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Theme: Mood disorders - Review

Mood stabilizers for patients with bipolar disorder: the state of the art

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Pages 85-99 | Published online: 09 Jan 2014

References

  • Fatemi SH, Reutiman TJ, Folsom TD. The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder. Biochem. Soc. Trans.37(Pt 5), 1090–1095 (2009).
  • Angst J. Bipolar disorder a seriously underestimated health burden. Eur. Arch. Psychiatry Clin. Neurosci.254, 59–60 (2004).
  • Altamura AC, Dell’Osso B, Berlin HA, Buoli M, Bassetti R, Mundo E. Duration of untreated illness and suicide in bipolar disorder: a naturalistic study. Eur. Arch. Psychiatry Clin. Neurosci.260(5), 385–391 (2010).
  • Angst J, Cui L, Swendsen J et al. Major depressive disorder with subthreshold bipolarity in the National Comorbidity Survey Replication. Am. J. Psychiatry167(10), 1194–1201 (2010).
  • Stewart C, El-Mallakh RS. Is bipolar disorder overdiagnosed among patients with substance abuse? Bipolar Disord.9(6), 646–648 (2007).
  • Goldberg JF, Garno JL, Callahan AM, Kearns DL, Kerner B, Ackerman SH. Overdiagnosis of bipolar disorder among substance use disorder inpatients with mood instability. J. Clin. Psychiatry69(11), 1751–1757 (2008).
  • Kahn JP. Comorbidity and bipolar disorders. Encephale32(Pt 2), S511–S514 (2006).
  • Dell’Osso B, Buoli M, Bortolussi S, Vecchi V, Camuri G, Altamura AC. Patterns of Axis I comorbidity in relation to age in patients with bipolar disorder: a cross-sectional analysis. J. Affect. Disord. DOI:10.1016/j.jad.2010.10.008 (2010) (Epub ahead of print).
  • Merikangas KR, Akiskal HS, Angst J et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry64(5), 543–552 (2007).
  • Novick DM, Swartz HA, Frank E. Suicide attempts in bipolar I and bipolar II disorder: a review and meta-analysis of the evidence. Bipolar Disord.12, 1–9 (2010).
  • Fajutrao L, Locklear J, Priaulx J et al. A systematic review of the evidence of the burden of bipolar disorder in Europe. Clin. Pract. Epidemiol. Ment. Health5, 3 (2009).
  • WHO. The global burden of disease: 2004 update. WHO, Geneva, Switzerland (2008).
  • Ventimiglia J, Kalali AH, McIntyre R. Treatment of bipolar disorder. Psychiatry (Edgmont)6(10), 12–14 (2009).
  • Sachs GS. Bipolar mood disorder: practical strategies for acute and maintenance phase treatment. J. Clin Psychopharmacol.16(2 Suppl. 1), S32–S47 (1996).
  • Bauer MS, Mitchner L. What is a ‘mood stabilizer’? An evidence-based response. Am. J. Psychiatry161(1), 3–18 (2004).
  • Keck PE Jr, McElroy SL, Richtand N, Tohen M. What makes a drug a primary mood stabilizer? Mol. Psychiatry7(Suppl. 1), S8–S14 (2002).
  • Ketter TA, Calabrese JR. Stabilization of mood from below versus above baseline in bipolar disorder: a new nomenclature. J. Clin Psychiatry63, 146–151 (2002).
  • Grof P. Selecting effective long-term treatment for bipolar patients: monotherapy and combinations. J. Clin. Psychiatry64(Suppl. 5), 53–61 (2003).
  • Harris M, Chandran S, Chakraborty N et al. Mood-stabilizers: the archeology of the concept. Bipolar Disord.5, 446–452 (2003).
  • Keck PE Jr, McElroy SL. Redefining mood stabilization. J. Affect. Disord.73, 163–169 (2003).
  • Yatham LN, Kennedy SH, Schaffer A et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009. Bipolar Disord.11(3), 225–255 (2009).
  • Grunze H, Kasper S, Goodwin G, Bowden C, Möller HJ; on behalf of the WFSBP Task Force on Treatment Guidelines for Bipolar Disorders The World Federation of Societies of Biological Psychiatry (WFSBP). World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders, part III: maintenance treatment. World J. Biol. Psychiatry5, 120–135 (2004).
  • Grunze H, Vieta E, Goodwin G et al. The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2009 on the treatment of acute mania. World J. Biol. Psychiatry10, 85–116 (2009).
  • Grunze H, Vieta E, Goodwin G et al. The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the treatment of acute bipolar depression. World J. Biol. Psychiatry11, 81–109 (2010).
  • Cade JF. Lithium salts in the treatment of psychotic excitement. Med. J. Aust.2(10), 349–352 (1949).
  • Jefferson JW, Greist JH. A computer-based lithium library. Am. J. Psychiatry134(9), 1049 (1977).
  • Kilts CD. In vivo imaging of the pharmacodynamics and pharmacokinetics of lithium. J. Clin. Psychiatry61(Suppl. 9), 41–46 (2000).
  • Finley PR, Warner MD, Peabody CA. Clinical relevance of drug interactions with lithium. Clin. Pharmacokinet.29(3), 172–191 (1995).
  • Plenge P, Stensgaard A, Jensen HV, Thomsen C, Mellerup ET, Henriksen O. 24-hour lithium concentration in human brain studied by Li-7 magnetic resonance spectroscopy. Biol. Psychiatry36(8), 511–516 (1994).
  • Schatzberg AF, Nemeroff CB. Lithium. In: Essentials of Clinical Psychopharmacology. American Psychiatric Publishing, VA, USA, 335–336 (2006).
  • Berridge MJ, Downes CP, Hanley MR. Neural and developmental actions of lithium: a unifying hypothesis. Cell59(3), 411–419 (1989).
  • Klein PS, Melton DA. A molecular mechanism for the effect of lithium on development. Proc. Natl Acad. Sci. USA93(16), 8455–8459 (1996).
  • Williams RS, Harwood AJ. Lithium therapy and signal transduction. Trends Pharmacol. Sci.21(2), 61–64 (2000).
  • Fountoulakis KN, Vieta E, Bouras C et al. A systematic review of existing data on long-term lithium therapy: neuroprotective or neurotoxic? Int. J. Neuropsychopharmacol.11(2), 269–287 (2008).
  • Lenox RH, Watson DG, Patel J, Ellis J. Chronic lithium administration alters a prominent PKC substrate in rat hippocampus. Brain Res.570(1–2), 333–340 (1992).
  • Berrettini WH, Nurnberger JI Jr, Narrow W, Simmons-Alling S, Gershon ES. Cerebrospinal fluid studies of bipolar patients with and without a history of suicide attempts. Ann. NY Acad. Sci.487, 197–201 (1986).
  • El-Mallakh RS. Ion homeostasis and the mechanism of action of lithium. Clin. Neurosci. Res.4(3–4), 227–231 (2004).
  • Sourial-Bassillious N, Rydelius PA, Aperia A, Aizman O. Glutamate-mediated calcium signaling: a potential target for lithium action. Neuroscience161(4), 1126–1134 (2009).
  • Dixon JF, Hokin LE. Lithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex. Proc. Natl Acad. Sci. USA95(14), 8363–8368 (1998).
  • Rao JS, Rapoport SI. Mood-stabilizers target the brain arachidonic acid cascade. Curr. Mol. Pharmacol.2(2), 207–214 (2009).
  • Kim HW, Rapoport SI, Rao JS. Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients. Mol. Psychiatry DOI: 10.1038/mp.2009.137 (2009) (Epub ahead of print).
  • Fenves AZ, Emmett M, White MG. Lithium intoxication associated with acute renal failure. South Med. J.77(11), 1472–1474 (1984).
  • Steckler TL. Lithium- and carbamazepine-associated sinus node dysfunction: nine-year experience in a psychiatric hospital. J. Clin. Psychopharmacol.14(5), 336–339 (1994).
  • Mitchell JE, Mackenzie TB. Cardiac effects of lithium therapy in man: a review. J. Clin. Psychiatry43(2), 47–51 (1982).
  • Hensen J, Haenelt M, Gross P. Lithium induced polyuria and renal vasopressin receptor density. Nephrol. Dial. Transplant.11(4), 622–627 (1996).
  • Gitlin M. Lithium and the kidney: an updated review. Drug Saf.20, 231–243 (1999).
  • Le Roy V, Delmas Y, Verdoux H. Chronic renal complications induced by lithium. Encephale35(6), 605–610 (2009).
  • Bocchetta A, Loviselli A. Lithium treatment and thyroid abnormalities. Clin. Pract. Epidemiol. Ment. Health.12, 2–23 (2006).
  • Kusalic M, Engelsmann F. Effect of lithium mainteinance therapy on thyroid and parathyroid function. J. Psychiatry Neurosci.24, 227–233 (1999).
  • Cohen LS, Friedman J, Jefferson JW, Johnson EM, Weiner ML. A re-evaluation of risk of in utero esposure to lithium. JAMA271, 146–150 (1994).
  • Nora JJ, Nora AH, Toews WH. Ebstein’s anomaly and other congenital heart defects. Lancet2, 594–595 (1974).
  • Menon SJ. Psychotropic medication during pregnancy and lactation. Arch. Gynecol. Obstet.277, 1–13 (2008).
  • Kallen B, Tandberg A. Lithium and pregnancy: a cohort study on manic depressive women. Acta Psychiatrica68, 134–139 (1983).
  • Schou M. What happenen later to the lithium babies? A follow-up study of children born without malformations. Acta Psychiatr. Scand.54, 193–197 (1976).
  • Viguera AC, Cohen LS, Baldessarini RJ, Nonacs R. Managing bipolar disorder during pregnancy: weighing the risks and benefits. Can. J. Psychiatry47, 426–436 (2002).
  • Grandjean EM, Aubry JM. Lithium: updated human knowledge using an evidence-based approach: part III: clinical safety. CNS Drugs23(5), 397–418 (2009).
  • Granneman GR, Schneck DW, Cavanaugh JH, Witt GF. Pharmacokinetic interactions and side effects resulting from concomitant administration of lithium and divalproex sodium. J. Clin. Psychiatry57(5), 204–206 (1996).
  • Shukla S, Godwin CD, Long LE, Miller MG. Lithium-carbamazepine neurotoxicity and risk factors. Am. J. Psychiatry141(12), 1604–1606 (1984).
  • Karle J, Bjørndal F. Serotonergic syndrome in combination therapy with lithium and fluoxetine. Ugeskr. Laeger.157(9), 1204–1205 (1995).
  • Sobanski T, Bagli M, Laux G, Rao ML. Serotonin syndrome after lithium add-on medication to paroxetine. Pharmacopsychiatry30(3), 106–107 (1997).
  • Mekler G, Woggon B. A case of serotonin syndrome caused by venlafaxine and lithium. Pharmacopsychiatry30(6), 272–273 (1997).
  • Ohman R, Spigset O. Serotonin syndrome induced by fluvoxamine-lithium interaction. Pharmacopsychiatry26(6), 263–264 (1993).
  • Finley PR, O’Brien JG, Coleman RW. Lithium and angiotensin-converting enzyme inhibitors: evaluation of a potential interaction. J. Clin. Psychopharmacol.16(1), 68–71 (1996).
  • Handler J. Lithium and antihypertensive medication: a potentially dangerous interaction. J. Clin. Hypertens.11(12) (2009).
  • Grunze HC. Anticonvulsants in bipolar disorder. Ment. Health19(2), 127–141 (2010).
  • Lambert PA, Carraz G, Borselli S et al. Dipropylacetamide in the treatment of manic-depressive psychosis. Encephale1(1), 25–31 (1975).
  • Gould TD, Quiroz JA, Singh J, Zarate CA, Manji HK. Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers. Mol. Psychiatry9(8), 734–755 (2004).
  • Hardman JG, Limbird LE, Molinoff PB, Ruddon RW (Eds). Goodman & Gilman’s The Pharmacological Basis of Therapeutics (11th Edition), McGraw-Hill, NY, USA (2006).
  • Ueda Y, Willmore LJ. Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis. Exp. Brain Res.133(3), 334–339 (2000).
  • Stahl SM. Anticonvulsants as mood stabilizers and adjuncts to antipsychotics: valproate, lamotrigine, carbamazepine, and oxcarbazepine and actions at voltage-gated sodium channels. J. Clin. Psychiatry65(6), 738–739 (2004).
  • Teo R, King J, Dalton E, Ryves J, Williams RS, Harwood AJ. PtdIns(3,4,5)P(3) and inositol depletion as a cellular target of mood stabilizers. Biochem. Soc. Trans.37(Pt 5), 1110–1114 (2009).
  • Haddad PM, Das A, Ashfaq M, Wieck A. A review of valproate in psychiatric practice. Expert Opin. Drug Metab. Toxicol.5(5), 539–551 (2009).
  • Hermida Ameijeiras J, Tutor Crespo MJ, Tutor Valcarce CJ. Lipase and total amylase and its isoenzymes as markers of pancreatic injury in patients treated with antiepileptic drugs. Farm. Hosp.31, 303–306 (2007).
  • Okuma T, Kishimoto A. A history of investigation on the mood stabilizing effect of carbamazepine in Japan. Psychiatry Clin. Neurosci.52(1), 3–12 (1998).
  • Ballenger JC, Post RM. Carbamazepine in manic–depressive illness: a new treatment. Am. J. Psychiatry137(7), 782–790 (1980).
  • Cloyd JC, Remmel RP. Antiepileptic drug pharmacokinetics and interactions: impact on treatment of epilepsy. Pharmacotherapy20(8 Pt 2), S139–S151 (2000).
  • Steinacher L, Vandel P, Zullino DF, Eap CB, Brawand-Amey M, Baumann P. Carbamazepine augmentation in depressive patients non-responding to citalopram: a pharmacokinetic and clinical pilot study. Eur. Neuropsychopharmacol.12(3), 255–260 (2002).
  • Besag FM, Berry D. Interactions between antiepileptic and antipsychotic drugs. Drug Saf.29(2), 95–118 (2006).
  • Stoner SC, Nelson LA, Lea JW, Marken PA, Sommi RW, Dahmen MM. Historical review of carbamazepine for the treatment of bipolar disorder. Pharmacotherapy27(1), 68–88 (2007).
  • Bazinet RP. Is the brain arachidonic acid cascade a common target of drugs used to manage bipolar disorder? Biochem. Soc. Trans.37(Pt 5), 1104–1109 (2009).
  • Bowden CL. Anticonvulsants in bipolar disorders: current research and practice and future directions. Bipolar Disord.11(Suppl. 2), 20–33 (2009).
  • Morrow J, Russell A, Guthrie E et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J. Neurol. Neurosurg. Psychiatry77(2), 193–198 (2006).
  • Misdrahi D, Tournier M, Droulout T et al. Efficiency and safety of oxcarbazepine in mood disorders: a naturalistic study exploring the interest of plasma dosages. Eur. Psychiatry23(6), 409–412 (2008).
  • Centorrino F, Albert MJ, Berry JM et al. Oxcarbazepine: clinical experience with hospitalized psychiatric patients. Bipolar Disord.5(5), 370–374 (2003).
  • Bowden CL, Asnis GM, Ginsberg LD, Bentley B, Leadbetter R, White R. Safety and tolerability of lamotrigine for bipolar disorder. Drug Saf.27(3), 173–184 (2004).
  • Gajwani P, Forsthoff A, Muzina D et al. Antiepileptic drugs in mood-disordered patients. Epilepsia46(Suppl. 4), 38–44 (2005).
  • Xie X, Hagan RM. Cellular and molecular actions of lamotrigine: possible mechanisms of efficacy in bipolar disorder. Neuropsychobiology38(3), 119–130 (1998).
  • Cohen AF, Land GS, Breimer DD et al. Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans. Clin. Pharmacol. Ther.42, 535–541 (1987).
  • Ramsay RE, Pellock JM, Garnett WR et al. Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy. Epilepsy Res.10, 191–200 (1991).
  • Goldsmith DR, Wagstaff AJ, Ibbotson T, Perry CM. Lamotrigine: a review of its use in bipolar disorder. Drugs63(19), 2029–2050 (2003).
  • Wong IC, Lhatoo SD. Adverse reactions to new anticonvulsant drugs. Drug Saf.23(1), 35–56 (2000).
  • Delay J, Deniker P, Ropert R. Study of 300 case histories of psychotic patients treated with chlorpromazine in closed wards since 1952, Encephale45(4), 528–535 (1956).
  • Stahl S. Essential Psychopharmacology: Neuroscientific Basis and Practical Application. Cambridge University Press, Cambridge, UK (2000).
  • Schatzberg AF, Nemeroff CB. Classic antipsychotic medication. In: Essentials of Clinical Psychopharmacology. American Psychiatric Publishing, VA, USA, 211–228 (2006).
  • Bowden CL, Krishnan AA. Pharmacotherapy for bipolar depression: an economic assessment. Expert Opin. Pharmacoter.5(5), 1101–1107 (2004).
  • Sajatovic M, Subramoniam M, Fuller MA. Risperidone in the treatment of bipolar mania. Neuropsychiatr. Dis. Treat.2(2), 127–138 (2006).
  • McIntyre RS. Pharmacology and efficacy of asenapine for manic and mixed states in adults with bipolar disorder. Expert Rev. Neurother.10(5), 645–649 (2010).
  • Baldwin DS, Montgomery SA. First clinical experience with olanzapine (LY 170053): results of an open-label and dose-ranging study in patients with schizophrenia. Int. Clin. Psychopharmacol.10(4), 239–244 (1995).
  • Schatzberg AF, Nemeroff CB. Olanzapine. In: Essentials of Clinical Psychopharmacology. American Psychiatric Publishing, VA, USA, 246 (2006).
  • Li X, Rosborough KM, Friedman AB, Zhu W, Roth KA. Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics. Int. J. Neuropsychopharmacol.10(1), 7–19 (2007).
  • Kapur S, Zipursky RB, Remington G et al. 5HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation. Am. J. Psychiatry155(7), 921–928 (1998).
  • Kassahun K, Mattiuz E, Nyhart E et al. Disposition and biotransformation of the antipsychotic agent olanzapine in humans. Drug Metab. Dispos.25(1), 81–93 (1997).
  • Callaghan JT, Bergstrom RF, Ptak LR, Beasley CM. Olanzapine. Pharmacokinetik and pharmacodynamic profile. Clin. Pharmacokinet.37(3), 177–193 (1999).
  • Ring BJ, Binkley SN, Vandenbranden M, Wrighton SA. In vitro interaction of the antipsychotic agent olanzapine with human cytochromes P450 CYP2C9, CYP2C19, CYP2D6 and CYP3A. Br. J. Clin. Pharamacol.41(3), 181–186 (1996).
  • Macias WL, Bergstrom RF, Cerimele BJ, Kassahun K, Tatum DE, Callaghan JT. Lack effect of olanzapine on the pharmacokinetics of a single aminophylline dose in healthy men. Pharmacotherapy18(6), 1237–1248 (1998).
  • American Diabetes Association Guidelines. Diabetes Care32(Suppl.1) (2009).
  • Schatzberg AF, Nemeroff CB. Quetiapine. In: Essentials of Clinical Psychopharmacology. American Psychiatric Publishing, VA, USA, 263 (2006).
  • Goldstein J. Quetiapine fumarate (Seroquel): a new atypical antipsychotic. Drugs Today (Barc.)35, 193–210 (1999).
  • Cascade E, Kalali AH, Mehra S, Meyer JM. Real-world data on atypical antipsychotic medication side effects,. Psychiatry (Edgmont.)7(7), 9–12 (2010).
  • Cutler A, Datto C, Nordenhem A et al. Effectiveness of the extended release formulation of quetiapine as monotherapy for the treatment of acute bipolar mania. Presented at: The 8th Annual International Review of Bipolar Disorders Conference. Copenhagen, Denmark, 14–16 April, 2008.
  • Suppes T, Datto C, Minkwitz M, Nordenhem A, Walker C, Darko D. Effectiveness of the extended release formulation of quetiapine as monotherapy for the treatment of acute bipolar depression. Presented at: The 8th Annual International Review of Bipolar Disorders Conference. Copenhagen, Denmark, 14–16 April, 2008.
  • Jurdi RK Al, Dixit LA, Sajatovic M. Role of extended release quetiapine in the management of bipolar disorders. Neuropsychiatr. Dis. Treat.6, 29–35 (2010).
  • Young AH, Mc Elroy, Bauer M et al. A double blind, placebo-controlled study of quetiapine and lithium monotherapy in adults in the acute phase of bipolar depression (EMBOLDEN I). J. Clin. Psychiatry71, 150 (2010).
  • McElroy SL, Weisler RH, Chang W et al. A double-blind, placebo-controlled study of quetiapine and paroxetine as monotherapy in adults with bipolar depression (EMBOLDEN II). J. Clin. Psychiatry71, 163 (2010).
  • Leysen JE, Janssen PM, Megens AA, Schotte A. Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J. Clin. Psychiatry55, 5–12 (1994).
  • Schotte A, Janssen PF, Gommeren W et al. Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptors binding. Psychopharmacology (Berl.)124(1–2), 57–73 (1996).
  • Heykants J, Huang ML, Mannens G. The pharmacokinetics of risperidone in humans: a summary. J. Clin. Psychiatry55, 13–17 (1994).
  • Burstein ES, Ma J, Wong S et al. Intrinsic efficacy of antipsychotics at human D2, D3 and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist. J. Pharmacol. Exp. Ther.315(3), 1278–1287 (2005).
  • Burris KD, Molski TF, Xu C et al. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J. Pharmacol. Exp. Ther.302(1), 381–389 (2002).
  • Jordan S, Koprivica V, Chen R, Tottori K, Kikuchi T, Altar CA. The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor. Eur. J. Pharmacol.441(3), 137–140 (2002).
  • Shapiro DA, Renock S, Arrington E. Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsychopharmacology28(8), 1400–1411(2003).
  • Currier GW, Citrome LL, Zimbroff DL et al. Intramuscular aripiprazole in the control of agitation. J. Psychiatr. Pract.13(3), 159–169 (2007).
  • Brown ES, Jeffress J, Liggin JD, Garza M, Beard L. Switching outpatients with bipolar or schizoaffective disorder and substance abuse from their current antipsychotic to aripiprazole. J. Clin. Psychiatry66(6), 756–760 (2005).
  • Kane JM, Carson WH, Saha AR et al. Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder. J. Clin. Psychiatry63(9), 763–771 (2002).
  • Potkin SG, Saha AR, Kujawa MJ et al. Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder. Arch. Gen. Psychiatry60(7), 681–690 (2003).
  • De Vane CL, Nemeroff CB. Clinical pharmacokinetics of quetiapine: an atypical antipsychotic. Clin. Pharmacokinet.40, 509–522 (2001).
  • Marek GJ, Carpenter LL, McDougle CJ, Price LH. Synergistic action of 5-HT2A antagonists and selective reuptake inhibitors in neuropsychiatric disorders. Neuropsychopharmacology28(2), 402–412 (2003).
  • Nemeroff CB, Lieberman JA, Weiden PJ et al. From clinical research to clinical practice: a 4-year review of ziprasidone. CNS Spectr.10(11), 1–20 (2005).
  • Shahid M, Walker GB, Zorn SH, Wong EH. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J. Psychopharmacol.23(1), 65–73 (2009).
  • Tohen M, Vieta E. Antipsychotic agents in the treatment of bipolar mania. Bipolar Disord.11(2), 45–54 (2009).
  • Frye MA, Ketter TA, Altshuler Ll et al. Clozapine in bipolar disorder: treatment implications for other atypical antipsychotics. J. Affect. Disord.48, 91–104 (1998).
  • Calabrese RJ, Kimmel SE, Woyshville MJ et al. Clozapine for tratment-refractory mania. Am. J. Psychiatry153, 759–764 (1996).
  • Green AI, Tohen M, Patel JK. Clozapine in the treatment of refractory psychotic mania. Am. J. Psichiatry157, 982–986 (2000).
  • Macedo-Soares MB, Moreno RA, Rigonatti SP, Lafer B. Efficacy of electroconvulsive therapy in treatment-resistant bipolar disorder: a case series. J. ECT21, 31–34 (2005).
  • Valentí M, Benabarre A, Bernardo M, García-Amador M, Amann B, Vieta E. Electroconvulsive therapy in the treatment of bipolar depression. Actas Esp. Psiquiatr.35(3), 199–207 (2007).
  • Hallam KT, Smith DI, Berk M. Differences between subjective and objective assessments of the utility of electroconvulsive therapy in patients with bipolar and unipolar depression. J. Affect. Disord.112, 212–218 (2009).
  • Ciapparelli A, Dell’Osso L, Tundo A et al. Electroconvulsive therapy in medication-nonresponsive patients with mixed mania and bipolar depression. J. Clin. Psychiatry62(7), 552–555 (2001).
  • Fountoulakis KN, Vieta E, Sanchez-Moreno J et al. Treatment guidelines for bipolar disorder: a critical review. J. Affect. Disord.86, 1–10 (2005).
  • Tohen M, Jacobs TG, Grundy SL et al. Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzapine HGGW Study Group. Arch. Gen. Psychiatry57(9), 841–849 (2000).
  • Goodwin FK, Jamison KR. Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression, 2nd Edition. Oxford University Press, NY, USA (2007).
  • McIntyre RS, Mancini DA, Parikh S, Kennedy SH. Lithium revisited. Can. J. Psychiatry46(4), 322–327 (2001).
  • Sachs GS, Grossman F, Ghaemi SN, Okamoto A, Bowden CL. Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety. Am. J. Psychiatry159(7), 1146–1154 (2002).
  • Yatham LN, Binder C, Riccardelli R, Leblanc J, Connolly M, Kusumakar V; RIS-CAN 25 Study Group. Risperidone in acute and continuation treatment of mania. Int. Clin. Psychopharmacol.18(4), 227–235 (2003).
  • Judd LL, Schettler PJ, Akiskal HS et al. Long-term symptomatic status of bipolar I vs. bipolar II disorders. Int. J. Neuropsychopharmacol.6(2), 127–137 (2003).
  • Kupka RW, Altshuler LL, Nolen WA et al. Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder. Bipolar Disord.9, 531–535 (2007).
  • Baldessarini RJ, Vieta E, Calabrese JR, Tohen M, Bowden CL. Bipolar depression: overview and commentary. Harv. Rev. Psychiatry18(3), 143–157 (2010).
  • Kupfer DJ. Models of bipolar disease and their clinical implications. Biol. Psychiatry48(6), 428–429 (2000).
  • Judd LL, Akiskal HS, Schettler PJ et al. The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch. Gen. Psychiatry59(6), 530–537 (2002).
  • Rihmer Z, Pestality P. Bipolar II disorder and suicidal behavior. Psychiatr. Clin. North Am.22(3), 667–673 (1999).
  • Jarema M. Atypical antipsychotics in the treatment of mood disorders. Curr. Opin. Psychiatry20(1), 23–29 (2007).
  • Altamura AC, Mundo E, Dell’osso B, Tacchini G, Buoli M, Calabrese JR. Quetiapine and classical mood stabilizer in the long-term treatment of bipolar disorder: a 4 years follow-up naturalistic study. J. Affect. Disord.110(1–2), 135–141 (2008).
  • Tondo L, Baldessarini RJ. Long-term lithium treatment in the prevention of suicidal behavior in bipolar disorder patients. Epidemiol. Psichiatr. Soc.18(3), 179–183 (2009).
  • Muller-Oelinghausen B, Lewitzka U. Lithium reduces pathological aggression and suicidality: a mini-review. Neuropsychobiology62(1), 43–49 (2010).
  • Grunze HC. Switching, induction of rapid cycling, and increased suicidality with antidepressants in bipolar patients: fact or overinterpretation? CNS Spectr.13(9), 790–795 (2008).
  • Amsterdam JD, Shults J. Efficacy and safety of long-term fluoxetine versus lithium monotherapy of bipolar II disorder: a randomized, double-blind, placebo-substitution study. Am. J. Psychiatry167(7), 792–800 (2010).
  • Amsterdam JD, Wang G, Shults J. Venlafaxine monotherapy in bipolar type II depressed patients unresponsive to prior lithium monotherapy. Acta Psychiatr. Scand.121(3), 201–208 (2010).
  • Amsterdam JD, Shults J. Efficacy and mood conversion rate of short-term fluoxetine monotherapy of bipolar II major depressive episode. J. Clin. Psychopharmacol.30(3), 306–311 (2010).
  • Altamura AC. Novel antipsychotics and the problem of clinical stabilization in schizophrenia: are they ‘stabilizer’ rather than typical compounds? Int. Clin. Psychopharmacol.11(3), 153–155 (1996).
  • Altamura AC. From the concept of ‘antipsychotic’ to that of ‘multidimensional normostabilizer’: the clinical-therapeutic itinerary of schizophrenia. Giorn. Ital. Psicopat.16, 87–103 (2010).
  • Post RM, Altshuler LL, Frye MA et al. Complexity of pharmacologic treatment required for sustained improvement in outpatients with bipolar disorder. J. Clin. Psychiatry71(9), 1176–1186 (2010).
  • Sanches M, Newberg AR, Soares JC. Emerging drugs for bipolar disorder. Expert Opin. Emerg. Drugs15(3), 453–466 (2010).

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