212
Views
9
CrossRef citations to date
0
Altmetric
Drug Profile

Inhaled iloprost for therapy in pulmonary arterial hypertension

, , &
Pages 145-152 | Published online: 09 Jan 2014

References

  • Simonneau G, Robbins IM, Beghetti M et al. Updated clinical classification of pulmonary hypertension. J. Am. Coll. Cardiol.54, S43–S54 (2009).
  • Badesch DB, Champion HC, Gomez Sanchez MA et al. Diagnosis and assessment of pulmonary arterial hypertension. J. Am. Coll. Cardiol.54, S55–S66 (2009).
  • Galié N, Hoeper MM, Humbert M et al. Guidelines for diagnosis and treatment of pulmonary hypertension. Eur. Heart J.30, 2493–2537 (2009).
  • Schulz A. Pharmacology of prostanoids. In: Iloprost in Intensive Care Medicine. Ewert R (Ed.). Uni-Med Verlag, Bremen, Germany, 10–30 (2006).
  • Fisher CA, Kappa JR, Sinha AK et al. Comparison of equimolar concentrations of iloprost, prostacyclin and prostaglandin E1, on human platelet function. J. Lab. Clin. Med.109, 184–190 (1987).
  • Belch JF, Green I, McLaren M et al. The effects of intravenous ZK 36374, a stable prostacyclin analogue, on normal volunteers. Prostaglandins28, 67–71 (1984).
  • Cowley AJ, Heptinstall S, Hampton JR. Effects of prostacyclin and of the stable prostacyclin analogue ZK 36374 on forearm blood flow and blood platelet behaviour in man. Thromb. Haemost.53, 90–94 (1985).
  • Wharton J, Davie N, Upton PD et al. Prostacyclin analogues differentially inhibits growth of distal and proximal human pulmonary smooth muscle cells. Circulation102, 3130–3136 (2000).
  • Clapp LH, Finney P, Turcato S et al. Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. Am. J. Respir. Cell. Mol. Biol.26, 194–201 (2002).
  • Gomberg-Maitland M, Olschewski H. Prostacyclin therapies for the treatment of pulmonary arterial hypertension. Eur. Respir. J.31, 891–901 (2008).
  • Hsu HH, Rubin LJ. Iloprost inhalation solution for the treatment of pulmonary arterial hypertension. Expert Opin. Pharmacother.6, 1921–1930 (2005).
  • Krause W, Krais T. Pharmacokinetics and pharmacodynamics of radio-labeled iloprost in elderly volunteers. Eur. J. Clin. Pharmacol.32, 597–605 (1987).
  • Schermuly RT, Schulz A, Ghofrani HA et al. Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs. J. Pharmacol. Exp. Ther.303, 741–745 (2002).
  • Olschewski H, Rohde B, Behr J et al. Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerosolized by three different devices, in severe pulmonary hypertension. Chest124, 1294–1304 (2003).
  • Pepke-Zaba J, Higenbottam TW, Dinh-Xuan AT et al. Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet338, 1173–1174 (1991).
  • Olschewski H, Walmrath D, Schermuly R et al. Aerosolized prostacyclin and iloprost in severe pulmonary hypertension. Ann. Intern. Med.124, 820–824 (1996).
  • Hoeper MM, Olschewski H, Ghofrani HA et al. A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension. German PPH study group. J. Am. Coll. Cardiol.35, 176–182 (2000).
  • Ewert R, Schäper C, Halank M et al. Inhalative iloprost – pharmacology and clinical application. Expert Opin. Pharmacother.10, 1–13 (2009).
  • Gessler T, Schmehl T, Hoeper MM et al. Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension. Eur. Respir. J.17, 14–19 (2001).
  • Krug S, Sablotzki A, Hammerschmidt S et al. Inhaled iloprost for the control of pulmonary hypertension. Vasc. Health Risk Manag.5, 465–474 (2009).
  • Tissot C, Beghetti M. Review of inhaled iloprost for the control of pulmonary artery hypertension in children. Vasc. Health Risk Manag.5, 325–331 (2009).
  • Ghofrani HA, Rose F, Schermuly RT et al. Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension. Crit. Care Med.30, 2489–2492 (2002).
  • Wilkens H, Guth A, König J et al. Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension. Circulation104, 1218–1222 (2001).
  • Ghofrani HA, Wiedemann R, Rose F et al. Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension. Ann. Intern. Med.136, 515–522 (2002).
  • Petkov V, Ziesche R, Mosgoeller W et al. Aerosolised iloprost improves pulmonary haemodynamics in patients with primary pulmonary hypertension receiving continuous epoprostenol treatment. Thorax56, 734–736 (2001).
  • Rich S, Brundage BH. High-dose calcium channel-blocking therapy for primary pulmonary hypertension: evidence for long-term reduction in pulmonary arterial pressure and regression of right ventricular hypertrophy. Circulation76, 135–141 (1987).
  • Barst RJ, McGoon M, Torbicki A et al. Diagnosis and differential assessment of pulmonary arterial hypertension. J. Am. Coll. Cardiol.43, 40S–47S (2004).
  • Sitbon O, Humbert M, Jaïs X et al. Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension. Circulation111, 3105–3111 (2005).
  • Montani D, Savale L, Natali D et al. Long-term response to calcium-channel blockers in non-idiopathic pulmonary arterial hypertension. Eur. Heart J.31, 1898–1907 (2010).
  • Jing ZC, Jiang X, Han ZY et al. Iloprost for pulmonary vasodilator testing in idiopathic pulmonary arterial hypertension. Eur. Respir. J.33, 1354–1360 (2009).
  • Tonelli AR, Alnuaimat H, Mubarak K. Pulmonary vasodilator testing and use of calcium channel blockers in pulmonary arterial hypertension. Respir. Med.104, 481–496 (2010).
  • Hoeper MM, Schwarze M, Ehlerding S et al. Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N. Engl. J. Med.342, 1866–1870 (2000).
  • Ewert R, Wensel R, Opitz CF. Aerosolized iloprost for primary pulmonary hypertension. N. Engl. J. Med.343, 1421–1422 (2000).
  • Ewert R, Opitz C, Wensel R et al. Iloprost as inhalational and intravenous long-term treatment of patients with primary pulmonary hypertension. Register of the Berlin Study Group for Pulmonary Hypertension. Z. Kardiol.89, 987–999 (2000).
  • Machherndl S, Kneussl M, Baumgartner H et al. Long-term treatment of pulmonary hypertension with aerosolized iloprost. Eur. Respir. J.17, 8–13 (2001).
  • Olschewski H, Ghofrani HA, Schmehl T et al. Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group. Ann. Intern. Med.132, 435–443 (2000).
  • Olschewski H, Simonneau G, Galiè N et al. Inhaled iloprost for severe pulmonary hypertension. N. Engl. J. Med.347, 322–329 (2002).
  • Hoeper MM, Taha N, Bekjarova A et al. Bosentan treatment in patients with primary pulmonary hypertension receiving nonparenteral prostanoids. Eur. Respir. J.22, 330–334 (2003).
  • Seyfarth HJ, Pankau H, Hammerschmidt S et al. Bosentan improves exercise tolerance and Tei index in patients with pulmonary hypertension and prostanoid therapy. Chest28, 709–713 (2005).
  • Ghofrani HA, Rose F, Schermuly RT et al. Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension. J. Am. Coll. Cardiol.42, 158–164 (2003).
  • Beyer S, Speich R, Fischler M et al. Long-term experience with oral or inhaled vasodilator combination therapy in patients with pulmonary hypertension. Swiss Med. Wkly136, 114–118 (2006).
  • Durongpisitkul K, Jakrapanichakul D, Laohaprasitiporn D et al. Combination therapy of prostacyclin for pulmonary hypertension in congenital heart disease. J. Med. Assoc. Thai.88(Suppl. 8), S60–S65 (2005).
  • McLaughlin VV, Oudiz RJ, Frost A et al. Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med.174, 1257–1263 (2006).
  • Hoeper MM, Leuchte H, Halank M et al. Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. Eur. Respir. J.28, 691–694 (2006).
  • Olschewski H, Hoeper MM, Behr J et al. Long-term therapy with inhaled iloprost in patients with pulmonary hypertension. Respir. Med.104, 731–740 (2010).
  • Reichenberger F, Mainwood A, Doughty N et al. Effects of nebulised iloprost on pulmonary function and gas exchange in severe pulmonary hypertension. Respir. Med.101, 217–222 (2007).
  • Ivy DD, Doran AK, Smith KJ et al. Short- and long-term effects of inhaled iloprost therapy in children with pulmonary arterial hypertension. J. Am. Coll. Cardiol.51, 161–169 (2008).
  • Opitz CF, Wensel R, Winkler J et al. Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension. Eur. Heart J.26, 1895–1902 (2005).
  • McLaughlin VV, Benza RL, Rubin LJ et al. Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension. J. Am. Coll. Cardiol.55, 1915–1922 (2010).
  • Garin MC, Clark L, Chumney EC et al. Cost-utility of treatments for pulmonary arterial hypertension a markov state-transition decision analysis model. Clin. Drug Investig.29, 635–646 (2009).
  • Hoeper MM, Seyfarth HJ, Hoeffken G et al. Experience with inhaled iloprost and bosentan in portopulmonary hypertension. Eur. Respir. J.30, 1096–1102 (2007).
  • Launay D, Hachulla E, Hatron PY et al. Aerosolized iloprost in CREST syndrome related pulmonary hypertension. J. Rheumatol.28, 2252–2256 (2001).
  • Fruhwald FM, Kjellström B, Perthold W et al. Continuous hemodynamic monitoring in pulmonary hypertensive patients treated with inhaled iloprost. Chest124, 351–359 (2003).
  • Melgosa MT, Ricci GL, García-Pagan JC et al. Acute and long-term effects of inhaled iloprost in portopulmonary hypertension. Liver Transpl.16, 348–356 (2010).
  • Reichenberger F, Mainwood A, Morrell NW, Parameshwar J, Pepke-Zaba J. Intravenous epoprostenol versus high dose inhaled iloprost for long-term treatment of pulmonary hypertension. Pulm. Pharmacol. Ther. DOI: 10.1016/j.pupt.2010.06.004 (2010) (Epub ahead of print).
  • Baughman RP, Judson MA, Lower EE et al. Inhaled iloprost for sarcoidosis associated pulmonary hypertension. Sarcoidosis Vasc. Diffuse Lung Dis.26, 110–120 (2009).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.