References
- Papers of special note have been highlighted as:
- • of interest
- •• of considerable interest
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• First account of a perceptual difference of individuals to phenylthiocarbamide.
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• Landmark study confirming the molecular basis of individual differences in perception of phenylthiocarbamide.
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•• Extensive study of the breadth of sensitivity of T2R receptors to both natural and synthetic bitter compounds.
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•• The first study to identify solitary chemosensory cells in mammals and demonstrate functional T2R expression in the respiratory epithelium.
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• First study to demonstrate that acyl-homoserine lactones activate murine solitary chemosensory cells via the canonical taste transduction cascade.
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•• Proof that bitter compounds produced by Pseudomonas aeruginosa stimulate intracellular transduction of taste signaling components in human respiratory epithelium.
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•• Study establishing that solitary chemosensory cells (SCCs) release acetylcholine to activate neurogenic inflammation and recruit the immune system.
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• Study identifying SCC-like cells in the trachea and establishing that they release acetylcholine to regulate respiratory rate.
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