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Themed article: CNS neoplasms - Review

Paraneoplastic neurological disorders

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Pages 1559-1568 | Published online: 09 Jan 2014

References

  • Dalmau J, Graus F. Paraneoplastic syndromes of the nervous system. In: Cancer of the Nervous System. Loeffler JS (Ed.). Blackwell Scietific Publications, Oxford, UK, 674–700 (1997).
  • Heidenreich F, Schober R, Brinck U, Hartung HP. Multiple paraneoplastic syndromes in a patient with antibodies to neuronal nucleoproteins (anti-Hu). J. Neurol.242(4), 210–216 (1995).
  • O´Neill JH, Murray NM, Newsom-Davis J. The Lambert–Eaton myasthenic syndrome. A review of 50 cases. Brain111(Pt 3), 577–596 (1988).
  • Graus F, DelattreJY, Antoine JC et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J. Neurol Neurosurg. Psychiatry75(8), 1135–1140 (2004).
  • Lang B, Vincent A. Autoimmune disorders of the neuromuscular junction. Curr. Opin. Pharmacol.9(3), 336–340 (2009).
  • Motomura M, Lang B, Johnston I, Palace J, Vincent A, Newsom-Davis J. Incidence of serum anti-P/Q-type and anti-N-type calcium channel autoantibodies in the Lambert–Eaton myasthenic syndrome. J. Neurol. Sci.147(1), 35–42 (1997).
  • Isaacs H. A syndrome of continuous muscle-fibre activity. J. Neurol. Neurosurg. Psychiatry24, 319–325 (1961).
  • Sinha S, Newsom-Davis J, Mills K, Byrne N, Lang B, Vincent A. Autoimmune etiology for acquired neuromyotonia. Lancet338, 75–77 (1991).
  • Partanen VSJ, Soininen H, Saksa M, Riekkinen P. Electromyographic and nerve conduction findings in a patient with neuromyotonia, normcalcemic tetany and small cell lung cancer. Acta Neurol. Scand.61, 216–226 (1980).
  • Evoli A, Lo Monaco M, Marra R, Lino MM, Batocchi AP, Tonali PA. Multiple paraneoplastic diseases associated with thymoma. Neuromuscul. Disord.9(8), 601–603 (1999).
  • Lahrmann H, Albrecht G, Drlicek M et al. Acquired neuromyotonia and peripheral neuropathy in a patient with Hodgkin´s disease. Muscle Nerve24(6), 834–838 (2001).
  • Voltz RD, Albrich WC, Nagele A et al. Paraneoplastic myasthenia gravis: detection of anti-MGT30 (titin) antibodies predicts thymic epithelial tumor. Neurology49(5), 1454–1457 (1997).
  • Yamamoto AM, Gajdos P, Eymard B et al. Anti-titin antibodies in myasthenia gravis. Arch. Neurol.58(6), 885–890 (2001).
  • Buckley C, Newsom-Davis J, Willcox N, Vincent A. Do titin and cytokine antibodies in MG patients predict thymoma or thymoma recurrence? Neurology57(9), 1579–1582 (2001).
  • Vural B, Chen LC, Saip P et al. Frequency of SOX Group B (SOX1, 2, 3) and ZIC2 antibodies in Turkish patients with small cell lung carcinoma and their correlation with clinical parameters. Cancer103(12), 2575–2583 (2005).
  • Sabater L, Titulaer M, Saiz A, Verschuuren J, Güre AO, Graus F. SOX1 antibodies are markers of paraneoplastic Lambert–Eaton myasthenic syndrome. Neurology70(12), 924–928 (2008).
  • Titulaer MJ, Klooster R, Potman M et al. SOX antibodies in small cell lung cancer and Lambert–Eaton myasthenic syndrome: frequency and relation with survival. J. Clin. Oncol.27(26), 4260–4267 (2009).
  • Vincent A. Immunology of acetylcholine receptors in relation to myasthenia gravis. Physiol. Rev.60(3), 756–824 (1980).
  • Vincent A, Jacobson L, Plested P et al. Antibodies affecting ion channel function in acquired neuromyotonia, in seropositive and seronegative myasthenia gravis, and in antibody-mediated arthrogryposis multiplex congenita. Ann. NY Acad. Sci.841, 482–496 (1998).
  • Roberts A, Perera S, Lang B, Vincent A, Newsom-Davis J. Paraneoplastic myasthenic syndrome IgG inhibits 45Ca2+ flux in a human small cell carcinoma cell line. Nature317(6039), 737–739 (1985).
  • Lang B, Newsom-Davis J, Wray D, Murray N. Autoimmune etiology for myasthenic (Eaton–Lambert) syndrome. Lancet2(8240), 224 (1981).
  • Venuta F, Rendina EA, De Giacomo T et al. Thymectomy for myasthenia gravis: a 27-year experience. Eur. J. Cardiothorac. Surg.15(5), 621–624 (1999).
  • Toyka KV. Myasthenia gravis. In: Current Therapy in Neurologic Diseases III. Johnson RT (Ed.). BC Decker, PA, USA, 385–391 (1990).
  • Gajdos PH, Chevret S, Clair B, Tranchant C, Chastang C. Clinical-trial of plasma exchange and high-dose intravenous immunoglobulin in myasthenia gravis. Ann. Neurol.41(6), 789–796 (1997).
  • McEvoy KM, Windebank AJ, Daube JR, Low PA. 3,4-Diaminopyridine in the treatment of Lambert–Eaton myasthenic syndrome. N. Engl. J. Med.321, 1567–1571 (1989).
  • Chalk CH, Murray NM, Newsom-Davis J et al. Response of the Lambert–Eaton myasthenic syndrome to treatment of associated small-cell lung carcinoma. Neurology40(10), 1552–1556 (1990).
  • Sanders DB. Lambert–Eaton myasthenic syndrome: clinical diagnosis, immune-mediated mechanisms, and update on therapies. Ann. Neurol.37(Suppl. 1), S63–S73 (1995).
  • Newsom-Davis J, Murray N, Wray D et al. Lambert–Eaton myasthenic syndrome: electrophysiological evidence for a humoral factor. Muscle Nerve5(9S), S17–S20 (1982).
  • Newsom-Davis J, Murray NM. Plasma exchange and immunosuppressive drug treatment in Lambert–Eaton myasthenic syndrome. Neurology34(4), 480–485 (1984).
  • Bain PG, Motomura M, Newsom-Davis J et al. Effect of intravenous immunoglobulin (IvIg) treatment on muscle weakness and calcium channel autoantibodies in the Lambert–Eaton myasthenic syndrome. Neurology47(3), 678–683 (1996).
  • Newsom-Davis J, Mills K. Immunological associations of acquired neuromyotonia (Isaacs´syndrome). Report of five cases and literature review. Brain116(Pt 2), 453–469 (1993).
  • Hayat GR, Kulkantrakorn K, Campbell WW, Giuliani MJ. Neuromyotonia: autoimmune pathogenesis and response to immune modulating therapy. J. Neurol. Sci.181(1–2), 38–43 (2000).
  • Graus F, Delattre JY, Antoine JC et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J. Neurol. Neurosurg. Psychiatry75(8), 1135–1140 (2004).
  • Camdessanché JP, Antoine JC, Honnorat J et al. Paraneoplastic peripheral neuropathy associated with anti-Hu antibodies. A clinical and electrophysiological study of 20 patients. Brain125(Pt 1), 166–175 (2002).
  • Vernino S, Low PA, Fealey RD, Stewart JD, Farrugia G, Lennon VA. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N. Engl. J. Med.343(12), 847–855 (2000).
  • Dalmau J, Rosenfeld MR. Paraneoplastic syndromes of the CNS. Lancet Neurol.7(4), 327–340 (2008).
  • Sabater L, Bataller L, Carpentier AF et al. Protein kinase C γ autoimmunity in paraneoplastic cerebellar degeneration and nonsmall-cell lung cancer. J. Neurol. Neurosurg. Psychiatry77, 1359–1362 (2006).
  • Sillevis Smitt P, Kinoshita A, De Leeuw B et al. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. N. Engl. J. Med.342(1), 21–27 (2000).
  • Luque FA, Furneaux HM, Ferziger R et al. Anti-Ri: an antibody associated with paraneoplastic opsoclonus and breast cancer. Ann. Neurol.29(3), 241–251 (1991).
  • Bataller L, Rosenfeld MR, Graus F, Vilchez JJ, Cheung NK, Dalmau J. Autoantigen diversity in the opsoclonus–myoclonus syndrome. Ann. Neurol.53(3), 347–353 (2003).
  • Didelot A, Honnorat J. Update on paraneoplastic neurological syndromes. Curr. Opin. Oncol.21(6), 566–572 (2009).
  • Dalmau J, Gleichman AJ, Hughes EG et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol.7(12), 1091–1098 (2008).
  • Vincent A, Buckley C, Schott JM et al. Potassium channel antibody-asociated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain127(Pt 3), 701–712 (2004).
  • Ances BM, Vitaliani R, Taylor RA et al. Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. Brain128(Pt 8), 1764–1777 (2005).
  • Lai M, Hughes EG, Peng X et al. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann. Neurol.65(4), 424–434 (2009).
  • De Camilli P, Thomas A, Cofiell R et al. The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-man syndrome with breast cancer. J. Exp. Med.178(6), 2219–2223 (1993).
  • Vernino S, Tuite P, Adler CH et al. Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma. Ann. Neurol.51(5), 625–630 (2002).
  • Honnorat J, Cartalat-Carel S, Ricard D et al. Onco-neural antibodies and tumour type determine survival and neurological symptoms in paraneoplastic neurological syndromes with Hu or CV2/CRMP5 antibodies. J. Neurol. Neurosurg. Psychiatry80(4), 412–416 (2009).
  • Cross SA, Salomao DR, Parisi JE et al. Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. Ann. Neurol.54(1), 38–50 (2003).
  • Graus F, Dalmau J, Valldeoriola F et al. Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin´s disease. J. Neuroimmunol.74(1–2), 55–61 (1997).
  • Vedeler CA, Antoine JC, Giometto B et al. Management of paraneoplastic neurological syndromes: report on an ENS task force. Eur. J. Neurol.13(7), 682–690 (2006).
  • Younes-Mhenni S, Janier MF, Cinotti L et al. FDG-PET improves tumour detection in patients with paraneoplastic neurological syndromes. Brain127(10), 2331–2338 (2004).
  • Graus F, Vega F, Delattre JY et al. Plasmapheresis and antineoplastic treatment in CNS paraneoplastic syndromes with antineuronal antibodies. Neurology42(3 Pt 1), 536–540 (1992).
  • Graus F, Keime-Guibert F, Rene R et al. Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain124(Pt 6), 1138–1148 (2001).
  • Blaes F, Strittmatter M, Merkelbach S et al. Intravenous immunoglobulins in the therapy of paraneoplastic neurological disorders. J. Neurol.246(4), 299–303 (1999).
  • Antoine JC, Mosnier JF, Absi L, Convers P, Honnorat J, Michel D. Carcinoma-associated paraneoplastic peripheral neuropathies in patients with and without anti-onconeural antibodies. J. Neurol. Neurosurg. Psychiatry67, 7–14 (1999).
  • Tschernatsch M, Stolz E, Strittmatter M, Kaps M, Blaes F. Antinuclear antibodies define a subgroup of paraneoplastic neuropathies – clinical and immunological data. J. Neurol. Neurosurg. Psychiatry76(12), 1702–1706 (2005).
  • Dalmau J, Graus F, Villarejo A et al. Clinical analysis of anti-Ma2-associated encephalitis. Brain127(Pt 8), 1831–1844 (2004).
  • Elovaara I, Apostolski S, van Doorn P et al. EFNS guidelines for the use of intravenous immunoglobulin in treatment of neurological diseases. Eur. J. Neurol.15(9), 893–908 (2008).
  • Wilkinson PC. Serologic findings in carcinomatous neuromyopathy. Lancet1, 1301–1303 (1964).
  • Dalmau J, Furneaux HM, Cordon-Cardo C, Posner JB. The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues. Am. J. Pathol.141(4), 881–886 (1992).
  • Anderson NE, Budde-Steffen C, Rosenblum MK et al. Opsoclonus, myoclonus, ataxia, and encephalopathy in adults with cancer: a distinct paraneoplastic syndrome. Medicine67(2), 100–109 (1988).
  • Yang YY, Yin GL, Darnell RB. The neuronal RNA-binding protein NOVA-2 is implicated as the autoantigen targeted in POMA patients with dementia. Proc. Natl. Acad. Sci. USA95(22), 13254–13259 (1998).
  • Pittock SJ, Lucchinetti CF, Lennon VA. Anti-neuronal nuclear autoantibody type 2: paraneoplastic accompaniments. Ann. Neurol.53(5), 580–587 (2003).
  • Dalmau J, Gultekin SH, Voltz R et al. Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. Brain122, 27–39 (1999).
  • Voltz R, Gultekin SH, Rosenfeld M et al. A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer. N. Engl. J. Med.340, 1788–1795 (1999).
  • Rosenfeld M, Eichen JG, Wade DF, Posner JB, Dalmau J. Molecular and clinical diversity in paraneoplastic immunity to Ma proteins. Ann. Neurol.50, 339–348 (2001).
  • Jaeckle KA, Graus F, Houghton A, Cardon-Cardo C, Nielsen SL, Posner JB. Autoimmune response of patients with paraneoplastic cerebellar degeneration to a Purkinje cell cytoplasmic protein antigen. Ann. Neurol.18(5), 592–600 (1985).
  • Honnorat J, Antoine JC, Derrington E, Aguera M, Belin MF. Antibodies to a subpopulation of glial cells and a 66 kDa developmental protein in patients with paraneoplastic neurological syndromes. J. Neurol. Neurosurg. Psychiatry61(3), 270–278 (1996).
  • Antoine JC, Honnorat J, Camdessanche JP et al. Paraneoplastic anti-CV2 antibodies react with peripheral nerve and are associated with a mixed axonal and demyelinating peripheral neuropathy. Ann. Neurol.49(2), 214–221 (2001).
  • Honnorat J, Byk T, Kusters I et al. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Eur. J. Neurosci.11(12), 4226–4232 (1999).
  • Giometto B, Grisold W, Vitaliani R, Graus F, Honnorat J, Bertolini G; PND Euronetwork. Paraneoplastic neurologic syndrome in the PND Euronetwork database: a European study from 20 centers. Arch. Neurol.67(3), 330–335 (2010).
  • Vernino S, Lennon VA. New Purkinje cell antibody (PCA-2): marker of lung cancer-related neurological autoimmunity. Ann. Neurol.47, 297–305 (2000).
  • Chan KH, Vernino S, Lennon VA. ANNA-3 anti-neuronal nuclear antibody: marker of lung cancer-related autoimmunity. Ann. Neurol.50, 301–311 (2001).
  • Tschernatsch M, Klotz M, Probst C et al. Synaptophysin is an autoantigen in paraneoplastic neuropathy. J. Neuroimmunol.197(1), 81–86 (2008).
  • Dropcho EJ. Antiamphiphysin antibodies with small cell lung carcinoma and paraneoplastic encephalomyelitis. Ann. Neurol.39(5), 659–667 (1996).
  • Sommer C, Weishaupt A, Brinkhoff J et al. Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin. Lancet365(9468), 1406–1411 (2005).
  • Adamus G. Autoantibody targets and their cancer relationship in the pathogenicity of paraneoplastic retinopathy. Autoimmun. Rev.8(5), 410–414 (2009).
  • Adamus G, Machnicki M, Seigel GM. Apoptotic retinal cell death induced by antirecoverin autoantibodies of cancer-associated retinopathy. Invest. Ophthalmol. Vis. Sci.38(2), 283–291 (1997).
  • Kimpinski K, Iodice V, Vernino S, Sandroni P, Low PA. Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganlgionopathy. Auton. Neurosci.150(1–2), 136–139 (2009).
  • Buckley C, Oger J, Clover L et al. Potassium channel antibodies in two patients with reversible limbic encephalitis. Ann. Neurol.50(1), 73–78 (2001).
  • Tan KM, Lennon VA, Klein CJ, Boeve BF, Pittock SJ. Clinical spectrum of voltage-gated potassium channel autoimmunity. Neurology70(20), 1883–1890 (2008).
  • Irani SR, Bera K, Waters P et al.N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain13(Pt 6), 1655–1667 (2010).
  • Lancaster E, Lai M, Peng X et al. Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol.9(1), 67–76 (2010).
  • Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J. Exp. Med.202(4), 473–477 (2005).
  • Pittock SJ, Lennon VA. Aquaporin-4 antibodies in a paraneoplastic context. Arch. Neurol.65(5), 629–632 (2008).
  • Verschuuren JJ, Dalmau J, Hoard R, Posner JB. Paraneoplastic anti-Hu serum: studies on human tumor cell lines. J. Neuroimmunol.79(2), 202–210 (1997).
  • Schäfer KH, Klotz M, Mergner D, Mestres P, Schimrigk K, Blaes F. IgG-mediated cytotoxicity to myenteric plexus cultures in patients with paraneoplastic neurological syndromes. J. Autoimmun.15(4), 479–484 (2000).
  • Greenlee JE, Parks, TN, Jaeckle KA. Type IIa (anti-Hu) antineuronal antibodies produce destruction of rat cerebellar granule neurones in vitro. Neurology43(10), 2049–2054 (1993).
  • Tanaka M, Tanaka K, Onodera O, Tsuji S. Trial to establish an animal model of paraneoplastic cerebellar degeneration with anti-Yo antibody. Clin. Neurol. Neurosurg.97(1), 95–100 (1995).
  • Albert ML, Darnell JC, Bender A, Francisco LM, Bhardwaj N, Darnell RB. Tumor-specific killer cells in paraneoplastic cerebellar degeneration. Nat. Med.4(11), 1321–1324 (1998).
  • Voltz R, Dalmau J, Posner JB, Rosenfeld MR. T-cell receptor analysis in anti-Hu associated paraneoplastic encephalomyelitis. Neurology51(4), 1146–1150 (1998).
  • Roberts WK, Deluca IJ, Thomas A et al. Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells. J. Clin. Invest.119(7), 2042–2051 (2009).
  • Pellkofer H, Schubart AS, Höftberger R et al. Modelling paraneoplastic CNS disease: T-cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in the rat. Brain127(Pt 8), 1822–1830 (2004).
  • Kazarian M, Calbo J, Proost N, Carpenter CL, Berns A, Laird-Offringa IA. Immune response in lung cancer mouse model mimics human anti-Hu reactivity. J. Neuroimmunol.217(1–2), 38–45 (2009).
  • Dalmau J, Furneaux HM, Gralla RJ, Kris MG, Posner JB. Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer – a quantitative Western Blot analysis. Ann. Neurol.27(5), 544–552 (1990).
  • Graus F, Dalmau J, Rene R et al. Anti-Hu antibodies in patients with small cell lung cancer: association with complete response to therapy and improved survival. J. Clin. Oncol.15(8), 2866–2872 (1997).
  • Blaes F, Klotz M, Huwer H et al. Antineural and antinuclear autoantibodies are of prognostic relevance in non-small cell lung cancer. Ann. Thorac. Surg.69(1), 254–258 (2000).
  • Altman AJ, Baehner RL. Favorable prognosis for survival in children with coincident opso–myoclonus and neuroblastoma. Cancer37(6), 846–852 (1976).
  • Dalmau J, Graus F, Cheung NK et al. Major histocompatibility proteins, anti-Hu antibodies, and paraneoplastic encephalomyelitis in neuroblastoma and small cell lung cancer. Cancer75(1), 99–109 (1995).
  • Cohn SL, Salwen H, Herst CV et al. Single copies of the n-myc oncogene in neuroblastomas from children presenting with the syndrome of opsoclonus–myoclonus. Cancer62(5), 723–726 (1988).
  • Hahn A, Claviez A, Brinkmann G, Altermatt HJ, Schneppenheim R, Stephani U. Paraneoplastic cerebellar degeneration in pediatric Hodgkin disease. Neuropediatrics31(1), 42–44 (2000).
  • Blaes F, Lang B. Opsoclonus–myoclonus syndrome in childhood. In: Autoantibodies in Neurological Diseases. Vincent A, Martino G (Eds). Springer, Milan, Italy, 144–151 (2001).
  • Korfei M, Fühlhuber V, Schmidt-Wöll T et al. Functional characterisation of autoantibodies from patients with pediatric opsoclonus–myoclonus syndrome. J. Neuroimmunol.170(1–2), 150–157 (2005).
  • Blaes F, Fühlhuber V, Korfei M et al. Surface-binding autoantibodies to cerebellar neurons in opsoclonus syndrome. Ann. Neurol.58(2), 313–317 (2005).
  • Sabater L, Xifro X, Saiz A, Alberch J, Graus F. Analysis of autoantibodies to neuronal surface antigens in adult opsoclonus myoclonus. J. Neuroimmunol.196(1–2), 188–191 (2008).
  • Fühlhuber V, Bick S, Kirsten A et al. Elevated B-cell activating factor BAFF, but not APRIL, correlates with CSF cerebellar autoantibodies in pediatric opsoclonus–myoclonus syndrome. J. Neuroimmunol.210(1–2), 87–91 (2009).
  • Pranzatelli MR, Tate ED, Travelstead AL et al. Rituximab (anti-CD20) adjunctive therapy for opsoclonus–myoclonus syndrome. J. Pediatr. Hematol. Oncol.28(9), 585–593 (2006).
  • Russo C, Cohn SL, Petruzzi MJ, Alarcon PA. Long-term neurologic outcome in children with opsoclonus–myoclonus associated with neuroblastoma: a report from the pediatric oncology group. Med. Pediatr. Oncol.28(4), 284–288 (1997).
  • Vernino S. Neuronal acetylcholine receptor autoimmunity. Ann. NY Acad. Sci.1132, 124–128 (2008).
  • McKeon A, Lennon VA, Lachance DH, Fealey RD, Pittock SJ. Ganglionic acetylcholine receptor autoantibody. Arch. Neurol.66(6), 735–741 (2009).

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