Novel insights into the cellular basis of atrial fibrillation

References

• Carnes CA, Chung MK, Nakayama T et al. Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation. Circ. Res.89, E32–E38 (2001).
   PubMed Web of Science ®Google Scholar
• Wattigney WA, Mensah GA, Croft JB. Increasing trends in hospitalization for atrial fibrillation in the United States, 1985 through 1999: implications for primary prevention. Circulation108, 711–716 (2003).
   PubMed Web of Science ®Google Scholar
• Friberg J, Buch P, Scharling H, Gadsbphioll N, Jensen GB. Rising rates of hospital admissions for atrial fibrillation. Epidemiology14, 666–672 (2003).
   PubMed Web of Science ®Google Scholar
• Feinberg WM, Blackshear JL, Laupacis A, Kronmal R, Hart RG. Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications. Arch. Intern. Med.155, 469–473 (1995).
   PubMed Web of Science ®Google Scholar
• Brand FN, Abbott RD, Kannel WB, Wolf PA. Characteristics and prognosis of lone atrial fibrillation. 30-year follow-up in the Framingham Study. J. Am. Med. Assoc.254, 3449–3453 (1985).
   PubMed Web of Science ®Google Scholar
• Levy S, Maarek M, Coumel P et al. Characterization of different subsets of atrial fibrillation in general practice in France: the ALFA study. The College of French Cardiologists. Circulation99, 3028–3035 (1999).
   PubMed Web of Science ®Google Scholar
• Haissaguerre M, Jais P, Shah DC et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N. Engl. J. Med.339, 659–666 (1998).
   PubMed Web of Science ®Google Scholar
• Cappato R, Calkins H, Chen SA et al. Up-dated worldwide survey on the methods, efficacy and safety of catheter ablation for human atrial fibrillation. Circ. Arrhythm. Electrophysiol.3, 32–38 (2010).
   PubMed Web of Science ®Google Scholar
• Dhruvakumar S, Gerstenfeld EP. Complications associated with catheter ablation of atrial fibrillation. Minerva Cardioangiol.55, 353–368 (2007).
   PubMedGoogle Scholar
• Sauer WH, McKernan ML, Lin D, Gerstenfeld EP, Callans DJ, Marchlinski FE. Clinical predictors and outcomes associated with acute return of pulmonary vein conduction during pulmonary vein isolation for treatment of atrial fibrillation. Heart Rhythm3, 1024–1028 (2006).
   PubMed Web of Science ®Google Scholar
• Bellandi F, Simonetti I, Leoncini M et al. Long-term efficacy and safety of propafenone and sotalol for the maintenance of sinus rhythm after conversion of recurrent symptomatic atrial fibrillation. Am. J. Cardiol.88(6), 640–645 (2001).
   PubMed Web of Science ®Google Scholar
• Kochiadakis GE, Marketou ME, Igoumenidis NE et al. Amiodarone, sotalol, or propafenone in atrial fibrillation: which is preferred to maintain normal sinus rhythm? Pacing Clin. Electrophysiol.23, 1883–1887 (2000).
   PubMed Web of Science ®Google Scholar
• Singh BN, Singh SN, Reda DJ et al. Amiodarone versus sotalol for atrial fibrillation. N. Engl J. Med.352(18), 1861–1872 (2005).
   PubMed Web of Science ®Google Scholar
• Levin MD, Lu MM, Peterenko NB et al. Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J. Clin. Invest.119, 3420–3436 (2009).
   PubMedGoogle Scholar
• Chen SA, Hsieh MH, Tai TC et al. Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins. Circulation100, 1879–1886 (1999).
   PubMed Web of Science ®Google Scholar
• Pappone C, Rosanio S, Oreto G et al. Circumferential radiofrequency ablation of pulmonary vein ostia: a new anatomic approach. Circulation102, 2619–2628 (2000).
   PubMed Web of Science ®Google Scholar
• Oral H, Knight BP, Tada H et al. Pulmonary vein isolation for paroxysmal and persistent atrial fibrillation. Circulation105, 1077–1081 (2002).
   PubMed Web of Science ®Google Scholar
• Hirose M, Laurita KR. Calcium-mediated triggered activity is an underlying cellular mechanism of ectopy originating from the pulmonary vein in dogs. Am. J. Physiol. Heart Circ. Physiol.292, H1861–H1867 (2007).
   PubMedGoogle Scholar
• Patterson E, Po S, Scherlag BJ, Lazzara R. Triggered firing in pulmonary veins initiated by in vitro autonomic nerve stimulation. Heart Rhythm2, 624–631 (2005).
   PubMed Web of Science ®Google Scholar
• Chou C-C, Nihei M, Zhou S et al. Intracellular calcium dynamics and anisotropic reentry in isolated canine pulmonary veins and left atrium. Circulation111, 2889–2897 (2005).
   PubMedGoogle Scholar
• Arora R, Verheule S, Scott L et al. Arrhythmogenic substrate of the pulmonary veins assessed by high-resolution optical mapping. Circulation107, 1816–1821 (2003).
   PubMed Web of Science ®Google Scholar
• Seol CA, Kim J, Kim WT et al. Simulation of spontaneous action potentials of cardiomyocytes in pulmonary veins of rabbits. Prog. Biophys. Mol. Biol.96, 132–151 (2008).
   PubMedGoogle Scholar
• Wongcharoen W, Chen YC, Chen YJ et al. Effects of a Na+/Ca2+ exchanger inhibitor on pulmonary vein electrical activity and ouabain-induced arrhythmogenicity. Cardiovasc. Res.70, 497–508 (2006).
   PubMedGoogle Scholar
• Melnyk P, Ehrlich JR, Pourrier M, Villeneuve L, Cha TJ, Nattel S. Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium. Circulation65, 104–116 (2005).
   Google Scholar
• Ehrlich JR, Cha TJ, Zhang L et al. Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties. J. Physiol.551, 801–813 (2003).
   PubMed Web of Science ®Google Scholar
• Tan AY, Chen P-S, Chen LS, Fishbein MC. Autonomic nerves in pulmonary veins. Heart Rhythm4, S57–S60 (2007).
   PubMed Web of Science ®Google Scholar
• Morel E, Meyronet D, Thivolet-Bejuy F, Chevalier P. Identification and distribution of interstitial Cajal cells in human pulmonary veins. Heart Rhythm5, 1063–1067 (2008).
   PubMedGoogle Scholar
• Gherghiceanu M, Hinescu ME, Andrei F et al. Interstitial Cajal-like cells (ICLC) in myocardial sleeves of human pulmonary veins. J. Cell Mol. Med.12, 1777–1781 (2008).
   PubMed Web of Science ®Google Scholar
• Perez-Lugones A, McMahon JT, Ratliff NB et al. Evidence of specialized conduction cells in human pulmonary veins of patients with atrial fibrillation. J. Cardiovasc. Electrophysiol.14, 803–809 (2003).
   PubMed Web of Science ®Google Scholar
• Gerstenfeld EP, Callans DJ, Dixit S, Zado E, Marchlinski FE. Incidence and location of focal atrial fibrillation triggers in patients undergoing repeat pulmonary vein isolation: implications for ablation strategies. J. Cardiovasc. Electrophysiol.14, 685–690 (2003).
   PubMedGoogle Scholar
• Kistler PM, Roberts-Thomson KC, Haqqani HM et al. P-wave morphology in focal atrial tachycardia: development of an algorithm to predict the anatomic site of origin. J. Am. Coll. Cardiol.48, 1010–1017 (2006).
   PubMed Web of Science ®Google Scholar
• Hillock RJ, Kalman JM, Roberts-Thomson KC, Haqqani H, Sparks PB. Multiple focal atrial tachycardias in a healthy adult population: characterization and description of successful radiofrequency ablation. Heart Rhythm4, 435–438 (2007).
   PubMedGoogle Scholar
• Kistler PM, Sanders P, Hussin A et al. Focal atrial tachycardia arising from the mitral annulus: electrocardiographic and electrophysiologic characterization. J. Am. Coll. Cardiol.41, 2212–2219 (2003).
   PubMedGoogle Scholar
• Lee HT, Hennig GW, Fleming NW et al. Septal interstitial cells of Cajal conduct pacemaker activity to excite muscle bundles in human jejunum. Gastroenterology133, 907–917 (2007).
   PubMedGoogle Scholar
• Sanders KM. A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology111, 492–515 (1996).
   PubMed Web of Science ®Google Scholar
• Dudley SC Jr, Hoch NE, McCann LA et al. Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases. Circulation112, 1266–1273 (2005).
   PubMed Web of Science ®Google Scholar
• Campbell DL, Stamler JS, Strauss HC. Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols. J. Gen. Physiol.108, 277–293 (1996).
   PubMed Web of Science ®Google Scholar
• Wang W, Ma J, Zhang P, Luo A. Redox reaction modulates transient and persistent sodium current during hypoxia in guinea pig ventricular myocytes. Pflugers Arch.454, 461–475 (2007).
   PubMedGoogle Scholar
• Lu Z, Abe J, Taunton J et al. Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity. Circ. Res.103, 269–278 (2008).
   PubMedGoogle Scholar
• Cable J, Jackson IJ, Steel KP. Mutations at the W locus affect survival of neural crestderived melanocytes in the mouse. Mech. Dev.50, 139–150 (1995).
   PubMedGoogle Scholar
• Steel KP, Davidson DR, Jackson IJ. TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor. Development115, 1111–1119 (1992).
   PubMed Web of Science ®Google Scholar
• Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature335, 88–89 (1988).
   PubMed Web of Science ®Google Scholar
• Geissler EN, Ryan MA, Housman DE. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell7, 185–192 (1988).
   Google Scholar
• Ardell JL. Structure and function of the mammalian intrinsic cardiac neurons. In: Neurocardiology. Armour JA, Ardell JL (Eds). Oxford University Press, NY, USA (1994).
   Google Scholar
• Armour JA, Murphy DA, Yuan BX, Macdonald S, Hopkins DA. Gross and microscopic anatomy of the human intrinsic cardiac nervous system. Anat. Rec.247, 289–298 (1997).
   PubMedGoogle Scholar
• Scherlag BJ, Yamanashi WS, Patel U, Lazzara R, Jackman WM. Autonomically induced conversion of pulmonary vein focal firing into atrial fibrillation. J. Am. Coll. Cardiol.45, 1575–1580 (2005).
   Google Scholar
• Lin J, Scherlag BJ, Lu Z et al. Inducibility of atrial and ventricular arrhythmias along the ligament of Marshall: role of autonomic factors. J. Cardiovasc. Electrophysiol.19, 955–962 (2008).
   PubMedGoogle Scholar
• Zimmermann M, Kalusche D. Fluctuation in autonomic tone is a major determinant of sustained atrial arrhythmias in patients with focal ectopy originating from the pulmonary veins. J. Cardiovasc. Electrophysiol.12, 285–291 (2001).
   PubMed Web of Science ®Google Scholar
• Lu Z, Scherlag BJ, Lin J et al. Autonomic mechanism for initiation of rapid firing from atria and pulmonary veins: evidence by ablation of ganglionated plexi. Cardiovasc. Res.84, 245–252 (2009).
   PubMed Web of Science ®Google Scholar
• Coumel P, Attuel P, Lavallee J, Flammang D, Leclercq JF, Slama R. The atrial arrhythmia syndrome of vagal origin. Arch. Mal. Coeur Vaiss.71, 645–656 (1978).
   PubMedGoogle Scholar
• Doshi RN, Wu T-J, Yashima M et al. Relation between ligament of Marshall and adrenergic atrial tachyarrhythmia. Circulation100, 876–883 (1999).
   PubMedGoogle Scholar
• Coumel P. Paroxysmal atrial fibrillation: a disorder of autonomic tone? Eur. Heart J.15, 9–16 (1994).
   PubMed Web of Science ®Google Scholar
• Oral H, Chugh A, Scharf C et al. Pulmonary vein isolation for vagotonic, adrenergic, and random episodes of paroxysmal atrial fibrillation. J. Cardiovasc. Electrophysiol.15, 402–408 (2004).
   PubMedGoogle Scholar
• Pappone C, Santinelli V, Manguso F et al. Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation. Circulation109, 327–334 (2004).
   PubMed Web of Science ®Google Scholar
• Lemola K, Chartier D, Yeh YH et al. Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia. Circulation117, 470–477 (2008).
   PubMedGoogle Scholar
• Patterson E, Lazzara R, Szabo B et al. Sodium–calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veins. J. Am. Coll. Cardiol.47, 1196–1206 (2006).
   PubMed Web of Science ®Google Scholar
• Genade S, Genis A, Ytehus K, Huisamen B, Lochner A. Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions. J. Pineal Res.45, 449–458 (2008).
   PubMed Web of Science ®Google Scholar