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Theme: Breast Cancer - Editorial

The oral tyrosine kinase inhibitors lapatinib and sunitinib: new opportunities for the treatment of brain metastases from breast cancer?

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Pages 139-142 | Published online: 10 Jan 2014

References

  • Lin NU, Bellon JR, Winer EP. CNS metastases in breast cancer. J. Clin. Oncol.22, 3608–3617 (2004).
  • Khuntia D, Brown P, Li J, Mehta MP. Whole-brain radiotherapy in the management of brain metastasis. J. Clin. Oncol.24(8), 1295–1304 (2006).
  • Phillips TL, Scott CB, Leibel SA, Rotman M, Weigensberg IJ. Results of a randomized comparison of radiotherapy and bromodeoxyuridine with radiotherapy alone for brain metastases: report of RTOG trial 89-05. Int. J. Radiat. Oncol. Biol. Phys.33(2), 339–348 (1995).
  • Bendell JC, Domchek SM, Burstein HJ et al. Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer97, 2972–2977 (2003).
  • Miller KD, Weathers T, Haney LG et al. Occult central nervous system involvement in patients with metastatic breast cancer: prevalence, predictive factors and impact on overall survival. Ann. Oncol.14, 1072–1077 (2003).
  • Lai R, Dang CT, Malkin MG, Abrey LE. The risk of central nervous system metastases after trastuzumab therapy in patients with breast carcinoma. Cancer101(4), 810–816 (2004).
  • Trudeau ME, Crump M, Charpentier D et al. Temozolomide in metastatic breast cancer (MBC): a Phase II trial of the National Cancer Institute of Canada – Clinical Trials Group (NCIC-CTG). Ann. Oncol.17, 952–995 (2006).
  • Rivera E, Meyers C, Groves M et al. Phase I study of capecitabine in combination with temozolomide in the treatment of patients with brain metastases from breast cancer. Cancer107, 1348–1354 (2006).
  • Addeo R, Caraglia M, Faiola V et al. Concomitant treatment of brain metastasis with whole brain radiotherapy [WBRT] and temozolomide [TMZ] is active and improves quality of life. BMC Cancer7, 18 (2007).
  • Antonadou D, Paraskevaidis M, Sarris G et al. Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases. J. Clin. Oncol.20, 3644–3650 (2002).
  • Wedge SR, Porteous JK, Glaser MG, Marcus K, Newlands ES. In vitro evaluation of temozolomide combined with X-irradiation. Anticancer Drugs8, 92–97 (1997).
  • Addeo R, De Rosa C, Faiola V et al. Phase II trial of temozolomide using protracted low-dose and whole-brain radiotherapy for non small cell lung cancer and breast cancer patients with brain metastases. Cancer113(9), 2524–2531 (2008).
  • Park YH, Park MJ, Ji SH et al. Trastuzumab treatment improves brain metastasis outcomes through control and durable prolongation of systemic extracranial disease in HER2-overexpressing breast cancer patients. Br. J. Cancer100(6), 894–900 (2009).
  • Kyoda S, Kinoshita S, Takeyama H, Uchida K, Morikawa T. HER-2 protein overexpression in metastatic breast carcinoma found at autopsy. Jpn. J. Clin. Oncol.38(11), 743–747 (2008).
  • Cabioglu N, Sahin AA, Morandi P. Chemokine receptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications. Ann. Oncol.20, 1013–1019 (2009).
  • Ito Y, Tokudome N, Sugihara T, Takahashi S, Hatake K. Does lapatinib, a small-molecule tyrosine kinase inhibitor, constitute a breakthrough in the treatment of breast cancer? Br. Cancer14(2), 156–162 (2007).
  • Geyer CE, Forster J, Lindquist D et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N. Engl. J. Med.355, 2733–2743 (2006).
  • Gril B, Palmieri D, Bronder JL et al. Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain. J. Natl Cancer Inst.100, 1092–1103 (2008).
  • Lin NU, Carey LA, Liu MC et al. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J. Clin. Oncol.26(12), 1993–1999 (2008).
  • Lin NU, Diéras V, Paul D et al. Multicenter Phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin. Cancer Res.15(4), 1452–1459 (2009).
  • Nathoo N, Chahlavi A, Barnett GH et al. Pathobiology of brain metastases. J. Clin. Pathol.58, 237–242 (2005).
  • Yang SX. Bevacizumab and breast cancer: current therapeutic progress and future perspectives. Expert Rev. Anticancer Ther.9(12), 1715–1725 (2009).
  • Labidi SI, Bachelot T, Ray-Coquard I et al. Bevacizumab and paclitaxel for breast cancer patients with central nervous system metastases: a case series. Clin. Breast Cancer9(2), 118–121 (2009).
  • Rini BI. Sunitinib. Expert Opin. Pharmacother.8(14), 2359–2369 (2007).
  • Abrams TJ, Murray LJ, Pesenti E et al. Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with ‘standard of care’ therapeutic agents for the treatment of breast cancer. Mol. Cancer Ther.10, 1011–1021 (2003).
  • Medioni J, Cojocarasu O, Belcaceres JL, Halimi P, Oudard S. Complete cerebral response with sunitinib for metastatic renal cell carcinoma. Ann. Oncol.18(7), 1282–1283 (2007).
  • Burstein HJ, Elias AD, Rugo HS et al. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J. Clin. Oncol.26(11), 1810–1816 (2008).
  • Patyna S, Peng J. Distribution of sunitinib and its active metabolite in brain and spinal cord tissue following oral or intravenous administration in rodents and monkeys. Eur. J. Cancer4, 21 (2006).

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