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Expert Review of Obstetrics & Gynecology Volume 7, 2012 - Issue 6
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Review

The role of reproductive hormones in the development and maintenance of eating disorders

Jessica H Baker Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, CB #7160, Chapel Hill, NC 27599, USA; Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, CB #7160, Chapel Hill, NC 27599, USA
,
Susan S Girdler Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, CB #7160, Chapel Hill, NC 27599, USA; Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, CB #7160, Chapel Hill, NC 27599, USA
&
Cynthia M Bulik Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, CB #7160, Chapel Hill, NC 27599, USA; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC USA. [email protected]; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC USA. [email protected]
Pages 573-583 | Published online: 10 Jan 2014

References

  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition Text Revision. American Psychiatric Press, DC, USA (2000).
  • Goldschmidt AB, Hilbert A, Manwaring JL et al. The significance of overvaluation of shape and weight in binge eating disorder. Behav. Res. Ther. 48(3), 187–193 (2010).
  • Hudson JI, Hiripi E, Pope HG Jr, Kessler RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol. Psychiatry 61(3), 348–358 (2007).
  • Gowers SG, Crisp AH, Joughin N, Bhat A. Premenarcheal anorexia nervosa. J. Child Psychol. Psychiatry 32(3), 515–524 (1991).
  • Swanson SA, Crow SJ, Le Grange D, Swendsen J, Merikangas KR. Prevalence and correlates of eating disorders in adolescents. Results from the National Comorbidity Survey Replication Adolescent Supplement. Arch. Gen. Psychiatry 68(7), 714–723 (2011).
  • Norman AW. Hormones. Academic Press, CA, USA (1997).
  • Farage MA, Neill S, MacLean AB. Physiological changes associated with the menstrual cycle: a review. Obstet. Gynecol. Surv. 64(1), 58–72 (2009).
  • Girdler SS, Light KC. Reproductive hormones and stages of life in women: moderators of mood and cardiovascular health. In: Handbook of Behavioral Medicine. Steptoe A (Ed.). Springer, Paris, France, 585–602 (2010).
  • Oka K, Hirano T, Noguchi M. Changes in the concentration of testosterone in serum during the menstrual cycle, as determined by liquid chromatography. Clin. Chem. 34(3), 557–560 (1988).
  • Brown LM, Clegg DJ. Central effects of estradiol in the regulation of food intake, body weight, and adiposity. J. Steroid Biochem. Mol. Biol. 122(1–3), 65–73 (2010).
  • Butera PC. Estradiol and the control of food intake. Physiol. Behav. 99(2), 175–180 (2010).
  • Eckel LA. The ovarian hormone estradiol plays a crucial role in the control of food intake in females. Physiol. Behav. 104(4), 517–524 (2011).
  • Asarian L, Geary N. Modulation of appetite by gonadal steroid hormones. Philos. Trans. R. Soc. Lond. B Biol. Sci. 361(1471), 1251–1263 (2006).
  • Buffenstein R, Poppitt SD, McDevitt RM, Prentice AM. Food intake and the menstrual cycle: a retrospective analysis, with implications for appetite research. Physiol. Behav. 58(6), 1067–1077 (1995).
  • Lyons PM, Truswell AS, Mira M, Vizzard J, Abraham SF. Reduction of food intake in the ovulatory phase of the menstrual cycle. Am. J. Clin. Nutr. 49(6), 1164–1168 (1989).
  • Gong EJ, Garrel D, Calloway DH. Menstrual cycle and voluntary food intake. Am. J. Clin. Nutr. 49(2), 252–258 (1989).
  • Geary N. Estradiol, CCK and satiation. Peptides 22(8), 1251–1263 (2001).
  • Becker JB, Arnold AP, Berkley KJ et al. Strategies and methods for research on sex differences in brain and behavior. Endocrinology 146(4), 1650–1673 (2005).
  • Geary N, Asarian L. Cyclic estradiol treatment normalizes body weight and test meal size in ovariectomized rats. Physiol. Behav. 67(1), 141–147 (1999).
  • Asarian L, Geary N. Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovariectomized rats. Horm. Behav. 42(4), 461–471 (2002).
  • Wade GN, Zucker I. Development of hormonal control over food intake and body weight in female rats. J. Comp. Physiol. Psychol. 70(2), 213–220 (1970).
  • Wade GN. Interaction between estradiol-17 beta and growth hormone in control of food intake in weanling rats. J. Comp. Physiol. Psychol. 86(2), 359–362 (1974).
  • Eckel LA. Estradiol: a rhythmic, inhibitory, indirect control of meal size. Physiol. Behav. 82(1), 35–41 (2004).
  • Pelkman CL, Chow M, Heinbach RA, Rolls BJ. Short-term effects of a progestational contraceptive drug on food intake, resting energy expenditure, and body weight in young women. Am. J. Clin. Nutr. 73(1), 19–26 (2001).
  • Wade GN. Some effects of ovarian hormones on food intake and body weight in female rats. J. Comp. Physiol. Psychol. 88(1), 183–193 (1975).
  • Chai JK, Blaha V, Meguid MM, Laviano A, Yang ZJ, Varma M. Use of orchiectomy and testosterone replacement to explore meal number-to-meal size relationship in male rats. Am. J. Physiol. 276(5 Pt 2), R1366–R1373 (1999).
  • Nohara K, Zhang Y, Waraich RS et al. Early-life exposure to testosterone programs the hypothalamic melanocortin system. Endocrinology 152(4), 1661–1669 (2011).
  • Himmerich H, Schönknecht P, Heitmann S, Sheldrick AJ. Laboratory parameters and appetite regulators in patients with anorexia nervosa. J. Psychiatr. Pract. 16(2), 82–92 (2010).
  • Monteleone P, Luisi M, Colurcio B et al. Plasma levels of neuroactive steroids are increased in untreated women with anorexia nervosa or bulimia nervosa. Psychosom. Med. 63(1), 62–68 (2001).
  • Autry JH, Stover ES, Reatig N, Casper R. Anorexia nervosa and bulimia. Annu. Rev. Public Health 7, 535–543 (1986).
  • Poyastro Pinheiro A, Thornton LM, Plotonicov KH et al. Patterns of menstrual disturbance in eating disorders. Int. J. Eat. Disord. 40(5), 424–434 (2007).
  • Edler C, Lipson SF, Keel PK. Ovarian hormones and binge eating in bulimia nervosa. Psychol. Med. 37(1), 131–141 (2007).
  • Klump KL, Keel PK, Culbert KM, Edler C. Ovarian hormones and binge eating: exploring associations in community samples. Psychol. Med. 38(12), 1749–1757 (2008).
  • Klump KL, Gobrogge KL, Perkins PS, Thorne D, Sisk CL, Breedlove SM. Preliminary evidence that gonadal hormones organize and activate disordered eating. Psychol. Med. 36(4), 539–546 (2006).
  • Racine SE, Keel P, Burt SA et al. Impulsivity as a moderator of associations between ovarian hormones and binge eating across the menstrual cycle. Presented at: The 2012 International Conference on Eating Disorders. Austin, TX, USA, 3–5 May 2012.
  • Racine SE, Culbert KM, Keel PK, Sisk CL, Burt SA, Klump KL. Differential associations between ovarian hormones and disordered eating symptoms across the menstrual cycle in women. Int. J. Eat. Disord. 45(3), 333–344 (2012).
  • Klump KL, Suisman JL, Culbert KM, Kashy DA, Keel PK, Sisk CL. The effects of ovariectomy on binge eating proneness in adult female rats. Horm. Behav. 59(4), 585–593 (2011).
  • Yu Z, Geary N, Corwin RL. Ovarian hormones inhibit fat intake under binge-type conditions in ovariectomized rats. Physiol. Behav. 95(3), 501–507 (2008).
  • Sundblad C, Bergman L, Eriksson E. High levels of free testosterone in women with bulimia nervosa. Acta Psychiatr. Scand. 90(5), 397–398 (1994).
  • Cotrufo P, Monteleone P, d’Istria M, Fuschino A, Serino I, Maj M. Aggressive behavioral characteristics and endogenous hormones in women with bulimia nervosa. Neuropsychobiology 42(2), 58–61 (2000).
  • Cassin SE, von Ranson KM. Personality and eating disorders: a decade in review. Clin. Psychol. Rev. 25(7), 895–916 (2005).
  • Jahanfar S, Eden JA, Nguyent TV. Bulimia nervosa and polycystic ovary syndrome. Gynecol. Endocrinol. 9(2), 113–117 (1995).
  • McSherry J. Bulimia nervosa and acne. Can. J. Psychiatry 37(10), 731–732 (1992).
  • Quinton SJ, Smith AR, Joiner T. The 2 to 4 digit ratio (2D:4D) and eating disorder diagnosis in women. Pers. Individ. Dif. 51(4), 402–405 (2011).
  • Culbert KM, Breedlove SM, Burt SA, Klump KL. Prenatal hormone exposure and risk for eating disorders: a comparison of opposite-sex and same-sex twins. Arch. Gen. Psychiatry 65(3), 329–336 (2008).
  • Baker JH, Lichtenstein P, Kendler KS. Intrauterine testosterone exposure and risk for disordered eating. Br. J. Psychiatry 194(4), 375–376 (2009).
  • Lydecker JA, Pisetsky EM, Mitchell KS et al. Association between co-twin sex and eating disorders in opposite sex twin pairs: evaluations in North American, Norwegian, and Swedish samples. J. Psychosom. Res. 72(1), 73–77 (2012).
  • Pisetsky EM. Eating Disorders, Psychopathology, and Temperament in Opposite Sex and Same Sex Twins. Unpublished Master’s thesis, University of North Carolina, NC, USA (2010).
  • Culbert KM, Burt SA, Sisk CL, Nigg JT, Klump KL. The effects of puberty and circulating testosterone on differential risk for disordered eating in adolescent males. Presented at: The 2012 International Conference on Eating Disorders. Austin, TX, USA, 3–5 May 2012.
  • Lester NA, Keel PK, Lipson SF. Symptom fluctuation in bulimia nervosa: relation to menstrual-cycle phase and cortisol levels. Psychol. Med. 33(1), 51–60 (2003).
  • Gladis MM, Walsh BT. Premenstrual exacerbation of binge eating in bulimia. Am. J. Psychiatry 144(12), 1592–1595 (1987).
  • Price WA, Torem MS, DiMarzio LR. Premenstrual exacerbation of bulimia. Psychosomatics 28(7), 378–379 (1987).
  • Jappe LM, Gardner RM. Body-image perception and dissatisfaction throughout phases of the female menstrual cycle. Percept. Mot. Skills 108(1), 74–80 (2009).
  • Altabe M. Ethnicity and body image: quantitative and qualitative analysis. Int. J. Eat. Disord. 23(2), 153–159 (1998).
  • Bulik CM, Sullivan PF, Kendler KS. Heritability of binge-eating and broadly defined bulimia nervosa. Biol. Psychiatry 44(12), 1210–1218 (1998).
  • Mazzeo SE, Mitchell KS, Bulik CM, Aggen SH, Kendler KS, Neale MC. A twin study of specific bulimia nervosa symptoms. Psychol. Med. 40(7), 1203–1213 (2010).
  • Keski-Rahkonen A, Bulik CM, Neale BM, Rose RJ, Rissanen A, Kaprio J. Body dissatisfaction and drive for thinness in young adult twins. Int. J. Eat. Disord. 37(3), 188–199 (2005).
  • Wade TD, Wilkinson J, Ben-Tovim D. The genetic epidemiology of body attitudes, the attitudinal component of body image in women. Psychol. Med. 33(8), 1395–1405 (2003).
  • Saunders KE, Hawton K. Suicidal behaviour and the menstrual cycle. Psychol. Med. 36(7), 901–912 (2006).
  • Tonks CM, Rack PH, Rose MJ. Attempted suicide and the menstrual cycle. J. Psychosom. Res. 11(4), 319–323 (1968).
  • Glass GS, Heninger GR, Lansky M, Talan K. Psychiatric emergency related to the menstrual cycle. Am. J. Psychiatry 128(6), 705–711 (1971).
  • Howards PP, Schisterman EF, Wactawski-Wende J, Reschke JE, Frazer AA, Hovey KM. Timing clinic visits to phases of the menstrual cycle by using a fertility monitor: the BioCycle Study. Am. J. Epidemiol. 169(1), 105–112 (2009).
  • Hendrick V, Altshuler LL, Suri R. Hormonal changes in the postpartum and implications for postpartum depression. Psychosomatics 39(2), 93–101 (1998).
  • Lemberg R, Phillips J. The impact of pregnancy on anorexia nervosa and bulimia. Int. J. Eat. Disord. 8, 285–295 (1989).
  • Lacey JH, Smith G. Bulimia nervosa. The impact of pregnancy on mother and baby. Br. J. Psychiatry 150, 777–781 (1987).
  • Bulik CM, Von Holle A, Hamer R et al. Patterns of remission, continuation and incidence of broadly defined eating disorders during early pregnancy in the Norwegian Mother and Child Cohort Study (MoBa). Psychol. Med. 37(8), 1109–1118 (2007).
  • Crow SJ, Agras WS, Crosby R, Halmi K, Mitchell JE. Eating disorder symptoms in pregnancy: a prospective study. Int. J. Eat. Disord. 41(3), 277–279 (2008).
  • Koubaa S, Kouba S, Hällström T, Lindholm C, Hirschberg AL. Pregnancy and neonatal outcomes in women with eating disorders. Obstet. Gynecol. 105(2), 255–260 (2005).
  • Micali N, Treasure J, Simonoff E. Eating disorders symptoms in pregnancy: a longitudinal study of women with recent and past eating disorders and obesity. J. Psychosom. Res. 63(3), 297–303 (2007).
  • Jacobi C, Hayward C, de Zwaan M, Kraemer HC, Agras WS. Coming to terms with risk factors for eating disorders: application of risk terminology and suggestions for a general taxonomy. Psychol. Bull. 130(1), 19–65 (2004).
  • Klump KL, Keel PK, Sisk C, Burt SA. Preliminary evidence that estradiol moderates genetic influences on disordered eating attitudes and behaviors during puberty. Psychol. Med. 40(10), 1745–1753 (2010).
  • Klump KL, Suisman JL, Culbert KM, Kashy DA, Sisk CL. Binge eating proneness emerges during puberty in female rats: a longitudinal study. J. Abnorm. Psychol. 120(4), 948–955 (2011).
  • Bulik CM, Sullivan PF, Wade TD, Kendler KS. Twin studies of eating disorders: a review. Int. J. Eat. Disord. 27(1), 1–20 (2000).
  • Culbert KM, Burt SA, McGue M, Iacono WG, Klump KL. Puberty and the genetic diathesis of disordered eating attitudes and behaviors. J. Abnorm. Psychol. 118(4), 788–796 (2009).
  • Klump KL, McGue M, Iacono WG. Differential heritability of eating attitudes and behaviors in prepubertal versus pubertal twins. Int. J. Eat. Disord. 33(3), 287–292 (2003).
  • Harden KP, Mendle J, Kretsch N. Environmental and genetic pathways between early pubertal timing and dieting in adolescence: distinguishing between objective and subjective timing. Psychol. Med. 42(1), 183–193 (2012).
  • Baker JH, Thornton LM, Bulik CM, Kendler KS, Lichtenstein P. Genetic covariation between age at menarche and disordered eating. J. Adolesc. Health 51, 491–496 (2012).
  • Golden NH, Lanzkowsky L, Schebendach J, Palestro CJ, Jacobson MS, Shenker IR. The effect of estrogen–progestin treatment on bone mineral density in anorexia nervosa. J. Pediatr. Adolesc. Gynecol. 15(3), 135–143 (2002).
  • Muñoz MT, Morandé G, García-Centenera JA, Hervás F, Pozo J, Argente J. The effects of estrogen administration on bone mineral density in adolescents with anorexia nervosa. Eur. J. Endocrinol. 146(1), 45–50 (2002).
  • Misra M, Katzman D, Miller KK et al. Physiologic estrogen replacement increases bone density in adolescent girls with anorexia nervosa. J. Bone Miner. Res. 26(10), 2430–2438 (2011).
  • Naessén S, Carlström K, Byström B, Pierre Y, Hirschberg AL. Effects of an antiandrogenic oral contraceptive on appetite and eating behavior in bulimic women. Psychoneuroendocrinology 32(5), 548–554 (2007).
  • Bergman L, Eriksson E. Marked symptom reduction in two women with bulimia nervosa treated with the testosterone receptor antagonist flutamide. Acta Psychiatr. Scand. 94(2), 137–139 (1996).
  • Sundblad C, Landén M, Eriksson T, Bergman L, Eriksson E. Effects of the androgen antagonist flutamide and the serotonin reuptake inhibitor citalopram in bulimia nervosa: a placebo-controlled pilot study. J. Clin. Psychopharmacol. 25(1), 85–88 (2005).
  • Miller KK, Grieco KA, Klibanski A. Testosterone administration in women with anorexia nervosa. J. Clin. Endocrinol. Metab. 90(3), 1428–1433 (2005).
  • Young JK. Estrogen and the etiology of anorexia nervosa. Neurosci. Biobehav. Rev. 15(3), 327–331 (1991).
  • Pike KM, Walsh BT, Vitousek K, Wilson GT, Bauer J. Cognitive behavior therapy in the posthospitalization treatment of anorexia nervosa. Am. J. Psychiatry 160(11), 2046–2049 (2003).
  • Keating C, Tilbrook A, Kulkarni J. Oestrogen: an overlooked mediator in the neuropsychopharmacology of treatment response? Int. J. Neuropsychopharmacol. 14(4), 553–566 (2011).
  • Westlund Tam L, Parry BL. Does estrogen enhance the antidepressant effects of fluoxetine? J. Affect. Disord. 77(1), 87–92 (2003).
  • Grigoriadis S, Kennedy SH. Role of estrogen in the treatment of depression. Am. J. Ther. 9(6), 503–509 (2002).
  • Hilbert A, de Zwaan M, Braehler E. How frequent are eating disturbances in the population? Norms of the eating disorder examination-questionnaire. PLoS ONE 7(1), e29125 (2012).

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