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Drug Profile

Qutenza®: a capsaicin 8% patch for the management of postherpetic neuralgia

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Pages 15-27 | Published online: 09 Jan 2014

References

  • Treede R, Jensen T, Campbell J et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology70(18), 1630–1635 (2008).
  • Bennett GJ. Neuropathic pain: new insights, new interventions. Hosp. Pract.33, 95–114 (1998).
  • Gustorff B, Dorner T, Likar R et al. Prevalence of self-reported neuropathic pain and impact on quality of life: a prospective representative survey. Acta Anaesthesiol. Scand.52(1), 132–136 (2008).
  • Bouhassira D, Lanteri-Minet M, Laurent B, Touboul C. Prevalence of chronic pain with neuropathic characteristics in the general population. Pain136(3), 380–387 (2008).
  • Rowbotham MC, Fields HL. The relationship of pain, allodynia and thermal sensation in post-herpetic neuralgia. Brain119(Pt 2), 347–354 (1996).
  • Attal N, Cruccu G, Baron R et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur. J. Neurol.17(9), 1113–e88 (2010).
  • Dworkin RH, O’Connor AB, Audette J et al. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin. Proc.85(3 Suppl.), S3–S14 (2010).
  • Moulin DE, Clark AJ, Gilron I et al. Pharmacological management of chronic neuropathic pain – consensus statement and guidelines from the Canadian Pain Society. Pain Res. Manag.12(1), 13–21 (2007).
  • Jackson KC. Pharmacotherapy for neuropathic pain. Pain Pract.6, 27–33 (2006).
  • Backonja M, Irving G, Argoff CE. Rationale multidrug therapy in the treatment of neuropathic pain. Curr. Pain Headache Rep.10, 34–38 (2006).
  • Field MJ, Hughes J, Singh L. Further evidence for the role of the α(2)δ subunit of voltage dependent calcium channels in models of neuropathic pain. Br. J. Pharmacol.131, 282–286 (2000).
  • Dworkin RH, Corbin AE, Young JP et al. Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology60, 1274–1288 (2003).
  • Rice AS, Maton S. Gabapentin in postherpetic neuralgia: a randomized, double blind, placebo controlled study. Pain94, 215–224 (2001).
  • Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA280, 1837–1863 (1998).
  • Rice A, Maton S. Gabapentin in postherpetic neuralgia: a randomized, double blind, placebo controlled study. Pain94(2), 215–224 (2001).
  • van Seventer R, Feister H, Young J, Stoker M, Versavel M, Rigaudy L. Efficacy and tolerability of twice daily gabapentin for treating pain and related sleep interference in post herpetic neuralgia: a 13 week randomized trial. Curr. Med. Res. Opin.22, 375–384 (2006).
  • Rowbotham MC, Davies PS, Verkempinck C, Galer BS. Lidocaine patch: double-blind controlled study of a new treatment method for post-herpetic neuralgia. Pain65, 39–44 (1996).
  • Rowbotham MC, Perander J, Friedman E. Topical lidocaine patch relieves postherpetic neuralgia more effectively than a vehicle topical patch: results of an enriched enrollment study. Pain80, 533–538 (1999).
  • Watson C, Evans R, Reed K, Goldsmith L, Warsh J. Amitriptylin versus placebo in postherpetic neuralgia. Neurology32(6), 671–673 (1982).
  • Max MB, Schafer SC, Culnane M, Smoller B, Dubner R, Gracely RH. Amitriptyline, but not lorazepam, relieves postherpetic neuralgia. Neurology38(9), 1427–1432 (1988).
  • Graff-Radford S, Shaw L, Naliboff N. Amitriptylin and fluphenazim in treatment of postherpetic neuralgia. Clin. J. Pain16(3), 188–192 (2000).
  • Max M, Schafer S, Gaughan A, Smoller B, Gracely R, Dubner R. Desipramine relieves postherpetic neuralgia. Clin. Pharmacol. Ther.47(3), 305–312 (1990).
  • Raja SN, Haythornthwaite JA, Pappagallo M et al. Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology59(7), 1015–1021 (2002).
  • Raja S, Haythornthwaite J, Pappagallo M et al. Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology59(7), 1015–1021 (2002).
  • Watson CP, Babul N. Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia. Neurology50(6), 1837–1841 (1998).
  • Harati Y, Gooch C, Swenson M et al. Double-blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy. Neurology50(6), 1842–1846 (1998).
  • Sindup SH, Andersen G, Madsen C, Smith T, Brosen K, Jensen T. Tramadol relieves pain and allodynia in polyneuropathy, a randomized, double-blind controlled trial. Pain83(1), 85–90 (1999).
  • Szallasi A, Blumberg PM. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol. Rev.51, 159–211 (1999).
  • Jancso N, Jancso A. Desensitization of sensory nerve endings. Kiserl. Orvostud.2(Suppl.), 15 (1949).
  • Derry S, Lloyd R, Moore R, McGuay H. ‘Topical Capsaisin for chronic neuropathic pain in adults’. Cochrane Database Syst. Rev. (4), CD007393 (2009).
  • Zhang WY, Li Wan Po A. The effectiveness of topically applied capsaicin. A meta-analysis. Eur. J. Clin. Pharmacol.46(6), 517–522 (1994).
  • Johnson W. Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. Int. J. Toxicol.26(Suppl. 1), 3–106 (2007).
  • Surh Y-J, Lee SS. Capsaicin in hot chili pepper: carcinogen, co-carcinogen, or anticarcinogen? Food Chem. Toxicol.34, 313–316 (1996).
  • Caterina MJ, Schumacher M, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature389, 816–824 (1997).
  • Spicarova D, Palecek J. The role of spinal cord vanilloid (TRPV1) receptors in pain modulation. Physiol. Res.57(Suppl. 3), S69–S77 (2008).
  • Nolano M, Simone DA, Wendelschafer-Crabb G, Johnson T, Hazen E, Kennedy WR. Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation. Pain81, 135–145 (1999).
  • McMahon SB. The consequence of long-term topical capsaicin application in the rat. Pain44, 301–310 (1991).
  • Kasting GB, Francis WR, Bowman LA, Kinnett GO. Percutaneous asborption of vanilloids: in vivo and in vitro studies. J. Pharm. Sci.86, 142–146 (1997).
  • Fang J-Y, Wu P-C, Huang Y-B, Tsai Y-H. In vivo permeation study of capsaicin and its synthetic derivatives from ointment bases using various skin types. Int. J. Pharm.126, 119–128 (1995).
  • Fang J-Y, Wu P-C, Huang SM, Tsai Y-H. In vivo percutaneous absorption of capsaicin, nonivamide and sodium nonivamide acetate from ointment bases: skin erythema test and non-invasive surface recovery technique in humans. Int. J. Pharm.131, 143–151 (1996).
  • Fang J-Y, Wu P-C, Huang SM, Tsai Y-H. In vivo percutaneous absorption of capsaicin, nonivamide and sodium nonivamide acetate ointment bases: pharmacokinetics analysis in rabbits. Int. J. Pharm.128, 169–177 (1996).
  • Babbar S, Marier JF, Mouksassi MS et al. Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain. Ther. Drug Monit.31(4), 502–510 (2009).
  • Malmberg AB, Mizisin AP, Calcutt NA, von Stein T, Robbins WR, Bley KR. Reduced heat sensitivity and epidermal nerve fiber immunostaining following single applications of a high-concentration capsaicin patch. Pain111(3), 360–367 (2004).
  • Kennedy WR, Vanhove GF, Lu SP et al. A randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteers. J. Pain11(6), 579–587 (2010).
  • Backonja MM, Malan TP, Vanhove GF, Tobias JK. NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomized, double-blind, controlled study with an open-label extension. Pain Med.11(4), 600–608 (2010).
  • Webster LR, Malan TP, Tuchman MM, Mollen MD, Tobias J, Vanhove GF. A multicenter, randomized, double-blind, conrolled dose finding study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia. J. Pain11(10), 972–982 (2010).
  • Webster LR, Tark M, Rauck R, Tobias JK, Vanhove GF. Effect of duration of postherpetic neuralgia on efficacy analyses in a multicenter, randomized, controlled study of NGX-4010, an 8% capsaicin patch evaluated for the treatment of postherpetic neuralgia. BMC Neurol.10, 92 (2010).
  • Backonja M, Wallace MS, Blonsky ER et al. NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. Lancet Neurol.7(12), 1106–1112 (2008).
  • Backonja M, Dunteman E, Irving G et al. One 60-minute application of a high-concentration capsaicin patch (NGX-4010) significantly reduced pain for up to 3 months in patients with postherpetic neuralgia: results from a randomized, double-blind, controlled Phase 3 study. Neurology70(Suppl. 1), A162–A163 (2008).
  • Yosipovitch G, Maibach H, Rowbotham MC. Effect of EMLA pre-treatment on capsaicin-induced burning and hyperalgesia. Acta Derm. Venereol.79, 118–121 (1999).
  • Ngom PI, Dubray C, Woda A, Dallel R. A human oral capsaicin pain model to assess topical anesthetic-analgesic drugs. Neurosci. Lett.316(3), 149–152 (2001).
  • Wallace M, Lam V, Schulteis G. Effect of lidocaine patch on thermal thresholds and experiments pain. J. Pain8(Suppl. 1), 790 (2007).
  • Wallace MS, Abrams DI, Yaksh TL. Concentration-effect relations for intravenous lidocaine infusions in human volunteers: effect on acute sensory thresholds and capsaicin-evoked hyperpathia. Anesthesiology86, 1262–1272 (1997).
  • Petersen KL, Maloney A, Hoke F, Dahl JB, Rowbotham MC. A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization. J. Pain4(7), 400–406 (2003).
  • Dirks J, Fabricius P, Petersen KL, Rowbotham MC, Dahl JB. The effect of systemic lidocaine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers. Anesth. Analg.9, 967–972 (2000).
  • Wallace M, Quessy S, Schulteis G. Lack of effect of two oral sodium channel antagonists, lamotrigine and 4030W92, on intradermal capsaicin-induced hyperalgesia model. Pharmacol. Biochem. Behav.78, 349–355 (2004).
  • LaMotte RH, Lundberg LE, Torebjork E. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. J. Physiol.448, 749–764 (1992).
  • Wallace MS, Ridgeway B, Leung A, Schulteis G, Yaksh TL. Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects upon acute thresholds and capsaicin-evoked hyperpathia. J. Clin. Pharmacol.42, 70–80 (2002).
  • Sethna NF, Liu M, Gracely R, Bennett GJ, Max MB. Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects. Anesth. Analg.86(6), 1250–1256 (1998).
  • Petersen KL, Jones B, Segredo V, Dahl JB, Rowbotham MC. Effect of remifentanil on pain and secondary hyperalgesia associated with the heat – capsaicin sensitization model in healthy volunteers. Anesthesiology94(1), 15–20 (2001).
  • Qutenza® capsaicin 8% patch. Package insert. NeurogesX, Inc., CA, USA.
  • Simpson DA, Gazda S, Brown S et al. Long-term safety of NGX-4010, a high-concentration patch in patients with peripheral neuropathic pain. J. Pain Sympt. Manage.39(6), 1053–1064 (2010).
  • Galler J, Pozo MA, Rebollo I, Belmonte C. Effects of capsaicin on corneal wound-healing. Clin. Invest. Ophthalmol. Vis. Sci.31(10), 1968–1974 (1990).
  • Ko F, Diaz M, Smith P et al. Toxic effects of capsaicin on keratinocytes and fibroblasts. J. Burn Care Rehabil.19(5), 409–413 (1998).
  • Watcher MA, Wheeland RG. The role of topical agents in the healing of full-thickness wounds. J. Dermatol. Surg. Oncol.15(11), 1188–1195 (1989).
  • Webster LR, Peppin JF, Murphy FT, Tobias JK, Vanhove GF. Tolerability of NGX-4010 in conjunction with three topical anesthetic formulations for the treatment of neuropathic pain. Presented at: The American Academy of Pain Medicine 2010 Annual Meeting, San Antonio, TX, USA, February 3–6 (2010).
  • Webster LR, Tran J, Wilson P et al. Tolerability of treatment with NGX-4010 in conjunction with pre-patch topical application of a lidocaine 2.5%/prilocaine 2.5% anesthetic cream. Presented at: The American Academy of Pain Medicine 2010 Annual Meeting, San Antonio, TX, USA, February 3–6 (2010).

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