1,171
Views
14
CrossRef citations to date
0
Altmetric
Theme: Breast Cancer - Editorial

Endotrophin in the tumor stroma: a new therapeutic target for breast cancer?

&
Pages 111-113 | Published online: 10 Jan 2014

References

  • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N. Engl. J. Med. 348(17), 1625–1638 (2003).
  • Park J, Euhus DM, Scherer PE. Paracrine and endocrine effects of adipose tissue on cancer development and progression. Endocr. Rev. 32(4), 550–570 (2011).
  • Scherer PE. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 55(6), 1537–1545 (2006).
  • Nieman KM, Kenny HA, Penicka CV et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat. Med. 17(11), 1498–1503 (2011).
  • Khan T, Muise ES, Iyengar P et al. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol. Cell. Biol. 29(6), 1575–1591 (2009).
  • Park J, Scherer PE. Adipocyte-derived endotrophin promotes malignant tumor progression. J. Clin. Invest. 122(11), 4243–4256 (2012).
  • Iyengar P, Espina V, Williams TW et al. Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. J. Clin. Invest. 115(5), 1163–1176 (2005).
  • Iyengar P, Combs TP, Shah SJ et al. Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene 22(41), 6408–6423 (2003).
  • Siegel PM, Massagué J. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nat. Rev. Cancer 3(11), 807–821 (2003).
  • Takahara T, Sollberg S, Muona P, Uitto J. Type VI collagen gene expression in experimental liver fibrosis: quantitation and spatial distribution of mRNAs, and immunodetection of the protein. Liver 15(2), 78–86 (1995).
  • Veidal SS, Karsdal MA, Vassiliadis E et al. MMP mediated degradation of type VI collagen is highly associated with liver fibrosis – identification and validation of a novel biochemical marker assay. PLoS ONE 6(9), e24753 (2011).
  • Groma V. Demonstration of collagen type VI and α-smooth muscle actin in renal fibrotic injury in man. Nephrol. Dial. Transplant. 13(2), 305–312 (1998).
  • Specks U, Nerlich A, Colby TV, Wiest I, Timpl R. Increased expression of type VI collagen in lung fibrosis. Am. J. Respir. Crit. Care Med. 151(6), 1956–1964 (1995).
  • Luther DJ, Thodeti CK, Shamhart PE et al. Absence of type VI collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction. Circ. Res. 110(6), 851–856 (2012).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.