Psychopharmacology of pediatric bipolar disorder

References

• Birmaher B, Axelson D, Goldstein B. Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: The course and outcome of bipolar youth (COBY) study. Am. J. Psychiatry166(7), 795–802 (2009).
   PubMed Web of Science ®Google Scholar
• Carter TD, Mundo E, Parikh SV, Kennedy JL. Early age at onset as a risk factor for poor outcome of bipolar disorder. J. Psychiatr. Res.37, 291–303 (2003).
   Google Scholar
• DelBello MP, Adler CM, Whitsel RM, Stanford KE, Strakowski SM. A 12-week single-blind trial of quetiapine for the treatment of mood symptoms in adolescents at high risk for developing bipolar I disorder. J. Clin. Psychiatry68, 789–795 (2007).
   PubMed Web of Science ®Google Scholar
• Geller B, Tillman R, Craney J, Bolhofner K. Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Arch. Gen. Psychiatry61(5), 459–467 (2004).
   PubMed Web of Science ®Google Scholar
• Lofthouse N, Fridstad M. Psychosocial interventions for children with early-onset bipolar spectrum disorder. Clin. Child Fam. Psychol. Rev.21, 71–89 (2004).
   Google Scholar
• Wozniak J, Beiderman, J, Kiely K et al. Manic-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. J. Am. Acad. Child Adolesc. Psychiatry34, 867–876 (1995).
   PubMed Web of Science ®Google Scholar
• Perlis R, Miyahara S, Marangell LB et al. Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol. Psychiatry55, 875–881 (2004).
   PubMed Web of Science ®Google Scholar
• Kogan J, Otto M, Bauer M et al. Demographic and diagnostic characteristics of the first 1000 patients enrolled in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Bipolar Disord.6(6), 460–469 (2004).
   PubMed Web of Science ®Google Scholar
• Youngstrom EA, Birhamer B, Findling RL. Pediatric bipolar disorder: validity, phenomenology, and recommendations for diagnosis. Bipolar Disord.10, 194–214 (2008).
   PubMed Web of Science ®Google Scholar
• Baroni A, Lunsford J, Luckenbaugh D. Towbin K, Leibenluft E. Practitioner review: the assessment of bipolar disorder in children and adolescents. J. Child Psychol. Psychiatry50, 203–215 (2008).
   Web of Science ®Google Scholar
• Bhangoo RK, Lowe CH, Myers FS et al. Medication use in children and adolescents treated in the community for bipolar disorder. J. Child Adolesc. Psychopharmacol.13, 515–522 (2003).
   PubMed Web of Science ®Google Scholar
• Hellander M. Lithium Testing In Children: A Public Health Necessity. Testimony to the US FDA, DC, USA (2002).
   Google Scholar
• Youngstrom E, Duax J. Evidence-based assessment of pediatric bipolar disorder, part I: base rate and family history. J. Am. Acad. Child Adolesc. Psychiatry44(7), 712–717 (2005).
   PubMed Web of Science ®Google Scholar
• Geller B, Luby J. Child and adolescent bipolar disorder: a review of the past 10 years. J. Am. Acad. Child Adolesc. Psychiatry36, 1168–1176 (1997).
   PubMed Web of Science ®Google Scholar
• Findling RL, Gracious BL, McNamara NK et al. Rapid, continuous cycling and psychiatric comorbidity in pediatric bipolar I disorder. Bipolar Disord.3, 202–210 (2001).
   PubMed Web of Science ®Google Scholar
• Biederman J, Mick E, Spencer TJ, Wilens TE, Faraone SV. Therapeutic dilemmas in the pharmacotherapy of bipolar depression in the young. J. Child Adolesc. Psychopharmacol.10, 185–192 (2000).
   PubMed Web of Science ®Google Scholar
• Moreno C, Laje G, Blanco C, Jiang H, Schmidt A, Olfson M. National trends in the outpatient diagnosis and treatment of bipolar disorder in youth. Arch. Gen. Psychiatry64, 1032–1039 (2007).
   PubMed Web of Science ®Google Scholar
• Coletti D. Leigh E, Gallelli K, Kafantaris V. Patterns of adherence to treatments in adolescents with bipolar disorder. J. Child Adolesc. Psychopharmacol.15(6), 913–917 (2005).
   PubMed Web of Science ®Google Scholar
• Lewinsohn P, Klein D, Seeley J. Bipolar disorders in a community sample of older adolescents: prevalence, phenomenology, comorbidity, and course. J. Am. Acad. Child Adolesc. Psychiatry34(4), 454–463 (1995).
   PubMed Web of Science ®Google Scholar
• Orvashel H, Puig-Antich J, Chambers WJ, Tabrizi MA, Johnson R. Retrospective assessment of prepubertal major depression the Kiddie-SADS-E. J. Am. Acad. Child Psychiatry21, 392–397 (1982).
   PubMedGoogle Scholar
• Youngstrom E, Findling R, Calabrese J et al. Comparing the diagnostic accuracy of six potential screening instruments for bipolar disorder in youth ages 5 to 17 years. J. Am. Acad. Child Adolesc. Psychiatry43(7), 847–858 (2004).
   PubMed Web of Science ®Google Scholar
• Youngstrom E, Duax J. Evidence-based assessment of pediatric bipolar disorder, part I: base rate and family history. J. Am. Acad. Child Adolesc. Psychiatry44(7), 712–717 (2005).
   PubMed Web of Science ®Google Scholar
• Lish JD, Dime-Meenan S, Whybrow PC, Price RA, Hirshfeld RM. The National Depressive and Manic-depressive Association (DMDA) survey of bipolar member. J. Affect. Disord.31, 281–294 (1994).
   PubMed Web of Science ®Google Scholar
• Soutullo CA, Chang, KD, Diez-Suarez A, Figueroa-Quintana A, Escamilla-Canales I. Bipolar disorder in children and adolescents: international perspective on epidemiology and phenomenology. Bipolar Disord.7, 497–506 (2005).
   PubMed Web of Science ®Google Scholar
• Bschor T, Lweitza U, Sasse J, Adli M, Koberle U, Bauer M. Lithium augmentation in treatment resistant depression. Clinical evidence, serotonergic and endocrine mechanisms. Pharmacopsychiatry36(3), S230–S234 (2003).
   Google Scholar
• Manji H, Lenox K. Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness. Biol. Psychiatry46(10), 1328–1351 (1999).
   PubMed Web of Science ®Google Scholar
• Geller B, Cooper T, Sun K et al. Double blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependence. J. Am. Acad. Child Adolesc. Psychiatry37, 171–178 (1998).
   PubMed Web of Science ®Google Scholar
• Kafantaris V, Coletti D, Dicker R, Padula G, Kane J. Lithium treatment of acute mania in adolescents: a large open trial. J. Am. Acad. Child Adolesc. Psychiatry42, 1038–1045 (2003).
   PubMed Web of Science ®Google Scholar
• Guy W (Ed.). ECDEU Assessment for Psychopharmacology. Revised Edition. NIMH Publication, MD, USA (1976).
   Google Scholar
• Young RC, Boggs KT, Ziegler VE, Meyers DA. A rating scale for mania: reliability, validity and sensitivity. Br. J. Psychiatry133429–435 (1978).
   PubMed Web of Science ®Google Scholar
• Kafantaris V, Coletti D, Dicker R et al. Lithium treatment of acute mania in adolescents: a placebo-controlled discontinuation study. J. Am. Acad. Child Adolesc. Psychiatry43(8), 984–993 (2004).
   PubMed Web of Science ®Google Scholar
• Strober M, DeAntonio M, Schmidy-Lackner S, Freeman R, Lampert C, Diamond J. Early childhood attention deficit hyperactivity disorder predicts poorer response to acute lithium therapy in adolescent mania. J. Affect. Disord.51, 148–151 (1998).
   Google Scholar
• Patel N, Delbello M, Bryan H et al. Open-label lithium for the treatment of adolescents with bipolar depression. J. Am. Acad. Child Adolesc. Psychiatry45(3), 289–297 (2006).
   PubMed Web of Science ®Google Scholar
• Pozanaski E, Freeman IN, Mokros H. The Children’s Depression Rating Scale Revised. Pscyhopharm. Bull.21, 979–989 (1985).
   Google Scholar
• Leibenluft E, Charney DS, Towbin KE, Bhangoo RK, Pine DS. Defining clinical phenotypes of juvenile mania. Am. J, Psychiatry160, 430–437 (2003).
   PubMed Web of Science ®Google Scholar
• Dickstein DP, Towbin KE, Van Der Veen JW et al. Randomized double-blind placebo-controlled trial of lithium in youths with severe mood dysregulation. J. Child Adolesc Psychopharmacol.19, 61–73 (2009).
   PubMed Web of Science ®Google Scholar
• Scahill L, Farkas L, Hamrin V. Lithium in children and adolescents. J. Child Adolesc. Psych. Nurs.14(2), 89–93 (2001).
   PubMedGoogle Scholar
• Stahl S. Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. 3rd Edition. Cambridge University Press, Cambridge, UK, 672 (2008).
   Google Scholar
• Wagner KD, Redden L, Kowatch RA et al. A double-blind, randomized, placebo-controlled trial of divalproex extended-release in the treatment of bipolar disorder in children and adolescents. J. Am. Acad. Child Adolesc. Psychiatry48(5), 519–532 (2009).
   PubMed Web of Science ®Google Scholar
• Wagner K, Kowatch R, Emslie G et al. A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents. Am. J. Psychiatry163, 1179–1186 (2006).
   PubMed Web of Science ®Google Scholar
• Delbello M, Findling R, Kushner S et al. A pilot controlled trial of topiramate for mania in children and adolescents with bipolar disorder. J. Am. Acad. Child Adolesc. Psychiatry44(6), 539–547 (2005).
   PubMed Web of Science ®Google Scholar
• Joshi G, Wozniak J, Mick E et al. A prospective open-label trial of extended release carbamazepine monotherapy in children with bipolar disorder. J. Child Adolesc. Psychopharmacol.20(1), 7–14. (2010).
   PubMed Web of Science ®Google Scholar
• Papatheodorou G, Kutcher SP, Katic M, Szalai JP. The efficacy and safety of divalproex sodium in the treatment of acute mania in adolescents and young adults; an open clinical trial. J. Clin. Pscyhopharmacol.15(2), 110–116 (1995).
   PubMed Web of Science ®Google Scholar
• Wagner K, Weller E, Carlson G et al. An open-label trial of divalproex in children and adolescents with bipolar disorder. J. Am. Acad. Child Adolesc. Psychiatry41, 1224–1230 (2002).
   PubMed Web of Science ®Google Scholar
• Findling RL, Frazier TW, Youngstrom EA et al. Double-blind, placebo-controlled trial of divalproex monotherapy in the treatment of symptomatic youth at high risk for developing bipolar disorder. J. Clin. Psychiatry68, 781–788 (2007).
   PubMed Web of Science ®Google Scholar
• Chang K, Dienes K, Blasey C, Adleman N, Ketter T, Steiner H. Divalproex monotherapy in the treatment of bipolar offspring with mood and behavioral disorders and at least mild affective symptoms. J. Clin. Psychiatry64(8), 936–942 (2003).
   PubMed Web of Science ®Google Scholar
• Redden L, DelBello M, Wagner K et al. Long-term safety of divalproex extended release in children and adolescents with bipolar I disorder. J. Child Adolesc. Psychopharmacol.19(1), 83–89 (2009).
   PubMed Web of Science ®Google Scholar
• Davanzo P, Gunderson B, Belin T et al. Mood stabilizers in hospitalized children with bipolar disorder: a retrospective review. Psychiatry Clin. Neurosci.57(5), 504–513 (2003).
   PubMed Web of Science ®Google Scholar
• Kowatch R, Suppes T, Carmody T et al. Effect size of lithium, divalproex sodium, and carbamazepine in children and adolescents with bipolar disorder. J. Am. Acad. Child Adolesc. Psychiatry39, 713–720 (2000).
   PubMed Web of Science ®Google Scholar
• Pavuluri MN, Henry, DB, Carbray JA, Naylor MW, Janicak PG. Divalproex sodium for pediatric mixed mania: a 6-month prospective trial. Bipolar Disord.7, 266–273 (2005).
   PubMed Web of Science ®Google Scholar
• Findling R, McNamara N, Gracious E et al. Combination lithium and divalproex sodium in pediatric bipolarity. J. Am. Acad. Child Adolesc. Psychiatry42, 895–901 (2005).
   Web of Science ®Google Scholar
• Goldsmith DR, Wagstaff AH, Ibbotson T, Perry CM. Lamotrigine: a review of its use in bipolar disorder. Drugs63, 2029–2050 (2003).
   PubMed Web of Science ®Google Scholar
• Pavuluri MN, Henry DB, Moss M, Mohammed T, Carbray JA, Sweeney JA. Effectiveness of lamotrigine in maintaining symptom control in pediatric bipolar disorder. J. Child Adolesc. Psychopharmacol.19(1), 75–82 (2009).
   PubMed Web of Science ®Google Scholar
• Chang K, Saxena K, Howe M. An open label study of lamotrigine adjunct or monotherapy for the treatment of adolescents with bipolar depression. J. Am. Acad. Child Adolesc. Psychiatry45, 298–304 (2006).
   PubMed Web of Science ®Google Scholar
• Biederman J, Joshi G, Mick E et al. A prospective open label trial of lamotrigine monotherapy in children and adolescents with bipolar disorder. CNS Neurosci. Ther.16, 91–102 (2010).
   PubMed Web of Science ®Google Scholar
• Joffe H, Cohen L, Suppes T et al. Valproate is associated with new onset oligoamenorrhea, with hyperandogenism in women with bipolar disorder. Biol. Psychiatry59(11), 1078–1084 (2006).
   PubMed Web of Science ®Google Scholar
• Kuehn B. FDA panel OKs 3 antipsychotic drugs for the pediatric use, cautions against overuse. JAMA302(8), 833–834 (2009).
   PubMed Web of Science ®Google Scholar
• Tohen M, Kryzhanovskaya L, Carlson G et al. Olanzapine versus placebo in the treatment of adolescents with bipolar mania. Am. J. Psychiatry164(10), 1547–1556 (2007).
   PubMed Web of Science ®Google Scholar
• Haas M, DelBello MP, Pandina G et al. Risperidone for the treatment of acute mania in children and adolescents with bipolar disorder: a randomized, double-blind, placebo-controlled study. Bipolar Disord.11, 687–700 (2009).
   PubMed Web of Science ®Google Scholar
• Findling RL, Nyilas M, Forbes RA et al. Acute treatment of pediatric bipolar I disorder, manic or mixed episode, with aripiprazole: a randomized, double-blind, placebo-controlled study. J. Clin. Psychiatry70(10), 1441–1451 (2009).
   PubMed Web of Science ®Google Scholar
• Tramontina S, Zeni C, Ketzer CR, Pheula GF, Narvaez J, Rohde LA. Aripiprazole in children and adolescents with bipolar disorder comorbid with attention-deficit/hyperactivity disorder: a pilot randomized clinical trial. J. Clin. Psychiatry70(5), 756–764 (2009).
   PubMed Web of Science ®Google Scholar
• DelBello MP, Chang K, Welge JA et al. A double-blind, placebo-controlled pilot study of quetiapine for depressed adolescents with bipolar disorder. Bipolar Disord.11, 483–493 (2009).
   PubMed Web of Science ®Google Scholar
• DelBello MP, Cecil KM, Adler CM, Daniels JP, Strakowski SM. Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study. Neuropsychopharmacology31, 1264–1273 (2006).
   PubMed Web of Science ®Google Scholar
• Wozniak J, Mick E, Waxmonsky J, Kotarski M, Hantsoo L, Biederman J. Comparison of open-label, 8-week trials of olanzapine monotherapy and topiramate augmentation of olanzapine for the treatment of pediatric bipolar disorder. J. Child Adolesc. Psychopharmacol.19(5), 539–545 (2009).
   PubMed Web of Science ®Google Scholar
• Frazier JA, Biederman J, Tohen M et al. A prospective open-label treatment trial of olanzapine monotherapy in children and adolescents with bipolar disorder. J. Child Adolesc. Psychopharmacol.11(3), 239–250 (2001).
   PubMed Web of Science ®Google Scholar
• Biederman J, Mick, E, Wozniak J, Aleardi M, Spencer T, Faraone SV. An open-label trial of risperidone in children and adolescents with bipolar disorder. J. Child Adolesc. Psychopharmacol.15(2), 311–317 (2005).
   PubMed Web of Science ®Google Scholar
• Biederman J, Hammerness P, Doyle R, Joshi G, Aleardi M, Mick E. Risperidone treatment for ADHD in children and adolescents with bipolar disorder. Neuropsychiatr. Dis. Treat.4(1), 203–207 (2008).
   PubMedGoogle Scholar
• Frazier JA, Meyer MC, Biederman J et al. Risperidone treatment for juvenile bipolar disorder: a retrospective chart review. J. Am. Acad. Child Adolesc. Psychiatry38(8), 960–965 (1999).
   PubMed Web of Science ®Google Scholar
• Durkin JP. Aripiprazole in the treatment of bipolar disorder in children and adolescents. J. Child Adolesc. Psychopharmacol.14(4), 505–506 (2004).
   PubMed Web of Science ®Google Scholar
• Barzman DH, DelBello MP, Kowatch RA et al. The effectiveness and tolerability of aripiprazole for pediatric bipolar disorders: a retrospective chart review. J. Child Adolesc. Psychopharmacol.14(4), 593–600 (2004).
   PubMed Web of Science ®Google Scholar
• Findling RL, Kauffman RE, Sallee FR et al. Tolerability and pharmacokinetics of aripiprazole in children and adolescents with psychiatric disorders: an open-label, dose-escalation study. J. Clin. Psychopharmacol.28, 441–446 (2008).
   PubMed Web of Science ®Google Scholar
• Biederman J, McDonnell MA, Wozniak J et al. Aripiprazole in the treatment of pediatric bipolar disorder: a systematic chart review. CNS Spectrum10(2), 141–148 (2005).
   PubMed Web of Science ®Google Scholar
• Tramontina S, Zeni C, Pheula GF, de Souza CK, Rohde LA. Aripiprazole in juvenile bipolar disorder comorbid with attention-deficit/hyperactivity disorder: an open clinical trial. CNS Spectrum12(10), 758–762 (2007).
   PubMed Web of Science ®Google Scholar
• Marchand WR, Wirth L, Simon C. Quetiapine adjunctive and monotherapy for pediatric bipolar disorder: A retrospective chart review. J. Child Adolesc. Psychopharmacology14(3), 405–411 (2004).
   PubMed Web of Science ®Google Scholar
• Duffy A, Milin R, Grof P. Maintenance treatment of adolescent bipolar disorder: open study of the effectiveness and tolerability of quetiapine. BMC Psychiatry9, 4 (2009).
   PubMed Web of Science ®Google Scholar
• Biederman J, Mick E, Spencer T, Dougherty M, Aleardi M, Wozniak J. A prospective open-label treatment trial of ziprasidone montherapy in children and adolescents with bipolar disorder. Bipolar Disord.9, 888–894 (2007).
   PubMed Web of Science ®Google Scholar
• Kowatch RA, Suppes T, Gilfillan SK, Fuentes RM, Grannemann BD, Emslie GJ. Clozapine treatment of children and adolescents with bipolar disorder and schizophrenia: a clinical case series. J. Child Adolesc. Psychopharmacol.5(4), 241–253 (1995).
   Web of Science ®Google Scholar
• Masi G, Mucci M, Millepiedi S. Clozapine in adolescent inpatients with acute mania. J. Child Adolesc. Psychopharmacol.12(2), 93–99 (2002).
   PubMed Web of Science ®Google Scholar
• Rugino TA, Janvier YM. Aripiprazole in children and adolescents: clinical experience. J. Child Neurology20(7), 603–610 (2005).
   PubMed Web of Science ®Google Scholar
• Gibson AP, Crison ML, Mican LM, Fischer C. Effectiveness and tolerability of aripiprazole in child and adolescent inpatients: a retrospective evaluation. Int. Clin. Psychopharmacol.22(2), 101–105 (2007).
   PubMed Web of Science ®Google Scholar
• DelBello MP, Versavel M, Ice K, Keller D, Miceli J. Tolerability of oral ziprasidone in children and adolescents with bipolar mania, schizophrenia, or schizoaffective disorder. J. Child Adolesc. Psychopharmacol.18(5), 491–499 (2008).
   PubMed Web of Science ®Google Scholar
• Versavel M, DelBello MP, Ice K, Kowatch R, Keller D, Miceli J. Ziprasidone dosing study in pediatric patients with bipolar disorder, schizophrenia or schizoaffective disorder. Neuropsychopharmacology30, S122–S123 (2005).
   Google Scholar
• Correll CU. Weight gain and metabolic effects of mood stabilizers and antipsychotics in pediatric bipolar disorder: a systematic review and pooled analysis of short-term trials. J. Am. Acad. Child Adolesc. Psychiatry46(6), 687–700 (2007).
   PubMed Web of Science ®Google Scholar
• Blair J, Scahill L, State M, Martin A. Electrocardiographic changes in children and adolescents treated with ziprazidone: a prospective study. J. Am. Acad. Child Adolesc. Psychiatry44, 73–79 (2005).
   PubMed Web of Science ®Google Scholar
• Klein DJ, Cottingham EM, Sorter M et al. A randomized double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents. Am. J. Psychiatry163(12), 2072–2079 (2006).
   PubMed Web of Science ®Google Scholar
• DelBello MP, Lowatch RA, Adler CM et al. A double-blind randomized pilot study comparing quetiapine and divalproex for adolescent mania. J. Am. Acad. Child Adolesc. Psychiatry45, 305–313 (2006).
   PubMed Web of Science ®Google Scholar
• Macmillan CM, Whitney JE, Korndorfer SR, Tilley CA, Mrakotsky C, Gonzalez-Heydrich JM. Comparative clinical responses to risperidone and divalproex in patients with pediatric bipolar disorder. J. Psychiatr. Pract.14(3), 160–169 (2008).
   PubMed Web of Science ®Google Scholar
• MacMillan CM, Korndorfer SR, Rao S, Fleisher CA, Mezzacappa E, Gonzalez HJ. A comparison of divalproex and oxcarbazepine in aggressive youth with bipolar disorder. J. Psychiatr. Pract.12(4), 214–222 (2006).
   PubMedGoogle Scholar
• Biederman J, Mick E, Hammerness P et al. Open-label 8-week trial of olanzapine and risperidone for the treatment of bipolar disorder for preschool-age children. Biol. Psychiatry58(7), 589–594 (2005).
   PubMed Web of Science ®Google Scholar
• Findling R, McNamara N, Gracious B et al. Combination lithium and divalproex sodium in pediatric bipolarity. J. Am. Acad. Child Adolesc. Psychiatry42(8), (2003).
   Google Scholar
• Findling R, McManera N, Stansbrey R et al. Combination lithium and divalproex sodium in pediatric bipolar symptom restabilization. J. Am. Acad. Child Adolesc. Psychiatry45(2), 142–148 (2006).
   PubMed Web of Science ®Google Scholar
• Delbello M, Schwiers M, Rosenberg H, Strakowski S. A double-blind, randomized, placebo-controlled study of quetapine, as adjunctive treatment for adolescent mania. J. Am. Acad. Child Adolesc. Psychiatry41, 1216–1223 (2002).
   PubMed Web of Science ®Google Scholar
• Pavuluri MN, Henry DB, Carbray JA, Sampson GA, Naylor MW, Janicak PG. A one-year open-label trial of risperidone augmentation in lithium nonresponder youth with preschool-onset bipolar disorder. J. Child Adolesc. Psychopharmacol.16, 336–350 (2006).
   PubMed Web of Science ®Google Scholar
• Pavuluri M, Henry D, Carbray J, Sampson G, Naylor M, Nanicak P. Open label prospective trial of ripseridone in combination with lithium or divalporex sodium in pediatric mania. J. Affect. Disord.82S, S103–S111 (2004).
   Google Scholar
• Chang K, Nayar D, Howe M, Rana M. Atomoxetine as an adjunct therapy in the treatment of co-morbid attention-deficit/hyperactivity disorder in children and adolescents with bipolar I or II disorder. J. Child Adolesc. Psychopharmacol.19, 547–555 (2009).
   PubMed Web of Science ®Google Scholar
• Scheffer R, Kowatch R, Carmody T, Rush A. Randomized, placebo controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium. Am. J. Psychiatry162, 58–64 (2005).
   PubMed Web of Science ®Google Scholar
• Baumer F, Howe M, Gallelli, Iorgova-Simeonava D, Hallmayer J, Chang K. A pilot study of antidepressant-induced mania in pediatric bipolar disorder: Characteristics, risk factors and the serotonin transporter gene. Biol. Psychiatry60(9), 1005–1012 (2006).
   PubMed Web of Science ®Google Scholar
• Cicero D, El-Mallakh, R, Holman, J Robertson J. Antidepressant exposure in bipolar children. Psychiatry66(4), 317–322 (2003).
   PubMed Web of Science ®Google Scholar
• Hamrin V, Scahill L. Selective serotonin reuptake inhibitors for children and adolescents with major depression: current controversies and recommendations. Issues Ment. Health Nurs.26(4) 433–450 (2005).
   PubMedGoogle Scholar
• Reinblatt S, DosReis S, Walkup J, Riddle M. Activation adverse events inducted by the selective serotonin reuptake inhibitor fluvoxamine in children and adolescents. J. Child Adolesc. Psychopharmacol.19(2), 119–126 (2009).
   PubMed Web of Science ®Google Scholar
• Findling R, McNamera N, Youngstrom E et al. A double blind 18 month trial of lithium versus divalproex maintenance treatment in children and adolescents with bipolar disorder. J. Am. Acad. Child Adolesc. Psychiatry44(5), 409–417 (2005).
   PubMed Web of Science ®Google Scholar
• Findling R, Frazier J, Kafantaris V et al. The collaborative lithium trials (CoLT): specific aims, methods, and implementation. Child Adolesc. Psychiatry Ment. Health2(1), 21 (2008).
   PubMedGoogle Scholar