IFN-γ release assay versus tuberculin skin test for monitoring TB infection in healthcare workers

References

• Sepkowitz KA, Eisenberg L. Occupational deaths among healthcare workers. Emerging Infect. Dis. 11(7), 1003–1008 (2005).
   PubMed Web of Science ®Google Scholar
• Ho PL, Becker M, Chan-Yeung MM. Emerging occupational lung infections. Int. J. Tuberc. Lung Dis. 11(7), 710–721 (2007).
   PubMed Web of Science ®Google Scholar
• Sepkowitz KA. Tuberculosis and the health care worker: a historical perspective. Ann. Intern. Med. 120(1), 71–79 (1994).
   PubMed Web of Science ®Google Scholar
• Baussano I, Nunn P, Williams B, Pivetta E, Bugiani M, Scano F. Tuberculosis among health care workers. Emerging Infect. Dis. 17(3), 488–494 (2011).
   PubMed Web of Science ®Google Scholar
• Menzies D, Joshi R, Pai M. Risk of tuberculosis infection and disease associated with work in health care settings. Int. J. Tuberc. Lung Dis. 11(6), 593–605 (2007).
   PubMed Web of Science ®Google Scholar
• Joshi R, Reingold AL, Menzies D, Pai M. Tuberculosis among health-care workers in low- and middle-income countries: a systematic review. PLoS Med. 3(12), e494 (2006).
   PubMed Web of Science ®Google Scholar
• Seidler A, Nienhaus A, Diel R. Review of epidemiological studies on the occupational risk of tuberculosis in low-incidence areas. Respiration. 72(4), 431–446 (2005).
   PubMedGoogle Scholar
• International Labour Organization (ILO). ILO List of Occupational Diseases (revised 2010).Occupational Safety and Health Series, No. 74. International Labour Office, Geneva, Switzerland (2010).
   Google Scholar
• Jensen PA, Lambert LA, Iademarco MF, Ridzon R; CDC. Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005. MMWR. Recomm. Rep. 54(RR-17), 1–141 (2005).
   PubMedGoogle Scholar
• Fennelly KP, Iseman MD. Health care workers and tuberculosis: the battle of a century. Int. J. Tuberc. Lung Dis. 3(5), 363–364 (1999).
   PubMedGoogle Scholar
• Fella P, Rivera P, Hale M, Squires K, Sepkowitz K. Dramatic decrease in tuberculin skin test conversion rate among employees at a hospital in New York City. Am. J. Infect. Control 23(6), 352–356 (1995).
   PubMedGoogle Scholar
• Baussano I, Bugiani M, Carosso A et al. Risk of tuberculin conversion among healthcare workers and the adoption of preventive measures. Occup. Environ. Med. 64(3), 161–166 (2007).
   PubMedGoogle Scholar
• Torres Costa J, Sá R, Cardoso MJ et al. Tuberculosis screening in Portuguese healthcare workers using the tuberculin skin test and the interferon-γ release assay. Eur. Respir. J. 34(6), 1423–1428 (2009).
   PubMedGoogle Scholar
• Torres Costa J, Silva R, Sá R, Cardoso MJ, Nienhaus A. Serial testing with the interferon-γ? Release assay in Portuguese healthcare workers. Int. Arch. Occup. Environ. Health 84(4), 461–469 (2011).
   PubMedGoogle Scholar
• Kiertiburanakul S, Suebsing S, Kehachindawat P et al. Five-year prospective study of tuberculin skin testing among new healthcare personnel at a university hospital in Thailand. J. Hosp. Infect. 80(2), 173–175 (2012).
   PubMedGoogle Scholar
• He GX, van denHof S, van der Werf MJ et al. Infection control and the burden of tuberculosis infection and disease in health care workers in china: a cross-sectional study. BMC Infect. Dis. 10, 313 (2010).
   PubMedGoogle Scholar
• Chai SJ, Mattingly DC, Varma JK. Protecting health care workers from tuberculosis in China: a review of policy and practice in China and the United States. Health Policy Plan. doi:10.1093/heapol/czs029 (2012) (Epub ahead of print).
   PubMedGoogle Scholar
• von Pirquet CL. Frequency of tuberculosis in childhood. J. Am Med. Assoc. LII(9), 675–678 (1909).
   Google Scholar
• Zwerling A, van den Hof S, Scholten J, Cobelens F, Menzies D, Pai M. Interferon-γ release assays for tuberculosis screening of healthcare workers: a systematic review. Thorax 67(1), 62–70 (2012).
   PubMed Web of Science ®Google Scholar
• Ringshausen FC, Schablon A, Nienhaus A. Interferon-γ release assays for the tuberculosis serial testing of health care workers: a systematic review. J. Occup. Med. Toxicol. 7(1), 6 (2012).
   PubMedGoogle Scholar
• Harada N, Nakajima Y, Higuchi K, Sekiya Y, Rothel J, Mori T. Screening for tuberculosis infection using whole-blood interferon-γ and Mantoux testing among Japanese healthcare workers. Infect. Control Hosp. Epidemiol. 27(5), 442–448 (2006).
   PubMedGoogle Scholar
• Tripodi D, Brunet-Courtois B, Nael V et al. Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workers. J. Occup. Med. Toxicol. 4, 30 (2009).
   PubMedGoogle Scholar
• Casas I, Latorre I, Esteve M et al. Evaluation of interferon-γ release assays in the diagnosis of recent tuberculosis infection in health care workers. PLoS ONE 4(8), e6686 (2009).
   Web of Science ®Google Scholar
• Stebler A, Iseli P, Mühlemann K, Bodmer T. Whole-blood interferon-γ release assay for baseline tuberculosis screening of healthcare workers at a Swiss university hospital. Infect. Control Hosp. Epidemiol. 29(7), 681–683 (2008).
   PubMedGoogle Scholar
• Khanna P, Nikolayevskyy V, Warburton F, Dobson E, Drobniewski F. Rate of latent tuberculosis infection detected by occupational health screening of nurses new to a London teaching hospital. Infect. Control Hosp. Epidemiol. 30(6), 581–584 (2009).
   PubMedGoogle Scholar
• Menzies D. Interpretation of repeated tuberculin tests. Boosting, conversion, and reversion. Am. J. Respir. Crit. Care Med. 159(1), 15–21 (1999).
   PubMed Web of Science ®Google Scholar
• Nienhaus A, Schablon A, Bâcle CL, Siano B, Diel R. Evaluation of the interferon-γ release assay in healthcare workers. Int. Arch. Occup. Environ. Health 81(3), 295–300 (2008).
   PubMedGoogle Scholar
• American Thoracic Society, American College of Chest Physicians. Diagnostic standards and classification of tuberculosis in adults and children. Am. J. Respir. Crit. Care Med. 161(4 Pt 1), 1376–1395 (2000).
   PubMedGoogle Scholar
• Powell K, Han D, Hung NV et al. Prevalence and risk factors for tuberculosis infection among personnel in two hospitals in Vietnam. Int. J. Tuberc. Lung Dis. 15(12), 1643–1649 (2011).
   PubMedGoogle Scholar
• Talebi-Taher M, Javad-Moosavi SA, Entezari AH, Shekarabi M, Parhizkar B. Comparing the performance of QuantiFERON-TB Gold and Mantoux test in detecting latent tuberculosis infection among Iranian health care workers. Int. J. Occup. Med. Environ. Health 24(4), 359–366 (2011).
   PubMedGoogle Scholar
• European Centre for Disease Prevention and Control. Use of interferon-γ release assays in support of TB diagnosis. ECDC, Stockholm, Sweden (2011).
   Google Scholar
• Brock I, Weldingh K, Leyten EM, Arend SM, Ravn P, Andersen P. Specific T-cell epitopes for immunoassay-based diagnosis of Mycobacterium tuberculosis infection. J. Clin. Microbiol. 42(6), 2379–2387 (2004).
   PubMed Web of Science ®Google Scholar
• Diel R, Loddenkemper R, Nienhaus A. Evidence-based comparison of commercial interferon-γ release assays for detecting active TB: a metaanalysis. Chest 137(4), 952–968 (2010).
   PubMed Web of Science ®Google Scholar
• Sester M, Sotgiu G, Lange C et al. Interferon-γ release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis. Eur. Respir. J. 37(1), 100–111 (2011).
   PubMed Web of Science ®Google Scholar
• Pai M, Zwerling A, Menzies D. Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update. Ann. Intern. Med. 149(3), 177–184 (2008).
   PubMed Web of Science ®Google Scholar
• Mazurek GH, Jereb J, Vernon A, LoBue P, Goldberg S, Castro K; IGRA Expert Committee; Centers for Disease Control and Prevention (CDC). Updated guidelines for using Interferon Gamma Release Assays to detect Mycobacterium tuberculosis infection – United States, 2010. MMWR. Recomm. Rep. 59(RR-5), 1–25 (2010).
   PubMedGoogle Scholar
• Diel R, Goletti D, Ferrara G et al. Interferon-γ release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis. Eur. Respir. J. 37(1), 88–99 (2011).
   PubMed Web of Science ®Google Scholar
• Torres Costa J, Silva R, Ringshausen FC, Nienhaus A. Screening for tuberculosis and prediction of disease in Portuguese healthcare workers. J. Occup. Med. Toxicol. 6, 19 (2011).
   PubMedGoogle Scholar
• Diel R, Loddenkemper R, Niemann S, Meywald-Walter K, Nienhaus A. Negative and positive predictive value of a whole-blood interferon-γ release assay for developing active tuberculosis: an update. Am. J. Respir. Crit. Care Med. 183(1), 88–95 (2011).
   PubMed Web of Science ®Google Scholar
• Diel R, Loddenkemper R, Nienhaus A. Predictive value of interferon-γ release assays and tuberculin skin testing for progression from latent TB infection to disease state: a meta-analysis. Chest 142(1), 63–75 (2012).
   PubMed Web of Science ®Google Scholar
• Rangaka MX, Wilkinson KA, Glynn JR et al. Predictive value of interferon-γ release assays for incident active tuberculosis: a systematic review and meta-analysis. Lancet Infect. Dis. 12(1), 45–55 (2012).
   PubMed Web of Science ®Google Scholar
• Diel R, Loddenkemper R, Meywald-Walter K, Gottschalk R, Nienhaus A. Comparative performance of tuberculin skin test, QuantiFERON-TB-Gold In Tube assay, and T-Spot.TB test in contact investigations for tuberculosis. Chest 135(4), 1010–1018 (2009).
   PubMedGoogle Scholar
• Mazurek GH, Jereb J, Lobue P, Iademarco MF, Metchock B, Vernon A; Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC). Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR. Recomm. Rep. 54(RR-15), 49–55 (2005).
   PubMedGoogle Scholar
• Diel R, Loytved G, Nienhaus A et al. New recommendations for contact tracing in tuberculosis. German Central Committee against Tuberculosis. Pneumologie 65(6), 359–378 (2011).
   PubMedGoogle Scholar
• Canadian Tuberculisis Committee. Updated recommendations on interferon γ release assays for latent tuberculosis infection. An Advisory Committee Statement (ACS). Can. Commun. Dis. Rep. 34(ACS-6), 1–13 (2008).
   Google Scholar
• Larcher C, Frizzera E, Pretto P, Lang M, Sonnleitner N, Huemer HP. Immunosurveillance for Mycobacterium tuberculosis of health care personnel in a third level care hospital. Med. Lav. 103(1), 26–36 (2012).
   PubMed Web of Science ®Google Scholar
• Freeman JT, Marshall RJ, Newton S et al. Screening for Mycobacterium tuberculosis infection among healthcare workers in New Zealand: prospective comparison between the tuberculin skin test and the QuantiFERON-TB Gold In-Tube assay. NZ Med. J. 125(1349), 21–29 (2012).
   Google Scholar
• Talbot EA, Harland D, Wieland-Alter W, Burrer S, Adams LV. Specificity of the tuberculin skin test and the T-SPOT.TB assay among students in a low-tuberculosis incidence setting. J Am. Coll. Health 60(1), 94–96 (2012).
   PubMed Web of Science ®Google Scholar
• Moon HW, Kim H, Hur M, Yun YM, Lee A. Latent tuberculosis infection screening for laboratory personnel using interferon-γ release assay and tuberculin skin test in Korea: an intermediate incidence setting. J. Clin. Lab. Anal. 25(6), 382–388 (2011).
   PubMedGoogle Scholar
• Khoury NZ, Binnicker MJ, Wengenack NL, Aksamit TR, Buchta WG, Molella RG. Preemployment screening for tuberculosis in a large health care setting: comparison of the tuberculin skin test and a whole-blood interferon-γ release assay. J. Occup. Environ. Med. 53(3), 290–293 (2011).
   PubMed Web of Science ®Google Scholar
• Storla DG, Kristiansen I, Oftung F et al. Use of interferon γ-based assay to diagnose tuberculosis infection in health care workers after short term exposure. BMC Infect. Dis. 9, 60 (2009).
   PubMedGoogle Scholar
• Dorman S, Belknap R, Weinfurter P, Teeter L, Thomas J, Daley C. Evaluation of new interferon-γ release assays (IGRAs) in the diagnosis of latent tuberculosis infection in US health care workers: baseline testing results. Am. J. Respir. Crit Care Med 179, A1010 (2009).
   Google Scholar
• Mirtskhulava V, Kempker R, Shields KL et al. Prevalence and risk factors for latent tuberculosis infection among health care workers in Georgia. Int. J. Tuberc. Lung Dis. 12(5), 513–519 (2008).
   PubMed Web of Science ®Google Scholar
• Ciaschetti A, Franchi A, Richeldi L et al. Screening of latent tuberculosis infection in health care workers by QuantiFERON-TB and tuberculin skin test. G. Ital. Med. Lav. Ergon. 29(3 Suppl.), 406–407 (2007).
   PubMedGoogle Scholar
• Alvarez-León EE, Espinosa-Vega E, Santana-Rodríguez E et al. Screening for tuberculosis infection in spanish healthcare workers: comparison of the QuantiFERON-TB gold in-tube test with the tuberculin skin test. Infect. Control Hosp. Epidemiol. 30(9), 876–883 (2009).
   PubMedGoogle Scholar
• Zhao X, Mazlagic D, Flynn EA, Hernandez H, Abbott CL. Is the QuantiFERON-TB blood assay a good replacement for the tuberculin skin test in tuberculosis screening? a pilot study at Berkshire Medical Center. Am. J. Clin. Pathol. 132(5), 678–686 (2009).
   PubMed Web of Science ®Google Scholar
• Cummings KJ, Smith TS, Shogren ES et al. Prospective comparison of tuberculin skin test and QuantiFERON-TB Gold In-Tube assay for the detection of latent tuberculosis infection among healthcare workers in a low-incidence setting. Infect. Control Hosp. Epidemiol. 30(11), 1123–1126 (2009).
   PubMed Web of Science ®Google Scholar
• Schablon A, Beckmann G, Harling M, Diel R, Nienhaus A. Prevalence of latent tuberculosis infection among health care workers in a hospital for pulmonary diseases. J. Occup. Med. Toxicol. 4, 1 (2009).
   PubMedGoogle Scholar
• Vinton P, Mihrshahi S, Johnson P, Jenkin GA, Jolley D, Biggs BA. Comparison of QuantiFERON-TB Gold In-Tube Test and tuberculin skin test for identification of latent Mycobacterium tuberculosis infection in healthcare staff and association between positive test results and known risk factors for infection. Infect. Control Hosp. Epidemiol. 30(3), 215–221 (2009).
   PubMed Web of Science ®Google Scholar
• Topic RZ, Dodig S, Zoricic-Letoja I. Interferon-γ and immunoglobulins in latent tuberculosis infection. Arch. Med. Res. 40(2), 103–108 (2009).
   PubMedGoogle Scholar
• Fox BD, Kramer MR, Mor Z et al. The QuantiFERON-TB-GOLD assay for tuberculosis screening in healthcare workers: a cost-comparison analysis. Lung 187(6), 413–419 (2009).
   PubMed Web of Science ®Google Scholar
• Girardi E, Angeletti C, Puro V et al. Estimating diagnostic accuracy of tests for latent tuberculosis infection without a gold standard among healthcare workers. Euro Surveill. 14(43), (2009).
   PubMedGoogle Scholar
• Kang YA, Lee HW, Yoon HI et al. Discrepancy between the tuberculin skin test and the whole-blood interferon gamma assay for the diagnosis of latent tuberculosis infection in an intermediate tuberculosis-burden country. JAMA 293(22), 2756–2761 (2005).
   PubMed Web of Science ®Google Scholar
• Ozekinci T, Ozbek E, Celik Y. Comparison of tuberculin skin test and a specific T-cell-based test, T-Spot.TB, for the diagnosis of latent tuberculosis infection. J. Int. Med. Res. 35(5), 696–703 (2007).
   PubMedGoogle Scholar
• Soborg B, Andersen AB, Larsen HK et al. Detecting a low prevalence of latent tuberculosis among health care workers in Denmark detected by M. tuberculosis specific IFN-γ whole-blood test. Scand. J. Infect. Dis. 39(6-7), 554–559 (2007).
   PubMed Web of Science ®Google Scholar
• Nienhaus A, Loddenkemper R, Hauer B, Wolf N, Diel R. Latent tuberculosis infection in healthcare workers – evaluation of an Interferon-gamma release assay. Pneumologie 61(4), 219–223 (2007).
   PubMedGoogle Scholar
• Hotta K, Ogura T, Nishii K et al. Whole blood interferon-gamma assay for baseline tuberculosis screening among Japanese healthcare students. PLoS ONE 2(8), e803 (2007).
   Google Scholar
• Choi JC, Shin JW, Kim JY, Park IW, Choi BW, Lee MK. The effect of previous tuberculin skin test on the follow-up examination of whole-blood interferon-γ assay in the screening for latent tuberculosis infection. Chest 133(6), 1415–1420 (2008).
   PubMed Web of Science ®Google Scholar
• Carvalho AC, Crotti N, Crippa M et al. QuantiFERON-TB Gold test for healthcare workers. J. Hosp. Infect. 69(1), 91–92 (2008).
   PubMedGoogle Scholar
• Barsegian V, Mathias KD, Wrighton-Smith P, Grosse-Wilde H, Lindemann M. Prevalence of latent tuberculosis infection in German radiologists. J. Hosp. Infect. 69(1), 69–76 (2008).
   PubMedGoogle Scholar
• Pai M, Gokhale K, Joshi R et al. Mycobacterium tuberculosis infection in health care workers in rural India: comparison of a whole-blood interferon γ assay with tuberculin skin testing. JAMA 293(22), 2746–2755 (2005).
   PubMed Web of Science ®Google Scholar
• Lien LT, Hang NT, Kobayashi N et al. Prevalence and risk factors for tuberculosis infection among hospital workers in Hanoi, Vietnam. PLoS ONE 4(8), e6798 (2009).
   PubMed Web of Science ®Google Scholar
• Nienhaus A, Schablon A, Diel R. Interferon-γ release assay for the diagnosis of latent TB infection – analysis of discordant results, when compared to the tuberculin skin test. PLoS ONE 3(7), e2665 (2008).
   PubMedGoogle Scholar
• Gandra S, Scott WS, Somaraju V, Wang H, Wilton S, Feigenbaum M. Questionable effectiveness of the QuantiFERON-TB Gold Test (Cellestis) as a screening tool in healthcare workers. Infect. Control Hosp. Epidemiol. 31(12), 1279–1285 (2010).
   PubMedGoogle Scholar
• Andersen P, Doherty TM, Pai M, Weldingh K. The prognosis of latent tuberculosis: can disease be predicted? Trends Mol. Med. 13(5), 175–182 (2007).
   PubMed Web of Science ®Google Scholar
• Ringshausen FC, Nienhaus A, Torres Costa J et al. Within-subject variability of Mycobacterium tuberculosis-specific γ interferon responses in German health care workers. Clin. Vaccine Immunol. 18(7), 1176–1182 (2011).
   PubMed Web of Science ®Google Scholar
• van Zyl-Smit RN, Zwerling A, Dheda K, Pai M. Within-subject variability of interferon-g assay results for tuberculosis and boosting effect of tuberculin skin testing: a systematic review. PLoS ONE 4(12), e8517 (2009).
   PubMed Web of Science ®Google Scholar
• van Zyl-Smit RN, Pai M, Peprah K et al. Within-subject variability and boosting of T-cell interferon-γ responses after tuberculin skin testing. Am. J. Respir. Crit. Care Med. 180(1), 49–58 (2009).
   PubMedGoogle Scholar
• Pai M, Joshi R, Dogra S et al. Serial testing of health care workers for tuberculosis using interferon-γ assay. Am. J. Respir. Crit. Care Med. 174(3), 349–355 (2006).
   PubMed Web of Science ®Google Scholar
• Chee CB, Lim LK, Barkham TM et al. Use of a T cell interferon-γ release assay to evaluate tuberculosis risk in newly qualified physicians in Singapore healthcare institutions. Infect. Control Hosp. Epidemiol. 30(9), 870–875 (2009).
   PubMedGoogle Scholar
• Lee K, Han MK, Choi HR et al. Annual incidence of latent tuberculosis infection among newly employed nurses at a tertiary care university hospital. Infect. Control Hosp. Epidemiol. 30(12), 1218–1222 (2009).
   PubMed Web of Science ®Google Scholar
• Yoshiyama T, Harada N, Higuchi K, Nakajima Y, Ogata H. Estimation of incidence of tuberculosis infection in health-care workers using repeated interferon-γ assays. Epidemiol. Infect. 137(12), 1691–1698 (2009).
   PubMedGoogle Scholar
• Rafiza S, Rampal KG. Serial testing of Malaysian health care workers with QuantiFERON®-TB Gold In-Tube. Int. J. Tuberc. Lung Dis. 16(2), 163–168 (2012).
   PubMedGoogle Scholar
• Zwerling AA, Cloutier Ladurantaye J, Pietrangelo F et al. Conversions and reversions in health care workers in Montreal, Canada using QuantiFERON-TB-gold in-tube. Am. J. Respir. Crit. Care Med. 179, Abstract A1012 (2009).
   Google Scholar
• Belknap R, Kelaher J, Wall K, Daley C, Schluger N, Reves R. Diagnosis of latent tuberculosis infection in US health care workers: reproducibility, repeatability and 6 month follow-up with interferon-γ release assays (IGRAs). Am. J. Respir. Crit. Care Med. 179, Abstract A4101 (2009).
   Google Scholar
• Joshi M, Monson TP, Woods GL. Use of interferon-γ release assays in a health care worker screening program: experience from a tertiary care centre in the United States. Can. Respir. J. 19(2), 84–88 (2012).
   PubMedGoogle Scholar
• Ringshausen FC, Nienhaus A, Schablon A, Schlösser S, Schultze-Werninghaus G, Rohde G. Predictors of persistently positive Mycobacterium-tuberculosis-specific interferon-γ responses in the serial testing of health care workers. BMC Infect. Dis. 10, 220 (2010).
   PubMed Web of Science ®Google Scholar
• Schablon A, Harling M, Diel R, Ringshausen FC, Torres Costa J, Nienhaus A. Serial testing with an interferon-γ release assay in German healthcare workers. GMS Krankenhhyg. Interdiszip. 5(2), Doc05 (2010).
   PubMedGoogle Scholar
• Schablon A, Diel R, Diner G et al. Specificity of a whole blood IGRA in German nursing students. BMC Infect. Dis. 11, 245 (2011).
   PubMedGoogle Scholar
• Fong KS, Tomford JW, Teixeira L et al. Challenges of interferon-γ release assay conversions in serial testing of health-care workers in a TB control program. Chest 142(1), 55–62 (2012).
   PubMed Web of Science ®Google Scholar
• Pollock NR, Campos-Neto A, Kashino S et al. Discordant QuantiFERON-TB Gold test results among US healthcare workers with increased risk of latent tuberculosis infection: a problem or solution? Infect. Control Hosp. Epidemiol. 29(9), 878–886 (2008).
   PubMed Web of Science ®Google Scholar
• Belknap R, Wall K, Teeter L et al. Interferon-γ Release Assays (IGRAs) in serial testing for latent tuberculosis infection In US health care workers. Am. J. Respir. Crit. Care Med. 181, Abstract A2263 (2010).
   Google Scholar
• Weldingh K, Andersen P. ESAT-6/CFP10 skin test predicts disease in M. tuberculosis-infected guinea pigs. PLoS ONE 3(4), e1978 (2008).
   Google Scholar
• Nienhaus A, Schablon A, Tripodi D, Tripoldi D, Torres Costa J. The prevalence of latent tuberculosis infections among health-care workers – a three-country comparison. Pneumologie 65(12), 726–729 (2011).
   PubMedGoogle Scholar
• Rubbo PA, Nagot N, Le Moing V et al. Multicytokine detection improves latent tuberculosis diagnosis in health care workers. J. Clin. Microbiol. 50(5), 1711–1717 (2012).
   PubMed Web of Science ®Google Scholar
• Sterling TR, Villarino ME, Borisov AS et al.; TB Trials Consortium PREVENT TB Study Team. Three months of rifapentine and isoniazid for latent tuberculosis infection. N. Engl. J. Med. 365(23), 2155–2166 (2011).
   PubMed Web of Science ®Google Scholar
• Leung CC, Rieder HL, Lange C, Yew WW. Treatment of latent infection with Mycobacterium tuberculosis: update 2010. Eur. Respir. J. 37(3), 690–711 (2011).
   PubMed Web of Science ®Google Scholar