Emergency contraception: presently available formulations and controversies surrounding their use

References

• World Health Organization. Emergency Contraception WHO/RHR/ Fact Sheet 244. WHO, Geneva, Switzerland (2000).
   Google Scholar
• World Health Organization. Emergency Contraception: A Guide for Service Delivery. WHO/FRH7FPP798.19. WHO, Geneva, Switzerland (1998).
   Google Scholar
• Trussell J, Rodriguez G, Ellerson C. Updated estimates of the effectiveness of the Yuzpe regimen of emergency contraception. Contraception59, 147–151 (1999).
   PubMed Web of Science ®Google Scholar
• Yuzpe AA, Turlow HJ, Ramzy I, Leyson JI. Post-coital contraception – a pilot study. J. Reprod. Med.30, 12–18 (1974).
   Google Scholar
• Hoffman KO. Postcoital contraception: experiences with ethynil estradiol/norgestrel and levonorgestrel only. In: Proceedings of the XIth Congress on Fertility and Sterility. Harrison RF, Bonnar J, Thompson W (Eds). MTP Press Ltd., Lancashire, UK, 311–316 (1984).
   Google Scholar
• World Health Organization. Task Force on Post-Ovulatory Methods for Fertility Regulation. Post coital contraception with levonorgestrel during the peri-ovulatory phase of the menstrual cycle. Contraception36, 257–286 (1987).
   Google Scholar
• Task Force on Postovulatory Methods of Fertility Regulation. Randomized controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception. Lancet352(9126), 428–433 (1998).
   PubMed Web of Science ®Google Scholar
• von Hertzen H, Piaggio G, Ding J et al. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomized trial. Lancet360, 1803–1810 (2002).
   PubMed Web of Science ®Google Scholar
• Piaggio G, Kapp N, von Hertzen H. Effect on pregnancy rates of the delay in the administration of levonorgestrel for emergency contraception: a combined analysis of four WHO trials. Contraception84(1), 35–39 (2011).
   PubMed Web of Science ®Google Scholar
• International Medical Advisory Panel, International Planned Parenthood Federation. IMAP statement on emergency contraception. IPPF Med. Bull.38(1), 1–3 (2004).
   Google Scholar
• Croxatto HB, Fuentealba B, Brache V et al. Effects of the Yuzpe regimen, given during the follicular phase on ovarian function. Contraception65, 121–128 (2002).
   PubMed Web of Science ®Google Scholar
• Hapangama D, Glasier AF, Baird DT. The effects of peri-ovulatory administration of levonorgestrel on the menstrual cycle. Contraception63, 123–129 (2001).
   PubMed Web of Science ®Google Scholar
• Landgren BM, Jhoannisson E, Aedo AR et al. The effect of levonorgestrel administered in large doses at different stages of the cycles on ovarian function and endometrial morphology. Contraception39, 275–289 (1989).
   PubMed Web of Science ®Google Scholar
• Durand M, Cravioto MC, Raymond EG et al. On the mechanism of action of short-term levonorgestrel administration in emergency contraception. Contraception64, 227–234 (2001).
   PubMed Web of Science ®Google Scholar
• Gemzell-Danielsson K. Mechanism of action of emergency contraception. Contraception82(5), 404–409 (2010).
   PubMed Web of Science ®Google Scholar
• Kesseru E, Garmendia F, Westphal N, Parada J. The hormonal peripheral effects of dl-norgestrel in post-coital contraception. Contraception10, 411–424 (1974).
   PubMed Web of Science ®Google Scholar
• Croxatto HB, Devoto L, Durand M et al. Mechanism of action of hormonal preparations used for emergency contraception: a review of the literature. Contraception63, 111–121 (2001).
   PubMed Web of Science ®Google Scholar
• Swahn ML, Westlund P, Johannisson E Bygdeman M. Effect of post-coital contraceptive methods on the endometrium and the menstrual cycle. Acta Obstet. Gynecol. Scand.75, 738–744 (1996).
   PubMed Web of Science ®Google Scholar
• Marions L, Hultenby K, Lindell I et al. Emergency contraception with mifepristone and levonorgestrel: mechanism of action. Obstet. Gynecol.100, 65–71 (2002).
   PubMed Web of Science ®Google Scholar
• Croxatto HB, Brache V, Pavez M et al. Pituitary-ovarian function following the standard levonorgestrel emergency contraceptive dose or a single 0.75 mg dose given on the days preceding ovulation. Contraception70, 442–450 (2004).
   PubMed Web of Science ®Google Scholar
• Lalitkumar PG, Lalitkumar S, Meng CX et al. Mifepristone, but not levonorgestrel, inhibits human blastocyst attachment to an in vitro endometrial three-dimensional cell culture model. Hum. Reprod.22, 3031–3037 (2007).
   PubMed Web of Science ®Google Scholar
• Meng CX, Andersson KL, Bentin-Ley U, Gemzell-Danielsson K, Lalitkumar PG. Effect of levonorgestrel and mifepristone on endometrial receptivity markers in a three-dimensional human endometrial cell culture model. Fertil. Steril.91, 256–264 (2009).
   PubMed Web of Science ®Google Scholar
• World Health Organization (WHO). Improving Access to Quality Care in Family Planning. Medical Eligibility Criteria for Contraceptive Use (4th Edition). WHO Geneva, Switzerland (2009).
   Google Scholar
• Chabbert-Buffet N, Meduri G, Bouchard P, Spitz IM. Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications. Hum. Reprod. Update11, 293–307 (2005).
   PubMed Web of Science ®Google Scholar
• Spitz IM. Progesterone antagonists and progesterone receptor modulators: an overview. Steroids68, 981–993 (2003).
   PubMed Web of Science ®Google Scholar
• Lahteemaki P, Heikinheimo O, Coxatto H et al. Pharmacokinetics and methabolism of RU-486. J. Steroid Biochem27, 859–865 (1987).
   PubMedGoogle Scholar
• Benagiano G, Bastianelli C, Farris M. Selective progesterone receptor modulators: 2. Use in reproductive medicine. Expert Opin. Pharmacotherapy9, 2473–2485 (2008).
   PubMed Web of Science ®Google Scholar
• Baird DT, Brown A, Cheng L et al. Mifepristone: a novel estrogen-free daily contraceptive pill. Steroids68, 1099–1105 (2003).
   PubMed Web of Science ®Google Scholar
• Baird DT, Brown A, Critchley HO, Williams AR, Lin S, Cheng L. Effect of long-term treatment with low-dose mifepristone on the endometrium. Hum. Reprod.18, 61–68 (2003).
   PubMed Web of Science ®Google Scholar
• Brown A, Cheng L, Lin S, Baird DT. Daily low-dose mifepristone has contraceptive potential by suppressing ovulation and menstruation: a doubleblind randomized control trial of 2 and 5 mg per day for 120 days. J. Clin. Endocrinol. Metab.87, 63–70 (2002).
   PubMed Web of Science ®Google Scholar
• World Health Organization. Task Force on Post-Ovulatory Methods for Fertility Regulation. Comparison of three single doses of mifepristone as emergency contraception: a randomized trials. Lancet353, 697–702 (1999).
   PubMed Web of Science ®Google Scholar
• von Hertzen H, Van Look PFA. Research on new methods of emergency contraception. Int. Fam. Plann. Perspect.22, 62–68 (1996).
   Google Scholar
• von Hertzen H, Piaggio G. Levonorgestrel and mifepristone in emergency contraception. Steroids68, 1107–1113 (2003).
   PubMed Web of Science ®Google Scholar
• Swahn M, Bygdeman M, Cekan S, Xing S, Masironi B, Johannisson E. The effect of RU486 administered during the early luteal phase on bleeding pattern, hormonal parameters and endometrium. Hum. Reprod.5, 402–408 (1990).
   PubMed Web of Science ®Google Scholar
• Gemzell-Danielsson K, Swahn M-L, Svalander P, Bygdeman M. Early luteal phase treatment with mifepristone (RU486) for fertility regulation. Hum. Reprod.8, 870–873 (1993).
   PubMed Web of Science ®Google Scholar
• Croxatto HB, Salvatierra AM, Croxatto HD, Fuentealba B, Effects of continuous treatment with low dose mifepristone throughout one menstrual cycle. Hum. Reprod.8, 201–207 (1993).
   PubMed Web of Science ®Google Scholar
• Gemzell-Danielsson K, Swahn L, Westlund P, Johannisson E, Seppälä M, Bygdeman M. Effect of low daily doses of mifepristone on ovarian function and endometrial development. Hum. Reprod.12, 124–131 (1997).
   PubMed Web of Science ®Google Scholar
• Ashok PW, Stalder C, Wagaarachchi PT et al. A randomized study comparing a low dose of mifepristone and the Yuzpe regimen for emergency contraception. BJOG109, 553–560 (2002).
   PubMed Web of Science ®Google Scholar
• Faculty of Sexual and Reproductive Healthcare Clinical Effectiveness Unit. December 2009. Frequently Asked Question on Ulipristal Acetate (Ellaone®) Emergency Contraception London; Royal College of Obstetricians and Gynaecologists, London, UK (2009).
   Google Scholar
• Glasier A, Cameron S, Fine P et al. Ulipristal acetate versus levonorgestrel for emergency contraception: randomized trial and metanalisis. Lancet375, 555–562 (2010).
   PubMed Web of Science ®Google Scholar
• Fine P, Matte H, Ginde Cullins V et al. Ulipristal acetate taken 48–120 hours after intercourse for emergency contraception Obstet. Gynecol.115, 257–263 (2010).
   PubMed Web of Science ®Google Scholar
• Brache V, Cochon L, Jesam C et al. Immediate pre-ovulatory administration of 30 mg ulipristal acetate significantly delays follicular rupture. Contraception81(5), 414–420 (2010).
   PubMed Web of Science ®Google Scholar
• No authors listed. Consensus statement on emergency contraception. Contraception52, 211–213 (1995).
   PubMed Web of Science ®Google Scholar
• Bastianelli C, Farris M, Benagiano G. Emergency contraception: a review. Eur. J. Contracept. Reprod. Health Care13, 9–16 (2008).
   PubMed Web of Science ®Google Scholar
• Westley E, Glasier A. Emergency contraception: dispelling the myths and misperceptions. Bull. World Health Organ.88, 243 (2010).
   PubMed Web of Science ®Google Scholar
• Sanfilippo SJ. Emergency contraception, the bottom line. J. Pediatr. Adolesc. Gynecol.24(1), 1 (2011).
   PubMed Web of Science ®Google Scholar
• Moreau C, Bajos N, Trussell J. The impact of pharmacy access to emergency contraceptive pills in France. Contraception73(6), 602–608 (2006).
   PubMed Web of Science ®Google Scholar
• Raymond EG, Trussell J, Polis CB. Population effect of increased access to emergency contraceptive pills: a systematic review. Obstet. Gynecol.109(1), 181–188 (2007).
   PubMed Web of Science ®Google Scholar
• Polis CB, Polis CB, Schaffer K, Blanchard K et al. Advance provision of emergency contraception for pregnancy prevention (full review). Cochrane Database Syst. Rev.2, CD005497 (2007).
   Google Scholar
• Glasier A, Baird D. The effects of self-administering emergency contraception. N. Engl. J. Med.339, 1–4 (1998).
   PubMed Web of Science ®Google Scholar
• Jackson RA, Schwarz EB, Freedman L et al. Advance supply of emergency contraception: effect on use and usual contraception: a randomized trial. Obstet. Gynecol.102, 8–16 (2003).
   PubMed Web of Science ®Google Scholar
• Gold MA, Wolford JE, Smith KA et al. The effects of advance provision of emergency contraception on adolescent women’s sexual and contraceptive behaviors. J. Pediatr. Adolesc. Gynecol.17, 87–96 (2004).
   PubMedGoogle Scholar
• Lo SS, Fan SYS, Ho PC et al. Effect of advanced provision of emergency contraception on women’s contraceptive behavior: a randomized controlled trial. Hum. Reprod.19, 2404–2410 (2004)
   PubMed Web of Science ®Google Scholar
• Raine TR, Harper CC, Rocca CH et al. Direct access to emergency contraception through pharmacies and effect on unintended pregnancy and STIs: a randomized controlled trial. JAMA293, 54–62 (2005).
   PubMed Web of Science ®Google Scholar
• Hu X, Cheng L, Hua X et al. Advanced provision of emergency contraception to postnatal women in China makes no difference in abortion rates: a randomized controlled trial. Contraception72, 111–116 (2005).
   PubMed Web of Science ®Google Scholar
• Belzer M, Sanchez K, Olson J et al. Advance supply of emergency contraception: a randomized trial in adolescent mothers. J. Pediatr. Adolesc. Gynecol.18, 347–354 (2005).
   PubMedGoogle Scholar
• Meyer JL, Gold M A. Haggerty Advance provision of emergency contraception among adolescent and young adult women: a systematic review of literature. J. Pediatr. Adolesc. Gynecol.24, 2–9 (2011).
   PubMed Web of Science ®Google Scholar
• Raymond EG, Stewart F, Weaver M et al. Impact of increased access to emergency contraceptive pills: a randomized controlled trial. Obstet. Gynecol.108, 1098–1106 (2006).
   PubMed Web of Science ®Google Scholar
• Hazari K. Use of emergency contraception by women as a back-up method. Health Popul.23, 115–122 (2000).
   Google Scholar
• Ekstrand M, Larsson M, Darj E et al. Advance provision of emergency contraceptive pills reduces treatment delay: a randomised controlled trial among Swedish teenage girls. Acta. Obstet. Gynecol. Scand.87, 354–359 (2008).
   PubMed Web of Science ®Google Scholar
• Edelman AB, Jensen JT, Hennebold JD. A nonhormonal model for emergency contraception: prostaglandin synthesis inhibitor effects on luteal function and lifespan, a pilot study. Contraception81, 496–500 (2010).
   PubMed Web of Science ®Google Scholar