References
- Cattaneo E, Zuccato C, Tartari M. Normal huntingtin function: an alternative approach to Huntington’s disease. Nat. Rev. Neurosci.6(12), 919–930 (2005).
- Harjes P, Wanker EE. The hunt for huntingtin function: interaction partners tell many different stories. Trends Biochem. Sci.28(8), 425–433 (2003).
- Li SH, Li XJ. Huntingtin–protein interactions and the pathogenesis of Huntington’s disease. Trends Genet.20(3), 146–154 (2004).
- Borrell-Pages M, Zala D, Humbert S, Saudou F. Huntington’s disease: from huntingtin function and dysfunction to therapeutic strategies. Cell Mol. Life Sci.63(22), 2642–2660 (2006).
- Page KJ, Potter L, Aronni S, Everitt BJ, Dunnett SB. The expression of Huntingtin-associated protein (HAP1) mRNA in developing, adult and ageing rat CNS: implications for Huntington’s disease neuropathology. Eur. J. Neurosci.10(5), 1835–1845 (1998).
- Li SH, Yu ZX, Li CL et al. Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington’s disease. J. Neurosci.23(17), 6956–6964 (2003).
- Li XJ, Li SH. HAP1 and intracellular trafficking. Trends Pharmacol. Sci.26(1), 1–3 (2005).
- Tang TS, Tu H, Chan EY et al. Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron39(2), 227–239 (2003).
- Gauthier LR, Charrin BC, Borrell-Pages M et al. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell118(1), 127–138 (2004).
- Twelvetrees AE, Yuen EY, Arancibia-Carcamo IL et al. Delivery of GABAARs to synapses is mediated by HAP1–KIF5 and disrupted by mutant huntingtin. Neuron65(1), 53–65 (2010).
- Metzger S, Rong J, Nguyen HP et al. Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington’s disease. Hum. Mol. Genet.17(8), 1137–1146 (2008).
- Satir P, Christensen ST. Structure and function of mammalian cilia. Histochem. Cell Biol.129(6), 687–693 (2008).
- Rosenbaum JL, Witman GB. Intraflagellar transport. Nat. Rev. Mol. Cell Biol.3(11), 813–825 (2002).
- Scholey JM. Intraflagellar transport motors in cilia: moving along the cell’s antenna. J. Cell Biol.180(1), 23–29 (2008).
- Keryer G, Pineda JR, Liot G et al. Ciliogenesis is regulated by a huntingtin–HAP1–PCM1 pathway and is altered in Huntington disease. J. Clin. Invest.121(11), 4372–4382 (2011).
- Badano JL, Mitsuma N, Beales PL, Katsanis N. The ciliopathies: an emerging class of human genetic disorders. Annu. Rev. Genomics Hum. Genet.7, 125–148 (2006).
- Sheng G, Xu X, Lin YF et al. Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. J. Clin. Invest.118(8), 2785–2795 (2008).
- Lancaster MA, Louie CM, Silhavy JL et al. Impaired Wnt–beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat. Med.15(9), 1046–1054 (2009).
- Simms RJ, Hynes AM, Eley L et al. Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development. Cell Mol. Life Sci. doi:10.1007/s00018-011-0826-z (2011) (Epub ahead of print).
- Li S, Li XJ. Multiple pathways contribute to the pathogenesis of Huntington disease. Mol. Neurodegener.1, 19 (2006).