Management of ventilator-associated pneumonia: epidemiology, diagnosis and antimicrobial therapy

References

• Davis KA. Ventilator-associated pneumonia: a review. J. Intensive Care Med. 21(4), 211–226 (2006).
   PubMedGoogle Scholar
• Chastre J, Fagon JY. Ventilator-associated pneumonia. Am. J. Respir. Crit. Care Med. 165(7), 867–903 (2002).
   PubMed Web of Science ®Google Scholar
• Lisboa T, Rello J. Diagnosis of ventilator-associated pneumonia: is there a gold standard and a simple approach? Curr. Opin. Infect. Dis. 21(2), 174–178 (2008).
   PubMed Web of Science ®Google Scholar
• Dudeck MA, Horan TC, Peterson KD et al. National Healthcare Safety Network (NHSN) Report, data summary for 2010, device-associated module. Am. J. Infect. Control. 39, 798–816 (2011).
   PubMed Web of Science ®Google Scholar
• Rello J, Ollendorf DA, Oster G et al. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 122(6), 2115–2121 (2002).
   PubMed Web of Science ®Google Scholar
• Giard M, Lepape A, Allaouchiche B et al. Early- and late-onset ventilator-associated pneumonia acquired in the intensive care unit: comparison of risk factors. J. Crit. Care. 23(1), 27–33 (2008).
   PubMed Web of Science ®Google Scholar
• Shorr AF, Zilberberg MD, Kollef M. Cost–effectiveness analysis of a silver-coated endotracheal tube to reduce the incidence of ventilator-associated pneumonia. Infect. Control. Hosp. Epidemiol. 30(8), 759–763 (2009).
   PubMed Web of Science ®Google Scholar
• Melsen WG, Rovers MM, Bonten MJ. Ventilator-associated pneumonia and mortality: a systematic review of observational studies. Crit. Care Med. 37(10), 2709–2718 (2009).
   PubMed Web of Science ®Google Scholar
• Bekaert M, Timsit JF, Vansteelandt S et al. Attributable mortality of ventilator associated pneumonia: a reappraisal using causal analysis. Am. J. Respir. Crit. Care Med. 184(10), 1133–1139 (2011).
   PubMed Web of Science ®Google Scholar
• Agrafiotis M, Siempos II, Ntaidou TK, Falagas ME. Attributable mortality of ventilator-associated pneumonia: a meta-analysis. Int. J. Tuberc. Lung Dis. 15(9), 1154–1163 (2011).
   PubMed Web of Science ®Google Scholar
• Makris D, Desrousseaux B, Zakynthinos E, Durocher A, Nseir S. The impact of COPD on ICU mortality in patients with ventilator-associated pneumonia. Respir. Med. 105(7), 1022–1029 (2011).
   PubMed Web of Science ®Google Scholar
• Magret M, Amaya-Villar R, Garnacho J et al. Ventilator-associated pneumonia in trauma patients is associated with lower mortality: results from EU-VAP study. J. Trauma 69(4), 849–854 (2010).
   PubMedGoogle Scholar
• Klompas M, Platt R. Ventilator-associated pneumonia – the wrong quality measure for benchmarking. Ann. Intern. Med. 147(11), 803–805 (2007).
   PubMed Web of Science ®Google Scholar
• Vanhems P, Benet T, Voirin N et al. Early-onset ventilator-associated pneumonia incidence in intensive care units: a surveillance-based study. BMC Infect. Dis. 11(1), 236 (2011).
   PubMed Web of Science ®Google Scholar
• Rosenthal VD, Bijie H, Maki DG et al. International Nosocomial Infection Control Consortium (INICC) Report, data summary of 36 countries, for 2004–2009. Am. J. Infect. Control. doi:10.1016/j.ajic.2009.12.004 (2011) (Epub ahead of print).
   Google Scholar
• Shorr AF, Chan CM, Zilberberg MD. Diagnostic and epidemiology in ventilator-associated pneumonia. Ther. Adv. Respir. Dis. 5(2), 121–130 (2011).
   PubMedGoogle Scholar
• Bouadma L, Mourvillier B, Deiler et al. A multifaceted program to prevent ventilator-associated pneumoniae. Crit. Care Med. 38(3), 789–796 (2010).
   PubMed Web of Science ®Google Scholar
• Giard M, Lepape A, Allaouchiche B et al. Early- and late-onset ventilator-associate pneumonia acquired in the intensive care unit: comparison of risk factors. J. Crit. Care. 23(1), 27–33 (2008).
   PubMed Web of Science ®Google Scholar
• Joseph NM, Sistla S, Dutta TK, Badhe AS, Parija SC. Ventilator-associated pneumonia: a review. Eur. J. Intern. Med. 21(5), 360–368 (2010).
   PubMed Web of Science ®Google Scholar
• Hidron AI, Edwards JR, Patel J et al. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007. Infect. Control. Hosp. Epidemiol. 29(11), 996–1011 (2008).
   Google Scholar
• Koulenti D, Lisboa T, Brun-Buisson C et al. Spectrum of practice in the diagnosis of nosocomial pneumonia in patients requiring mechanical ventilation in European intensive care units. Crit. Care Med. 37(8), 2360–2368 (2009).
   PubMed Web of Science ®Google Scholar
• Peterson LR. Bad bugs, no drugs: no ESCAPE revisited. Clin. Infect. Dis. 49(6), 992–993 (2009).
   PubMed Web of Science ®Google Scholar
• Giske CG, Monnet DL, Cars O, Carmeli Y. Clinical and economic impact of common multidrug-resistant Gram-negative bacilli. Antimicrob. Agents Chemother. 52(3), 813–821 (2008).
   PubMed Web of Science ®Google Scholar
• Depuydt PO, Vandijck DM, Bekaert MA et al. Determinants and impact of multidrug antibiotic resistance in pathogens causing ventilator-associated-pneumonia. Crit. Care 12(6), R142 (2008).
   PubMed Web of Science ®Google Scholar
• Kallen AJ, Srinivasan A. Current epidemiology of multidrug resistan Gram-negative bacilli in the United States. Infect. Control. Hosp. Epidemiol. 31(Suppl. 1), S51–S54 (2010).
   PubMed Web of Science ®Google Scholar
• European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2009. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). European Centre for Disease Prevention and Control, Stockholm, Sweden (2010).
   Google Scholar
• Maragakis LL. Recognition and prevention of multidrug-resistant Gram-negative bacteria in the intensive care unit. Crit. Care Med. 38(Suppl. 8), S345–S351 (2010).
   Google Scholar
• Pfeifer Y, Cullik A, Witte W. Resistance to cephalosporins and carbapenems in Gram-negative bacterial pathogen. Int. J. Med. Microbiol. 300(6), 371–379 (2010).
   PubMed Web of Science ®Google Scholar
• Walsh TR. Emerging carbapenemases: a global perspective. Int. J. Antimicrob. Agents 36(Suppl. 3), S8–S14 (2010).
   PubMed Web of Science ®Google Scholar
• Lister PD, Wolter DJ, Hanson ND. Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin. Microbiol. Rev. 22(4), 582–610 (2009).
   PubMed Web of Science ®Google Scholar
• Goossens H. Susceptibility ofmulti-drug-resistant Pseudomonas aeruginosa in intensive care units: results from the European MYSTIC study group. Clin. Microbiol. Infect. 9(9), 980–983 (2003).
   PubMed Web of Science ®Google Scholar
• Jones RN, Stilwell MG, Rhomberg PR, Sader HS. Antipseudomonal activity of piperacillin/tazobactam: more than a decade of experience from the SENTRY Antimicrobial Surveillance Program (1997–2007). Diagn. Microbiol. Infect. Dis. 65(3), 331–334 (2009).
   Google Scholar
• Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin. Infect. Dis. 39(3), 309–317 (2004).
   PubMed Web of Science ®Google Scholar
• Berger-Bächi B, Rohrer S. Factors influencing methicillin resistance in staphylococci. Arch. Microbiol. 178(3), 165–171 (2002).
   PubMed Web of Science ®Google Scholar
• Athanassa Z, Siempos II, Falagas ME. Impact of methicillin resistance on mortality in Staphylococcus aureus VAP: a systematic review. Eur. Respir. J. 31(3), 625–632 (2008).
   PubMed Web of Science ®Google Scholar
• Sakoulas G, Moise-Broder PA, Schentag J, Forrest A, Moellering RC Jr, Eliopoulus GM. Relationship of MIC and bactericidal activity to efficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteremia. J. Clin. Microbiol. 42(6), 2398–2402 (2004).
   PubMed Web of Science ®Google Scholar
• Soriano A, Marco F, Martinez JA et al. Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremia. Clin. Infect. Dis. 46(2), 193–200 (2008).
   PubMed Web of Science ®Google Scholar
• Bassetti M, Ginocchio F, Giacobbe DR. New approaches for empiric theraphy in Gram-positive sepsis. Minerva Anestesiol. 77(8), 821–827 (2011).
   PubMed Web of Science ®Google Scholar
• Annane D, Aegerter P, Jars-Guincestre MC, Guidet B. Current epidemiology of septic shock: the CUB-Rea Network. Am. J. Respir. Crit. Care Med. 168(2), 165–172 (2003).
   PubMed Web of Science ®Google Scholar
• Conte JE Jr, Golden JA, Kipps J, Zurlinden E. Intrapulmonary pharmacokinetics of linezolid. Antimicrob. Agents Chemother. 46(5), 1475–1480 (2002).
   PubMed Web of Science ®Google Scholar
• Wong A, Reddy SP, Smyth DS Aquero-Rosenfeld ME, Sakoulas G, Robinson DA. Polyphyletic emergence of linezolid-resistant Staphylococci in the United States. Antimicrob. Agents Chemother. 54(2), 742–748 (2010).
   PubMed Web of Science ®Google Scholar
• Silverman JA, Mortin LI, Vanpraagh AD, Li T, Alder J. Inhibition of daptomycin by pulmonary surfactant: in vitro modeling and clinical impact. J. Infect. Dis. 191(12), 2149–2152 (2005).
   PubMed Web of Science ®Google Scholar
• Andrews CP, Coalson JJ, Smith JD, Johanson WG Jr. Diagnosis of nosocomial bacterial pneumonia in acute, diffuse lung injury. Chest 80, 254–258 (1981).
   PubMed Web of Science ®Google Scholar
• Johanson WG Jr, Pierce AK, Sanford JP, Thomas GD. Nosocomial respiratory infections with Gram-negative bacilli. The significance of colonization of the respiratory tract. Ann. Intern. Med. 77, 701–706 (1972).
   PubMed Web of Science ®Google Scholar
• Torres A, Ewig S, Lode H, Carlet J; European HAP working group. Defining, treating and preventing hospital acquired pneumonia: European perspective. Intensive Care Med. 35, 9–29 (2009).
   PubMed Web of Science ®Google Scholar
• Fàbregas N, Ewig S, Torres A et al. Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate post-mortem lung biopsies. Thorax 54, 867–873 (1999).
   PubMed Web of Science ®Google Scholar
• Pugin J, Auckenthaler R, Mili N, Janssens JP, Lew PD,
Suter PM. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic “blind” bronchoalveolar lavage fluid. Am. Rev. Respir. Dis. 143, 1121–1129 (1991).
   PubMed Web of Science ®Google Scholar
• Zilberberg MD, Shorr AF. Ventilator-associated pneumonia: the Clinical Pulmonary Infection Score as a surrogate for diagnostics and outcome. Clin. Infect. Dis. 51(Suppl. 1), S131–S135 (2010).
   PubMed Web of Science ®Google Scholar
• Fartoukh M, Maitre B, Honoré S, Cerf C, Zahar JR, Brun-Buisson C. Diagnosing pneumonia during mechanical ventilation: the Clinical Pulmonary Infection Score revisited. Am. J. Respir. Crit. Care Med. 168, 173–179 (2003).
   PubMed Web of Science ®Google Scholar
• Papazian L, Thomas P, Garbe L et al. Bronchoscopic or blind sampling techniques for the diagnosis of ventilator-associated pneumonia. Am. J. Respir. Crit. Care Med. 152, 1982–1991 (1995).
   PubMed Web of Science ®Google Scholar
• Croce MA, Swanson JM, Magnotti LJ et al. The futility of the Clinical Pulmonary Infection Score in trauma patients. J. Trauma 60, 523–527 (2006).
   PubMedGoogle Scholar
• Luyt CE, Chastre J, Fagon JY. Value of the Clinical Pulmonary Infection Score for the identification and management of ventilator-associated pneumonia. Intensive Care Med. 30, 844–852 (2004).
   PubMed Web of Science ®Google Scholar
• Schurink CA, Van Nieuwenhoven CA, Jacobs JA et al. Clinical Pulmonary Infection Score for ventilator-associated pneumonia: accuracy and inter-observer variability. Intensive Care Med. 30, 217–224 (2004).
   PubMed Web of Science ®Google Scholar
• Flanagan PG, Findlay GP, Magee JT, Ionescu A, Barnes RA, Smithies M. The diagnosis of ventilator-associated pneumonia using non-bronchoscopic, non-directed lung lavages. Intensive Care Med. 26, 20–30 (2000).
   PubMed Web of Science ®Google Scholar
• Pham TN, Neff MJ, Simmons JM, Gibran NS, Heimbach DM, Kelin MB. The Clinical Pulmonary Infection Score poorly predicts pneumonia in patients with burns. J. Burn Care Res. 28, 76–79 (2007).
   PubMed Web of Science ®Google Scholar
• Torres A, el-Ebiary M, Padró L et al. Validation of different techniques for the diagnosis of ventilator-associated pneumonia. Comparison with immediate postmortem pulmonary biopsy. Am. J. Respir. Crit. Care Med. 149, 324–331 (1994).
   PubMed Web of Science ®Google Scholar
• Pelosi P, Barassi A, Severgnini P et al. Prognostic role of clinical and laboratory criteria to identify early ventilator-associated pneumonia in brain injury. Chest 134(1), 101–108 (2008).
   PubMed Web of Science ®Google Scholar
• Luna CM, Blanzaco D, Niederman MS et al. Resolution of ventilator-associated pneumonia: prospective evaluation of the Clinical Pulmonary Infection Score as an early clinical predictor of outcome. Crit. Care Med. 31, 676–662 (2003).
   PubMed Web of Science ®Google Scholar
• Dennesen PJ, van der Ven AJ, Kessels AG, Ramsay G, Bonten MJ. Resolution of infectious parameters after antimicrobial therapy in patients with ventilator-associated pneumonia. Am. J. Respir. Crit. Care Med. 163, 1371–1375 (2001).
   PubMed Web of Science ®Google Scholar
• Singh N, Rogers P, Atwood CW, Wagener MM, Yu VL. Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription. Am. J. Respir. Crit. Care Med. 162, 505–511 (2000).
   PubMed Web of Science ®Google Scholar
• Luyt CE, Chastre J, Fagon JY. Value of the Clinical Pulmonary Infection Score for the identification and management of ventilator-associated pneumonia. Intensive Care Med. 30, 844–852 (2004).
   PubMed Web of Science ®Google Scholar
• Rea-Neto A, Youssef NC, Tuche F et al. Diagnosis of ventilator-associated pneumonia: a systematic review of the literature. Critical Care 12, R56 (2008).
   PubMed Web of Science ®Google Scholar
• Palazzo SJ, Simpson T, Schnapp L. Biomarkers for ventilator-associated pneumonia: review of the literature. Heart Lung 40, 293–298 (2011).
   PubMed Web of Science ®Google Scholar
• Meersseman W, Lagrou K, Maertens J et al. Galactomannan in bronchoalveolar lavage fluid: a tool for diagnosing aspergillosis in intensive care unit patients. Am. J. Respir. Crit. Care Med. 177, 27–34 (2008).
   PubMed Web of Science ®Google Scholar
• Jean SS, Hsueh PR. Current review of antimicrobial treatment of nosocomial pneumonia caused by multidrug-resistant pathogens. Expert Opin. Pharmacother. 12(14), 2145–2148 (2011).
   PubMed Web of Science ®Google Scholar
• Kollef MH. What is ventilator-associated pneumonia and why is it important? Respir. Care. 50(6), 714–721 (2005).
   PubMedGoogle Scholar
• Gupta A, Agrawal A, Mehrotra S, Singh A, Malik S, Khanna A. Incidence, risk stratification, antibiogram of pathogens isolated and clinical outcome of ventilator associated pneumonia. Indian J. Crit. Care Med. 15(2), 96–101 (2011).
   PubMedGoogle Scholar
• Porzecanski I, Bowton DL. Diagnosis and treatment of ventilator-associated pneumonia. Chest 130(2), 597–604 (2006).
   PubMed Web of Science ®Google Scholar
• Wilke M, Grube RF, Bodmann KF. Guideline-adherent initial intravenous antibiotic therapy for hospital-acquired/ventilator-associated pneumonia is clinically superior, saves lives and is cheaper than non guideline adherent therapy. Eur. J. Med. Res. 16(7), 315–323 (2011).
   PubMed Web of Science ®Google Scholar
• Rello J. Bench-to-bedside review: therapeutic options and issues in the management of ventilator-associated bacterial pneumonia. Crit. Care 9(3), 259–265 (2004).
   PubMed Web of Science ®Google Scholar
• Niederman MS, Soulountsi V. De-escalation therapy: is it valuable for the management of ventilator-associated pneumonia? Clin. Chest Med. 32(3), 517–534 (2011).
   PubMed Web of Science ®Google Scholar
• Kollef MH, Morrow LE, Niederman MS et al. Clinical characteristics and treatment patterns among patients with ventilator-associated pneumonia. Chest 129(5), 1210–1218 (2006).
   PubMed Web of Science ®Google Scholar
• Giantsou E, Liratzopoulos N, Efraimidou E et al. De-escalation therapy rates are significantly higher by bronchoalveolar lavage than by tracheal aspirate. Intensive Care Med. 33(9), 1533–1540 (2007).
   PubMed Web of Science ®Google Scholar
• Rello J, Vidaur L, Sandiumenge A et al. De-escalation therapy in ventilator-associated pneumonia. Crit. Care Med. 32(11), 2183–2190 (2004).
   PubMed Web of Science ®Google Scholar
• Niederman MS, Craven DE. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am. J. Respir. Crit. Care Med. 171, 388–416 (2005).
   PubMed Web of Science ®Google Scholar
• Chastre J, Wolff M, Fagon JY et al. Comparison of 8 vs. 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA 290(19), 2588–2598 (2003).
   PubMed Web of Science ®Google Scholar
• Li H, Luo YF, Blackwell TS, Xie CM. Meta-analysis and systematic review of procalcitonin-guided therapy in respiratory tract infections. Antimicrob. Agents Chemother. 55(12), 5900–5906 (2011).
   PubMed Web of Science ®Google Scholar
• Grammatikos AP, Siempos II, Michalopoulos A, Falagas ME. Optimal duration of the antimicrobial treatment of ventilator-acquired pneumonia. Expert Rev. Anti Infect. Ther. 6(6), 861–866 (2008).
   PubMed Web of Science ®Google Scholar
• Stein GE, Wells EM. The importance of tissue penetration in achieving successful antimicrobial treatment of nosocomial pneumonia and complicated skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus: vancomycin and linezolid. Curr. Med. Res. Opin. 26(3), 571–588 (2010).
   PubMed Web of Science ®Google Scholar
• Roberts JA, Kirkpatrick CM, Lipman J. Monte Carlo simulations: maximizing antibiotic pharmacokinetic data to optimize clinical practice for critically ill patients. J. Antimicrob. Chemother. 66(2), 227–231 (2011).
   PubMed Web of Science ®Google Scholar
• American Thoracic Society. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am. J. Respir. Crit. Care Med. 171, 388–416 (2005).
   PubMed Web of Science ®Google Scholar
• Kett DH, Cano E, Quartin AA et al.; Improving Medicine through Pathway Assessment of Critical Therapy of Hospital-Acquired Pneumonia (IMPACT-HAP) Investigators. Implementation of guidelines for management of possible multidrug-resistant pneumonia in intensive care: an observational, multicentre cohort study. Lancet Infect. Dis. 11(3), 181–189 (2011).
   PubMed Web of Science ®Google Scholar
• Bassetti M, Repetto E, Righi E et al. Colistin and rifampicin in the treatment of multidrug-resistant Acinetobacter baumannii infections. J. Antimicrob. Chemother. 61(2), 417–420 (2008).
   PubMed Web of Science ®Google Scholar
• Yahav D, Lador A, Paul M, Leibovici L. Efficacy and safety of tigecycline: a systematic review and meta-analysis. J. Antimicrob. Chemother. 66(9), 1963–1971 (2011).
   PubMed Web of Science ®Google Scholar
• Rubinstein E, Lalani T, Corey GR et al. Telavancin versus vancomycin for hospital-acquired pneumonia due to gram-positive pathogens. Clin. Infect. Dis. 52(1), 31–40 (2011).
   PubMed Web of Science ®Google Scholar
• van Hal SJ, Paterson DL. New Gram-positive antibiotics: better than vancomycin? Curr. Opin. Infect. Dis. 24(6), 515–520 (2011).
   PubMed Web of Science ®Google Scholar
• Bouza E, Burillo A. Advances in the prevention and management of ventilator-associated pneumonia. Curr. Opin. Infect. Dis. 22(4), 345–351 (2009).
   PubMed Web of Science ®Google Scholar
• Kollef MH, Rello J, Cammarata SK, Croos-Dabrera RV, Wunderink RG. Clinical cure and survival in Gram-positive ventilator-associated pneumonia: retrospective analysis of two double-blind studies comparing linezolid with vancomycin. Intensive Care Med. 30(3), 388–394 (2004).
   PubMed Web of Science ®Google Scholar
• Wunderink RG, Niederman MS, Kollef MH et al. Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study. Clin. Infect. Dis. doi:10.1093/cid/cir895 (2012) (Epub ahead of print).
   Google Scholar
• Liu C, Bayer A, Cosgrove SE et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin. Infect. Dis. 52, 285–292 (2011).
   PubMed Web of Science ®Google Scholar
• Lodise TP, Patel N, Lomaestro BM, Rodvold KA, Drusano GL. Relationship between initial vancomycin concentration-time profile and nephrotoxicity among hospitalized patients. Clin. Infect. Dis. 49, 507–514 (2009).
   PubMed Web of Science ®Google Scholar