85
Views
14
CrossRef citations to date
0
Altmetric
Diagnostic Profile

Diagnosis of uncertain primary tumors with the Pathwork® tissue-of-origin test

&
Pages 17-25 | Published online: 09 Jan 2014

References

  • Oien KA. Pathologic evaluation of unknown primary cancer. Semin. Oncol.36(1), 8–37 (2009).
  • Pavlidis N, Fizazi K. Carcinoma of unknown primary (CUP). Crit. Rev. Oncol. Hematol.69(3), 271–278 (2009).
  • Bahrami A, Truong LD, Ro JY. Undifferentiated tumor: true identity by immunohistochemistry. Arch. Pathol. Lab. Med.132(3), 326–348 (2008).
  • Varadhachary GR, Abbruzzese JL, Lenzi R. Diagnostic strategies for unknown primary cancer. Cancer100(9), 1776–1785 (2004).
  • Schapira DV, Jarrett AR. The need to consider survival, outcome, and expense when evaluating and treating patients with unknown primary carcinoma. Arch. Intern. Med.155(19), 2050–2054 (1995).
  • Pavlidis N, Fizazi K. Cancer of unknown primary (CUP). Crit. Rev. Oncol. Hematol.54(3), 243–250 (2005).
  • van de Wouw AJ, Janssen-Heijnen ML, Coebergh JW, Hillen HF. Epidemiology of unknown primary tumours; incidence and population-based survival of 1285 patients in Southeast Netherlands, 1984–1992. Eur. J. Cancer38(3), 409–413 (2002).
  • Abbruzzese JL, Abbruzzese MC, Lenzi R, Hess KR, Raber MN. Analysis of a diagnostic strategy for patients with suspected tumors of unknown origin. J. Clin. Oncol.13(8), 2094–2103 (1995).
  • Greco FA, Pavlidis N. Treatment for patients with unknown primary carcinoma and unfavorable prognostic factors. Semin. Oncol.36(1), 65–74 (2009).
  • Hainsworth JD, Fizazi K. Treatment for patients with unknown primary cancer and favorable prognostic factors. Semin. Oncol.36(1), 44–51 (2009).
  • Winn RJ, McClure JS. Occult Primary. V.I.2009. In: NCCN Clinical Practice Guidelines in Oncology. National Comprehensive Cancer Network, GA, USA (2009).
  • Bishop JF, Tracey E, Glass P, Jelfs P, Roder D. Prognosis of sub-types of cancer of unknown primary (CUP) compared to metastatic cancer. J. Clin. Oncol.25(Suppl. 18), 21010 (2007).
  • Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science270(5235), 467–470 (1995).
  • Golub TR, Slonim DK, Tamayo P et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science286(5439), 531–537 (1999).
  • Su AI, Welsh JB, Sapinoso LM et al. Molecular classification of human carcinomas by use of gene expression signatures. Cancer Res.61(20), 7388–7393 (2001).
  • Ramaswamy S, Tamayo P, Rifkin R et al. Multiclass cancer diagnosis using tumor gene expression signatures. Proc. Natl Acad. Sci. USA98(26), 15149–15154 (2001).
  • Bhattacharjee A, Richards WG, Staunton J et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc. Natl Acad. Sci. USA98(24), 13790–13795 (2001).
  • Weigelt B, Glas AM, Wessels LF, Witteveen AT, Peterse JL, van’t Veer LJ. Gene expression profiles of primary breast tumors maintained in distant metastases. Proc. Natl Acad. Sci. USA100(26), 15901–15905 (2003).
  • Bloom G, Yang IV, Boulware D et al. Multi-platform, multi-site, microarray-based human tumor classification. Am. J. Pathol.164(1), 9–16 (2004).
  • Tothill RW, Kowalczyk A, Rischin D et al. An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin. Cancer Res.65(10), 4031–4040 (2005).
  • Tan PK, Downey TJ, Spitznagel EL Jr et al. Evaluation of gene expression measurements from commercial microarray platforms. Nucleic Acids Res.31(19), 5676–5684 (2003).
  • Johnson K, Lin S. QA/QC as a pressing need for microarray analysis: meeting report from CAMDA’02. BioTechniques (Suppl.), 62–63 (2003).
  • Ma C, Lyons-Weiler M, Liang W et al.In vitro transcription amplification and labeling methods contribute to the variability of gene expression profiling with DNA microarrays. J. Mol. Diagn.8(2), 183–192 (2006).
  • Larkin JE, Frank BC, Gavras H, Sultana R, Quackenbush J. Independence and reproducibility across microarray platforms. Nat. Methods2(5), 337 (2005).
  • Bammler T, Beyer RP, Bhattacharya S et al. Members of the toxicogenomics research consortium. standardizing global gene expression analysis between laboratories and across platforms. Nat. Methods2(5), 351 (2005).
  • Dobbin KK, Beer DG, Meyerson M et al. Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays. Clin. Cancer Res.11(2 Pt 1), 565–572 (2005).
  • Irizarry RA, Warren D, Spencer F et al. Multiple-laboratory comparison of microarray platforms. Nat. Methods2(5), 345 (2005).
  • Moraleda J, Grove N, Tran Q et al. Gene expression data analytics with interlaboratory validation for identifying anatomical sites of origin of metastatic carcinomas. J. Clin. Oncol.22(Suppl. 14), 9625 (2004).
  • Dumur CI, Lyons-Weiler M, Sciulli C et al. Interlaboratory performance of a microarray-based gene expression test to determine tissue of origin in poorly differentiated and undifferentiated cancers. J. Mol. Diagn.10(1), 67–77 (2008).
  • Monzon FA, Lyons-Weiler M, Buturovic LJ et al. Multicenter validation of a 1,550-gene expression profile for identification of tumor tissue of origin. J. Clin. Oncol.27(15), 2503–2508 (2009).
  • Ma XJ, Patel R, Wang X et al. Molecular classification of human cancers using a 92-gene real-time quantitative polymerase chain reaction assay. Arch. Pathol. Lab. Med.130(4), 465–473 (2006).
  • Glas A, Floore A, Delahaye L et al. Converting a breast cancer microarray signature into a high-throughput diagnostic test. BMC Genomics7(1), 278 (2006).
  • Bridgewater J, van Laar R, Floore A, Van TVL. Gene expression profiling may improve diagnosis in patients with carcinoma of unknown primary. Br. J. Cancer98(8), 1425–1430 (2008).
  • Rosenfeld N, Aharonov R, Meiri E et al. MicroRNAs accurately identify cancer tissue origin. Nat. Biotechnol.26(4), 462–469 (2008).
  • Simon R. Roadmap for developing and validating therapeutically relevant genomic classifiers. J. Clin. Oncol.23(29), 7332–7341 (2005).
  • Simon R, Radmacher MD, Dobbin K, McShane LM. Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification. J. Natl Cancer Inst.95(1), 14–18 (2003).
  • Jennings L, Van Deerlin VM, Gulley ML. Recommended principles and practices for validating clinical molecular pathology tests. Arch. Pathol. Lab. Med.133(5), 743–755 (2009).
  • Levi F, Te VC, Erler G, Randimbison L, La Vecchia C. Epidemiology of unknown primary tumours. Eur. J. Cancer38(13), 1810–1812 (2002).
  • Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer Statistics, 2009. CA Cancer J. Clin.59(4), 225–249 (2009).
  • Pillai R, Deeter R, Rigl CT, Halks-Miller M, Henner WD, Buturovic L. Validation of a microarray-based gene expression test for tumors with uncertain origins using formalin-fixed paraffin-embedded (FFPE) specimens. J. Clin. Oncol.27(Suppl. 15), e22015 (2009).
  • Werner M, Chott A, Fabiano A, Battifora H. Effect of formalin tissue fixation and processing on immunohistochemistry. Am. J. Surg. Pathol.24(7), 1016–1019 (2000).
  • Masuda N, Ohnishi T, Kawamoto S, Monden M, Okubo K. Analysis of chemical modification of RNA from formalin-fixed samples and optimization of molecular biology applications for such samples. Nucleic Acids Res.27(22), 4436–4443 (1999).
  • Pentheroudakis G, Greco FA, Pavlidis N. Molecular assignment of tissue of origin in cancer of unknown primary may not predict response to therapy or outcome: a systematic literature review. Cancer Treat Rev.35(3), 221–227 (2009).
  • Greco FA, Spigel DR, Yardley DA et al. Unknown primary cancer (UPC): accuracy of tissue of origin prediction by molecular profiling. J. Clin. Oncol.27(Suppl. 15), 11070 (2009).
  • Dennis JL, Hvidsten TR, Wit EC et al. Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm. Clin. Cancer Res.11(10), 3766–3772 (2005).
  • Horlings HM, van Laar RK, Kerst JM et al. Gene expression profiling to identify the histogenetic origin of metastatic adenocarcinomas of unknown primary. J. Clin. Oncol.26(27), 4435–4441 (2008).
  • Varadhachary GR, Talantov D, Raber MN et al. Molecular profiling of carcinoma of unknown primary and correlation with clinical evaluation. J. Clin. Oncol.26(27), 4442–4448 (2008).
  • Varadhachary GR, Raber MN, Matamoros A, Abbruzzese JL. Carcinoma of unknown primary with a colon-cancer profile-changing paradigm and emerging definitions. Lancet Oncol.9(6), 596–599 (2008).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.