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Theme: Pediatric & Geriatric Cardiology - Review

The older patient with heart failure: high risk for frailty and cognitive impairment

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Pages 779-795 | Published online: 10 Jan 2014

References

  • Zipos DP, Libby P, Bonow RO, Braunwald E. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine (7th Edition). WB Saunders, PA, USA, 603–651 (2005).
  • Arnold JM, Liu P, Demers C et al.; Canadian Cardiovascular Society. Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: diagnosis and management. Can. J. Cardiol. 22(1), 23–45 (2006).
  • Lam CS, Donal E, Kraigher-Krainer E, Vasan RS. Epidemiology and clinical course of heart failure with preserved ejection fraction. Eur. J. Heart Fail. 13(1), 18–28 (2011).
  • Lee DS, Gona P, Vasan RS et al. Relation of disease etiology and risk factors to heart failure with preserved or reduced ejection fraction: insights from the National Heart, Lung, and Blood Institute’s Framingham Heart Study. Circulation 119(24), 3070–3077 (2009).
  • Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N. Engl. J. Med. 355(3), 251–259 (2006).
  • Curtis LH, Whellan DJ, Hammill BG et al. Incidence and prevalence of heart failure in elderly persons, 1994–2003. Arch. Intern. Med. 168(4), 418–424 (2008).
  • Miller LW. Heart failure: who we treat versus who we study. Cardiol. Clin. 26(1), 113–125, viii (2008).
  • Roger VL, Go AS, Lloyd-Jones DM et al.; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics–2011 update: a report from the American Heart Association. Circulation 123(4), e18–e209 (2011).
  • Velagaleti RS, Vasan RS. Heart failure in the twenty-first century: is it a coronary artery disease or hypertension problem? Cardiol. Clin. 25(4), 487–495, v (2007).
  • Stewart S, MacIntyre K, Hole DJ, Capewell S, McMurray JJ. More ‘malignant’ than cancer? Five-year survival following a first admission for heart failure. Eur. J. Heart Fail. 3(3), 315–322 (2001).
  • Ko DT, Alter DA, Austin PC et al. Life expectancy after an index hospitalization for patients with heart failure: a population-based study. Am. Heart J. 155(2), 324–331 (2008).
  • Novack V, Pencina M, Zahger D et al. Routine laboratory results and thirty day and one-year mortality risk following hospitalization with acute decompensated heart failure. PLoS ONE 5(8), e12184 (2010).
  • Liao L, Allen LA, Whellan DJ. Economic burden of heart failure in the elderly. Pharmacoeconomics 26(6), 447–462 (2008).
  • Fang J, Mensah GA, Croft JB, Keenan NL. Heart failure-related hospitalization in the U.S., 1979 to 2004. J. Am. Coll. Cardiol. 52(6), 428–434 (2008).
  • Butler J, Kalogeropoulos A. Worsening heart failure hospitalization epidemic we do not know how to prevent and we do not know how to treat! J. Am. Coll. Cardiol. 52(6), 435–437 (2008).
  • Jiang W, Alexander J, Christopher E et al. Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure. Arch. Intern. Med. 161(15), 1849–1856 (2001).
  • Bergman H, Ferrucci L, Guralnik J et al. Frailty: an emerging research and clinical paradigm–issues and controversies. J. Gerontol. A Biol. Sci. Med. Sci. 62(7), 731–737 (2007).
  • Heckman GA. Integrated care for the frail elderly. Healthc. Pap. 11(1), 62–68; discussion 86–91 (2011).
  • Rockwood K, Song X, Mitnitski A. Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey. CMAJ 183(8), E487–E494 (2011).
  • Espinoza S, Walston JD. Frailty in older adults: insights and interventions. Cleve. Clin. J. Med. 72(12), 1105–1112 (2005).
  • Fried LP, Tangen CM, Walston J et al.; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J. Gerontol. A Biol. Sci. Med. Sci. 56(3), M146–M156 (2001).
  • Rockwood K, Song X, MacKnight C et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 173(5), 489–495 (2005).
  • Rockwood K, Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin. Geriatr. Med. 27(1), 17–26 (2011).
  • Seene T, Kaasik P, Riso EM. Review on aging, unloading and reloading: changes in skeletal muscle quantity and quality. Arch. Gerontol. Geriatr. 54(2), 374–380 (2012).
  • Thomas DR. Sarcopenia. Clin. Geriatr. Med. 26(2), 331–346 (2010).
  • Doherty TJ. Invited review: aging and sarcopenia. J. Appl. Physiol. 95(4), 1717–1727 (2003).
  • Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K. Frailty, body mass index, and abdominal obesity in older people. J. Gerontol. A Biol. Sci. Med. Sci. 65(4), 377–381 (2010).
  • Springer J, Filippatos G, Akashi YJ, Anker SD. Prognosis and therapy approaches of cardiac cachexia. Curr. Opin. Cardiol. 21(3), 229–233 (2006).
  • Anker SD, Coats AJ. Cardiac cachexia: a syndrome with impaired survival and immune and neuroendocrine activation. Chest 115(3), 836–847 (1999).
  • von Haehling S, Schefold JC, Lainscak M, Doehner W, Anker SD. Inflammatory biomarkers in heart failure revisited: much more than innocent bystanders. Heart Fail. Clin. 5(4), 549–560 (2009).
  • Freeman LM. The pathophysiology of cardiac cachexia. Curr. Opin. Support. Palliat. Care 3(4), 276–281 (2009).
  • Anker SD, Steinborn W, Strassburg S. Cardiac cachexia. Ann. Med. 36(7), 518–529 (2004).
  • Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J. Gerontol. A Biol. Sci. Med. Sci. 59(3), 255–263 (2004).
  • Abellan van Kan G, Rolland Y, Houles M, Gillette-Guyonnet S, Soto M, Vellas B. The assessment of frailty in older adults. Clin. Geriatr. Med. 26(2), 275–286 (2010).
  • Purser JL, Kuchibhatla MN, Fillenbaum GG, Harding T, Peterson ED, Alexander KP. Identifying frailty in hospitalized older adults with significant coronary artery disease. J. Am. Geriatr. Soc. 54(11), 1674–1681 (2006).
  • Abellan van Kan G, Rolland Y, Andrieu S et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J. Nutr. Health Aging 13(10), 881–889 (2009).
  • Lupón J, González B, Santaeugenia S et al. Prognostic implication of frailty and depressive symptoms in an outpatient population with heart failure. Rev. Esp. Cardiol. 61(8), 835–842 (2008).
  • Freiheit EA, Hogan DB, Eliasziw M et al. Development of a frailty index for patients with coronary artery disease. J. Am. Geriatr. Soc. 58(8), 1526–1531 (2010).
  • Newman AB, Gottdiener JS, McBurnie MA et al.; Cardiovascular Health Study Research Group. Associations of subclinical cardiovascular disease with frailty. J. Gerontol. A Biol. Sci. Med. Sci. 56(3), M158–M166 (2001).
  • Newman AB, Gottdiener JS, Mcburnie MA et al.; Cardiovascular Health Study Research Group. Associations of subclinical cardiovascular disease with frailty. J. Gerontol. A Biol. Sci. Med. Sci. 56(3), M158–M166 (2001).
  • Afilalo J. Frailty in patients with cardiovascular disease: why, when, and how to measure. Curr. Cardiovasc. Risk Rep. 5(5), 467–472 (2011).
  • Abou-Raya S, Abou-Raya A. Osteoporosis and congestive heart failure (CHF) in the elderly patient: double disease burden. Arch. Gerontol. Geriatr. 49(2), 250–254 (2009).
  • Singh M, Rihal CS, Lennon RJ, Spertus JA, Nair KS, Roger VL. Influence of frailty and health status on outcomes in patients with coronary disease undergoing percutaneous revascularization. Circ. Cardiovasc. Qual. Outcomes 4(5), 496–502 (2011).
  • Sündermann S, Dademasch A, Praetorius J et al. Comprehensive assessment of frailty for elderly high-risk patients undergoing cardiac surgery. Eur. J. Cardiothorac. Surg. 39(1), 33–37 (2011).
  • Afilalo J, Karunananthan S, Eisenberg MJ, Alexander KP, Bergman H. Role of frailty in patients with cardiovascular disease. Am. J. Cardiol. 103(11), 1616–1621 (2009).
  • Cacciatore F, Abete P, Mazzella F et al. Frailty predicts long-term mortality in elderly subjects with chronic heart failure. Eur. J. Clin. Invest. 35(12), 723–730 (2005).
  • Tjam EY, Heckman GA, Smith S et al. Predicting heart failure mortality in frail seniors: comparing the NYHA functional classification with the Resident Assessment Instrument (RAI) 2.0. Int. J. Cardiol. 155(1), 75–80 (2012).
  • Boxer R, Kleppinger A, Ahmad A, Annis K, Hager D, Kenny A. The 6-minute walk is associated with frailty and predicts mortality in older adults with heart failure. Congest. Heart Fail. 16(5), 208–213 (2010).
  • Buck HG, Riegel B. The impact of frailty on health related quality of life in heart failure. Eur. J. Cardiovasc. Nurs. 10(3), 159–166 (2011).
  • Wolinsky FD, Smith DM, Stump TE, Overhage JM, Lubitz RM. The sequelae of hospitalization for congestive heart failure among older adults. J. Am. Geriatr. Soc. 45(5), 558–563 (1997).
  • Chan Carusone SB, Walter SD, Brazil K, Loeb MB. Pneumonia and lower respiratory infections in nursing home residents: predictors of hospitalization and mortality. J. Am. Geriatr. Soc. 55(3), 414–419 (2007).
  • Hak E, Bont J, Hoes AW, Verheij TJ. Prognostic factors for serious morbidity and mortality from community-acquired lower respiratory tract infections among the elderly in primary care. Fam. Pract. 22(4), 375–380 (2005).
  • Ovbiagele B, Hills NK, Saver JL, Johnston SC; California Acute Stroke Prototype Registry Investigators. Frequency and determinants of pneumonia and urinary tract infection during stroke hospitalization. J. Stroke Cerebrovasc. Dis. 15(5), 209–213 (2006).
  • French DD, Bass E, Bradham DD, Campbell RR, Rubenstein LZ. Rehospitalization after hip fracture: predictors and prognosis from a national veterans study. J. Am. Geriatr. Soc. 56(4), 705–710 (2008).
  • Bozkurt B, Mann DL, Deswal A. Biomarkers of inflammation in heart failure. Heart Fail. Rev. 15(4), 331–341 (2010).
  • Kanapuru B, Ershler WB. Inflammation, coagulation, and the pathway to frailty. Am. J. Med. 122(7), 605–613 (2009).
  • Yao X, Li H, Leng SX. Inflammation and immune system alterations in frailty. Clin. Geriatr. Med. 27(1), 79–87 (2011).
  • Hunt KJ, Walsh BM, Voegeli D, Roberts HC. Inflammation in aging part 2: implications for the health of older people and recommendations for nursing practice. Biol. Res. Nurs. 11(3), 253–260 (2010).
  • Parissis JT, Adamopoulos S, Rigas A et al. Comparison of circulating proinflammatory cytokines and soluble apoptosis mediators in patients with chronic heart failure with versus without symptoms of depression. Am. J. Cardiol. 94(10), 1326–1328 (2004).
  • Corwin EJ. Understanding cytokines. Part I: physiology and mechanism of action. Biol. Res. Nurs. 2(1), 30–40 (2000).
  • Kronfol Z, Remick DG. Cytokines and the brain: implications for clinical psychiatry. Am. J. Psychiatry 157(5), 683–694 (2000).
  • Vaccarino V, Kasl SV, Abramson J, Krumholz HM. Depressive symptoms and risk of functional decline and death in patients with heart failure. J. Am. Coll. Cardiol. 38(1), 199–205 (2001).
  • Rumsfeld JS, Havranek E, Masoudi FA et al.; Cardiovascular Outcomes Research Consortium. Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure. J. Am. Coll. Cardiol. 42(10), 1811–1817 (2003).
  • Metra M, Zacà V, Parati G et al.; Heart Failure Study Group of the Italian Society of Cardiology. Cardiovascular and noncardiovascular comorbidities in patients with chronic heart failure. J. Cardiovasc. Med. (Hagerstown) 12(2), 76–84 (2011).
  • Krum H, Gilbert RE. Demographics and concomitant disorders in heart failure. Lancet 362(9378), 147–158 (2003).
  • Ahluwalia SC, Gross CP, Chaudhry SI, Leo-Summers L, Van Ness PH, Fried TR. Change in comorbidity prevalence with advancing age among persons with heart failure. J. Gen. Intern. Med. 26(10), 1145–1151 (2011).
  • Morley JE. Diabetes, sarcopenia, and frailty. Clin. Geriatr. Med. 24(3), 455–469, vi (2008).
  • Chen LK, Chen YM, Lin MH, Peng LN, Hwang SJ. Care of elderly patients with diabetes mellitus: a focus on frailty. Ageing Res. Rev. 9(Suppl. 1), S18–S22 (2010).
  • Araki A, Ito H. Diabetes mellitus and geriatric syndromes. Geriatr. Gerontol. Int. 9(2), 105–114 (2009).
  • Wilhelm-Leen ER, Hall YN, Deboer IH, Chertow GM. Vitamin D deficiency and frailty in older Americans. J. Intern. Med. 268(2), 171–180 (2010).
  • Heppner HJ, Bauer JM, Sieber CC, Bertsch T. Laboratory aspects relating to the detection and prevention of frailty. Int. J. Prev. Med. 1(3), 149–157 (2010).
  • Anderson JL, May HT, Horne BD et al.; Intermountain Heart Collaborative (IHC) Study Group. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Am. J. Cardiol. 106(7), 963–968 (2010).
  • Witham MD. Vitamin D in chronic heart failure. Curr. Heart Fail. Rep. 8(2), 123–130 (2011).
  • Patel R, Rizvi AA. Vitamin D deficiency in patients with congestive heart failure: mechanisms, manifestations, and management. South. Med. J. 104(5), 325–330 (2011).
  • Boxer RS, Dauser DA, Walsh SJ, Hager WD, Kenny AM. The association between vitamin D and inflammation with the 6-minute walk and frailty in patients with heart failure. J. Am. Geriatr. Soc. 56(3), 454–461 (2008).
  • Liu LC, Voors AA, van Veldhuisen DJ et al. Vitamin D status and outcomes in heart failure patients. Eur. J. Heart Fail. 13(6), 619–625 (2011).
  • Lauretani F, Maggio M, Valenti G, Dall’Aglio E, Ceda GP. Vitamin D in older population: new roles for this ‘classic actor’? Aging Male 13(4), 215–232 (2010).
  • Wong CY, Chaudhry SI, Desai MM, Krumholz HM. Trends in comorbidity, disability, and polypharmacy in heart failure. Am. J. Med. 124(2), 136–143 (2011).
  • Liu L. Changes in cardiovascular hospitalization and comorbidity of heart failure in the United States: findings from the National Hospital Discharge Surveys 1980–2006. Int. J. Cardiol. 149(1), 39–45 (2011).
  • Braunstein JB, Anderson GF, Gerstenblith G et al. Noncardiac comorbidity increases preventable hospitalizations and mortality among medicare beneficiaries with chronic heart failure. J. Am. Coll. Cardiol. 42(7), 1226–1233 (2003).
  • Dai S, Walsh P, Wielgosz A, Gurevich Y, Bancej C, Morrison H. Comorbidities and mortality associated with hospitalized heart failure in Canada. Can. J. Cardiol. 28(1), 74–79 (2012).
  • Grossniklaus DA, O’Brien MC, Clark PC, Dunbar SB. Nutrient intake in heart failure patients. J. Cardiovasc. Nurs. 23(4), 357–363 (2008).
  • Sandek A, Doehner W, Anker SD, von Haehling S. Nutrition in heart failure: an update. Curr. Opin. Clin. Nutr. Metab. Care 12(4), 384–391 (2009).
  • Dunn SP, Bleske B, Dorsch M, Macaulay T, Van Tassell B, Vardeny O. Nutrition and heart failure: impact of drug therapies and management strategies. Nutr. Clin. Pract. 24(1), 60–75 (2009).
  • McKelvie RS. Exercise training in patients with heart failure: clinical outcomes, safety, and indications. Heart Fail. Rev. 13(1), 3–11 (2008).
  • Bosworth HB, Steinhauser KE, Orr M, Lindquist JH, Grambow SC, Oddone EZ. Congestive heart failure patients’ perceptions of quality of life: the integration of physical and psychosocial factors. Aging Ment. Health 8(1), 83–91 (2004).
  • Heckman GA, Patterson CJ, Demers C, St Onge J, Turpie ID, McKelvie RS. Heart failure and cognitive impairment: challenges and opportunities. Clin. Interv. Aging 2(2), 209–218 (2007).
  • Fayers PM, Hjermstad MJ, Ranhoff AH et al. Which mini-mental state exam items can be used to screen for delirium and cognitive impairment? J. Pain Symptom Manage. 30(1), 41–50 (2005).
  • Anstey KJ, Low LF. Normal cognitive changes in aging. Aust. Fam. Physician 33(10), 783–787 (2004).
  • Yankner BA, Lu T, Loerch P. The aging brain. Annu. Rev. Pathol. 3, 41–66 (2008).
  • Budson AE, Price BH. Memory dysfunction. N. Engl. J. Med. 352(7), 692–699 (2005).
  • Chertkow H, Nasreddine Z, Joanette Y et al. Mild cognitive impairment and cognitive impairment, no dementia: part A, concept and diagnosis. Alzheimers. Dement. 3(4), 266–282 (2007).
  • Bouchard RW. Diagnostic criteria of dementia. Can. J. Neurol. Sci. 34(Suppl. 1), S11–S18 (2007).
  • Ross GW, Bowen JD. The diagnosis and differential diagnosis of dementia. Med. Clin. North Am. 86(3), 455–476 (2002).
  • Petersen RC, Roberts RO, Knopman DS et al. Mild cognitive impairment: ten years later. Arch. Neurol. 66(12), 1447–1455 (2009).
  • Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12(3), 189–198 (1975).
  • Vogels RL, Scheltens P, Schroeder-Tanka JM, Weinstein HC. Cognitive impairment in heart failure: a systematic review of the literature. Eur. J. Heart Fail. 9(5), 440–449 (2007).
  • Tombaugh TN, McIntyre NJ. The mini-mental state examination: a comprehensive review. J. Am. Geriatr. Soc. 40(9), 922–935 (1992).
  • Brodaty H, Low LF, Gibson L, Burns K. What is the best dementia screening instrument for general practitioners to use? Am. J. Geriatr. Psychiatry 14(5), 391–400 (2006).
  • Borson S, Scanlan JM, Chen P, Ganguli M. The Mini-Cog as a screen for dementia: validation in a population-based sample. J. Am. Geriatr. Soc. 51(10), 1451–1454 (2003).
  • Milne A, Culverwell A, Guss R, Tuppen J, Whelton R. Screening for dementia in primary care: a review of the use, efficacy and quality of measures. Int. Psychogeriatr. 20(5), 911–926 (2008).
  • Mitchell AJ, Malladi S. Screening and case finding tools for the detection of dementia. Part I: evidence-based meta-analysis of multidomain tests. Am. J. Geriatr. Psychiatry 18(9), 759–782 (2010).
  • Ismail Z, Rajji TK, Shulman KI. Brief cognitive screening instruments: an update. Int. J. Geriatr. Psychiatry 25(2), 111–120 (2010).
  • Cameron J, Worrall-Carter L, Page K, Riegel B, Lo SK, Stewart S. Does cognitive impairment predict poor self-care in patients with heart failure? Eur. J. Heart Fail. 12(5), 508–515 (2010).
  • Athilingam P, King KB, Burgin SW, Ackerman M, Cushman LA, Chen L. Montreal cognitive assessment and mini-mental status examination compared as cognitive screening tools in heart failure. Heart Lung 40(6), 521–529 (2011).
  • Riegel B, Bennett JA, Davis A et al. Cognitive impairment in heart failure: issues of measurement and etiology. Am. J. Crit. Care 11(6), 520–528 (2002).
  • Cameron J, Ski CF, Thompson DR. Cognitive impairment in chronic heart failure and the need for screening. Am. J. Cardiol. 107(10), 1547–1548 (2011).
  • Hachinski V, Iadecola C, Petersen RC et al. National Institute of Neurological Disorders and Stroke – Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke. 37(9), 2220–2241 (2006).
  • Harkness K, Demers C, Heckman GA, McKelvie RS. Screening for cognitive deficits using the Montreal cognitive assessment tool in outpatients ≥65 years of age with heart failure. Am. J. Cardiol. 107(8), 1203–1207 (2011).
  • Jorm AF. The informant questionnaire on cognitive decline in the elderly (IQCODE): a review. Int. Psychogeriatr. 16(3), 275–293 (2004).
  • Graham JE, Rockwood K, Beattie BL et al. Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet 349(9068), 1793–1796 (1997).
  • Lopez CL, Jagust JJ, DeKosky ST et al. Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study. Arch. Neurol. 60(10), 1385–1389 (2003).
  • Qiu C, Winblad B, Marengoni A, Klarin I, Fastbom J, Fratiglioni L. Heart failure and risk of dementia and Alzheimer disease: a population-based cohort study. Arch. Intern. Med. 166(9), 1003–1008 (2006).
  • Tilvis RS, Kähönen-Väre MH, Jolkkonen J, Valvanne J, Pitkala KH, Strandberg TE. Predictors of cognitive decline and mortality of aged people over a 10-year period. J. Gerontol. A Biol. Sci. Med. Sci. 59(3), 268–274 (2004).
  • Bennett SJ, Sauvé MJ. Cognitive deficits in patients with heart failure: a review of the literature. J. Cardiovasc. Nurs. 18(3), 219–242 (2003).
  • Pressler SJ. Cognitive functioning and chronic heart failure: a review of the literature (2002–July 2007). J. Cardiovasc. Nurs. 23(3), 239–249 (2008).
  • Vogels RL, Oosterman JM, van Harten B et al. Profile of cognitive impairment in chronic heart failure. J. Am. Geriatr. Soc. 55(11), 1764–1770 (2007).
  • Bauer L, Pozehl B, Hertzog M et al. A brief neuropsychological battery for use in chronic heart failure population. Eur. J. Cardiovas. Nurs. 11(2), 223–230 (2012).
  • Zuccalà G, Pedone C, Cesari M et al. The effects of cognitive impairment on mortality among hospitalized patients with heart failure. Am. J. Med. 115(2), 97–103 (2003).
  • Fong TG, Tulebaev SR, Inouye SK. Delirium in elderly adults: diagnosis, prevention and treatment. Nat. Rev. Neurol. 5(4), 210–220 (2009).
  • Rudolph JL, Inouye SK, Jones RN et al. Delirium: an independent predictor of functional decline after cardiac surgery. J. Am. Geriatr. Soc. 58(4), 643–649 (2010).
  • McCusker J, Cole M, Dendukuri N, Belzile E, Primeau F. Delirium in older medical inpatients and subsequent cognitive and functional status: a prospective study. CMAJ 165(5), 575–583 (2001).
  • Baldasseroni S, Mossello E, Romboli B et al. Relationship between cognitive function and 6-minute walking test in older outpatients with chronic heart failure. Aging Clin. Exp. Res. 22(4), 308–313 (2010).
  • Alosco ML, Spitznagel MB, Cohen R et al. Cognitive impairment is independently associated with reduced instrumental activities of daily living in persons with heart failure. J. Cardiovasc. Nurs. 27(1), 44–50 (2012).
  • Rogers AE, Addington-Hall JM, Abery AJ et al. Knowledge and communication difficulties for patients with chronic heart failure: qualitative study. BMJ 321(7261), 605–607 (2000).
  • Sloan RS, Pressler SJ. Cognitive deficits in heart failure: re-cognition of vulnerability as a strange new world. J. Cardiovasc. Nurs. 24(3), 241–248 (2009).
  • Pressler SJ, Subramanian U, Kareken D et al. Cognitive deficits and health-related quality of life in chronic heart failure. J. Cardiovasc. Nurs. 25(3), 189–198 (2010).
  • Bennett SJ, Pressler ML, Hays L, Firestine LA, Huster GA. Psychosocial variables and hospitalization in persons with chronic heart failure. Prog. Cardiovasc. Nurs. 12(4), 4–11 (1997).
  • Riegel B, Moser DK, Anker SD et al. State of the science. Promoting self-care in persons with heart failure. A scientific statement from the American Heart Association. Circulation. 120(12), 1141–1163 (2009).
  • Cameron J, Worrall-Carter L, Riegel B, Lo SK, Stewart S. Testing a model of patient characteristics, psychologic status, and cognitive function as predictors of self-care in persons with chronic heart failure. Heart Lung 38(5), 410–418 (2009).
  • Dickson VV, Tkacs N, Riegel B. Cognitive influences on self-care decision making in persons with heart failure. Am. Heart J. 154(3), 424–431 (2007).
  • Welstand J, Carson A, Rutherford P. Living with heart failure: an integrative review. Int. J. Nurs. Stud. 46(10), 1374–1385 (2009).
  • Fang ZY, Prins JB, Marwick TH. Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications. Endocr. Rev. 25(4), 543–567 (2004).
  • Román G. Managing Vascular Dementia. Science Press, London, UK (2003).
  • Singh-Manoux A, Sabia S, Lajnef M et al. History of coronary heart disease and cognitive performance in midlife: the Whitehall II study. Eur. Heart J. 29(17), 2100–2107 (2008).
  • Roberts RO, Knopman DS, Geda YE, Cha RH, Roger VL, Petersen RC. Coronary heart disease is associated with non-amnestic mild cognitive impairment. Neurobiol. Aging 31(11), 1894–1902 (2010).
  • McMurray JJ, Carson PE, Komajda M et al. Heart failure with preserved ejection fraction: clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial. Eur. J. Heart Fail. 10(2), 149–156 (2008).
  • Sharp SI, Aarsland D, Day S, Sønnesyn H, Ballard C; Alzheimer’s Society Vascular Dementia Systematic Review Group. Hypertension is a potential risk factor for vascular dementia: systematic review. Int. J. Geriatr. Psychiatry 26(7), 661–669 (2011).
  • Roberts RO, Geda YE, Knopman DS et al. Association of duration and severity of diabetes mellitus with mild cognitive impairment. Arch. Neurol. 65(8), 1066–1073 (2008).
  • Cukierman T, Gerstein HC, Williamson JD. Cognitive decline and dementia in diabetes–systematic overview of prospective observational studies. Diabetologia 48(12), 2460–2469 (2005).
  • Gnanasekaran G. Epidemiology of depression in heart failure. Heart Fail. Clin. 7(1), 1–10 (2011).
  • Bilato C, Corti MC, Baggio G et al. Prevalence, functional impact, and mortality of atrial fibrillation in an older Italian population (from the Pro.V.A. study). Am. J. Cardiol. 104(8), 1092–1097 (2009).
  • Sharma B, Owens R, Malhotra A. Sleep in congestive heart failure. Med. Clin. North Am. 94(3), 447–464 (2010).
  • Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J. Am. Coll. Cardiol. 48(8), 1527–1537 (2006).
  • Muliyala KP, Varghese M. The complex relationship between depression and dementia. Ann. Indian Acad Neurlol. 13(Suppl. 2), S69–S73 (2011).
  • Wilkins VM, Kiosses D, Ravdin LD. Late-life depression with comorbid cognitive impairment and disability: nonpharmacological interventions. Clin. Interv. Aging 5, 323–331 (2010).
  • Huang CQ, Wang ZR, Li YH, Xie YZ, Liu QX. Cognitive function and risk for depression in old age: a meta-analysis of published literature. Int. Psychogeriatr. 23(4), 516–525 (2011).
  • Cairns JA, Connolly S, McMurtry S, Stephenson M, Talajic M; CCS Atrial Fibrillation Guidelines Committee. Canadian Cardiovascular Society atrial fibrillation guidelines 2010: prevention of stroke and systemic thromboembolism in atrial fibrillation and flutter. Can. J. Cardiol. 27(1), 74–90 (2011).
  • Mead GE, Keir S. Association between cognitive impairment and atrial fibrillation: a systematic review. J. Stroke Cerebrovasc. Dis. 10(2), 35–43 (2001).
  • Dublin S, Anderson ML, Haneuse SJ et al. Atrial fibrillation and risk of dementia: a prospective cohort study. J. Am. Geriatr. Soc. 59(8), 1369–1375 (2011).
  • Bunch TJ, Weiss JP, Crandall BG et al. Atrial fibrillation is independently associated with senile, vascular, and Alzheimer’s dementia. Heart Rhythm 7(4), 433–437 (2010).
  • Marzona I, O’Donnell M, Teo K et al. Increased risk of cognitive and functional decline in patients with atrial fibrillation: results of the ONTARGET and TRANSCEND studies. CMAJ 184(6), E329–E336 (2012).
  • Riegel B, Weaver TE. Poor sleep and impaired self-care: towards a comprehensive model linking sleep, cognition, and heart failure outcomes. Eur. J. Cardiovasc. Nurs. 8(5), 337–344 (2009).
  • Bagai K. Obstructive sleep apnea, stroke, and cardiovascular diseases. Neurologist 16(6), 329–339 (2010).
  • Morrell MJ, Glasser M. The brain in sleep-disordered breathing: a vote for the chicken? Am. J. Respir. Crit. Care Med. 183(10), 1292–1294 (2011).
  • Kahwash R, Kikta D, Khayat R. Recognition and management of sleep-disordered breathing in chronic heart failure. Curr. Heart Fail. Rep. 8(1), 72–79 (2011).
  • Karavidas A, Kapsimalis F, Lazaros G et al. The impact of positive airway pressure on cardiac status and clinical outcomes in patients with advanced heart failure and sleep disordered breathing: a preliminary report. Sleep Breath. 15(4), 701–709 (2011).
  • Pullicino P, Mifsud V, Wong E, Graham S, Ali I, Smajlovic D. Hypoperfusion-related cerebral ischemia and cardiac left ventricular systolic dysfunction. J. Stroke Cerebrovasc. Dis. 10(4), 178–182 (2001).
  • Howard R, Trend P, Russell RW. Clinical features of ischemia in cerebral arterial border zones after periods of reduced cerebral blood flow. Arch. Neurol. 44(9), 934–940 (1987).
  • MacKenzie JM. Are all cardio–embolic strokes embolic? An autopsy study of 100 consecutive acute ischaemic strokes. Cerebrovasc. Dis. 10(4), 289–292 (2000).
  • Georgiadis D, Sievert M, Cencetti S et al. Cerebrovascular reactivity is impaired in patients with cardiac failure. Eur. Heart J. 21(5), 407–413 (2000).
  • Lip GY, Gibbs CR. Does heart failure confer a hypercoagulable state? Virchow’s triad revisited. J. Am. Coll. Cardiol. 33(5), 1424–1426 (1999).
  • Witt BJ, Gami AS, Ballman KV et al. The incidence of ischemic stroke in chronic heart failure: a meta-analysis. J. Card. Fail. 13(6), 489–496 (2007).
  • Jin YP, Di Legge S, Ostbye T, Feightner JW, Hachinski V. The reciprocal risks of stroke and cognitive impairment in an elderly population. Alzheimers Dement. 2(3), 171–178 (2006).
  • Inouye SK. Delirium in older persons. N. Engl. J. Med. 354(11), 1157–1165 (2006).
  • Tune L, Carr S, Cooper T, Klug B, Golinger RC. Association of anticholinergic activity of prescribed medications with postoperative delirium. J. Neuropsychiatry Clin. Neurosci. 5(2), 208–210 (1993).
  • Tune LE. Anticholinergic effects of medication in elderly patients. J. Clin. Psychiatry 62(Suppl. 21), 11–14 (2001).
  • McDonnell-Cooke D. The use of central nervous system manifestations in early detection of digitalis toxicity. Heart Lung. 22(6), 477–481 (1993).
  • Antonelli Incalzi R, Trojano L, Acanfora D et al.; CHF Italian Study Investigators. Verbal memory impairment in congestive heart failure. J. Clin. Exp. Neuropsychol. 25(1), 14–23 (2003).
  • Keller S, Frishman WH. Neuropsychiatric effects of cardiovascular drug therapy. Cardiol. Rev. 11(2), 73–93 (2003).
  • Dickstein K, Cohen-Solal A, Filippatos G et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur. Heart J. 29(19), 2388–2442 (2008).
  • Hunt S, Abraham W, Chin M et al. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Circulation 112(12), e154–e235 (2005).
  • Wagner EH, Austin BT, Von Korff M. Organizing care for patients with chronic illness. Milbank Q. 74(4), 511–544 (1996).
  • Covinsky KE, Pierluissi E, Johnston CB. Hospitalization-associated disability: “she was probably able to ambulate, but I’m not sure”. JAMA 306(16), 1782–1793 (2011).
  • Sandhaus S, Zalon ML, Valenti D, Dzielak E, Smego RA Jr, Arzamasova U. A volunteer-based Hospital Elder Life Program to reduce delirium. Health Care Manag. (Frederick) 29(2), 150–156 (2010).
  • Caplan JP, Rabinowitz T. An approach to the patient with cognitive impairment: delirium and dementia. Med. Clin. North Am. 94(6), 1103–1116, ix (2010).
  • Inouye SK, Bogardus ST Jr, Charpentier PA et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N. Engl. J. Med. 340(9), 669–676 (1999).
  • Phillips CO, Wright SM, Kern DE, Singa RM, Shepperd S, Rubin HR. Comprehensive discharge planning with postdischarge support for older patients with congestive heart failure: a meta-analysis. JAMA 291(11), 1358–1367 (2004).
  • Mesteig M, Helbostad JL, Sletvold O, Røsstad T, Saltvedt I. Unwanted incidents during transition of geriatric patients from hospital to home: a prospective observational study. BMC Health Serv. Res. 10, 1 (2010).
  • Naylor MD, Bowles KH, McCauley KM et al. High-value transitional care: translation of research into practice. J. Eval. Clin. Pract. doi:10.1111/j.1365-2753.2011.01659.x (2011) (Epub ahead of print).
  • Naylor M, Keating SA. Transitional care. Am. J. Nurs. 108(Suppl. 9), 58–63; quiz 63 (2008).
  • Scott IA. Preventing the rebound: improving care transition in hospital discharge processes. Aust. Health Rev. 34(4), 445–451 (2010).
  • Inglis SC, Clark RA, McAlister FA, Stewart S, Cleland JG. Which components of heart failure programmes are effective? A systematic review and meta-analysis of the outcomes of structured telephone support or telemonitoring as the primary component of chronic heart failure management in 8323 patients: Abridged Cochrane Review. Eur. J. Heart Fail. 13(9), 1028–1040 (2011).
  • Vedel I, Monette M, Beland F, Monette J, Bergman H. Ten years of integrated care: backwards and forwards. The case of the province of Québec, Canada. Int. J. Integr. Care 11, e004 (2011).
  • Johri M, Beland F, Bergman H. International experiments in integrated care for the elderly: a synthesis of the evidence. Int. J. Geriatr. Psychiatry 18(3), 222–235 (2003).
  • Hébert R, Durand PJ, Dubuc N, Tourigny A; PRISMA Group. Frail elderly patients. New model for integrated service delivery. Can. Fam. Physician 49, 992–997 (2003).
  • MacAdam M. Home care: it’s time for a Canadian model. Healthc. Pap. 1(4), 9–36 (2000).
  • Shannon K, Van Reenen C. PACE: innovative care for the frail elderly. Health Prog. 79(41), 46 (1998).
  • Kane RL, Homyak P, Bershadsky B. Consumer reactions to the Wisconsin Partnership Program and its parent, the Program for All-Inclusive Care of the Elderly (PACE). Gerontologist 42(3), 314–320 (2002).
  • Kodner DL. Whole-system approaches to health and social care partnerships for the frail elderly: an exploration of North American models and lessons. Health Soc. Care Community 14(5), 384–390 (2006).
  • McAdam M. Frameworks of Integrated Care for the Elderly: a Systematic Review. Canadian Policy Research Networks Inc., ON, Canada (2008).
  • Wakefield BJ, Boren SA, Groves PS, Conn VS. Heart Failure Care Management Programs. A review of study interventions and meta-analysis of outcomes. J. Cardiovasc. Nurs. doi:10.1097/JCN.0b013e31829f9e1 (2011) (Epub ahead of print).
  • Eggert GM, Zimmer JG, Hall WJ, Friedman B. Case management: a randomized controlled study comparing a neighborhood team and a centralized individual model. Health Serv. Res. 26(4), 471–507 (1991).
  • Hollander MJ, Prince MJ. Organizing healthcare delivery systems for persons with ongoing care needs and their families: a best practices framework. Healthc. Q. 11(1), 44–54, 2 (2008).
  • Suter E, Oelke ND, Adair CE, Armitage GD. Ten key principles for successful health systems integration. Healthc. Q. 13, 16–23 (2009).
  • Williams AP, Lum JM, Deber R et al. Aging at home: integrating community-based care for older persons. Healthc. Pap. 10(1), 8–21 (2009).
  • Morley JE, Haren MT, Rolland Y, Kim MJ. Frailty. Med. Clin. North Am. 90(5), 837–847 (2006).
  • Cheng JW, Nayar M. A review of heart failure management in the elderly population. Am. J. Geriatr. Pharmacother. 7(5), 233–249 (2009).
  • Heckman GA, Patterson CJ, Demers C, St Onge J, Turpie ID, McKelvie RS. Heart failure and cognitive impairment: challenges and opportunities. Clin. Interv. Aging 2(2), 209–218 (2007).
  • Jugdutt BJ. Aging and heart failure: changing demographics and implications for therapy in the elderly. Heart Fail. Rev. 15, 401–405 (2010).
  • Nobili A, Licata G, Salerno F et al.; SIMI Investigators. Polypharmacy, length of hospital stay, and in-hospital mortality among elderly patients in internal medicine wards. The REPOSI study. Eur. J. Clin. Pharmacol. 67(5), 507–519 (2011).
  • Rich MW. Pharmacotherapy of heart failure in the elderly: adverse events. Heart Fail. Rev. 17(4–5), 589–595 (2012).
  • Hanratty CG, McGlinchey P, Johnston GD, Passmore AP. Differential pharmacokinetics of digoxin in elderly patients. Drugs Aging 17(5), 353–362 (2000).
  • Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM. Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA 289(7), 871–878 (2003).
  • Daniels R, van Rossum E, de Witte L, Kempen GI, van den Heuvel W. Interventions to prevent disability in frail community-dwelling elderly: a systematic review. BMC Health Serv. Res. 8, 278 (2008).
  • Weening-Dijksterhuis E, de Greef MGH, Slaets JPJ, van der Schans CP. Frail institutionized older persons. Am. J. Phys. Med. Rehabil. 90(2), 156–168 (2011).
  • Liu CK, Fielding RA. Exercise as an intervention for frailty. Clin. Geriatr. Med. 27(1), 101–110 (2011).
  • Peterson MJ, Giuliani C, Morey MC et al.; Health, Aging and Body Composition Study Research Group. Physical activity as a preventative factor for frailty: the health, aging, and body composition study. J. Gerontol. A Biol. Sci. Med. Sci. 64(1), 61–68 (2009).
  • Taaffe DR. Sarcopenia – exercise as a treatment strategy. Aust. Fam. Physician 35(3), 130–134 (2006).
  • Heckman GA, McKelvie RS. Cardiovascular aging and exercise in healthy older adults. Clin. J. Sport Med. 18(6), 479–485 (2008).
  • O’Connor CM, Whellan DJ, Lee KL et al.; HF-ACTION Investigators. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301(14), 1439–1450 (2009).
  • Flynn KE, Piña IL, Whellan DJ et al.; HF-ACTION Investigators. Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301(14), 1451–1459 (2009).
  • Edelmann R, Gelbrick G, Dungen HD et al. Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction. J. Am. Coll. Cardiol. 58(17), 1780–1791 (2011).
  • Kitzman DW, Brubaker PH, Morgan TM, Stewart KP, Little WC. Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. Circ. Heart Fail. 3(6), 659–667 (2010).
  • Smart N, Haluska B, Jeffriess L, Marwick TH. Exercise training in systolic and diastolic dysfunction: effects on cardiac function, functional capacity, and quality of life. Am. Heart J. 153(4), 530–536 (2007).
  • Gunn E, Smith KM, McKelvie RS, Arthur HM. Exercise and the heart failure patient: aerobic vs strength training – is there a need for both? Prog. Cardiovasc. Nurs. 21(3), 146–150 (2006).
  • Fleg JL. Exercise therapy for elderly heart failure patients. Clin. Geriatr. Med. 23(1), 221–234 (2007).
  • Witham MD, Gray JM, Argo IS, Johnston DW, Struthers AD, McMurdo ME. Effect of a seated exercise program to improve physical function and health status in frail patients > or = 70 years of age with heart failure. Am. J. Cardiol. 95(9), 1120–1124 (2005).
  • Pihl E, Cider A, Strömberg A, Fridlund B, Mårtensson J. Exercise in elderly patients with chronic heart failure in primary care: effects on physical capacity and health-related quality of life. Eur. J. Cardiovasc. Nurs. 10(3), 150–158 (2011).
  • Austin J, Williams R, Ross L, Moseley L, Hutchison S. Randomised controlled trial of cardiac rehabilitation in elderly patients with heart failure. Eur. J. Heart Fail. 7(3), 411–417 (2005).
  • Tanne D, Freimark D, Poreh A et al. Cognitive functions in severe congestive heart failure before and after an exercise training program. Int. J. Cardiol. 103(2), 145–149 (2005).
  • Challis D, Clarkson P, Williamson J et al. The value of specialist clinical assessment of older people prior to entry to care homes. Age Ageing 33(1), 25–34 (2004).
  • Schmader KE, Hanlon JT, Pieper CF et al. Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly. Am. J. Med. 116(6), 394–401 (2004).
  • Beswick AD, Rees K, Dieppe P et al. Complex interventions to improve physical function and maintain independent living in elderly people: a systematic review and meta-analysis. Lancet 371(9614), 725–735 (2008).
  • Ellis G, Whitehead MA, Robinson D, O’Neill D, Langhorne P. Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials. BMJ 343, d6553 (2011).
  • Inouye SK, Charpentier PA. Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. JAMA 275(11), 852–857 (1996).

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