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Drug Profile

Canakinumab: a human anti-IL-1β monoclonal antibody for the treatment of cryopyrin-associated periodic syndromes

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Pages 831-841 | Published online: 10 Jan 2014

References

  • Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J. NALP3 forms an IL-l β-processing inflammasome with increased activity in Muckle–Wells autoinflammatory disorder. Immunity20(3), 319–325 (2004).
  • Kile RL, Rusk HA. A case of cold urticaria with an unusual family history. JAMA114, 1067–1068 (1940).
  • Church LD, Churchman SM, Hawkins PN, McDermott MF. Hereditary auto-inflammatory disorders and biologics. Springer Semin. Immunopathol.27(4), 494–508 (2006).
  • Muckle T, Wells M. Urticaria, deafness, and amyloidosis: a new heredo-familial syndrome. Q. J. Med.31235–31248 (1962).
  • Lorber J. Syndrome for diagnosis: dwarfing, persistently open fontanelle; recurrent meningitis; recurrent subdural effusions with temporary alternate-sided hemiplegia; high-tone deafness; visual defect with pseudopapilloedema; slowing intellectual development; recurrent acute polyarthritis; erythema marginatum, splenomegaly and iron-resistant hypochromic anaemia. Proc. R. Soc. Med.66(11), 1070–1071 (1973).
  • Kummer JA, Broekhuizen R, Everett H et al. Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J. Histochem. Cytochem.55(5), 443–452 (2007).
  • Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell10(2), 417–426 (2002).
  • Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature440(7081), 237–241 (2006).
  • Cassel SL, Eisenbarth SC, Iyer SS et al. The Nalp3 inflammasome is essential for the development of silicosis. Proc. Natl Acad. Sci. USA105(26), 9035–9040 (2008).
  • Eisenbarth SC, Colegio OR, O’Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature453(7198), 1122–1126 (2008).
  • Muruve DA, Petrilli V, Zaiss AK et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature452(7183), 103–107 (2008).
  • Petrilli V, Papin S, Dostert C, Mayor A, Martinon F, Tschopp J. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ.14(9), 1583–1589 (2007).
  • Lachmann HJ, Lowe P, Felix SD et al.In vivo regulation of interleukin 1b in patients with cryopyrin-associated periodic syndromes. J. Exp. Med.206(5), 1029–1036 (2009).
  • Hawkins PN, Lachmann HJ, McDermott MF. Interleukin-1-receptor antagonist in the Muckle–Wells syndrome. N. Engl. J. Med.348(25), 2583–2584 (2003).
  • Goldbach-Mansky R, Dailey NJ, Canna SW et al. Neonatal-onset multisystem inflammatory disease responsive to interleukin-1β inhibition. N. Engl. J. Med.355(6), 581–592 (2006).
  • Hoffman HM, Throne ML, Amar NJ et al. Efficacy and safety of rilonacept (interleukin-1 trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum.58(8), 2443–2452 (2008).
  • Dode C, Cuisset L, Delpech M, Grateau G. TNFRSF1A-associated periodic syndrome (TRAPS), Muckle–Wells syndrome (MWS) and renal amyloidosis. J. Nephrol.16(3), 435–437 (2003).
  • Hashkes PJ, Lovell DJ. Recognition of infantile-onset multisystem inflammatory disease as a unique entity. J. Pediatr.130(4), 513–515 (1997).
  • Church LD, Cook GP, McDermott MF. Primer: inflammasomes and interleukin 1b in inflammatory disorders. Nat. Clin. Pract. Rheumatol.4(1), 34–42 (2008).
  • Hawkins PN, Bybee A, Aganna E, McDermott MF. Response to anakinra in a de novo case of neonatal-onset multisystem inflammatory disease. Arthritis Rheum.50(8), 2708–2709 (2004).
  • Hoffman HM, Rosengren S, Boyle DL et al. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet364(9447), 1779–1785 (2004).
  • Leslie KS, Lachmann HJ, Bruning E et al. Phenotype, genotype, and sustained response to anakinra in 22 patients with autoinflammatory disease associated with CIAS-1/NALP3 mutations. Arch. Dermatol.142(12), 1591–1597 (2006).
  • Maksimovic L, Stirnemann J, Caux F et al. New CIAS1 mutation and anakinra efficacy in overlapping of Muckle–Wells and familial cold autoinflammatory syndromes. Rheumatology (Oxford)47(3), 309–310 (2008).
  • Mirault T, Launay D, Cuisset L et al. Recovery from deafness in a patient with Muckle–Wells syndrome treated with anakinra. Arthritis Rheum.54(5), 1697–1700 (2006).
  • O’Connell SM, O’Regan GM, Bolger T et al. Response to IL-1-receptor antagonist in a child with familial cold autoinflammatory syndrome. Pediatr. Dermatol.24(1), 85–89 (2007).
  • Ross JB, Finlayson LA, Klotz PJ et al. Use of anakinra (Kineret) in the treatment of familial cold autoinflammatory syndrome with a 16-month follow-up. J. Cutan. Med. Surg.12(1), 8–16 (2008).
  • Rynne M, Maclean C, Bybee A, McDermott MF, Emery P. Hearing improvement in a patient with variant Muckle–Wells syndrome in response to interleukin 1 receptor antagonism. Ann. Rheum. Dis.65(4), 533–534 (2006).
  • Neven B, Marvillet I, Terrada C et al. Long-term efficacy of the interleukin-1 receptor antagonist anakinra in ten patients with neonatal-onset multisystem inflammatory disease/chronic infantile neurologic, cutaneous, articular syndrome. Arthritis Rheum.62(1), 258–267 (2010).
  • Miyamae T, Inaba Y, Nishimura G et al. Effect of anakinra on arthropathy in CINCA/NOMID syndrome. Pediatr. Rheumatol. Online J.8, 9 (2010).
  • Ratner M. IL-1 trap go-ahead. Nat. Biotechnol.26(5), 485 (2008).
  • Goldbach-Mansky R, Shroff SD, Wilson M et al. A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 trap) in patients with familial cold autoinflammatory syndrome. Arthritis Rheum.58(8), 2432–2442 (2008).
  • Hashkes P, Lovell D, Giannini E, Huang B, Kastner D. Rilonacept (IL-1 trap) for treatment of colchicine resistant familial mediterranean fever: a randomized, multicenter double-blinded, alternating treatment (n of 1) trial. Clin. Exp. Rheumatol.26(2), 193 (2008).
  • Lovell D, Giannini E, Kimura Y et al. Preliminary evidence for bioactivity of IL-1 trap (rilonacept), a long acting IL-1 inhibitor, in systemic juvenile idiopathic arthritis. Ann. Rheum. Dis.65(Suppl. 2), 693 (2006).
  • Lovell DJ, Giannini EH, Kimura Y et al. Preliminary evidence for bioactivity of IL-1 trap (rilonacept), a long acting IL-1 inhibitor, in systemic juvenile idiopathic arthritis (SJIA). Arthritis Rheum.54(9), S325–S326 (2006).
  • Radin A, Terkeltaub R, Schumacher H et al. Placebo-controlled pilot study of rilonacept (IL-1 trap), a long acting IL-1 inhibitor, in refractory chronic active gouty arthritis. Clin. Exp. Rheumatol.26(2), 181–181 (2008).
  • Terkeltaub R, Schumacher HR, Sundy J et al. Placebo-controlled pilot study of rilonacept (IL-1 trap), a long acting IL-1 inhibitor, in refractory chronic active gouty arthritis. Arthritis Rheum.56(12), 4231–4232 (2007).
  • Novartis preclinical research day. Novartis AG Company Presentation. 3 May 2005.
  • Investor relations: pharmaceutical pipeline event. Novartis AG company presentation. 20 September 2005.
  • Cook GP, Savic S, Wittmann M, McDermott MF. The NLRP3 inflammasome, a target for therapy in diverse disease states. Eur. J. Immunol.40(3), 631–634 (2010).
  • Fishwild DM, O’Donnell SL, Bengoechea T et al. High-avidity human IgG κ monoclonal antibodies from a novel strain of minilocus transgenic mice. Nat. Biotechnol.14(7), 845–851 (1996).
  • Bonner J, Lloyd P, Lowe P, Golor G, Woessner R, Pascoe S. PK/PD, safety and tolerability of a human anti-IL-1β monoclonal antibody (ACZ885) in healthy subjects. Presented at: 16th Annual Congress of the European Respiratory Society. Munich, Germany, 2–6 September 2006 (Abstract 748).
  • Alten R, Gram H, Joosten LA et al. The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis. Arthritis Res.Ther.10(3), R67 (2008).
  • Alten R, Pohl C, Batard Y et al. ACR 20/50/70 responses in methotrexate(MTX)-resistent rheumatoid arthritis (RA) patients in a double-blind, placebo (PBO)-controlled Phase I/II evaluation of the pharmacokinetics/pharmacodynamics (PK/PD), safety, and preliminary efficacy of a fully human anti interleukin 1 antibody. Ann. Rheum. Dis.67(Suppl. 2), OP0178 (2007).
  • Gattorno M, Tassi S, Carta S et al. Pattern of interleukin-1β secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations. Arthritis Rheum.56(9), 3138–3148 (2007).
  • Lachmann HJ, Kone-Paut I, Kuemmerle-Deschner JB et al. Use of canakinumab in the cryopyrin-associated periodic syndrome. N. Engl. J. Med.360(23), 2416–2425 (2009).
  • Kuemmerle-Deschner JB, Tzaribachev N, Hausmann S et al. Long-lasting response to ACZ885 (a new human IgG1 anti-IL-1β monoclonal antibody) in patients with Muckle–Wells syndrome (MWS). Clin. Exp. Rheumatol.26(2), 180 (2008).
  • Lachmann HJ, Jung T, Bobadilla M et al. Treatment of Muckle–Wells syndrome with a fully human anti-IL-1β monoclonal antibody (ACZ885) – initial results from a proof of concept study. Ann. Rheum. Dis.65(Suppl. 2), 76 (2006).
  • Lachmann H, Jung T, Felix S et al. Treatment of cryopyrin associated periodic fever syndrome with a fully human anti-IL-1β monoclonal antibody (ACZ885): results from a subcutaneous administration study. Clin. Exp. Rheumatol.26(2), 181 (2008).
  • Kuemmerle-Deschner JB, Tzaribachev N, Hansmann S et al. Long lasting response to ACZ885 in patients with Muckle–Wells syndrome (MWS). Ann. Rheum. Dis.67(Suppl. 2), 104 (2008).
  • Kuemmerle-Deschner JB, Blank N, Roesdler J et al. ACZ885 (canakinumab), a new IL-1β blocking monoclonal antibody provides long-lasting remission in children with cryopyrin asociated periodic syndromes (CAPS). Arthritis Rheum.58(9 Suppl.), S633 (2008).
  • Ruperto N, Quartier P, Wulffraat N et al. ACZ885 (canakinumab), a new IL-1β blocking monoclonal antibody has a beneficial effect in children with systemic juvenile idiopathic arthritis (SJIA). Arthritis Rheum.58(9 Suppl.), S942–S943 (2008).
  • Ruperto N, Quartier P, Wulffraat N et al. A Phase II trial with canakinumab, a new IL-1β blocking monoclonal antibody (ACZ885), to evaluate preliminary dosing, safety and efficacy profile in children with systemic juvenile idiopathic arthritis (SJIA). Paediatr. Rheumatol. Online J.6(Suppl. 1), S2 (2008).
  • Pascoe S, Kanniess F, Bonner J et al. A monoclonal antibody to IL-1β attenuates the late asthmatic response to antigen challenge in patients with mild asthma. Presented at: 16th Annual Congress of the European Respiratory Society. Munich, Germany, 2–6 September 2006 (Abstract 752).
  • Kuemmerle-Deschner JB, Blank N, Roesler J et al. ACZ885 (canakinumab), a new IL-1β blocking monoclonal antibody provides long-lasting remission in children with cryopyrin associated periodic syndrome. Paediatr. Rheumatol. Online J.6(Suppl. 1), S26 (2008).
  • Allantaz F, Chaussabel D, Stichweh D et al. Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. J. Exp. Med.204(9), 2131–2144 (2007).
  • Buch M, Bingham S, Seto Y et al. Lack of response to anakinra in rheumatoid arthritis following failure of tumor necrosis factor a blockade. Arthritis Rheum.50(3), 725–728 (2004).

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