Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

References

• Angulo P. Nonalcoholic fatty liver disease. N. Engl. J. Med.346, 1221–1231 (2002).
   PubMed Web of Science ®Google Scholar
• Wieckowska A, Feldstein AE. Nonalcoholic fatty liver disease in the pediatric population: a review. Curr. Opin. Pediatr.17, 636–641 (2005).
   PubMed Web of Science ®Google Scholar
• Brunt EM, Tiniakos DG. Pathological features of NASH. Front Biosci.10, 1475–1484 (2005).
   PubMed Web of Science ®Google Scholar
• Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest.114, 147–152 (2004).
   PubMed Web of Science ®Google Scholar
• Cheung O, Sanyal AJ. Abnormalities of lipid metabolism in nonalcoholic fatty liver disease. Semin. Liver Dis.28, 351–359 (2008).
   PubMed Web of Science ®Google Scholar
• Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest.115, 1343–1351 (2005).
   PubMed Web of Science ®Google Scholar
• McClain CJ, Barve S, Deaciuc I. Good fat/bad fat. Hepatology45, 1343–1346 (2007).
   PubMed Web of Science ®Google Scholar
• Day CP, James OF. Steatohepatitis: a tale of two ‘hits’? Gastroenterology114, 842–845 (1998).
   PubMed Web of Science ®Google Scholar
• Monetti M, Levin MC, Watt MJ et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab.6, 69–78 (2007).
   PubMed Web of Science ®Google Scholar
• Listenberger LL, Han X, Lewis SE et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc. Natl Acad. Sci. USA100, 3077–3082 (2003).
   PubMed Web of Science ®Google Scholar
• Yamaguchi K, Yang L, McCall S et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology45, 1366–1374 (2007).
   PubMed Web of Science ®Google Scholar
• Unger RH. Lipotoxic diseases. Annu. Rev. Med.53, 319–336 (2002).
   PubMed Web of Science ®Google Scholar
• Li ZZ, Berk M, McIntyre TM, Feldstein AE. Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-coA desaturase. J. Biol. Chem.284, 5637–5644 (2009).
   PubMed Web of Science ®Google Scholar
• Feldstein AE, Canbay A, Angulo P et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology125, 437–443 (2003).
   PubMed Web of Science ®Google Scholar
• Delhalle S, Duvoix A, Schnekenburger M, Morceau F, Dicato M, Diederich M. An introduction to the molecular mechanisms of apoptosis. Ann. NY Acad. Sci.1010, 1–8 (2003).
   PubMed Web of Science ®Google Scholar
• Yuan J, Horvitz HR. A first insight into the molecular mechanisms of apoptosis. Cell116(2 Suppl.), S53–S56, S59 (2004).
   PubMedGoogle Scholar
• Feldstein AE, Canbay A, Guicciardi ME, Higuchi H, Bronk SF, Gores GJ. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J. Hepatol.39, 978–983 (2003).
   PubMed Web of Science ®Google Scholar
• Malhi H, Barreyro FJ, Isomoto H, Bronk SF, Gores GJ. Free fatty acids sensitize hepatocytes to TRAIL mediated cytotoxicity. Gut56, 1124–1131 (2007).
   PubMed Web of Science ®Google Scholar
• Bouchier-Hayes L, Lartigue L, Newmeyer DD. Mitochondria: pharmacological manipulation of cell death. J. Clin. Invest.115, 2640–2647 (2005).
   PubMed Web of Science ®Google Scholar
• Caldwell SH, Chang CY, Nakamoto RK, Krugner-Higby L. Mitochondria in nonalcoholic fatty liver disease. Clin. Liver Dis.8, 595–617 (2004).
   PubMedGoogle Scholar
• Fromenty B, Robin MA, Igoudjil A, Mansouri A, Pessayre D. The ins and outs of mitochondrial dysfunction in NASH. Diabetes Metab.30, 121–138 (2004).
   PubMed Web of Science ®Google Scholar
• Feldstein AE, Werneburg NW, Canbay A et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway. Hepatology40, 185–194 (2004).
   PubMed Web of Science ®Google Scholar
• Malhi H, Bronk SF, Werneburg NW, Gores GJ. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J. Biol. Chem.281, 12093–12101 (2006).
   PubMed Web of Science ®Google Scholar
• Feldstein AE, Werneburg NW, Li Z, Bronk SF, Gores GJ. Bax inhibition protects against free fatty acid-induced lysosomal permeabilization. Am. J. Physiol. Gastrointest. Liver Physiol.290, G1339–G1346 (2006).
   PubMed Web of Science ®Google Scholar
• Li Z, Berk M, McIntyre TM, Gores GJ, Feldstein AE. The lysosomal–mitochondrial axis in free fatty acid-induced hepatic lipotoxicity. Hepatology47, 1495–1503 (2008).
   PubMed Web of Science ®Google Scholar
• Mao C, Dong D, Little E, Luo S, Lee AS. Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo. Nat. Med.10, 1013–1014 (2004).
   PubMed Web of Science ®Google Scholar
• Wei Y, Wang D, Pagliassotti MJ. Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells. Mol. Cell. Biochem.303, 105–113 (2007).
   PubMed Web of Science ®Google Scholar
• Wei Y, Wang D, Topczewski F, Pagliassotti MJ. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am. J. Physiol. Endocrinol. Metab.291, E275–E281 (2006).
   PubMed Web of Science ®Google Scholar
• Wang D, Wei Y, Pagliassotti MJ. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology147, 943–951 (2006).
   PubMed Web of Science ®Google Scholar
• Puri P, Mirshahi F, Cheung O et al. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology134, 568–576 (2008).
   PubMed Web of Science ®Google Scholar
• Mari M, Fernandez-Checa JC. Sphingolipid signalling and liver diseases. Liver Int.27, 440–450 (2007).
   PubMed Web of Science ®Google Scholar
• Kolesnick RN, Kronke M. Regulation of ceramide production and apoptosis. Annu. Rev. Physiol.60, 643–665 (1998).
   PubMed Web of Science ®Google Scholar
• Morales A, Lee H, Goni FM, Kolesnick R, Fernandez-Checa JC. Sphingolipids and cell death. Apoptosis12, 923–939 (2007).
   PubMed Web of Science ®Google Scholar
• Summers SA. Ceramides in insulin resistance and lipotoxicity. Prog. Lipid Res.45, 42–72 (2006).
   PubMed Web of Science ®Google Scholar
• Greco D, Kotronen A, Westerbacka J et al. Gene expression in human NAFLD. Am. J. Physiol. Gastrointest. Liver Physiol.294, G1281–G1287 (2008).
   PubMed Web of Science ®Google Scholar
• Mari M, Caballero F, Colell A et al. Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab.4, 185–198 (2006).
   PubMed Web of Science ®Google Scholar
• Puri P, Baillie RA, Wiest MM et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology46, 1081–1090 (2007).
   PubMed Web of Science ®Google Scholar
• Duncan RE, El-Sohemy A, Archer MC. Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin. Cancer Lett.224, 221–228 (2005).
   PubMedGoogle Scholar
• Sanyal AJ, Campbell-Sargent C, Mirshahi F et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology120, 1183–1192 (2001).
   PubMed Web of Science ®Google Scholar
• Caballero F, Fernandez A, De Lacy AM, Fernandez-Checa JC, Caballeria J, Garcia-Ruiz C. Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. J. Hepatol.50, 789–796 (2009).
   PubMed Web of Science ®Google Scholar
• Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol.1, 135–145 (2001).
   PubMed Web of Science ®Google Scholar
• Igolnikov AC, Spatz K, Green RM. C3H/HEJ mice with mutations of the Toll-like receptor 4 (TLR-4) are resistant to the methioninecholine deficient (MCD) diet induced non-alcoholic steatohepatitis (NASH). Hepatology36, A404 (2002).
   Google Scholar
• Szabo G, Velayudham A, Romics L Jr, Mandrekar P. Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of Toll-like receptors 2 and 4. Alcohol. Clin. Exp. Res.29(11 Suppl.), S140–S145 (2005).
   PubMed Web of Science ®Google Scholar
• Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest.116, 3015–3025 (2006).
   PubMed Web of Science ®Google Scholar