References
- Fan E, Merritt EA, Verlinde CL, Hol WGJ. AB5 toxins: structures and inhibitor design. Curr. Opin. Struct. Biol.10, 680–686 (2000).
- Kitov PI, Sadowska JM, Mulvey G et al. Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands. Nature403, 669–672 (2000).
- Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WG, Fan E. Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat labile enterotoxin. J. Am. Chem. Soc.124, 8818–8824 (2002).
- Nishikawa K, Matsuoka K, Watanabe M et al. Identification of the optimal structure required for a Shiga toxin neutralizer with oriented carbohydrates to function in the circulation. J. Infect. Dis.191, 2097–2105 (2005).
- Kitov PI, Mulvey GL, Griener TP et al. In vivo supramolecular templating enhances the activity of multivalent ligands: a potential therapeutic against the Escherichia coli O157 AB5 toxins. Proc. Natl Acad. Sci. USA105, 16837–16842 (2008).
- Paton AW, Morona R, Paton JC. Designer probiotics for prevention of enteric infections. Nat. Rev. Microbiol.4, 193–200 (2006).
- Paton AW, Morona R, Paton JC. A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans. Nat. Med.6, 265–270 (2000).
- Paton AW, Morona R, Paton JC. Neutralization of Shiga toxins Stx1, Stx2c and Stx2e by recombinant bacteria expressing mimics of globotriose and globotetraose. Infect. Immun.69, 1967–1970 (2001).
- Paton AW, Jennings MP, Morona R, Focareta A, Roddam LF, Paton JC. Recombinant probiotics for treatment and prevention of travellers’ diarrhea. Gastroenterology128, 1219–1228 (2005).
- Focareta A, Paton JC, Morona R, Cook J, Paton AW. A recombinant probiotic for treatment and prevention of cholera. Gastroenterology130, 1688–1695 (2006).
- Paton JC, Rogers TJ, Morona R, Paton AW. Oral administration of formalin-killed recombinant bacteria expressing a mimic of the Shiga toxin receptor protects mice from fatal challenge with Shiga toxigenic Escherichia coli. Infect. Immun.69, 1389–1393 (2001).