References
- Abdool Karim Q, Abdool Karim SS, Frohlich JA et al.; CAPRISA 004 Trial Group. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 329(5996), 1168–1174 (2010).
- Kiser PF, Johnson TJ, Clark JT. State of the art in intravaginal ring technology for topical prophylaxis of HIV infection. AIDS Rev. 14(1), 62–77 (2012).
- Romano JW, Robbiani M, Doncel GF, Moench T. Non-specific microbicide product development: then and now. Curr. HIV Res. 10(1), 9–18 (2012).
- Grant RM, Lama JR, Anderson PL et al.; iPrEx Study Team. Pre-exposure chemoprophylaxis for HIV prevention in men who have sex with men. N. Engl. J. Med. 363(27), 2587–2599 (2010).
- Karim SS, Kashuba AD, Werner L, Karim QA. Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women. Lancet 378(9787), 279–281 (2011).
- Anderson PL, Glidden DV, Liu A et al.; For the iPrEx Study Team. Emtricitabine–tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men. Sci. Transl. Med. 4(151), 151ra125 (2012).
- van der Straten A, Van Damme L, Haberer JE, Bangsberg DR. Unraveling the divergent results of pre-exposure prophylaxis trials for HIV prevention. AIDS 26(7), F13–F19 (2012).
- Malcolm RK, Edwards KL, Kiser P, Romano J, Smith TJ. Advances in microbicide vaginal rings. Antiviral Res. 88(Suppl. 1), S30–S39 (2010).
- van der Straten A, Montgomery ET, Cheng H et al. High acceptability of a vaginal ring intended as a microbicide delivery method for HIV prevention in African women. AIDS Behav. 16(7), 1775–1786 (2012).
- Montgomery ET, van der Straten A, Cheng H et al. Vaginal ring adherence in sub-saharan Africa: expulsion, removal, and perfect use. AIDS Behav. 16(7), 1787–1798 (2012).
- Singer R, Mawson P, Derby N et al. An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques. Sci. Transl. Med. 4(150), 150ra123 (2012).
- Kenney J, Aravantinou M, Singer R et al. An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques. PLoS ONE 6(1), e15835 (2011).
- Dobard C, Sharma S, Martin A et al. Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue. J. Virol. 86(2), 718–725 (2012).
- Romano J, Variano B, Coplan P et al. Safety and availability of dapivirine (TMC120) delivered from an intravaginal ring. AIDS Res. Hum. Retroviruses 25(5), 483–488 (2009).
- Malcolm RK, Veazey RS, Geer L et al. Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques. Antimicrob. Agents Chemother. 56(5), 2251–2258 (2012).
- Clark JT, Johnson TJ, Clark MR et al. Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir. J. Control. Release 163(2), 240–248 (2012).
- Johnson TJ, Clark MR, Albright TH et al. A ninety day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis. Antimicrob. Agents Chemother. 56(12), 6272–6283 (2012).
- Johnson TJ, Gupta KM, Fabian J, Albright TH, Kiser PF. Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir. Eur. J. Pharm. Sci. 39(4), 203–212 (2010).
- Baum MM, Butkyavichene I, Gilman J et al. An intravaginal ring for the simultaneous delivery of multiple drugs. J. Pharm. Sci. 101(8), 2833–2843 (2012).
- Moss JA, Malone AM, Smith TJ et al. Simultaneous delivery of tenofovir and acyclovir via an intravaginal ring. Antimicrob. Agents Chemother. 56(2), 875–882 (2012).
- Fernández-Romero JA, Abraham CJ, Rodriguez A et al. Zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge. Antimicrob. Agents Chemother. 56(1), 358–368 (2012).
- Han YA, Singh M, Saxena BB. Development of vaginal rings for sustained release of nonhormonal contraceptives and anti-HIV agents. Contraception 76(2), 132–138 (2007).
- Nuttall J, Kashuba A, Wang R et al. Pharmacokinetics of tenofovir following intravaginal and intrarectal administration of tenofovir gel to rhesus macaques. Antimicrob. Agents Chemother. 56(1), 103–109 (2012).
- Aravantinou M, Singer R, Derby N et al. The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT infection. AIDS Res. Hum. Retroviruses 28(11), 1467–1475 (2012).
- Kenney J, Singer R, Derby N et al. A single dose of a MIV-150/zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8–24 h after gel use. AIDS Res. Hum. Retroviruses 28(11), 1476–1484 (2012).
- Parikh UM, Dobard C, Sharma S et al. Complete protection from repeated vaginal simian-human immunodeficiency virus exposures in macaques by a topical gel containing tenofovir alone or with emtricitabine. J. Virol. 83(20), 10358–10365 (2009).
- Gunawardana M, Moss JA, Smith TJ et al. Microbial biofilms on the surface of intravaginal rings worn in non-human primates. J. Med. Microbiol. 60(Pt 6), 828–837 (2011).
- Garg S, Goldman D, Krumme M, Rohan LC, Smoot S, Friend DR. Advances in development, scale-up and manufacturing of microbicide gels, films, and tablets. Antiviral Res. 88(Suppl. 1), S19–S29 (2010).
- Ball CS, Krogstad EK, Chaowanachan TC, Woodrow KA. Nanofibers for HIV-1 inhibition and contraception. PLoS ONE doi:10.1371/journal.pone.0049792 (2012).
Website
- Phase III Trial of Dapivirine Ring Begins in Africa: ASPIRE testing new HIV prevention approach for women. Pittsburgh: Microbicide Trials Network, 24 July 2012. www.mtnstopshiv.org/node/4546