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Original research

Cardiovascular risk in pulmonary alveolar proteinosis

, , , , , , , , , , & show all
Pages 235-240 | Received 08 Aug 2015, Accepted 02 Nov 2015, Published online: 27 Nov 2015

References

•  A review paper of interest about all forms of pulmonary alveolar proteinosis focusing on new evidence about the role of new treatments, mostly inhaled GM-CSF, in autoimmune pulmonary alveolar proteinosis

•• An excellent review describing the history and the progress concerning pulmonary alveolar proteinosis

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•• An excellent research paper demonstrating that idiopathic pulmonary alveolar proteinosis is an autoimmune disease related with neutralizing antibody against granulocyte macrophage colony stimulating factor leading to alveolar macrophage dysfunction

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• An important paper about the characteristics of 223 patients with autoimmune PAP in Japan as well as about the role of the disease severity score and biomarkers in the outcome of the disease

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• Important paper about the characteristics of 70 patients with PAP in Europe. Significant insights are provided about the role of environmental exposures and smoking as well as about the response of patients to treatment with whole lung lavage

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•• An excellent paper about the role of anti-GM-CSF antibodies in pediatric pulmonary alveolar proteinosis

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•• Excellent research paper about inhaled GM-CSF as treatment for autoimmune pulmonary alveolar proteinosis.

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•• Excellent paper about how the loss of GM-CSF signaling blocks terminal differentiation of alveolar macrophages impairing processing of surfactant as well as many host defenses

  • Bonella F, Theegarten D, Guzman J, et al. Alveolar lipoproteinosis syndromes. Eur Respir Mon. 2011;54:171–186.

• An important review paper about lipoproteinosis syndromes.

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