49
Views
0
CrossRef citations to date
0
Altmetric
Editorial

JAK inhibition: the key to treating myeloproliferative neoplasm?

, &
Pages 583-585 | Published online: 10 Jan 2014

References

  • Tibes R, Mesa RA. Myeloproliferative neoplasms 5 years after discovery of JAK2V617F: what is the impact of JAK2 inhibitor therapy? Leuk. Lymphoma 52(7), 1178–1187 (2011).
  • Verstovsek S, Mesa RA, Gotlib J et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N. Engl. J. Med. 366(9), 799–807 (2012).
  • Verstovsek S, Kantarjian HM, Estrov Z et al. Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: survival advantage in comparison to matched historical controls. Blood 120(6), 1202–1209 (2012).
  • Harrison C, Kiladjian JJ, Al-Ali HK et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N. Engl. J. Med. 366(9), 787–798 (2012).
  • Tefferi A, Litzow MR, Pardanani A. Long-term outcome of treatment with ruxolitinib in myelofibrosis. N. Engl. J. Med. 365(15), 1455–1457 (2011).
  • Tibes R, Bogenberger JM, Geyer HL, Mesa RA. JAK2 inhibitors in the treatment of myeloproliferative neoplasms. Expert Opin. Investig. Drugs (2012) (In Press).
  • Tibes R, Mesa RA. Evolution of clinical trial endpoints in chronic myeloid leukemia: efficacious therapies require sensitive monitoring techniques. Leuk. Res. 36(6), 664–671 (2012).
  • Verstovsek S, Mesa RA, Rhoades SK et al. Phase I study of the JAK2 V617F inhibitor, LY2784544, in patients with myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET). ASH Annual Meeting Abstracts 118(21), 2814 (2011).
  • Pardanani A, Gotlib JR, Jamieson C et al. Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis. J. Clin. Oncol. 29(7), 789–796 (2011).
  • Beer PA, Delhommeau F, LeCouédic JP et al. Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm. Blood 115(14), 2891–2900 (2010).
  • Bogani C, Ponziani V, Guglielmelli P et al.; Myeloproliferative Disorders Research Consortium. Hypermethylation of CXCR4 promoter in CD34+ cells from patients with primary myelofibrosis. Stem Cells 26(8), 1920–1930 (2008).
  • Wang X, Zhang W, Ishii T et al. Correction of the abnormal trafficking of primary myelofibrosis CD34+ cells by treatment with chromatin-modifying agents. Cancer Res. 69(19), 7612–7618 (2009).
  • Scherber R, Dueck AC, Johansson P et al. The myeloproliferative neoplasm symptom assessment form (MPN-SAF): international prospective validation and reliability trial in 402 patients. Blood 118(2), 401–408 (2011).
  • Tibes R, Mesa RA. Blood consult: resistant and progressive essential thrombocythemia. Blood 118(2), 240–242 (2011).
  • Verstovsek S. Waltzman RJ, Sandor V et al. Response: a randomized, open label, Phase III study of INC424 in polycythemia vera (PV) patients resistant to or intolerant of hydroxyurea (HU). J. Clin. Oncol. 29(Suppl.), Abstract TPS203 (2011).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.