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Special Report

The clinical potential of ex vivo lung perfusion

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Pages 27-35 | Published online: 09 Jan 2014

References

  • Ware LB, Wang Y, Fang X et al. Assessment of lungs rejected for transplantation and implications for donor selection. Lancet360(9333), 619–620 (2002).
  • Avlonitis VS, Fisher AJ, Kirby JA, Dark JH. Pulmonary transplantation: the role of brain death in donor lung injury. Transplantation75(12), 1928–1933 (2003).
  • de Perrot M, Liu M, Waddell T, Keshavjee S. Ischemia-reperfusion-induced lung injury. Am. J. Respir. Cell Mol. Biol.28(5), 616–625 (2003).
  • Aigner C, Winkler G, Jaksch P et al. Extended donor criteria for lung transplantation – a clinical reality. Eur. J. Cardiothorac. Surg.27(5), 757–761 (2005).
  • Van Raemdonck D, Neyrinck A, Verleden GM et al. Lung donor selection and management. Proc. Am. Thorac. Soc.6(1), 28–38 (2009).
  • Cypel M, Yeung JC, Keshavjee S. Novel approaches to expanding the lung donor pool: donation after cardiac death and ex vivo conditioning. Clin. Chest Med.32(2), 233–244 (2011).
  • De Oliveira NC, Osaki S, Maloney JD et al. Lung transplantation with donation after cardiac death donors: long-term follow-up in a single center. J. Thorac. Cardiovasc. Surg.139(5), 1306–1315 (2010).
  • Cypel M, Sato M, Yildirim E et al. Initial experience with lung donation after cardiocirculatory death in Canada. J. Heart Lung Transplant.28(8), 753–758 (2009).
  • Snell GI, Levvey BJ, Oto T et al. Early lung transplantation success utilizing controlled donation after cardiac death donors. Am. J. Transplant.8(6), 1282–1289 (2008).
  • Mason DP, Thuita L, Alster JM et al. Should lung transplantation be performed using donation after cardiac death? The United States experience. J. Thorac. Cardiovasc. Surg.136(4), 1061–1066 (2008).
  • Aigner C, Mazhar S, Jaksch P et al. Lobar transplantation, split lung transplantation and peripheral segmental resection – reliable procedures for downsizing donor lungs. Eur. J. Cardiothorac. Surg.25(2), 179–183 (2004).
  • Yamane M, Date H, Okazaki M, Toyooka S, Aoe M, Sano Y. Long-term improvement in pulmonary function after living donor lobar lung transplantation. J. Heart Lung Transplant.26(7), 687–692 (2007).
  • Carrel A, Lindbergh CA. The culture of whole organs. Science81(2112), 621–623 (1935).
  • Jirsch DW, Fisk RL, Couves CM. Ex vivo evaluation of stored lungs. Ann. Thorac. Surg.10(2), 163–168 (1970).
  • Fisk RL, Symes JF, Aldridge LL, Couves CM. The pathophysiology and experimental therapy of acid pneumonitis in ex vivo lungs. Chest57(4), 364–370 (1970).
  • Cushman DW, Wang FL, Fung WC et al. Comparisons in vitro, ex vivo, and in vivo of the actions of seven structurally diverse inhibitors of angiotensin converting enzyme (ACE). Br. J. Clin. Pharmacol.28(Suppl. 2), S115–S130; discussion S130–S131 (1989).
  • Kanekal S, Plopper C, Morin D, Buckpitt A. Metabolic activation and bronchiolar Clara cell necrosis from naphthalene in the isolated perfused mouse lung. J. Pharmacol. Exp. Ther.252(1), 428–437 (1990).
  • Kaplan E, Diehl JT, Peterson MB et al. Extended ex vivo preservation of the heart and lungs. Effects of acellular oxygen-carrying perfusates and indomethacin on the autoperfused working heart-lung preparation. J. Thorac. Cardiovasc. Surg.100(5), 687–697; discussion 697–688 (1990).
  • Seeger W, Schneider U, Kreusler B et al. Reproduction of transfusion-related acute lung injury in an ex vivo lung model. Blood76(7), 1438–1444 (1990).
  • Townsley MI, Barman SA, Taylor AE. Pulmonary embolism: emboli and fibrinolysis inhibition in isolated canine lungs. Am. J. Physiol.258(3 Pt 2), H754–H758 (1990).
  • Wang LS, Yoshikawa K, Miyoshi S et al. The effect of ischemic time and temperature on lung preservation in a simple ex vivo rabbit model used for functional assessment. J. Thorac. Cardiovasc. Surg.98(3), 333–342 (1989).
  • Brasile L, Stubenitsky BM, Kootstra G. Solving the organ shortage: potential strategies and the likelihood of success. ASAIO J.48(3), 211–215 (2002).
  • Brasile L, Stubenitsky BM, Booster MH et al. Overcoming severe renal ischemia: the role of ex vivo warm perfusion. Transplantation73(6), 897–901 (2002).
  • Brasile L, Buelow R, Stubenitsky BM, Kootstra G. Induction of heme oxygenase-1 in kidneys during ex vivo warm perfusion. Transplantation76(8), 1145–1149 (2003).
  • Brasile L, Stubenitsky BM, Booster MH, Haisch C, Kootstra G. NOS: the underlying mechanism preserving vascular integrity and during ex vivo warm kidney perfusion. Am. J. Transplant.3(6), 647–649 (2003).
  • Brasile L, Stubenitsky BM, Haisch CE, Kon M, Kootstra G. Repair of damaged organs in vitro. Am. J. Transplant.5(2), 300–306 (2005).
  • Imber CJ, St Peter SD, Lopez de Cenarruzabeitia I et al. Advantages of normothermic perfusion over cold storage in liver preservation. Transplantation73(5), 701–709 (2002).
  • Steen. S, Liao Q, Wierup PN, Bolys R, Pierre L, Sjöberg T. Transplantation of lungs from non-heart-beating donors after functional assessment ex vivo. Ann. Thorac. Surg.76(1), 244–252 (2003).
  • Daemen JW, Kootstra G, Wijnen RM, Yin M, Heineman E. Nonheart-beating donors: the Maastricht experience. Clin. Transpl.303–316 (1994).
  • Steen S, Sjoberg T, Pierre L, Liao Q, Eriksson L, Algotsson L. Transplantation of lungs from a non-heart-beating donor. Lancet357, 825–829 (2001).
  • Meers CM, Tsagkaropoulos S, Wauters S et al. A model of ex vivo perfusion of porcine donor lungs injured by gastric aspiration: a step towards pretransplant reconditioning. J. Surg. Res.170(1), e159–e167 (2011).
  • Egan TM, Haitchcock JA, Nicotra WA, Koukoulis G, Inokawa H, Sevala M. Ex vivo evaluation of human lungs for transplant suitability. Ann. Thorac. Surg.81(4), 1205–1213 (2006).
  • Snell GI, Oto T, Levvey B et al. Evaluation of techniques for lung transplantation following donation after cardiac death. Ann. Thorac. Surg.81(6), 2014–2019 (2006).
  • Neyrinck AP, Van De Wauewer C, Geudens N, Rega FR, Verleden GM, Wouters Comparative study of donor lung injury in heart-beating versus non-heart-beating donors. Eur. J. Cardiothorac. Surg.30(4), 628–636 (2006).
  • Rega FR, Vanaudenaerde BM, Wuyts WA et al. IL-1beta in bronchial lavage fluid is a non-invasive marker that predicts the viability of the pulmonary graft from the non-heart-beating donor. J. Heart Lung Transplant.24(1), 20–28 (2003).
  • Cypel M, Yeung JC, Hirayama S et al. Technique for prolonged normothermic ex vivo lung perfusion. J. Heart Lung Transplant.27(12), 1319–1325 (2008).
  • Cypel M, Rubacha M, Yeung J et al. Normothermic ex vivo perfusion prevents lung injury compared to extended cold preservation for transplantation. Am. J. Transplant.9(10), 2262–2269 (2009).
  • Cypel M, Liu M, Rubacha M et al. Functional repair of human donor lungs by IL-10 gene therapy. Sci. Transl. Med.1(4), 1–9 (2009).
  • Steen S, Sjoberg T, Pierre L, Liao Q, Eriksson L, Algotsson L. Transplantation of lungs from a non-heart-beating donor. Lancet357(9259), 825–829 (2001).
  • Ingemansson R, Eyjolfsson A, Mared L et al. Clinical transplantation of initially rejected donor lungs after reconditioning ex vivo. Ann. Thorac. Surg.87(1), 255–260 (2009).
  • Lindstedt S, Hlebowicz J, Koul B et al. Comparative outcome of double lung transplantation using conventional donor lungs and non-acceptable donor lungs reconditioned ex vivo. Interact. Cardiovasc. Thorac. Surg.12(2), 162–165 (2011).
  • Cypel M, Yeung JC, Liu M et al. Normothermic ex vivo lung perfusion in clinical lung transplantation. N. Engl. J. Med.364(15), 1431–1440 (2011).
  • Christie JD, Sager JS, Kimmel SE et al. Impact of primary graft failure on outcomes following lung transplantation. Chest127(1), 161–165 (2005).
  • Yeung C, Koike T, Cypel M et al. Airway pressure and compliance in the evaluation of donor lung injury during protective ex vivo lung perfusion in a porcine brain death model. J. Heart Lung Transplant.30(4), S143 (2011).
  • Orens JB, Boehler A, de Perrot M et al. A review of lung transplant donor acceptability criteria. J. Heart Lung Transplant.22(11), 1183–1200 (2003).
  • Kaneda H, Waddell TK, de Perrot M et al. Pre-implantation multiple cytokine mRNA expression analysis of donor lung grafts predicts survival after lung transplantation in humans. Am. J. Transplant.6(3), 544–551 (2006).
  • Cypel M, Yildirim E, Boasquevisque C et al. Donor scoring does not predict early outcome. J. Heart Lung Transplant.26(2 Suppl. 1), S212–S213 (2008).
  • Christie JD, Carby M, Bag R, Corris P, Hertz M, Weill D. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation. J. Heart Lung Transplant.24(10), 1454–1459 (2005).
  • de Perrot M, Bonser RS, Dark J et al. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part III: donor-related risk factors and markers. J. Heart Lung Transplant.24(10), 1460–1467 (2005).
  • De Perrot M, Sekine Y, Fischer S et al. Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation. Am. J. Respir. Crit. Care Med.165(2), 211–215 (2002).
  • Fisher AJ, Donnelly SC, Hirani N et al. Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation. Am. J. Respir. Crit. Care Med.163(1), 259–265 (2001).
  • Anraku M, Cameron MJ, Waddell TK et al. Impact of Human Donor Lung Gene Expression Profiles on Survival after Lung Transplantation: a case–control study. Am. J. Transplant.8(10), 2140–2148 (2008).
  • Kang CH, Anraku M, Cypel M et al. Transcriptional signatures in donor lungs from donation after cardiac death vs after brain death: a functional pathway analysis. J. Heart Lung Transplant.30(3), 289–298 (2011).
  • Ray M, Dharmarajan S, Freudenberg J, Zhang W, Patterson GA. Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation. Am. J. Transplant.7(10), 2396–2405 (2007).
  • Das J, Kelley SO. Protein detection using arrayed microsensor chips: tuning sensor footprint to achieve ultrasensitive readout of CA-125 in serum and whole blood. Anal. Chem.83(4), 1167–1172 (2011).
  • Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am. J. Physiol. Lung Cell Mol. Physiol.293(1), 52–59 (2007).
  • Sakuma T, Gu X, Wang Z et al. Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Crit. Care Med.34(3), 676–681 (2006).
  • Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am. J. Physiol. Lung Cell Mol. Physiol.293(1), L52–59 (2007).
  • Planes C, Blot-Chabaud M, Matthay MA, Couette S, Uchida T, Clerici C. Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. J. Biol. Chem.277(49), 47318–47324 (2002).
  • Oto T, Excell L, Griffiths AP, Levvey BJ, Snell GI. The implications of pulmonary embolism in a multiorgan donor for subsequent pulmonary, renal, and cardiac transplantation. J. Heart Lung Transplant.27(1), 78–85 (2008).
  • Inci I, Zhai W, Arni S et al. Fibrinolytic treatment improves the quality of lungs retrieved from non-heart-beating donors. J. Heart Lung Transplant.26(10), 1054–1060 (2007).
  • Karamanou DM, Perry J, Walden HR et al. The effect of ex-vivo perfusion on the microbiological profile of the donor lung. J. Heart Lung Transplant.29(2 Suppl.), S88 (2010).
  • Inci I, Ampollini L, Arni S et al.Ex vivo reconditioning of marginal donor lungs injured by acid aspiration. J. Heart Lung Transplant.27(11), 1229–1236 (2008).
  • Hirayama S, Cypel M, Sato M et al. Activated protein C in ischemia-reperfusion injury after experimental lung transplantation. J. Heart Lung Transplant.28(11), 1180–1184 (2009).
  • Nita I, Hollander C, Westin U, Janciauskiene SM. Prolastin, a pharmaceutical preparation of purified human alpha1-antitrypsin, blocks endotoxin-mediated cytokine release. Respir. Res.6, 12 (2005).
  • Ishiyama T, Dharmarajan S, Hayama M, Moriya H, Grapperhaus K, Patterson GA. Inhibition of nuclear factor kappaB by IkappaB superrepressor gene transfer ameliorates ischemia-reperfusion injury after experimental lung transplantation. J. Thorac. Cardiovasc. Surg.130(1), 194–201 (2005).
  • Fischer S, Liu M, MacLean AA et al.In vivo transtracheal adenovirus-mediated transfer of human interleukin-10 gene to donor lungs ameliorates ischemia–reperfusion injury and improves early posttransplant graft function in the rat. Hum. Gene Ther.12(12), 1513–1526 (2001).
  • Martins S, de Perrot M, Imai Y et al. Transbronchial administration of adenoviral-mediated interleukin-10 gene to the donor improves function in a pig lung transplant model. Gene Ther.11(24), 1786–1796 (2004).
  • Zhao M, Fernandez LG, Doctor A et al. Alveolar macrophage activation is a key initiation signal for acute lung ischemia–reperfusion injury. Am. J. Physiol. Lung Cell Mol. Physiol.291(5), L1018–L1026 (2006).
  • Ritter T, Kupiec-Weglinski JW. Gene therapy for the prevention of ischemia/reperfusion injury in organ transplantation. Curr. Gene Ther.5(1), 101–109 (2005).
  • Cassivi SD, Cardella JA, Fischer S, Liu M, Slutsky AS, Keshavjee S. Transtracheal gene transfection of donor lungs prior to organ procurement increases transgene levels at reperfusion and following transplantation. J. Heart Lung Transplant.18(12), 1181–1188 (1999).
  • Chapelier A, Danel C, Mazmanian M et al. Gene therapy in lung transplantation: feasibility of ex vivo adenovirus-mediated gene transfer to the graft. Hum. Gene Ther.7(15), 1837–1845 (1996).
  • Pellegrini C, O’Brien T, Jeppsson A et al. Influence of temperature on adenovirus-mediated gene transfer. Eur. J. Cardiothorac. Surg.13(5), 599–603 (1998).
  • Yeung JC, Wagnetz D, Koike T, Rubacha M, Cypel M, Keshavjee S. Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre- and post-lung transplantation. J. Heart Lung Transplant.29(2 Suppl.), S95 (2010).
  • Lee JW, Fang X, Gupta N, Serikov V, Matthay MA. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc. Natl Acad. Sci. USA106(38), 16357–16362 (2009).
  • Ott HC, Clippinger B, Conrad C et al. Regeneration and orthotopic transplantation of a bioartificial lung. Nat. Med.16(8), 927–933 (2010).
  • Petersen TH, Calle EA, Zhao L et al. Tissue-engineered lungs for in vivo implantation. Science329(5991), 538–541 (2010).
  • Grootenboers MJ, Heeren J, van Putte BP et al. Isolated lung perfusion for pulmonary metastases, a review and work in progress. Perfusion21(5), 267–276 (2006).
  • Van Schil PE, Hendriks JM, van Putte BP et al. Isolated lung perfusion and related techniques for the treatment of pulmonary metastases. Eur. J. Cardiothorac. Surg.33(3), 487–496 (2008).
  • Den Hengst WA, Van Putte BP, Hendriks JM et al. Long-term survival of a Phase I clinical trial of isolated lung perfusion with melphalan for resectable lung metastases. Eur. J. Cardiothorac. Surg.38(5), 621–627 (2010).

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