References
- Jemal A, Bray F, Center MM et al. Global cancer statistics. CA Cancer J. Clin.61, 69–90 (2011).
- American Cancer Society. Cancer Facts & Figures 2010. American Cancer Society, Atlanta, GA, USA (2010).
- Orlando L, Schiavone P, Fedele P et al. Molecularly targeted endocrine therapies for breast cancer. Cancer Treat. Rev.36, S67–S71 (2010).
- Perou CM, Sorlie T, Eisen MB et al. Molecular portraits of human breast tumors. Nature406, 747–752 (2000).
- Ismail-Khan R, Bui MM. A review of triple-negative breast cancer. Cancer Control17, 173–176 (2008).
- Chacon RD, Costanzo MV. Triple-negative breast cancer. Breast Cancer Res.12(S2), S3 (2010).
- De Ruijter TC, Weeck J, de Hoon JPJ et al. Characteristics of triple-negative breast cancer. J. Cancer Res. Clin. Oncol.137, 183–192 (2011).
- Vona-Davis L, Rose DP. The influence of socioeconomic disparities on breast cancer tumor biology and prognosis: a review. J. Womens Health18, 883–893 (2009).
- Anders CK, Carey LA. Biology, metastatic patterns, and treatment of patients with triple-negative breast cancer. Clin. Breast Cancer9, S73–S81 (2009).
- Davies E, Hiscox S. New therapeutic approaches in breast cancer. Maturitas68, 121–128 (2011).
- Cleary MP, Grossmann ME, Ray A. Effect of obesity on breast cancer development. Vet. Pathol.47, 202–213 (2010).
- Porter GA, Inglis KM, Wood LA et al. Effect of obesity on presentation of breast cancer. Ann. Surg. Oncol.13, 327–332 (2006).
- Surmacz E. Obesity hormone leptin: a new target in breast cancer? Breast Cancer Res.9, 301 (2007).
- Otvos L Jr, Kovalszky I, Riolfi M et al. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. Eur. J. Cancer47, 1578–1584 (2011).
- McMurtry V, Simeone AM, Nieves-Alicea R et al. Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells. Clin. Exp. Metastasis26, 197–204 (2009).
- Vona-Davis L, Rose DP. Angiogenesis, adipokines and breast cancer. Cytokine Growth Factor Rev.20, 193–201 (2009).
- Fusco R, Galgani M, Procaccini C et al. Cellular and molecular crosstalk between leptin receptor and estrogen receptor-α in breast cancer: molecular basis for a novel therapeutic setting. Endocr. Relat. Cancer17, 373–382 (2010).
- Fiorio E, Mercanti A, Terrasi M et al. Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis. BMC Cancer8, 305 (2008).
- Ray A, Cleary MP. Leptin as a potential therapeutic target for breast cancer prevention and treatment. Expert Opin. Ther. Targets14, 443–51 (2010).
- Peelman F, Van Beneden L, Zabeau H et al. Mapping of the leptin binding sites and design of a leptin antagonist. J. Biol. Chem.279, 41038–41046 (2004).
- Elinav E, Niv-Spector L, Katz M et al. Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity. Endocrinology150, 3083–3091 (2009).
- Shpilman M, Niv-Spector L, Katz M et al. Development and characterization of high affinity leptins and leptin antagonists. J. Biol. Chem.286, 4429–4442 (2011).
- Gonzalez R, Watters A, Xu Y et al. Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer. Breast Cancer Res.11, R36 (2009).
- Otvos L Jr, Terrasi M, Cascio S et al. Development of a pharmacologically improved peptide agonist of the leptin receptor. Biochim. Biophys. Acta1783, 1745–1754 (2008).
- Otvos L Jr, Kovalszky I, Scolaro L et al. Peptide-based receptor antagonists for cancer treatment and appetite regulation. Biopolymers96, 117–125 (2011).
- Ferla R, Bonomi M, Otvos L Jr et al. Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer (2011) (In Press).
- Otvos L Jr, Shao W-H, Vanniasinghe A et al. Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis. Peptides DOI: 10.1016/j.peptides.2011.06.015 (2011) (Epub ahead of print).
- Hanson LR, Frey WH 2nd. Strategies for intranasal delivery of therapeutics for the prevention and treatment of neuroAIDS. J. Neuroimmune Pharmacol.2, 81–86 (2007).
Website
- ClinicalTrials.gov http://clinicaltrials.gov