86
Views
10
CrossRef citations to date
0
Altmetric
Theme: Sarcoma - Editorial

The cancer stem cell paradigm in Ewing’s sarcoma: what can we learn about these rare cells from a rare tumor?

, &
Pages 143-145 | Published online: 10 Jan 2014

References

  • Suva ML, Riggi N, Stehle JC et al. Identification of cancer stem cells in Ewing’s sarcoma. Cancer Res.69, 1776–1781 (2009).
  • Riggi N, Suva ML, De Vito C et al. EWS–FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells. Genes Dev.24(9), 916–932 (2010).
  • Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell137(4), 647–658 (2009).
  • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell126(4), 663–676 (2006).
  • Jaenisch R, Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell132(4), 567–582 (2008).
  • Yu J, Vodyanik MA, Smuga-Otto K et al. Induced pluripotent stem cell lines derived from human somatic cells. Science318(5858), 1917–1920 (2007).
  • Liu Y, Clem B, Zuba-Surma EK et al. Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype. Cell Stem Cell4(4), 336–347 (2009).
  • Kawamura T, Suzuki J, Wang YV et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature460(7259), 1140–1144 (2009).
  • Banito A, Rashid ST, Acosta JC et al. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev.23(18), 2134–2139 (2009).
  • Marion RM, Strati K, Li H et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature460(7259), 1149–1153 (2009).
  • Newman MA, Thomson JM, Hammond SM. Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA14(8), 1539–1549 (2008).
  • Heo I, Joo C, Cho J, Ha M, Han J, Kim VN. Lin28 mediates the terminal uridylation of let-7 precursor microRNA. Mol. Cell32(2), 276–284 (2008).
  • Yu F, Yao H, Zhu P et al. Let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell131(6), 1109–1123 (2007).
  • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell136(2), 215–233 (2009).
  • Mallanna SK, Rizzino A. Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells. Dev. Biol.344(1), 16–25 (2010).
  • Melo SA, Ropero S, Moutinho C et al. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat. Genet.41(3), 365–370 (2009).
  • Melo SA, Moutinho C, Ropero S et al. A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell.18(4), 303–315 (2010).
  • Shimono Y, Zabala M, Cho RW et al. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell138(3), 592–603 (2009).
  • Iliopoulos D, Lindahl-Allen M, Polytarchou C, Hirsch HA, Tsichlis PN, Struhl K. Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol. Cell39(5), 761–772 (2010).
  • Ma S, Tang KH, Chan YP et al. miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell7(6), 694–707 (2010).
  • Ben-Porath I, Thomson MW, Carey VJ et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet.40(5), 499–507 (2008).
  • Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E, Chang HY. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell2(4), 333–344 (2008).
  • Kim J, Woo AJ, Chu J et al. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell143(2), 313–324 (2010).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.