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Review

Late-onset neutropenia following rituximab therapy: incidence, clinical features and possible mechanisms

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Pages 619-625 | Published online: 10 Jan 2014

References

  • McLaughlin P, Grillo-Lopez AJ, Link BK et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J. Clin. Oncol.16, 2825–2833 (1998).
  • Coiffier B. Rituximab therapy in malignant lymphoma. Oncogene26, 3603–3613 (2007).
  • Cooper N, Arnold DM. The effect of rituximab on humoral and cell mediated immunity and infection in the treatment of autoimmune diseases. Br. J. Haematol.149, 3–13 (2010).
  • Weiner GJ. Rituximab: mechanism of action. Semin. Hematol.47, 115–123 (2010).
  • Leandro MJ, Cambridge G, Ehrenstein MR, Edwards JC. Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis. Arthritis Rheum.54, 613–620 (2006).
  • Ram R, Ben-Bassat I, Shpilberg O, Polliack A, Raanani P. The late adverse events of rituximab therapy – rare but there! Leuk. Lymphoma50, 1083–1095 (2009).
  • Chaiwatanatorn K, Lee N, Grigg A, Filshie R, Firkin F. Delayed-onset neutropenia associated with rituximab therapy. Br. J. Haematol.121, 913–918 (2003).
  • Lemieux B, Tartas S, Traulle C et al. Rituximab-related late-onset neutropenia after autologous stem cell transplantation for aggressive non-Hodgkin’s lymphoma. Bone Marrow Transplant33, 921–923 (2004).
  • Dunleavy K, Hakim F, Kim HK et al. B-cell recovery following rituximab-based therapy is associated with perturbations in stromal derived factor-1 and granulocyte homeostasis. Blood106, 795–802 (2005).
  • Nitta E, Izutsu K, Sato T et al. A high incidence of late-onset neutropenia following rituximab-containing chemotherapy as a primary treatment of CD20-positive B-cell lymphoma: a single-institution study. Ann. Oncol.18, 364–369 (2007).
  • Cattaneo C, Spedini P, Casari S et al. Delayed-onset peripheral blood cytopenia after rituximab: frequency and risk factor assessment in a consecutive series of 77 treatments. Leuk. Lymphoma47, 1013–1017 (2006).
  • Fukuno K, Tsurumi H, Ando N et al. Late-onset neutropenia in patients treated with rituximab for non-Hodgkin’s lymphoma. Int. J. Hematol.84, 242–247 (2006).
  • Tesfa D, Gelius T, Sander B et al. Late-onset neutropenia associated with rituximab therapy: evidence for a maturation arrest at the (pro)myelocyte stage of granulopoiesis. Med. Oncol.25, 374–379 (2008).
  • Lai GG, Lim ST, Tao M, Chan A, Li H, Quek R. Late-onset neutropenia following RCHOP chemotherapy in diffuse large B-cell lymphoma. Am. J. Hematol.84, 414–417 (2009).
  • Cairoli R, Grillo G, Tedeschi A, D’Avanzo G, Marenco P, Morra E. High incidence of neutropenia in patients treated with rituximab after autologous stem cell transplantation. Haematologica89, 361–363 (2004).
  • Hirayama Y, Kohda K, Konuma Y et al. Late-onset neutropenia and immunoglobulin suppression of the patients with malignant lymphoma following autologous stem cell transplantation. Intern. Med.48, 57–60 (2009).
  • Marotte H, Paintaud G, Watier H, Miossec P. Rituximab-related late-onset neutropenia in a patient with severe rheumatoid arthritis. Ann. Rheum. Dis.67, 893–894 (2008).
  • Rios-Fernandez R, Gutierrez-Salmeron MT, Callejas-Rubio JL, Fernandez-Pugnaire M, Ortego-Centeno N. Late-onset neutropenia following rituximab treatment in patients with autoimmune diseases. Br. J. Dermatol.157, 1271–1273 (2007).
  • Jones RB, Ferraro AJ, Chaudhry AN et al. A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum.60, 2156–2168 (2009).
  • Rhee EP, Laliberte KA, Niles JL. Rituximab as maintenance therapy for anti-neutrophil cytoplasmic antibody-associated vasculitis. Clin. J. Am. Soc. Nephrol.5, 1359–1362 (2010).
  • Tesfa D, Ajeganova S, Hagglund H et al. Late-onset neutropenia following rituximab therapy in rheumatic diseases: association with B lymphocyte depletion and infections. Arthritis Rheum.63, 2209–2214 (2011).
  • Andersohn F, Konzen C, Garbe E. Systemic review: agranulocytosis induced by nonchemotherpy drugs. Ann. Intern. Med.146, 657–665 (2007).
  • Mosyagin I, Cascorbi I, Schaub R et al. Drug-induced agranulocytosis: impact of different fcgamma receptor polymorphisms? J. Clin. Psychopharmacol.25, 435–440 (2005).
  • Tesfa D, Keisu M, Palmblad J. Idiosyncratic drug-induced agranulocytosis: possible mechanisms and management. Am. J. Hematol.84, 428–434 (2009).
  • Weng WK, Negrin RS, Lavori P, Horning SJ. Immunoglobulin G Fc receptor FcγRIIIa 158 V/F polymorphism correlates with rituximab-induced neutropenia after autologous transplantation in patients with non-Hodgkin’s lymphoma. J. Clin. Oncol.28, 279–284 (2010).
  • Li SC, Chen YC, Evens AM et al. Rituximab-induced late-onset neutropenia in newly diagnosed B-cell lymphoma correlates with Fc receptor FcγRIIIa 158(V/F) polymorphism. Am. J. Hematol.85, 810–812 (2010).
  • Voog E, Morschhauser F, Solal-Celigny P. Neutropenia in patients treated with rituximab. N. Engl. J. Med.348, 2691–2694; discussion 2691–2694 (2003).
  • Papadaki T, Stamatopoulos K, Stavroyianni N, Paterakis G, Phisphis M, Stefanoudaki-Sofianatou K. Evidence for T-large granular lymphocyte-mediated neutropenia in rituximab-treated lymphoma patients: report of two cases. Leuk. Res.26, 597–600 (2002).
  • Coakley G, Iqbal M, Brooks D, Panayi GS, Lanchbury JS. CD8+, CD57+ T cells from healthy elderly subjects suppress neutrophil development in vitro: implications of felty’s and large granular lymphocyte syndromed. Arthritis Rheum.43, 834–843 (2000).
  • Liu JH, Wei S, Lamy T et al. Chronic neutropenia mediated by fas ligand. Blood95, 3219–3222 (2000).
  • Stamatopoulos K, Papadaki T, Pontikoglou C et al. Lymphocyte subpopulation imbalances, bone marrow hematopoiesis and histopathology in rituximab-treated lymphoma patients with late-onset neutropenia. Leukemia22, 1446–1449 (2008).
  • Papadaki T, Stamatopoulos K, Anagnostopoulos A, Fassas A. Rituximab-associated immune myelopathy. Blood102, 1557–1558 (2003).
  • Rezvany MR, Jeddi-Tehrani M, Wigzell H, Osterborg A, Mellstedt H. Leukemia-associated monoclonal and oligoclonal TCR-BV use in patients with B-cell chronic lymphocytic leukemia. Blood101, 1063–1070 (2003).
  • Terrier B, Ittah M, Tourneur L et al. Late-onset neutropenia following rituximab results from a hematopoietic lineage competition due to an excessive BAFF-induced B-cell recovery. Haematologica92, e20–e3 (2007).
  • Ueda Y, Kondo M, Kelsoe G. Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. J. Exp. Med.201, 1771–1780 (2005).
  • Welte K, Zeidler C, Dale DC. Severe congenital neutropenia. Semin. Hematol.43, 185–195 (2006).
  • Carlsson G, Andersson M, Putsep K et al. Kostmann syndrome or infantile genetic agranulocytosis, part one: celebrating 50 years of clinical and basic research on severe congenital neutropenia. Acta Paediatr.95, 1526–1532 (2006).
  • Carlsson G, Andersson M, Putsep K et al. Kostmann syndrome or infantile genetic agranulocytosis, part two: understanding the underlying genetic defects in severe congenital neutropenia. Acta Paediatr.96, 813–819 (2006).
  • Carlsson G, Aprikyan AG, Tehranchi R et al. Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome C, and excessive apoptosis of myeloid progenitor cells. Blood103, 3355–3361 (2004).
  • Anolik JH, Campbell D, Felgar RE et al. The relationship of FcγRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus. Arthritis Rheum.48, 455–459 (2003).
  • Cartron G, Dacheux L, Salles G et al. Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene. Blood99, 754–758 (2002).
  • Kato H, Yamamoto K, Matsuo K et al. Clinical impact and predisposing factors of delayed-onset neutropenia after autologous hematopoietic stem-cell transplantation for B-cell non-Hodgkin lymphoma: association with an incremental risk of infectious events. Ann. Oncol.21, 1699–1705 (2010).
  • Davis TA, Grillo-Lopez AJ, White CA et al. Rituximab anti-CD 20 monoclonal antibody therapy in non-Hodgkin`s lymphoma : safety and efficay of re-treatment. J. Clin. Oncol.18, 3135–3143 (2000).
  • Van Oers MH, Klasa R, Marcus RE et al. Rituximab maintenance improves clinical outcome of relapsed/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction : results of a prospective randomized Phase 3 intergroup trial. Blood108, 3295–3301 (2006).
  • Forstpointner R, Unterhalt M, Dreyling M et al. Maintenance therapy with rituximab leads to a significant prolongation of response duration after salvage therapy with a combination of rituximab of rituximab, fludarabine, cyclophosphamide and mitoxantrone (R-FCM) in patients with recurring and refractory follicular and mantel cell lymphomas: results of a prospective randomized study of the German Low Grade Lymphoma Study group (GLSG). Blood108, 4003–4008 (2006).
  • Gottenberg J, Ravaud P, Bardin T et al. Risk factors of severe infections in patients with rheumatoid arthritis treated with rituximab in the AutoImmunity and Rituximab (AIR) registry. Arthritis Rheum.62, 2625–2632 (2010).

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