previously undiagnosed elite athletes with exercise-induced bronchoconstriction. Br J Sports Med 2011;45(14):1126-31
   Google Scholar
• Parsons JP, Kaeding C, Phillips G, et al. Prevalence of exercise-induced bronchospasm in a cohort of varsity college athletes. Med Sci Sports Exerc 2007;39(9):1487
   PubMed Web of Science ®Google Scholar
• Hallstrand TS, Curtis JR, Koepsell TD, et al. Effectiveness of screening examinations to detect unrecognized exercise-induced bronchoconstriction. J Pediatr 2002;141(3):343-9
   PubMed Web of Science ®Google Scholar
• Boulet LP. Asymptomatic airway hyperresponsiveness: a curiosity or an opportunity to prevent asthma? Am J Respir Crit Care Med 2003;167(3):371
   PubMed Web of Science ®Google Scholar
• Yoo Y, Choung JT, Yu J, et al. Comparison of Percentage Fall in FVC at the Provocative Concentration of Methacholine Causing a 20% Fall in FEV1 Between Patients With Asymptomatic Bronchial Hyperresponsiveness and Mild Asthma*. Chest 2007;132(1):106-11
   PubMed Web of Science ®Google Scholar
• Carlsen K, Anderson S, Bjermer L, et al. Exercise-induced asthma, respiratory and allergic disorders in elite athletes: epidemiology, mechanisms and diagnosis: Part I of the report from the Joint Task Force of the European Respiratory Society (ERS) and the European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA2LEN. Allergy 2008;63(4):387-403
   PubMed Web of Science ®Google Scholar
• Kujala UM, Sarna S, Kaprio J, Koskenvuo M. Asthma and other pulmonary diseases in former elite athletes. Thorax 1996;51(3):288-92
   PubMed Web of Science ®Google Scholar
• Becker JM, Rogers J, Rossini G, et al. Asthma deaths during sports: report of a 7-year experience. J Allergy Clin Immunol 2004;113(2):264-7
   PubMed Web of Science ®Google Scholar
• Amital H, Glikson M, Burstein M, et al. Clinical characteristics of unexpected death among young enlisted military personnel results of a three-decade retrospective surveillance. Chest 2004;126(2):528-33
   Google Scholar
• Abramson MJ, Walters J, Walters EH. Adverse Effects of β-Agonists. Am J Respir Med 2003;2(4):287-97
   PubMedGoogle Scholar
• Bonini M, Di Mambro C, Calderon MA, et al. Beta2-agonists for exercise-induced asthma. Cochrane Database System Rev 2013;(10): CD003564
   Google Scholar
• World Anti-Doping Agency. Medical information to support the decisions of TUECs asthma (Version 5.0); 2013. Available from: www.wada-ama.org/Documents/Science_Medicine/Medical_info_to_support_TUECs/WADA-Medical-info-Asthma-5.0-EN.pdf
   Google Scholar
• Anderson S, Brusasco V, Haahtela T, Popov T. Criteria for diagnosis of asthma, EIB and AHR for athletes: lessons from the Olympic Games. Eur Respir Mon 2005;33:48
   Google Scholar
• Anderson SD. Indirect Challenge TestsAirway Hyperresponsiveness in Asthma: its Measurement and Clinical Significance. Chest 2010;138(2 Suppl):25S-30S
   PubMed Web of Science ®Google Scholar
• Crapo R, Casaburi R, Coates A, et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 2000;161(1):309
   PubMed Web of Science ®Google Scholar
• Weiler JM, Anderson SD, Randolph C, et al. Pathogenesis, prevalence, diagnosis, and management of exercise-induced bronchoconstriction: a practice parameter. Ann Allergy Asthma Immunol 2010;105(6):S1-S47
   PubMedGoogle Scholar
• Cockcroft DW. Direct Challenge tests airway hyper responsiveness in asthma: its measurement and clinical significance. Chest 2010;138(2 Suppl):18S-24S
   PubMed Web of Science ®Google Scholar
• Rundell KW, Slee JB. Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes. J Allergy Clin Immunol 2008;122(2):238-46
   PubMed Web of Science ®Google Scholar
• Anderson SD, Holzer K. Exercise-induced asthma: is it the right diagnosis in elite athletes? J Allergy Clin Immunol 2000;106(3):419-28
   PubMed Web of Science ®Google Scholar
• Porsbjerg C, Brannan JD. Alternatives to exercise challenge for the objective assessment of exercise-induced bronchospasm: eucapnic voluntary hyperpnoea and the osmotic challenge tests. Breathe 2010;7:52-63
   Google Scholar
• Dryden DM, Spooner CH, Stickland MK, et al. Exercise-induced bronchoconstriction and asthma. Evidence report/technology asssessment 189. Agency for Healthcare Research and Quality; Rockville, MD, USA: 2010
   Google Scholar
• Sumino K, Sugar EA, Irvin CG, et al. Methacholine challenge test: diagnostic characteristics in asthmatic patients receiving controller medications. J Allergy Clin Immunol 2012;130(1):69-75. e66
   PubMed Web of Science ®Google Scholar
• Bhagat R, Grunstein M. Comparison of responsiveness to methacholine, histamine, and exercise in subgroups of asthmatic children. Am Rev Respir Dis 1984;129(2):221-4
   PubMedGoogle Scholar
• Toelle B, Peat J, Salome C, et al. Comparison of two epidemiological protocols for measuring airway responsiveness and allergic sensitivity in adults. Eur Respir J 1994;7(10):1798-804
   Google Scholar
• Juniper E, Frith P, Dunnett C, et al. Reproducibility and comparison of responses to inhaled histamine and methacholine. Thorax 1978;33(6):705-10
   PubMed Web of Science ®Google Scholar
• Chatham M, Bleecker E, Smith P, et al. A comparison of histamine, methacholine, and exercise airway reactivity in normal and asthmatic subjects. Am Rev Respir Dis 1982;126(2):235
   PubMed Web of Science ®Google Scholar
• Higgins B, Britton J, Chinn S, et al. Comparison of histamine and methacholine for use in bronchial challenge tests in community studies. Thorax 1988;43(8):605-10
   Web of Science ®Google Scholar
• Anderson SD, Charlton B, Weiler JM, et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res 2009;10:4
   Google Scholar
• Cockcroft DW, Davis BE, Todd DC, Smycniuk AJ. Methacholine challenge comparison of two methods. Chest 2005;127(3):839-44
   Google Scholar
• Ryan G, Dolovich M, Roberts R, et al. Standardization of inhalation provocation tests: two techniques of aerosol generation and inhalation compared. Am Rev Respir Dis 1981;123(2):195-9
   PubMed Web of Science ®Google Scholar
• Todd DC, Davis BE, Hurst TS, Cockcroft DW. Dosimeter methacholine challenge: comparison of maximal versus submaximal inhalations. J Allergy Clin Immunol 2004;114(3):517-19
   Google Scholar
• Allen ND, Davis BE, Hurst TS, Cockcroft DW. Difference between dosimeter and tidal breathing methacholine challengecontributions of dose and deep inspiration bronchoprotection. Chest 2005;128(6):4018-23
   PubMed Web of Science ®Google Scholar
• Cockcroft DW, Davis BE. The bronchoprotective effect of inhaling methacholine by using total lung capacity inspirations has a marked influence on the interpretation of the test result. J Allergy Clin Immunol 2006;117(6):1244-8
   Google Scholar
• Holzer K, Anderson SD, Douglass J. Exercise in elite summer athletes: challenges for diagnosis. J Allergy Clin Immunol 2002;110(3):374-80
   PubMed Web of Science ®Google Scholar
• Silverman M, Anderson SD. Standardization of exercise tests in asthmatic children. Arch Dis Child 1972;47(256):882-9
   PubMed Web of Science ®Google Scholar
• Rundell KW, Wilber RL, Szmedra L, et al. Exercise-induced asthma screening of elite athletes: field versus laboratory exercise challenge. Med Sci Sports Exerc 2000;32(2):309-16
   PubMed Web of Science ®Google Scholar
• Anderson SD, Pearlman DS, Rundell KW, et al. Reproducibility of the airway response to an exercise protocol standardized for intensity, duration, and inspired air conditions, in subjects with symptoms suggestive of asthma. Respir Res 2010;11:120
   PubMed Web of Science ®Google Scholar
• Eliasson A, Phillips Y, Rajagopal K, Howard R. Sensitivity and specificity of bronchial provocation testing. An evaluation of four techniques in exercise-induced bronchospasm. Chest 1992;102(2):347-55
   PubMed Web of Science ®Google Scholar
• Holzer K, Douglass J. Exercise induced bronchoconstriction in elite athletes: measuring the fall. Thorax 2006;61(2):94-6
   Google Scholar
• Mannix ET, Manfredi F, Farber MO. A comparison of two challenge tests for identifying exercise-induced bronchospasm in figure skaters. Chest 1999;115(3):649-53
   PubMed Web of Science ®Google Scholar
• Rundell KW, Anderson SD, Spiering BA, Judelson DA. Field exercise vs laboratory eucapnic voluntary hyperventilation to identify airway hyperresponsiveness in elite cold weather athletes. Chest 2004;125(3):909-15
   PubMed Web of Science ®Google Scholar
• Argyros GJ, Roach JM, Hurwitz KM, et al. Eucapnic voluntary hyperventilation as a bronchoprovocation technique. Chest 1996;109(6):1520-4
   PubMed Web of Science ®Google Scholar
• Anderson S, Argyros G, Magnussen H, Holzer K. Provocation by eucapnic voluntary hyperpnoea to identify exercise induced bronchoconstriction. Br J Sports Med 2001;35(5):344-7
   PubMed Web of Science ®Google Scholar
• Brummel NE, Mastronarde JG, Rittinger D, et al. The clinical utility of eucapnic voluntary hyperventilation testing for the diagnosis of exercise-induced bronchospasm. J Asthma 2009;46(7):683-6
   PubMed Web of Science ®Google Scholar
• Hurwitz KM, Argyros GJ, Roach JM, et al. Interpretation of eucapnic voluntary hyperventilation in the diagnosis of asthma. Chest 1995;108(5):1240-5
   Google Scholar
• Stadelmann K, Stensrud T, Carlsen KH. Respiratory symptoms and bronchial responsiveness in competitive swimmers. Med Sci Sports Exerc 2011;43(3):375-81
   PubMed Web of Science ®Google Scholar
• Brannan J, Gulliksson M, Anderson S, et al. Evidence of mast cell activation and leukotriene release after mannitol inhalation. Eur Respir J 2003;22(3):491-6
   PubMed Web of Science ®Google Scholar
• Brannan J, Gulliksson M, Anderson S, et al. Inhibition of mast cell PGD2 release protects against mannitol-induced airway narrowing. Eur Respir J 2006;27(5):944-50
   PubMed Web of Science ®Google Scholar
• Smith C, Anderson S. Inhalational challenge using hypertonic saline in asthmatic subjects: a comparison with responses to hyperpnoea, methacholine and water. Eur Respir J 1990;3(2):144-51
   PubMed Web of Science ®Google Scholar
• Brannan JD, Anderson SD, Perry CP, et al. The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline. Respir Res 2005;6(1):144
   Google Scholar
• Riedler J, Reade T, Dalton M, et al. Hypertonic saline challenge in an epidemiologic survey of asthma in children. Am J Respir Crit Care Med 1994;150(6):1632-9
   Google Scholar
• Bonini M, Braido F, Baiardini I, et al. AQUA: allergy questionnaire for athletes. Development and validation. Med Sci Sports Exerc 2009;41(5):1034-41
   PubMedGoogle Scholar
• Helenius IJ, Tikkanen HO, Haahtela T. Occurrence of exercise induced bronchospasm in elite runners: dependence on atopy and exposure to cold air and pollen. Br J Sports Med 1998;32(2):125
   PubMedGoogle Scholar
• Lee JH, Lee YW, Shin YS, et al. Exercise-induced airway obstruction in young asthmatics measured by impulse oscillometry. J Investig Allergol Clin Immunol 2010;20(7):575-81
   PubMed Web of Science ®Google Scholar
• Carvalhaes-Neto N, Lorino H, Gallinari C, et al. Cognitive function and assessment of lung function in the elderly. Am J Respir Crit Care Med 1995;152(5):1611-15
   Google Scholar
• Zerah F, Lorino A-M, Lorino H, et al. Forced oscillation technique vs spirometry to assess bronchodilatation in patients with asthma and COPD. Chest 1995;108(1):41-7
   Google Scholar
• Vink GR, Arets HG, van der Laag J, van der Ent CK. Impulse oscillometry: a measure for airway obstruction. Pediatr Pulmonol 2003;35(3):214-19
   PubMed Web of Science ®Google Scholar
• Buhr W, Jörres R, Berdel D, Làndsér FJ. Correspondence between forced oscillation and body plethysmography during bronchoprovocation with carbachol in children. Pediatr Pulmonol 1990;8(4):280-8
   Google Scholar
• Naji N, Keung E, Kane J, et al. Comparison of changes in lung function measured by plethymography and IOS after bronchoprovocation. Respir Med 2013;107(4):503-10
   Google Scholar
• Rundell KW, Evans TM, Baumann JM, Kertesz MF. Lung function measured by impulse oscillometry and spirometry following eucapnic voluntary hyperventilation. Can Respir J 2005;12(5):257-63
   Google Scholar
• Evans TM, Rundell KW, Beck KC, et al. Impulse oscillometry is sensitive to bronchoconstriction after eucapnic voluntary hyperventilation or exercise. J Asthma 2006;43(1):49-55
   PubMed Web of Science ®Google Scholar
• Evans TM, Rundell KW, Beck KC, et al. Airway narrowing measured by spirometry and impulse oscillometry following room temperature and cold temperature exercise. Chest 2005;128(4):2412-19
   PubMedGoogle Scholar
• Carraro S, Corradi M, Zanconato S, et al. Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise-induced bronchoconstriction. J Allergy Clin Immunol 2005;115(4):764-70
   PubMed Web of Science ®Google Scholar
• Peroni DG, Chinellato I, Piazza M, et al. Exhaled breath temperature and exercise‐induced bronchoconstriction in asthmatic children. Pediatr Pulmonol 2012;47(3):240-4
   Google Scholar
• ElHalawani SM, Ly NT, Mahon RT, Amundson DE. Exhaled nitric oxide as a predictor of exercise-induced bronchoconstriction. Chest 2003;124(2):639-43
   PubMed Web of Science ®Google Scholar
• Barreto M, Zambardi R, Villa MP. Exhaled Nitric Oxide and other exhaled biomarkers in bronchial challenge with exercise in asthmatic children: current knowledge. Paediatr Respir Rev 2013. [Epub ahead of print]
   Google Scholar
• Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 2012;184:5
   Google Scholar
• Feitosa L, Dornelas de Andrade A, Reinaux C, Britto M. Diagnostic accuracy of exhaled nitric oxide in exercise-induced bronchospasm: systematic review. Rev Port Pneumol 2012;18(4):198-204
   Google Scholar
• Hull JH, Ansley L, Robson-Ansley P, Parsons JP. Managing respiratory problems in athletes. Clin Med 2012;12(4):351-6
   PubMed Web of Science ®Google Scholar
• Walsted NE, Hull JH, Backer V. High prevalence of exercise-induced laryngeal obstruction in athletes. Med Sci Sports Exerc 2013;45(11):2030-5
   Google Scholar
• Rundell KW, Weiss P. Exercise-induced bronchoconstriction and vocal cord dysfunction: two sides of the same coin? Curr Sports Med Rep 2013;12(1):45-50
   Google Scholar
• Anderson SD, Brannan JD. Methods for “indirect” challenge tests including exercise, eucapnic voluntary hyperpnea, and hypertonic aerosols. Clin Rev Allergy Immunol 2003;24(1):27-54
   PubMed Web of Science ®Google Scholar
• Price OJ, Hull JH. Asthma in elite athletes – who cares? Clin Pulm Med 2013; In press
   Google Scholar