Brain functional domains inform therapeutic interventions in attention-deficit/hyperactivity disorder and pediatric bipolar disorder

References

• Insel TR, Cuthbert BN. Endophenotypes: bridging genomic complexity and disorder heterogeneity. Biol. Psychiatry66(11), 988–989 (2009).
   PubMed Web of Science ®Google Scholar
• Galanter CA, Leibenluft E. Frontiers between attention deficit hyperactivity disorder and bipolar disorder. Child Adolesc. Psychiatr. Clin. N. Am.17, 325–346 (2008).
   PubMed Web of Science ®Google Scholar
• Singh MK, Chang KD, Mazaika P et al. Neural correlates of response inhibition in pediatric bipolar disorder. J. Child Adolesc. Psychopharmacol.20(1), 15–24 (2010).
   PubMedGoogle Scholar
• Geller B, Warner K, Williams M, Zimerman B. Prepubertal and young adolescent bipolarity versus ADHD: assessment and validity using the WASH-U-KSADS, CBCL, and TRF. J. Affect. Disord.51(2), 93–100 (1998).
   PubMed Web of Science ®Google Scholar
• Biederman J, Mick E, Faraone SV, Spencer T, Wilens TE, Wozniak J. Pediatric mania: a developmental subtype of bipolar disorder? Biol. Psychiatry48, 458–466 (2000).
   PubMed Web of Science ®Google Scholar
• Dickstein DP, Garvey M, Pradella AG et al. Neurologic examination abnormalities in children with bipolar disorder or attention deficit/hyperactivity disorder. Biol. Psychiatry58, 517–524 (2005).
   PubMed Web of Science ®Google Scholar
• Biederman J, Faraone SV. Attention-deficit hyperactivity disorder. Lancet366, 237–248 (2005).
   PubMed Web of Science ®Google Scholar
• Barkley RA. Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychol. Bull.121(1), 65–94 (1997).
   PubMed Web of Science ®Google Scholar
• Barkley RA. Psychosocial treatments for attention-deficit/hyperactivity disorder in children. J. Clin. Psychiatry63(Suppl. 12), 36–43 (2002).
   PubMed Web of Science ®Google Scholar
• Barkley RA, Fischer M. The unique contribution of emotional impulsiveness to impairment in major life activities in hyperactive children as adults. J. Am. Acad. Child Adolesc. Psychiatry49(5), 503–513 (2010).
   PubMed Web of Science ®Google Scholar
• Sonuga-Barke EJS. The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics. Neurosci. Biobehav. Rev.27, 593–604 (2003).
   PubMed Web of Science ®Google Scholar
• Tripp G, Wickens JR. Research review: dopamine transfer deficit: a neurobiological theory of altered reinforcement mechanisms in ADHD. J. Child Psychol. Psychiatry49(7), 691–704 (2008).
   PubMed Web of Science ®Google Scholar
• Scheres A, Milham MP, Knutson B, Castellanos FX. Ventral striatal hyper- responsiveness during reward anticipation in attention deficit/hyperactivity disorder. Biol. Psychiatry61(5), 720–724 (2007).
   PubMed Web of Science ®Google Scholar
• Rubia K, Taylor E, Smith H, Oksannen H, Overmeyer S, Newman S. Neuropsychological analyses of impulsiveness in childhood hyperactivity. Br. J. Psychiatry179, 138–143 (2001).
   PubMed Web of Science ®Google Scholar
• Bush G, Frazier JA, Rauch SL et al. Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the counting stroop. Biol. Psychiatry45, 1542–1552 (1999).
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders IV-TR. American Psychiatric Association, Washington DC, USA (2000).
   Google Scholar
• Pavuluri MN, Birmaher B, Naylor M. Pediatric bipolar disorder: ten year review. J. Am. Acad. Child Adolesc. Psychiatry44(9), 846–871 (2005).
   PubMed Web of Science ®Google Scholar
• Leibenluft E, Charney DS, Towbin KE, Bhangoo RK, Pine DS. Defining clinical phenotypes of juvenile mania. Am. J. Psychiatry160, 430–437 (2003).
   PubMed Web of Science ®Google Scholar
• Geller B, Zimerman B, Williams M et al. DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J. Child Adolesc. Psychopharmacol.12(1), 11–25 (2002).
   PubMed Web of Science ®Google Scholar
• Rich BA, Schmajuk M, Perez-Edgar KE, Pine DS, Fox NA, Leibenluft E. The impact of reward, punishment, and frustration on attention in pediatric bipolar disorder. Biol. Psychiatry58, 532–539 (2005).
   PubMed Web of Science ®Google Scholar
• Dickstein DP, Nelson EE, McClure EB et al. Cognitive flexibility in phenotypes of pediatric bipolar disorder. J. Am. Acad. Child Adolesc. Psychiatry46(3), 341–355 (2007).
   PubMed Web of Science ®Google Scholar
• Biederman J, Faraone S, Mick E et al. Attention-deficit hyperactivity disorder and juvenile mania: an overlooked comorbidity? J. Am. Acad. Child Adolesc. Psychiatry35(8), 997–1008 (1996).
   PubMed Web of Science ®Google Scholar
• Pavuluri MN, Schenkel LS, Aryal S et al. Neurocognitive function in unmedicated manic and medicated euthymic pediatric bipolar patients. Am. J. Psychiatry163, 286–293 (2006).
   PubMed Web of Science ®Google Scholar
• Pavuluri MN, West A, Hill K, Jindal K, Sweeney JA. Neurocognitive function in pediatric bipolar disorder: three-year follow-up shows cognitive development lagging behind healthy youth. J. Am. Acad. Child Adolesc. Psychiatry48(3), 299–307 (2009).
   PubMed Web of Science ®Google Scholar
• Lewinsohn PM, Shankman SA, Gau JM, Klein DN. The prevalence and co-morbidity of subthreshold psychiatric conditions. Psychol. Med.34(4), 613–622 (2004).
   PubMed Web of Science ®Google Scholar
• DelBello MP, Hanseman D, Adler CM, Fleck DE, Strakowski SM. Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode. Am. J. Psychiatry164(4), 582–590 (2007).
   PubMed Web of Science ®Google Scholar
• Birmaher B. Longitudinal course of pediatric bipolar disorder. Am. J. Psychiatry164(4), 537–539 (2007).
   PubMed Web of Science ®Google Scholar
• Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. Annu. Rev. Neurosci.24, 167–202 (2001).
   PubMed Web of Science ®Google Scholar
• Giedd JN, Blumenthal J, Jeffries NO et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nat. Neurosci.2(10), 861–863 (1999).
   PubMed Web of Science ®Google Scholar
• Casey BJ, Castellanos FX, Giedd JN et al. Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder. J. Am. Acad. Child Adolesc. Psychiatry36, 374–383 (1997).
   PubMed Web of Science ®Google Scholar
• Luna B, Thulborn KR, Munoz DP et al. Maturation of widely distributed brain function subserves cognitive development. NeuroImage13, 786–793 (2001).
   PubMed Web of Science ®Google Scholar
• Luna B, Garver KE, Urban TN, Lazar N, Sweeney JA. Maturation of cognitive processes from late childhood to adulthood. Child Dev.75, 1357–1372 (2004).
   PubMed Web of Science ®Google Scholar
• Posner MI, Rothbart MK. Developing mechanisms of self-regulation. Dev. Psychopathol.12, 427–441 (2000).
   PubMed Web of Science ®Google Scholar
• Blakemore SJ, Choudhury S. Development of the adolescent brain: implications for executive function and social cognition. J. Child Psychol. Psychiatry47, 296–312 (2006).
   PubMed Web of Science ®Google Scholar
• Gorrindo T, Blair RJR, Budhani S, Dickstein DP, Pine DS, Leibenluft E. Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder. Am. J. Psychiatry, 162, 1975–1977 (2005).
   PubMed Web of Science ®Google Scholar
• Rich BA, Holroyd T, Carver FW et al. A preliminary study of the neural mechanisms of frustration in pediatric bipolar disorder using magnetoencephalography. Depress. Anxiety27(3), 276–286 (2010).
   PubMed Web of Science ®Google Scholar
• Pizzagalli DA, Goetz E, Ostacher M, Iosifescu DV, Perlis RH. Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward task. Biol. Psychiatry64(2), 162–168 (2008).
   PubMed Web of Science ®Google Scholar
• Doyle AE, Willcutt EG, Seidman LJ et al. Attention-deficit/hyperactivity disorder endophenotypes. Biol. Psychiatry57, 1324–1335 (2005).
   PubMed Web of Science ®Google Scholar
• Rucklidge JJ. Impact of ADHD on the neurocognitive functioning of adolescents with bipolar disorder. Biol. Psychiatry60, 921–928 (2006).
   PubMed Web of Science ®Google Scholar
• Barkley RA. Deficient emotional self-regulation: a core component of attention deficit/hyperactivity disorder. J. ADHD Rela. Disord.1(2), 5–37, (2009).
   Google Scholar
• Skirrow C, McLoughlin G, Kuntsi J, Asherson P. Behavioral, neurocognitive and treatment overlap between attention-deficit/hyperactivity disorder and mood instability. Expert Rev. Neurother.9(4), 489–503 (2009).
   PubMed Web of Science ®Google Scholar
• Casey BJ. Emotional competence in children with externalizing and internalizing disorders. In: Emotional Development in Atypical Children. Lewis M, Sullivan M (Eds). Erlbaum, NJ, USA, 161–183 (1996).
   Google Scholar
• Braaten EB, Rosen LA. Self-regulation of affect in attention-deficit hyperactivity disorder (ADHD) and non-ADHD boys: differences in empathic responding. J. Consult. Clin. Psychol.68, 313–321 (2000).
   PubMed Web of Science ®Google Scholar
• Friedman SR, Rapport LJ, Lumley M et al. Aspects of social and emotional competence in adult attention-deficit/hyperactivity disorder. Neuropsychology17(1), 50–58 (2003).
   PubMed Web of Science ®Google Scholar
• Brotman MA, Rich BA, Guyer AE et al. Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder. Am. J. Psychiatry167(1), 61–69 (2010).
   PubMed Web of Science ®Google Scholar
• Logan GD, Cowan WB, Davis KA. On the ability of inhibit simple and choice reaction time responses: a model and a method. J. Exp. Psychol. Hum. Percept. Perform.10, 276–291 (1984).
   PubMed Web of Science ®Google Scholar
• Hoeksma JB, Osterlaan J, Schipper E. Emotion regulation and the dynamics of feelings: a conceptual and methodological framework. Child Dev.75(2), 354–360 (2004).
   PubMed Web of Science ®Google Scholar
• Rubia K, Overmeyer S, Taylor E et al. Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI. Am. J. Psychiatry156, 891–896 (1999).
   PubMed Web of Science ®Google Scholar
• Garavan H, Ross TJ, Murphy K, Roche RA, Stein EA. Dissociable executive functions in the dynamic control of behavior: inhibition, error detection, and correction. Neuroimage17, 1820–1829 (2002).
   PubMed Web of Science ®Google Scholar
• Casey BJ, Giedd JN, Thomas KM. Structural and functional brain development and its relation to cognitive development. Biol. Psychol.54(1–3), 241–257 (2000)
   PubMed Web of Science ®Google Scholar
• Durston S, Thomas KM, Worden MS, Yang Y, Casey BJ. The effect of preceding context on inhibition: an event-related fMRI study. Neuroimage2, 449–453 (2002).
   Google Scholar
• Oosterlaan J, Logan GD, Sergeant JA. Response inhibition in AD/HD, CD, comorbid AD/HD + CD, anxious, and control children: a meta-analysis of studies with the stop task. J. Child Psychol. Psychiatry39(3), 411–425 (1998).
   PubMed Web of Science ®Google Scholar
• Nigg JT. Is ADHD a disinhibitory disorder? Psychol. Bull.127, 571–598 (2001).
   PubMed Web of Science ®Google Scholar
• Adams ZW, Derefinko KJ, Milich R, Fillmore MT. Inhibitory functioning across ADHD subtypes: recent findings, clinical implications, and future directions. Dev. Disabil. Res. Rev.14(4), 268–275 (2008).
   PubMed Web of Science ®Google Scholar
• Fillmore MT, Milich R, Lorch EP. Inhibitory deficits in children with attention-deficit/hyperactivity disorder: intentional versus automatic mechanisms of attention. Dev. Psychopathol.21(2), 539–554 (2009).
   PubMed Web of Science ®Google Scholar
• Shaw P, Eckstrand K, Sharp W, Blumenthal J, Lerch JP, Greenstein D et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc. Natl Acad. Sci. USA104, 19649–19654 (2007).
   PubMed Web of Science ®Google Scholar
• Sonuga-Barke EJS, Sergeant JA, Nigg J, Willcutt, S. Executive dysfunction and delay aversion in attention deficit hyperactivity disorder: nosologic and diagnostic implications. Child Adolesc. Psychiatry Clin. N. Am.17, 367–384 (2008).
   PubMed Web of Science ®Google Scholar
• Nigg JT, Casey BJ. An integrative theory of attention-deficit/hyperactivity disorder based on the cognitive and affective neurosciences. Dev. Psychopathol.17(3), 785–806 (2005).
   PubMed Web of Science ®Google Scholar
• Castellanos FX, Sonuga-Barke EJ, Milham MP, Tannock R. Characterizing cognition in ADHD: beyond executive dysfunction. Trends Cogn. Sci.10, 117–123 (2006).
   PubMed Web of Science ®Google Scholar
• Rubia K. ‘Cool’ inferior frontostriatal dysfunction in attention-deficit/hyperactivity disorder versus ‘hot’ ventromedial orbitofrontal-limbic dysfunction in conduct disorder: a review. Biol. Psychiatry (2010) DOI: 10.1016/j.biopsych.2010.09.023 (Epub ahead of print).
   PubMedGoogle Scholar
• Solanto MV. Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research. Behav. Brain Res.130, 65–71 (2002).
   PubMed Web of Science ®Google Scholar
• Diamond A, Prevor MB, Callender G, Druin DP. Prefrontal cortex cognitive deficits in children treated early and continuously for PKU. Monogr. Soc. Res. Child Dev.62(4), i-v, 1–208 (1997).
   PubMedGoogle Scholar
• Sagvolden T, Johansen EB, Aase H, Russell VA. A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes. Behav. Brain Sci.28, 397–419 (2005).
   PubMed Web of Science ®Google Scholar
• Russell VA, Sagvolden T, Johansen EB. Animal models of attention-deficit hyperactivity disorder. Behav. Brain Funct.1, 9 (2005).
   PubMedGoogle Scholar
• Paine TA, Neve RL, Carlezon, A. Attention deficits and hyperactivity following inhibition of cAMP-dependent protein kinase within the medial prefrontal cortex of rats. Neuropsychopharmacology34, 2143–2155 (2009).
   PubMedGoogle Scholar
• Leibenluft E, Rich BA, Vinton DT et al. Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder. Am. J. Psychiatry164, 52–60 (2007).
   PubMed Web of Science ®Google Scholar
• Passarotti AM, Sweeney JA, Pavuluri MN. Neural correlates of response inhibition deficits in pediatric bipolar disorder and attention deficit hyperactivity disorder. Psychiatry Res.181(1), 36–43 (2010).
   PubMed Web of Science ®Google Scholar
• Pavuluri MN, Passarotti AM, Harral EM, Sweeney JA. Enhanced prefrontal function with pharmacotherapy on a response inhibition task in adolescent bipolar disorder. J. Clin. Psychiatry71, 1–9 (2010).
   Google Scholar
• Eagle DM, Robbins, TW. Inhibitory control in rats performing a stop-signal reaction-time task: effects of lesions of the medial striatum and D-amphetamine. Behav. Neurosci.117(6), 1302–1317 (2003).
   PubMedGoogle Scholar
• Aron AR, Poldrack, RA. The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder. Biol. Psychiatry57, 1285–1292 (2005).
   PubMed Web of Science ®Google Scholar
• Verbruggen F, Logan GD. Response inhibition in the stop-signal paradigm. Trends Cogn. Sci.12(11), 418–424 (2008).
   PubMed Web of Science ®Google Scholar
• Tillman CM, Thorell LB, Brocki KC, Bohlin G. Motor response inhibition and execution in the stop signal task: development and relation to ADHD behaviors. Child Neuropsychology14(1), 42–59 (2008).
   PubMed Web of Science ®Google Scholar
• Johnstone SJ, Dimoska A, Smith JL et al. The development of stop-signal and Go/Nogo response inhibition in children aged 7–12 years: performance and event-related potential indices. Int. J.Psychophysiol.63(1), 25–38 (2007).
   PubMed Web of Science ®Google Scholar
• Plitzka SR, Glahn DC, Semrud-Clikeman M et al. Neuroimaging of inhibitory control areas in children with attention deficit hyperactivity disorder who were treatment naïve or in long-term treatment. Am. J. Psychiatry163(6), 1052–1060 (2006).
   PubMedGoogle Scholar
• Durston S, Tottenham NT, Thomas KM et al. Differential patterns of striatal activation in young children with and without ADHD. Biol. Psychiatry53(10), 871–878 (2003).
   PubMed Web of Science ®Google Scholar
• Durston S, Mulder M, Casey BJ, Ziermans T, van Engeland H. Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for attention deficit hyperactivity disorder. Biol. Psychiatry60, 1062–1070 (2006).
   PubMed Web of Science ®Google Scholar
• Tamm L, Menon V, Ringel J, Reiss AL. Event-related fMRI evidence of frontotemporal involvement in aberrant response inhibition and task switching in attention-deficit/hyperactivity disorder. J. Am. Acad. Child Adolesc. Psychiatry43, 1430–1440 (2004).
   PubMed Web of Science ®Google Scholar
• Castellanos FX, Giedd JN, Marsh WL et al. Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. Arch. Gen. Psychiatry53(7), 607–616 (1996).
   PubMed Web of Science ®Google Scholar
• Filipek PA, Semrud-Clikeman M, Steingard RJ, Renshaw PF, Kennedy DN, Biederman, J. Volumetric MRI analysis comparing subjects having attention-deficit hyperactivity disorder with normal controls. Neurology48(3), 589–601 (1997).
   PubMed Web of Science ®Google Scholar
• Castellanos FX, Tannock R. Neuroscience of attention-deficit hyperactivity disorder: the search for endophenotypes. Nat. Neurosci.3, 617–628 (2002).
   Google Scholar
• Pavuluri MN, O’Connor MM, Harral EM, Sweeney JA. An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder. Psychiatry Res.162(3), 244–255 (2008).
   PubMed Web of Science ®Google Scholar
• Blumberg HP, Leung HC, Skudlarski P et al. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Arch. Gen.Psychiatry60, 601–609 (2003).
   PubMed Web of Science ®Google Scholar
• Konishi S, Nakajima K, Uchida I, Kikyo H, Kameyama M, Miyashita Y. Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI. Brain122, 981–991 (1999).
   PubMed Web of Science ®Google Scholar
• Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci.9, 357–338 (1986).
   PubMed Web of Science ®Google Scholar
• D’Esposito M, Postle BR, Rypma B. Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies. Exp. Brain Res.133(1), 3–11 (2000).
   PubMed Web of Science ®Google Scholar
• Pavuluri MN, Yang S, Kamineni K et al. DTI Study of white matter fiber tracts: in pediatric bipolar disorder and attention deficit hyperactivity disorder. Biol. Psychiatry65(7), 586–593 (2009).
   PubMed Web of Science ®Google Scholar
• Passarotti AM, Sweeney JA, Pavuluri MN. Differential engagement of cognitive and affective neural systems in pediatric bipolar disorder and attention deficit hyperactivity disorder. J. Int. Neuropsychol. Soc.16(1), 106–117 (2010).
   PubMed Web of Science ®Google Scholar
• Passarotti AM, Sweeney JA, Pavuluri MN. Emotion processing influences working memory circuits in pediatric bipolar disorder and attention deficit hyperactivity disorder. J. Am. Acad. Child Adolesc. Psychiatry9(10), 1064–1080 (2010).
   Google Scholar
• Petrides M, Pandya DN. Comparative cytoarchitectonic analysis of the human and the macaque ventrolateral prefrontal cortex and corticocortical connection patterns in the monkey. Eur. J. Neurosci.16, 291–310 (2002).
   PubMed Web of Science ®Google Scholar
• Frangou S, Haldane M, Roddy D, Kumari V. Evidence for deficit in tasks of ventral, but not dorsal, prefrontal executive function as an endophenotypic marker for bipolar disorder. Biol. Psychiatry58(10), 838–839 (2005).
   PubMed Web of Science ®Google Scholar
• Bush G. Attention-deficit hyperactivity disorder and attention networks. Neuropsychopharmacology35, 278–300 (2010).
   PubMed Web of Science ®Google Scholar
• Haber SN, Knutson B. The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacol. Rev.1–23 (2009).
   PubMedGoogle Scholar
• Robbins TW, Everitt BJ. Neurobehavioural mechanisms of reward and motivation. Curr. Opin. Neurobiol.6, 228–236 (1996).
   PubMed Web of Science ®Google Scholar
• Rolls ET. The orbitofrontal cortex and reward. Cerebral Cortex10, 284–294 (2000).
   PubMed Web of Science ®Google Scholar
• McClure SM, Laibson DI, Lowenstein G, Cohen JD. Separate neural systems value immediate and delayed monetary rewards. Science306, 503–507 (2004).
   PubMed Web of Science ®Google Scholar
• Balleine BW, Delgado MR, Hikosaka O. The role of the dorsal striatum in reward and decision-making. J. Neurosci.27, 8161–8165 (2007).
   PubMed Web of Science ®Google Scholar
• Fareri D, Martin L, Delgado M. Reward-related processing in the human brain: Developmental considerations. Dev. Psychopathol.20, 1191–1211 (2008).
   PubMed Web of Science ®Google Scholar
• Passarotti AM, Sweeney JA, Pavuluri MN. Neural correlates of incidental and directed facial emotion processing in adolescents and adults. Soc.Cogn. Affect. Neurosci.4, 387–398 (2009).
   PubMedGoogle Scholar
• Geier C, Luna B. The maturation of incentive processing and cognitive control. Pharmacol. Biochem. Behav.93, 212–221 (2009).
   PubMed Web of Science ®Google Scholar
• Ernst M, Nelson, EE, Jazbec, S et al. Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents. Neuroimage25, 1279–1291 (2005).
   PubMed Web of Science ®Google Scholar
• Ernst M, Pine DS, Hardin M. Triadic model of the neurobiology of motivated behavior in adolescence. Psychol. Med.36, 299–312 (2006).
   PubMed Web of Science ®Google Scholar
• May JC, Delgado MR, Dahl RE et al. Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescents. Biol. Psychiatry55, 359–366 (2004).
   PubMedGoogle Scholar
• Bjork JM, Smith AR, Danube CL, Hommer DW. Developmental differences in posterior mesofrontal cortex recruitment by risky rewards. J. Neurosci.27, 4839–4849 (2007).
   PubMedGoogle Scholar
• Eshel N, Nelson EE, Blair RJ, Pine, DS, Ernst M. Neural substrates of choice selection in adults and adolescents: Development of the ventrolateral prefrontal and anterior cingulate cortices. Neuropsychologia45, 1270–1279 (2007).
   PubMed Web of Science ®Google Scholar
• Luman M, Oosterlaan J, Sergeant JA. The impact of reinforcement contingencies on AD/HD: a review and theoretical appraisal. Clin. Psychol. Rev.25(2), 183–213 (2005).
   PubMed Web of Science ®Google Scholar
• Luman M, Tripp G, Scheres A. Identifying the neurobiology of altered reinforcement sensitivity in ADHD: a review and research agenda. Neurosci. Biobehav. Rev.34, 744–754 (2010).
   PubMed Web of Science ®Google Scholar
• Sonuga-Barke EJS, Taylor E, Sembi E, Smith J. Hyperactivity and delay aversion. I. The effect of delay on choice. J. Child Psychol. Psychiatry33387–398 (1992).
   PubMed Web of Science ®Google Scholar
• Drechsler R, Rizzo P, Steinhausen HC. Decision-making on an explicit risk-taking task in preadolescents with attention-deficit/hyperactivity disorder, J. Neural Transm.115, 201–209 (2008).
   PubMed Web of Science ®Google Scholar
• Faregh N, Derevensky J. Gambling behavior among adolescents with attention deficit/hyperactivity disorder. J. Gambl. Stud. DOI: 10.1007/s10899-010-9211-3 (2010) (Epub ahead of print).
   Google Scholar
• Dibbets P, Evers L, Hurks P, Marchetta N, Jolles J. Differences in feedback- and inhibition- related neural activity in adult ADHD. Brain Cogn.70, 73–83 (2009).
   PubMed Web of Science ®Google Scholar
• Pavuluri MN, O’Connor MM, Harral EM, Sweeney JA. Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biol. Psychiatry62, 158–167 (2007).
   PubMed Web of Science ®Google Scholar
• Passarotti AM, Sweeney JA, Pavuluri MN. Fronto-limbic dysfunction in mania pre-treatment and persistent amygdala over-activity post-treatment in pediatric bipolar disorder. Psychopharmacology (Berl.) DOI: 10.1007/s00213-011-2243-2 (2011) (Epub ahead of print).
   PubMedGoogle Scholar
• Dickstein DP, Finger EC, Skup M, Pine DS, Blair JR, Leibenluft E. Altered neural function in pediatric bipolar disorder during reversal learning. Bipolar Disord.12(7), 707–719 (2010).
   PubMedGoogle Scholar
• Abler B, Greenhouse I, Ongur D, Walter H, Heckers S. Abnormal reward system activation in mania. Neuropsychopharmacology33(9), 2217–2227 (2008).
   PubMedGoogle Scholar
• Strakowski SM, DelBello MP, Fleck DE, Arndt S. The impact of substance abuse on the course of bipolar disorder. Biol. Psychiatry48(6), 477–485 (2000).
   PubMed Web of Science ®Google Scholar
• Marsh R, Zhu H, Schultz RT et al. A developmental fMRI study of self-regulatory control. Hum. Brain Mapp.27(11), 848–863 (2009).
   Google Scholar
• Pavuluri MN, Passarotti AM. Neural bases of emotional processing in pediatric bipolar disorder. Expert Rev. Neurother.8(9), 1381–1387 (2008).
   PubMedGoogle Scholar
• Pavuluri MN, Passarotti AM, Harral EM, Sweeney JA. An fMRI study of the neural correlates of incidental versus directed emotion processing in pediatric bipolar disorder. J. Am. Acad. Child Adolesc. Psychiatry48, 308–319 (2009).
   PubMed Web of Science ®Google Scholar
• Tricomi EM, Delgado MR, Fiez JA. Modulation of caudate activity by action contingency. Neuron41(2), 281–292 (2004).
   PubMed Web of Science ®Google Scholar
• Barto AG. Adaptive critics and the basal ganglia. In: Models of Information Processing in the Basal Ganglia. Houk JC, Davis JL Beiser DG (Eds). MIT Press, MA, USA 215–232 (1995).
   Google Scholar
• O’Doherty J, Dayan P, Schultz J, Deichmann R, Friston K, Dolan RJ. Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science304, 452–454 (2004).
   PubMed Web of Science ®Google Scholar
• Bechara A, Tranel D, Damasio H. Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain123(11), 2189–2202 (2000).
   PubMed Web of Science ®Google Scholar
• Knutson B, Fong GW, Bennett SM, Adams CM, Homme D. A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRI. Neuroimage18, 263–272 (2003).
   PubMed Web of Science ®Google Scholar
• Hampton AN, Adolphs R, Tyszka MJ, O’Doherty JP. Contributions of the amygdala to reward expectancy and choice signals in human prefrontal cortex. Neuron55(4), 545–555 (2007).
   PubMed Web of Science ®Google Scholar
• Knutson B, Fong GW, Adams CS, Hommer D. Dissociation of reward anticipation versus outcome with event-related fMRI. Neuroreport12, 3683–3687 (2001).
   PubMed Web of Science ®Google Scholar
• Hare TA, O’Doherty J, Camerer CF, Schultz W, Rangel A. Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors. J. Neurosci.28(22), 5623–5630 (2008).
   PubMed Web of Science ®Google Scholar
• Carter R, MacInnes J, Huettel SA, Adcock R. Activation in the VTA and nucleus accumbens increases in anticipation of both gains and losses. Front. Behav. Neurosci.3, 21 (2009).
   PubMed Web of Science ®Google Scholar
• Levita L, Hare TA, Voss HU, Glover G, Ballon DJ, Casey BJ. The bivalent side of the nucleus accumbens. Neuroimage44(3), 1178–1187 (2009).
   PubMedGoogle Scholar
• Adolphs R. Neural systems for recognizing emotion. Curr. Opin. Neurobiol.12, 169–177 (2002).
   PubMed Web of Science ®Google Scholar
• Paton JJ, Belova MA, Morrison SE, Salzman CD. The primate amygdala represents the positive and negative value of visual stimuli during learning. Nature439(7078), 865–870 (2006).
   PubMed Web of Science ®Google Scholar
• Salzman CD, Paton JJ, Belova MA, Morrison SE. Flexible neural representations of value in the primate brain. Ann. NY Acad. Sci.1121, 336–354 (2007).
   PubMedGoogle Scholar
• Gottfried JA, O’Doherty J, Dolan RJ. Encoding predictive reward value in human amygdala and orbitofrontal cortex. Science301(5636), 1104–1107 (2003).
   PubMed Web of Science ®Google Scholar
• Cardinal RN, Parkinson JA, Lachenal, G et al. Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats. Behav. Neurosci.116, 553–567 (2002).
   PubMed Web of Science ®Google Scholar
• Passarotti AM, Ellis J, Wegbreit E, Varghese B, Stevens MC, Pavuluri MN. Working memory networks are influenced by facial emotions in pediatric bipolar disorder. Presented at: The Pediatric Bipolar Conference, Boston, MA, USA, 24–25 March (2011).
   Google Scholar
• Foland LC, Altshuler LL, Bookheimer SY, Eisenberger N, Townsend J, Thompson PM. Evidence for deficitent modulation of amygdala response by prefrontal cortex in bipolar mania. Psychiatry Res.162, 27–37 (2008).
   PubMed Web of Science ®Google Scholar
• Coghill D, Seth S. Do the diagnostic criteria for ADHD need to change? Comments on the preliminary proposals of the DSM-5 ADHD and disruptive behavior disorders committee. Eur. J. Adolesc. Psychiatry20, 75–81 (2011).
   PubMedGoogle Scholar
• Leibenluft E, Blair RJ, Charney DS, Pine DS. Irritability in pediatric mania and other childhood psychopathology. Ann. NY Acad. Sci.1008, 201–218 (2003b).
   PubMedGoogle Scholar
• Leibenluft E. Severe mood dysregulation, irritability, and the diagnostic boundaries of bipolar disorder in youths. Am. J. Psychiatry168(2), 129–142 (2011).
   PubMed Web of Science ®Google Scholar
• Rich BA, Brotman MA, Dickstein DP, Mitchell DG, Blair RJ, Leibenluft E. Deficits in attention to emotional stimuli distinguish youth with severe mood dysregulation from youth with bipolar disorder. J. Abnorm. Child Psychol.38(5): 695–706 (2010).
   PubMed Web of Science ®Google Scholar
• Rau G, Blair KS, Berghorst L et al. Processing of differentially valued rewards and punishments in youths with bipolar disorder or severe mood dysregulation. J. Child Adolesc. Psychopharmacol.18(2), 185–196 (2008).
   PubMedGoogle Scholar
• Daly BP, Creed T, Xanthopoulos M, Brown RT. Psychosocial treatments for children with attention deficit/hyperactivity disorder. Neuropsychol. Rev.17(1), 73–89 (2007).
   PubMed Web of Science ®Google Scholar
• Pelham WE Jr, Fabiano GA. Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. J. Clin. Child Adolesc. Psychol.37(1), 184–214 (2008).
   PubMed Web of Science ®Google Scholar
• Fehlings DL, Roberts W, Humphries T, Dawe G. Attention deficit hyperactivity disorder: does cognitive behavioral therapy improve home behavior? J. Dev. Behav. Pediatr.12(4), 223–228 (1991).
   PubMed Web of Science ®Google Scholar
• Chronis AM, Fabiano GA, Gnagy EM, Wymbs B, Burrows-Mac-Lean L, Pelham WE. Comprehensive, sustained behavioral and pharmacological treatment for ADHD: a case study. Cogn. Behav. Practice, 8, 346 (2001).
   Web of Science ®Google Scholar
• Pavuluri MN, Graczyk PA, Henry DB, Carbray JA, Heidenreich J, Miklowitz DJ. Child- and family-focused cognitive-behavioral therapy for pediatric bipolar disorder: development and preliminary results. J. Am. Acad. Child Adolesc. Psychiatry43(5), 528–537 (2004).
   PubMed Web of Science ®Google Scholar
• West AE, Henry DB, Pavuluri MN. Maintenance model of integrated psychosocial treatment in pediatric bipolar disorder: a pilot feasibility study. J. Am. Acad. Child Adolesc. Psychiatry46(2), 205–212 (2007).
   PubMed Web of Science ®Google Scholar
• West AE, Pavuluri MN. Psychosocial treatments for childhood and adolescent bipolar disorder. Child Adolesc. Psychiatr. Clin. N. Am.18(2), 471–482 (2009).
   PubMed Web of Science ®Google Scholar
• Klingberg T, Fernell E, Olesen PJ et al. Computerized traininig of working memory in children with ADHD – a randomized controlled trial. J. Am. Acad. Child Adolesc. Psychiatry44, 177–186 (2005).
   PubMed Web of Science ®Google Scholar
• Holmes J, Gathercole SE, Dunning GL. Adaptive training leads t osustained enhancement of poor working memory in children. Dev. Sci.12(4), F9–15 (2009).
   PubMed Web of Science ®Google Scholar
• Thorell LB, Linqvist S, Bergman nutley S, Bolin G, Klingberg T. Training and transfer effects of executive function in preschool children Dev. Sci.12(1), 106–113 (2009).
   PubMed Web of Science ®Google Scholar
• Tannock R (1998). Attention deficit hyperactivity disorder: advances in cognitive, neurobiological, and genetic research. J. Child Psychol. Psychiatry39, 65–99 (1998).
   PubMed Web of Science ®Google Scholar
• Sheridan MA, Hinshaw S, D’Esposito M. Stimulant medication and prefrontal functional connectivity during working memory in ADHD: a preliminary report. J. Atten. Disord.14(1), 69–78 (2010).
   PubMed Web of Science ®Google Scholar
• Volkow ND, Wang G, Fowler JS et al. Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain. J. Neurosci.21(2), RC121 (2001).
   PubMed Web of Science ®Google Scholar
• Wilens TE. Attention-deficit/hyperactivity disorder and the substance use disorders: the nature of the relationship, subtypes at risk, and treatment issues. Psychiatr. Clin. North Am.27(2), 283–301 (2004).
   PubMed Web of Science ®Google Scholar
• Vaidya CJ, Austin G, Kirkorian G et al. Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance imaging study. Proc. Natl Acad. Sci. USA95, 14494–14499 (1998).
   PubMed Web of Science ®Google Scholar
• Shafritz KM, Marchione KE, Gore JC, Shaywitz SE, Shaywitz BA. The effects of methylphenidate on neural systems of attention in attention deficit hyperactivity disorder. Am. J. Psychiatry161, 1990–1997 (2004).
   PubMed Web of Science ®Google Scholar
• Rubia K, Halari R, Cubillo A, Mohammad AM, Brammer M, Taylor E. Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance task. Neuropharmacology57(7–8), 640–652 (2009).
   PubMed Web of Science ®Google Scholar
• Wigal SB, Chae S, Patel A, Steinberg-Epstein R. Advances in the treatment of attention-deficit/hyperactivity disorder: a guide for pediatric neurologists. Semin. Pediatr. Neurol.17(4), 230–236 (2010).
   PubMedGoogle Scholar
• Groom MJ, Scerif G, Liddle PF et al. Effects of motivation and medication on electrophysiological markers of response inhibition in children with attention deficit/hyperactivity disorder. Biol. Psychiatry67, 624–631 (2010).
   PubMed Web of Science ®Google Scholar
• Chen J, Fang Y, Kemp DE, Calabrese JR, Gao K. Switching to hypomania and mania: differential neurochemical, neuropsychological, and pharmacologic triggers and their mechanisms. Curr. Psychiatry Rep.12(6), 512–521 (2010).
   PubMedGoogle Scholar
• Pavuluri MN, Passarotti AM, Parnes SA, Fitzgerald JM, Sweeney, JA. A pharmacological fMRI study probing the interface of cognitive and emotional brain systems in pediatric bipolar disorder. J. Child Adolesc. Psychopharmacol.20(5), 395–406 (2010).
   PubMedGoogle Scholar
• Pavuluri MN, Passarotti AM, Fitzgerald JM, Sweeney JA. Risperidone and divalproex differentially engange the fronto–striato–temporal circuitry in pediatric mania: a pharmacological fMRI study. J. Am. Acad. Child Adolesc. Psychiatry (2011) (In press).
   Google Scholar
• Pavuluri MN, Passarotti AM, Mohammed T, Carbray J, Sweeney JA. Enhanced working and verbal memory after lamotrigine treatment in pediatric bipolar disorder. Bipolar Disord.12(2), 213–220 (2010).
   PubMedGoogle Scholar
• Pavuluri MN, Passarotti AM, Lu LH, Carbray JA, Sweeney JA. Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes. Psychiatry Res. (In press).
   Google Scholar
• Kessler RC, Berglund, P et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national Comorbidity Survey replication. Arch. Gen. Psychiatry62(6), 593–602 (2005).
   PubMed Web of Science ®Google Scholar
• Insel TR. Foreword. Developmental cognitive neuroscience. Dev. Cogn. Neurosci.1, 1–2 (2011).
   PubMedGoogle Scholar
• Rich BA, Schmajuk M, Perez-Edgar KE, Fox NA, Pine DS, Leibenluft E. Different psychophysiological and behavioral responses elicited by frustration in pediatric bipolar disorder and severe mood dysregulation. Am. J. Psychiatry164, 309–317 (2007).
   PubMed Web of Science ®Google Scholar
• Calhoun V, Wu L, Kiehl K, Eichele T, Pearlson G. Aberrant processing of deviant stimuli in schizophrenia revealed by fusion of fMRI and EEG data. Acta Neuropsychiatr.22(3), 127–138 (2010).
   PubMedGoogle Scholar
• Stevens MC. The developmental cognitive neuroscience of functional connectivity. Brain Cogn.70, 1–12 (2009).
   PubMed Web of Science ®Google Scholar
• Calhoun VD, Maciejewski PK, Pearlson GD, Kiehl KA. Temporal lobe and ‘default’ hemodynamic brain modes discriminate between schizophrenia and bipolar disorder. Hum. Brain Mapp.29(11), 1265–1275 (2008).
   PubMed Web of Science ®Google Scholar
• Zhu CZ, Zang YF, Cao QJ et al. Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder. Neuroimage40, 110–120 (2008).
   PubMedGoogle Scholar
• Castellanos FX, Margulies DS, Kelly C et al. Cingulate–precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biol. Psychiatry63, 332–337 (2008).
   PubMed Web of Science ®Google Scholar
• Rich BA, Fromm SJ, Berghorst LH et al. Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit. J Child Psychol. Psychiatry49(1), 88–96 (2008).
   PubMed Web of Science ®Google Scholar
• Stevens MC, Kiehl KA, Pearlson GD, Calhoun VD. Functional neural networks underlying response inhibition in adolescents and adults. Behav. Brain Res.181(1), 12–22 (2007).
   PubMed Web of Science ®Google Scholar
• Faraone SV, Perlis RH, Doyle AE et al. Molecular genetics of attention-deficit/hyperactivity disorder. Biol. Psychiatry57(11), 1313–1323 (2005).
   PubMed Web of Science ®Google Scholar
• Stein MA, Waldman ID, Sarampote CS, et al. Dopamine transporter genotype and methylphenidate dose–response in children with ADHD. Neuropsychopharmacology30, 1374–1382 (2005).
   PubMed Web of Science ®Google Scholar
• Stollstoff MA, Foss-Feig J, Cook EH, Stein MA, Gaillard WD. Neural response to working memory load varies by dopamine transporter genotype in children. Neuroimage 53, 970–977 (2010).
   Google Scholar
• MacQueen GM, Hajek T, Alda M. The phenotypes of bipolar disorder: relevance for genetic investigations. Mol. Psychiatry10(9), 811–826 (2005).
   PubMedGoogle Scholar
• Gau SS, Shang CY. Executive functions as endophenotypes in ADHD: evidence from the Cambridge Neuropsychological Test Battery (CANTAB). J. Child Psychol. Psychiatry.51(7), 838–849 (2010).
   PubMed Web of Science ®Google Scholar
• Fan J, Fossella J, Sommer T, Wu Y, Posner MI. Mapping the genetic variation of executive attention onto brain activity. Proc. Natl Acad. Sci. USA100, 7406–7411 (2003).
   PubMed Web of Science ®Google Scholar
• Gourovitch ML, Torrey EF, Gold JM, Randolph C, Weinberger DR, Goldberg TE. Neuropsychological performance of monozygotic twins discordant for bipolar disorder. Biol. Psychiatry45, 639–646 (1999).
   PubMed Web of Science ®Google Scholar
• Kulkarni SK. Re-engineering pharmacology teaching and research: can we adopt translational approach? Indian J. Pharmacol.42(5), 259–260 (2010).
   PubMedGoogle Scholar
• Zalla T, Joyce C, Szoke A et al. Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia. Psychiatry Res.121(3), 207–271 (2004).
   PubMed Web of Science ®Google Scholar
• Ladouceur CD, Almeida JR, Birmaher B et al. Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder? J. Am. Acad. Child Adolesc. Psychiatry47(5), 532–539 (2008).
   PubMed Web of Science ®Google Scholar
• Donnelly M, Haby MM, Carter R, Andrews G, Vos T. Cost–effectiveness of dexamphetamine and metylphenidate for the treatment of childhood attention deficit hyperactivity disorder. Aust. NZ J. Psychatry38, 592–601 (2004).
   PubMed Web of Science ®Google Scholar
• Wozniak J, Biederman J, Mundy E, Mennin D, Faraone SV. A pilot family study of childhood-onset mania. J. Am. Acad. Child Adolesc. Psychiatry34(12), 1577–1583 (2005).
   Google Scholar