Sexual and reproductive dysfunction associated with antiepileptic drug use in men with epilepsy

References

• Baker GA, Brooks J, Buck D, Jacoby A. The stigma of epilepsy: a European perspective. Epilepsia41, 98–104 (2000).
   PubMed Web of Science ®Google Scholar
• Bishop M, Allen CA. The impact of epilepsy on quality of life: a qualitative analysis. Epilepsy Behav.4, 226–233 (2003).
   PubMed Web of Science ®Google Scholar
• Jacoby A, Snape D, Baker GA Determinants of quality of life in people with epilepsy. Neurol. Clin.27, 843–863 (2009).
   PubMed Web of Science ®Google Scholar
• Guekht AB, Mitrokhina TV, Lebedeva AV et al. Factors influencing on quality of life in people with epilepsy. Seizure16, 128–133 (2007).
   PubMed Web of Science ®Google Scholar
• Leidy NK, Elixhauser A, Vickrey B, Means E, Willian MK. Seizure frequency and the health-related quality of life of adults with epilepsy. Neurology53, 162–166 (1999).
   PubMed Web of Science ®Google Scholar
• Leutmezer F, Serles W, Bacher J et al. Genital automatisms in complex partial seizures. Neurology52, 1188–1191 (1999).
   PubMedGoogle Scholar
• Aull-Watschinger S, Pataraia E, Baumgartner C. Sexual auras: predominance of epileptic activity within the mesial temporal lobe. Epilepsy Behav.12, 124–127 (2008).
   PubMed Web of Science ®Google Scholar
• Mascia A, Di Gennaro G, Esposito V et al. Genital and sexual manifestations in drug-resistant partial epilepsy. Seizure14, 133–138 (2005).
   PubMedGoogle Scholar
• Ozkara C, Ozdemir S, Yilmaz A, Uzan M, Yeni N, Ozmen M. Orgasm-induced seizures: a study of six patients. Epilepsia47, 2193–2197 (2006).
   PubMed Web of Science ®Google Scholar
• Toone, B.K. Sexual disorders in epilepsy. In: Recent Advances in Epilepsy Volume 3. Pedley TA, Meldrum BS (Eds). Churchill Livingstone, Edinburgh, UK, 233–259 (1986).
   Google Scholar
• Gastaut H, Collomb H. [Sexual behavior in psychomotor epileptics]. Annales Medico-Psychologiques112, 657–659 (1954).
   PubMedGoogle Scholar
• Murialdo G, Galimberti CA, Fonzi S et al. Sex hormones and pituitary function in male epileptic patients with altered or normal sexuality. Epilepsia36, 360–365 (1995).
   PubMed Web of Science ®Google Scholar
• Taylor DC. Sexual behavior and temporal lobe epilepsy. Arch. Neurol.21, 510–516 (1969).
   PubMed Web of Science ®Google Scholar
• Husain AM, Carwile ST, Miller PP, Radtke RA. SD in male veterans with epilepsy. J. Epilepsy11, 144–147 (1998).
   Google Scholar
• Morrell MJ, Sperling MR, Stecker M, Dichter MA. SD in partial epilepsy: a deficit in physiologic sexual arousal. Neurology44, 243–247 (1994).
   PubMed Web of Science ®Google Scholar
• Smaldone M, Sukkarieh T, Reda A, Khan A. Epilepsy and erectile dysfunction: a review. Seizure13, 453–459 (2004).
   PubMedGoogle Scholar
• Toone BK, Edeh J, Nanjee MN, Wheeler M. Hyposexuality and epilepsy: a community survey of hormonal and behavioural changes in male epileptics. Psychol. Med.19, 937–943 (1989).
   PubMedGoogle Scholar
• Spector IP, Carey MP. Incidence and prevalence of the SDs: a critical review of the empirical literature. Arch. Sex. Behav.19, 389–408 (1990).
   PubMed Web of Science ®Google Scholar
• Nicolosi A, Glasser DB, Moreira ED, Villa M; Erectile Dysfunction Epidemiology Cross National Study Group. Prevalence of erectile dysfunction and associated factors among men without concomitant diseases: a population study. Int. J. Impot. Res.15, 253–257 (2003).
   PubMed Web of Science ®Google Scholar
• Nikoobakht M, Motamedi M, Orandi A, Meysamie A, Emamzadeh A. SD in epileptic men. Urol. J.4, 111–117 (2007).
   PubMedGoogle Scholar
• Jensen P, Jensen SB, Sørensen PS et al. SD in male and female patients with epilepsy: a study of 86 outpatients. Arch. Sex. Behav.19, 1–14 (1990).
   PubMed Web of Science ®Google Scholar
• Duncan S, Blacklaw J, Beastall GH, Brodie MJ. Antiepileptic drug therapy and sexual function in men with epilepsy. Epilepsia40, 197–204 (1999).
   PubMed Web of Science ®Google Scholar
• Herzog AG. Disorders of reproduction in patients with epilepsy: primary neurological mechanisms. Seizure17, 101–110 (2008).
   PubMed Web of Science ®Google Scholar
• Edwards HE, Burnham WM, MacLusky NJ. Partial and generalized seizures affect reproductive physiology differentially in the male rat. Epilepsia40, 1490–1498 (1999).
   PubMed Web of Science ®Google Scholar
• Saunders M, Rawson M. Sexuality in male epileptics. J. Neurol. Sci.10, 577–583 (1970).
   PubMed Web of Science ®Google Scholar
• Shukla GD, Srivastava ON, Katiyar BC. Sexual disturbances in temporal lobe epilepsy: a controlled study. Br. J. Psychiatry134, 288–292 (1979).
   PubMed Web of Science ®Google Scholar
• Kuba R, Pohanka M, Zákopcan J, Novotná I, Rektor I. SDs and blood hormonal profile in men with focal epilepsy. Epilepsia47, 2135–2140 (2006).
   PubMed Web of Science ®Google Scholar
• Fenwick PB, Toone BK, Wheeler MJ, Nanjee MN, Grant R, Brown D. Sexual behaviour in a centre for epilepsy. Acta Neurol. Scand.71, 428–435 (1985).
   PubMedGoogle Scholar
• Hamed S, Mohamed K, El-Taher A, Hamed E, Omar H. The sexual and reproductive health in men with generalized epilepsy: a multidisciplinary evaluation. Int. J. Impot. Res.18, 287–295 (2006).
   PubMed Web of Science ®Google Scholar
• Herzog AG, Drislane FW, Schomer DL et al. Abnormal pulsatile secretion of luteinizing hormone in men with epilepsy: relationship to laterality and nature of paroxysmal discharges. Neurology40, 1557–1561 (1990).
   PubMed Web of Science ®Google Scholar
• Daniele A, Azzoni A, Bizzi A, Rossi A, Gainotti G, Mazza S. Sexual behavior and hemispheric laterality of the focus in patients with temporal lobe epilepsy. Biol. Psychiatry42, 617–624 (1997).
   PubMed Web of Science ®Google Scholar
• Peuskens J, Sienaert P, De Hert M. Sexual dysfunction: the unspoken side effect of antipsychotics. Eur. Psychiatry13(13 Suppl. 1), S23–S30 (1998).
   PubMed Web of Science ®Google Scholar
• Lambert MV, Robertson MM. Depression in epilepsy: etiology, phenomenology, and treatment. Epilepsia40(Suppl. 10), S21–S47 (1999).
   PubMed Web of Science ®Google Scholar
• Suurmeijer TP, Reuvekamp MF, Aldenkamp BP. Social functioning, psychological functioning, and quality of life in epilepsy. Epilepsia42, 1160–1168 (2001).
   PubMed Web of Science ®Google Scholar
• de Boer HM. Epilepsy stigma: moving from a global problem to global solutions. Seizure19, 630–636 (2010).
   PubMed Web of Science ®Google Scholar
• Talbot JA, Sheldrick R, Caswell H, Duncan S. Sexual function in men with epilepsy: how important is testosterone? Neurology70, 1346–1352 (2008).
   PubMed Web of Science ®Google Scholar
• Duncan S, Talbot A, Sheldrick R, Caswell H. Erectile function, sexual desire, and psychological well-being in men with epilepsy. Epilepsy Behav.15, 351–357 (2009).
   PubMedGoogle Scholar
• Lambert MV. Seizures, hormones and sexuality. Seizure10, 319–340 (2001).
   PubMed Web of Science ®Google Scholar
• Wibowo E, Schellhammer P, Wassersug RJ Role of estrogen in normal male function: clinical implications for patients with prostate cancer on androgen deprivation therapy. J. Urol.185, 17–23 (2011).
   PubMed Web of Science ®Google Scholar
• Montouris G, Morris GL 3rd. Reproductive and SD in men with epilepsy. Epilepsy Behav.7(Suppl. 2), S7–S14 (2005).
   Google Scholar
• Bauer J, Blumenthal S, Reuber M, Stoffel-Wagner B. Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy. Neurology62, 243–246 (2004).
   PubMedGoogle Scholar
• Rättyä J, Turkka J, Pakarinen AJ et al. Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy. Neurology56, 31–36 (2001).
   PubMed Web of Science ®Google Scholar
• Kapoor P, Luttrell BM, Williams D. The free androgen index is not valid for adult males. J. Steroid Biochem. Mol. Biol.45, 325–326 (1993).
   PubMed Web of Science ®Google Scholar
• Bancroft J. The endocrinology of sexual arousal. J. Endocrinol.186, 411–427 (2005).
   PubMed Web of Science ®Google Scholar
• Morales A, Buvat J, Gooren LJ et al. Endocrine aspects of SD in men. J. Sex. Med.1, 69–81 (2004).
   PubMed Web of Science ®Google Scholar
• Isidori AM, Giannetta E, Gianfrilli D et al. Effects of testosterone on sexual function in men: results of a meta-analysis. Clin. Endocrinol. (Oxf.)63, 381–394 (2005).
   PubMed Web of Science ®Google Scholar
• Mölleken D, Richter-Appelt H, Stodieck S, Bengner T. Sexual quality of life in epilepsy: correlations with sex hormone blood levels. Epilepsy Behav.14, 226–231 (2009).
   PubMed Web of Science ®Google Scholar
• Gates JR. Epilepsy versus antiepileptic drugs and gonadal function in men. Neurology62, 174–175 (2004).
   PubMedGoogle Scholar
• Hamed SA. Neuroendocrine hormonal conditions in epilepsy: relationship to reproductive and sexual functions. Neurologist14, 157–169 (2008).
   PubMed Web of Science ®Google Scholar
• Herzog AG, Levesque LA, Drislane FW, Ronthal M, Schomer DL. Phenytoin-induced elevation of serum estradiol and reproductive dysfunction in men with epilepsy. Epilepsia32, 550–553 (1991).
   PubMed Web of Science ®Google Scholar
• Isojärvi JI, Löfgren E, Juntunen KS et al. Effect of epilepsy and antiepileptic drugs on male reproductive health. Neurology62, 247–253 (2004).
   PubMed Web of Science ®Google Scholar
• Isojärvi J. Disorders of reproduction in patients with epilepsy: antiepileptic drug related mechanisms. Seizure17, 111–119 (2008).
   PubMed Web of Science ®Google Scholar
• Olafsson E, Hauser WA, Gudmundsson G. Fertility in patients with epilepsy: a population-based study. Neurology51, 71–73 (1998).
   PubMed Web of Science ®Google Scholar
• Artama M, Isojärvi JI, Raitanen J, Auvinen A. Birth rate among patients with epilepsy: a nationwide population-based cohort study in Finland. Am. J. Epidemiol.159, 1057–1063 (2004).
   PubMed Web of Science ®Google Scholar
• Artama M, Isojärvi JI, Auvinen A. Antiepileptic drug use and birth rate in patients with epilepsy – a population-based cohort study in Finland. Hum. Reprod.21, 2290–2295 (2006).
   PubMedGoogle Scholar
• Luef G, Krämer G, Stefan H. Oxcarbazepine treatment in male epilepsy patients improves pre-existing SD. Acta Neurol. Scand.119, 94–99 (2009).
   PubMed Web of Science ®Google Scholar
• Herzog AG, Drislane FW, Schomer DL et al. Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy. Neurology65, 1016–1020 (2005).
   PubMed Web of Science ®Google Scholar
• Luef G, Krämer G, Stefan H. Oxcarbazepine treatment in male epilepsy patients improves pre-existing SD. Acta Neurol. Scand.119, 94–99 (2009).
   PubMed Web of Science ®Google Scholar
• Gil-Nagel A, López-Muñoz F, Serratosa JM, Moncada I, García-García P, Alamo C. Effect of lamotrigine on sexual function in patients with epilepsy. Seizure15, 142–149 (2006).
   PubMed Web of Science ®Google Scholar
• Calabrò RS, Ferlazzo E, Italiano D, Bramanti P. Dose-dependent oxcarbazepine-related anorgasmia. Epilepsy Behav.17, 287–288 (2010).
   PubMed Web of Science ®Google Scholar
• Calabrò RS, Ferlazzo E, Bramanti P. Oxcarbazepine-related male infertility. Epilepsy Behav.19(4), 665 (2010).
   PubMedGoogle Scholar
• Grabowska-Grzyb A, Naganska E, Wolanczyk T. Hypersexuality in two patients with epilepsy treated with lamotrigine. Epilepsy Behav.8, 663–665 (2006).
   PubMed Web of Science ®Google Scholar
• Holtkamp M, Weissinger F, Meierkord H. Erectile dysfunction with topiramate. Epilepsia46, 166–167 (2005).
   PubMed Web of Science ®Google Scholar
• Calabrò RS, Bramanti P, Italiano D, Ferlazzo E. Topiramate-induced erectile dysfunction. Epilepsy Behav.14, 560–561 (2009).
   PubMed Web of Science ®Google Scholar
• Sun C, Lay C, Broner S, Silberstein S, Tepper S, Newman L. Reversible anorgasmia with topiramate therapy for headache: a report of 7 patients. Headache46, 1450–1453 (2006).
   PubMed Web of Science ®Google Scholar
• Maschio M, Saveriano F, Dinapoli L, Jandolo B. Reversible erectile dysfunction in a patient with brain tumor-related epilepsy in therapy with zonisamide in add-on. J. Sex. Med. DOI: 10.1111/j.1743–6109.2009.01373.x (2009) (Epub ahead of print).
   PubMedGoogle Scholar
• Calabrò RS, Italiano D, Bramanti P, Ferlazzo E. Zonisamide-related erectile dysfunction. J. Sex. Med.8(4), 1256–1257 (2010).
   Google Scholar
• Hitiris N, Barrett JA, Brodie MJ. Erectile dysfunction associated with pregabalin add-on treatment in patients with partial seizures: five case reports. Epilepsy Behav.8, 418–421 (2006).
   PubMed Web of Science ®Google Scholar
• Calabrò RS, Bramanti P. Pregabalin-induced severe delayed ejaculation. Epilepsy Behav.19(3), 543 (2010).
   PubMed Web of Science ®Google Scholar
• Brannon GE, Rolland PD. Anorgasmia in a patient with bipolar disorder type 1 treated with gabapentin. J. Clin. Psychopharmacol.20, 379–381 (2000).
   PubMed Web of Science ®Google Scholar
• Labbate LA, Rubey RN. Gabapentin-induced ejaculatory failure and anorgasmia. Am. J. Psychiatry156, 972 (1999).
   PubMed Web of Science ®Google Scholar
• Svalheim S, Taubøll E, Luef G et al. Differential effects of levetiracetam, carbamazepine, and lamotrigine on reproductive endocrine function in adults. Epilepsy Behav.16, 281–287 (2009).
   PubMed Web of Science ®Google Scholar
• Ettinger AB, Kanners AM (Eds). Psychiatric Issues in Epilepsy: a Practical Guide to Diagnosis and Treatment. Lippincott William & Wilkins, PA, USA (2001).
   Google Scholar
• Hellmis E. Sexual problems in males with epilepsy – an interdisciplinary challenge! Seizure17, 136–140 (2008).
   PubMed Web of Science ®Google Scholar
• Stimmel GL, Gutierrez MA. Pharmacologic treatment strategies for SD in patients with epilepsy and depression. CNS Spectr.11(8 Suppl. 9), 31–37 (2006).
   PubMedGoogle Scholar
• Harden CL. Treatment of sexual disorders in people with epilepsy. Epilepsy Behav.3(S5), 38–41 (2002).
   PubMedGoogle Scholar
• Herzog AG, Klein P, Jacobs AR. Testosterone versus testosterone and testolactone in treating reproductive and SD in men with epilepsy and hypogonadism. Neurology50, 782–784 (1998).
   PubMed Web of Science ®Google Scholar
• Harden C, MacLusky NJ. Aromatase inhibitors as add-on treatment for men with epilepsy. Expert Rev. Neurother.5, 123–127 (2005).
   PubMedGoogle Scholar
• Herzog AG, Farina EL, Drislane FW et al. A comparison of anastrozole and testosterone versus placebo and testosterone for treatment of SD in men with epilepsy and hypogonadism. Epilepsy Behav.17, 264–271 (2010).
   PubMedGoogle Scholar
• Gilad R, Lampl Y, Eshel Y, Sadeh M. Tonic–clonic seizures in patients taking sildenafil. BMJ325, 869 (2002).
   PubMed Web of Science ®Google Scholar
• Dorsey P, Keel C, Klavens M, Hellstrom WJ. Phosphodiesterase type 5 (PDE5) inhibitors for the treatment of erectile dysfunction. Expert Opin. Pharmacother.11, 1109–1122 (2010).
   PubMed Web of Science ®Google Scholar
• Calabrò RS, Polimeni G, Bramanti P. Current and future therapies of erectile dysfunction in neurological disorders. Recent Pat. CNS Drug Discov.6, 48–64 (2011).
   PubMedGoogle Scholar
• McMahon CG. Dapoxetine for premature ejaculation. Expert Opin. Pharmacother.11, 1741–1752 (2010).
   PubMed Web of Science ®Google Scholar
• Calabrò RS. Male SD in Neurological Disorders: From Pathophysiology to Rehabilitation. Nova Publisher Inc., NY, USA (2011).
   Google Scholar