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Review

Adiposopathy and thyroid disease: tracing the pathway to cardiovascular risk

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Pages 797-803 | Published online: 10 Jan 2014

References

  • Bessesen DH. Update on obesity. J. Clin. Endocrinol. Metab. 93(6), 2027–2034 (2008).
  • Unger RH, Orci L. Lipoapoptosis: its mechanism and its diseases. Biochim. Biophys. Acta 1585(2–3), 202–212 (2002).
  • Drenick EJ, Bale GS, Seltzer F, Johnson DG. Excessive mortality and causes of death in morbidly obese men. JAMA 243(5), 443–445 (1980).
  • Roth J, Qiang X, Marbán SL, Redelt H, Lowell BC. The obesity pandemic: where have we been and where are we going? Obes. Res. 12(Suppl. 2), S88–S101 (2004).
  • Ogden CL, Carroll MD, Flegal KM. Epidemiologic trends in overweight and obesity. Endocrinol. Metab. Clin. North Am. 32(4), 741–760, vii (2003).
  • Golden SH, Robinson KA, Saldanha I, Anton B, Ladenson PW. Clinical review: prevalence and incidence of endocrine and metabolic disorders in the United States: a comprehensive review. J. Clin. Endocrinol. Metab. 94(6), 1853–1878 (2009).
  • Vague J. La différenciation sexuelle, facteur déterminant des formes de l’obésité. Presse Med. 30, 339–340 (1947).
  • Bray GA, Glennon JA, Salans LB, Horton ES, Danforth E Jr, Sims EA. Spontaneous and experimental human obesity: effects of diet and adipose cell size on lipolysis and lipogenesis. Metab. Clin. Exp. 26(7), 739–747 (1977).
  • Halaas JL, Gajiwala KS, Maffei M et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269(5223), 543–546 (1995).
  • O’Rahilly S. Leptin: defining its role in humans by the clinical study of genetic disorders. Nutr. Rev. 60(10 Pt 2), S30–S34; discussion S68 (2002).
  • Bays HE, González-Campoy JM, Henry RR et al.; Adiposopathy Working Group. Is adiposopathy (sick fat) an endocrine disease? Int. J. Clin. Pract. 62(10), 1474–1483 (2008).
  • Bays H, Abate N, Chandalia M. Adiposopathy: sick fat causes high blood sugar, high blood pressure and dyslipidemia. Future Cardiol. 1(1), 39–59 (2005).
  • Bays HE. “Sick fat,” metabolic disease, and atherosclerosis. Am. J. Med. 122(Suppl. 1), S26–S37 (2009).
  • Danforth E Jr. The role of thyroid hormones and insulin in the regulation of energy metabolism. Am. J. Clin. Nutr. 38, 1006–1017 (1983).
  • Duntas L, Hauner H, Rosenthal J, Pfeiffer EF. Thyrotropin releasing hormone (TRH) immunoreactivity and thyroid function in obesity. Int. J. Obes. 15(1), 83–87 (1991).
  • Taneichi H, Sasai T, Ohara M et al. Higher serum free triiodothyronine levels within the normal range are associated with metabolic syndrome components in Type 2 diabetic subjects with euthyroidism. Tohoku J. Exp. Med. 224(3), 173–178 (2011).
  • Alemany M. The defense of adipose tissue against excess substrate-induced hyperthrophia: immune system cell infiltration and arrested metabolic activity. J. Clin. Endocrinol. Metab. 96(1), 66–68 (2011).
  • Apovian CM, Bigornia S, Mott M et al. Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler. Thromb. Vasc. Biol. 28(9), 1654–1659 (2008).
  • Wang B, Wood IS, Trayhurn P. Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflugers Arch. 455(3), 479–492 (2007).
  • Heilbronn LK, Campbell LV. Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr. Pharm. Des. 14(12), 1225–1230 (2008).
  • Nathan C. Epidemic inflammation: pondering obesity. Mol. Med. 14(7–8), 485–492 (2008).
  • Bays HE. Adiposopathy is “sick fat” a cardiovascular disease? J. Am. Coll. Cardiol. 57(25), 2461–2473 (2011).
  • Klimcáková E, Roussel B, Márquez-Quiñones A et al. Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: decreased metabolism and increased immune response. J. Clin. Endocrinol. Metab. 96(1), E73–E82 (2011).
  • Obregon MJ. Thyroid hormone and adipocyte differentiation. Thyroid 18(2), 185–195 (2008).
  • Nomura E, Toyoda N, Harada A et al. Type 2 iodothyronine deiodinase is expressed in human preadipocytes. Thyroid 21(3), 305–310 (2011).
  • Calvo RM, Obregon MJ. Presence and regulation of D1 and D2 deiodinases in rat white adipose tissue. Metab. Clin. Exp. 60(9), 1207–1210 (2011).
  • López M, Varela L, Vázquez MJ et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat. Med. 16(9), 1001–1008 (2010).
  • Jéquier E. Leptin signaling, adiposity, and energy balance. Ann. NY Acad. Sci. 967, 379–388 (2002).
  • Menendez C, Baldelli R, Camiña JP et al. TSH stimulates leptin secretion by a direct effect on adipocytes. J. Endocrinol. 176(1), 7–12 (2003).
  • Ravussin E, Smith SR. Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and Type 2 diabetes mellitus. Ann. NY Acad. Sci. 967, 363–378 (2002).
  • Hsieh CJ, Wang PW, Wang ST et al. Serum leptin concentrations of patients with sequential thyroid function changes. Clin. Endocrinol. (Oxf.) 57(1), 29–34 (2002).
  • Ortega FJ, Jílková ZM, Moreno-Navarrete JM et al. Type I iodothyronine 5′-deiodinase mRNA and activity is increased in adipose tissue of obese subjects. Int. J. Obes. (Lond.) 36(2), 320–324 (2012).
  • al-Adsani H, Hoffer LJ, Silva JE. Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement. J. Clin. Endocrinol. Metab. 82(4), 1118–1125 (1997).
  • Kok P, Roelfsema F, Langendonk JG et al. High circulating thyrotropin levels in obese women are reduced after body weight loss induced by caloric restriction. J. Clin. Endocrinol. Metab. 90(8), 4659–4663 (2005).
  • Mantzoros CS, Magkos F, Brinkoetter M et al. Leptin in human physiology and pathophysiology. Am. J. Physiol. Endocrinol. Metab. 301(4), E567–E584 (2011).
  • Iacobellis G, Ribaudo MC, Zappaterreno A, Iannucci CV, Leonetti F. Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clin. Endocrinol. (Oxf.) 62(4), 487–491 (2005).
  • Rotondi M, Leporati P, La Manna A et al. Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism? Eur. J. Endocrinol. 160(3), 403–408 (2009).
  • Reinehr T, de Sousa G, Andler W. Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids. J. Clin. Endocrinol. Metab. 91(8), 3088–3091 (2006).
  • Chikunguwo S, Brethauer S, Nirujogi V et al. Influence of obesity and surgical weight loss on thyroid hormone levels. Surg. Obes. Relat. Dis. 3(6), 631–635; discussion 635 (2007).
  • Taleb S, Herbin O, Ait-Oufella H et al. Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 27(12), 2691–2698 (2007).
  • Mattioli B, Giordani L, Quaranta MG, Viora M. Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway. FEBS Lett. 583(7), 1102–1106 (2009).
  • Paz-Filho GJ, Delibasi T, Erol HK, Wong ML, Licinio J. Cellular immunity before and after leptin replacement therapy. J. Pediatr. Endocrinol. Metab. 22(11), 1069–1074 (2009).
  • Dayspring TD, Pokrywka G. Impact of triglycerides on lipid and lipoprotein biology in women. Gend. Med. 7(3), 189–205 (2010).
  • Brunzell JD. Dyslipidemia of the metabolic syndrome. In: Obesity. Mechanisms and Clinical Management. Eckel RH (Ed.). Lippincott Williams & Wilkins, PA, USA, 378–398 (2003).
  • Duntas LH. Thyroid disease and lipids. Thyroid 12(4), 287–293 (2002).
  • Lopez D, Abisambra Socarrás JF, Bedi M, Ness GC. Activation of the hepatic LDL receptor promoter by thyroid hormone. Biochim. Biophys. Acta 1771(9), 1216–1225 (2007).
  • Sharma R, Sharma TK, Kaushik GG, Sharma S, Vardey SK, Sinha M. Subclinical hypothyroidism and its association with cardiovascular risk factors. Clin. Lab. 57(9–10), 719–724 (2011).
  • Mikhail GS, Alshammari SM, Alenezi MY, Mansour M, Khalil NA. Increased atherogenic low-density lipoprotein cholesterol in untreated subclinical hypothyroidism. Endocr. Pract. 14(5), 570–575 (2008).
  • Lu L, Wang B, Shan Z et al. The correlation between thyrotropin and dyslipidemia in a population-based study. J. Korean Med. Sci. 26(2), 243–249 (2011).
  • Asvold BO, Bjøro T, Nilsen TI, Vatten LJ. Association between blood pressure and serum thyroid-stimulating hormone concentration within the reference range: a population-based study. J. Clin. Endocrinol. Metab. 92(3), 841–845 (2007).
  • Samaranayake NR, Ong KL, Leung RY et al. Management of obesity in the National Health and Nutrition Examination Survey (NHANES), 2007–2008. Ann. Epidemiol. 22(5), 349–353 (2012).
  • Williams PT, Krauss RM, Stefanick ML, Vranizan KM, Wood PD. Effects of low-fat diet, calorie restriction, and running on lipoprotein subfraction concentrations in moderately overweight men. Metab. Clin. Exp. 43(5), 655–663 (1994).
  • Tuomilehto J, Lindström J, Eriksson JG et al.; Finnish Diabetes Prevention Study Group. Prevention of Type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N. Engl. J. Med. 344(18), 1343–1350 (2001).
  • Wadden TA, Volger S, Sarwer DB et al. A two-year randomized trial of obesity treatment in primary care practice. N. Engl. J. Med. 365(21), 1969–1979 (2011).
  • Bays HE. Lorcaserin and adiposopathy: 5-HT2C agonism as a treatment for ‘sick fat’ and metabolic disease. Expert Rev. Cardiovasc. Ther. 7(11), 1429–1445 (2009).
  • Tam CS, Lecoultre V, Ravussin E. Novel strategy for the use of leptin for obesity therapy. Expert Opin. Biol. Ther. 11(12), 1677–1685 (2011).
  • Tancevski I, Rudling M, Eller P. Thyromimetics: a journey from bench to bed-side. Pharmacol. Ther. 131(1), 33–39 (2011).
  • Ladenson PW, Kristensen JD, Ridgway EC et al. Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia. N. Engl. J. Med. 362(10), 906–916 (2010).
  • Tancevski I, Demetz E, Eller P. Sobetirome: a selective thyromimetic for the treatment of dyslipidemia. Recent Pat. Cardiovasc. Drug Discov. 6(1), 16–19 (2011).
  • Scanlan TS. Sobetirome: a case history of bench-to-clinic drug discovery and development. Heart Fail. Rev. 15(2), 177–182 (2010).
  • Appachi S, Kelly KR, Schauer PR et al. Reduced cardiovascular risk following bariatric surgeries is related to a partial recovery from “adiposopathy”. Obes. Surg. 21(12), 1928–1936 (2011).

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