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Review

Update on exhaled nitric oxide in pulmonary disease

, &
Pages 105-115 | Published online: 09 Jan 2014

References

  • Barnes PJ, Dweik RA, Gelb AF et al. Exhaled nitric oxide in pulmonary diseases: a comprehensive review. Chest138(3), 682–692 (2010).
  • Ricciardolo FL, Sterk PJ, Gaston B, Folkerts G. Nitric oxide in health and disease of the respiratory system. Physiol. Rev.84(3), 731–765 (2004).
  • Bove PF, van der Vliet A. Nitric oxide and reactive nitrogen species in airway epithelial signaling and inflammation. Free Radic. Biol. Med.41(4), 515–527 (2006).
  • Stewart L, Katial R. Exhaled nitric oxide. Immunol. Allergy Clin. North Am.27(4), 571–586, v (2007).
  • Silkoff PE, McClean P, Spino M, Erlich L, Slutsky AS, Zamel N. Dose–response relationship and reproducibility of the fall in exhaled nitric oxide after inhaled beclomethasone dipropionate therapy in asthma patients. Chest119(5), 1322–1328 (2001).
  • Hamid Q, Springall DR, Riveros-Moreno V et al. Induction of nitric oxide synthase in asthma. Lancet342(8886–8887), 1510–1513 (1993).
  • Kharitonov SA, Chung KF, Evans D, O’Connor BJ, Barnes PJ. Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract. Am. J. Respir. Crit. Care Med.153(6 Pt 1), 1773–1780 (1996).
  • Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax53(2), 91–95 (1998).
  • Gustafsson LE, Leone AM, Persson MG, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem. Biophys. Res. Commun.181(2), 852–857 (1991).
  • Kharitonov SA, Barnes PJ. Nasal contribution to exhaled nitric oxide during exhalation against resistance or during breath holding. Thorax52(6), 540–544 (1997).
  • Kimberly B, Nejadnik B, Giraud GD, Holden WE. Nasal contribution to exhaled nitric oxide at rest and during breathholding in humans. Am. J. Respir. Crit. Care Med.153(2), 829–836 (1996).
  • Kharitonov SA, Gonio F, Kelly C, Meah S, Barnes PJ. Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children. Eur. Respir. J.21(3), 433–438 (2003).
  • Hemmingsson T, Linnarsson D, Gambert R. Novel hand-held device for exhaled nitric oxide-analysis in research and clinical applications. J. Clin. Monit. Comput.18(5–6), 379–387 (2004).
  • Alving K, Janson C, Nordvall L. Performance of a new hand-held device for exhaled nitric oxide measurement in adults and children. Respir. Res.7, 67 (2006).
  • Pisi R, Aiello M, Tzani P, Marangio E, Olivieri D, Chetta A. Measurement of fractional exhaled nitric oxide by a new portable device: comparison with the standard technique. J. Asthma47(7), 805–809 (2010).
  • Kharitonov S, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force. Eur. Respir. J.10(7), 1683–1693 (1997).
  • American Thoracic Society, European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am. J. Respir. Crit. Care Med.171(8), 912–930 (2005).
  • Dweik RA, Boggs PB, Erzurum SC et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am. J. Respir. Crit. Care Med.184(5), 602–615 (2011).
  • Lundberg JO, Weitzberg E, Lundberg JM, Alving K. Nitric oxide in exhaled air. Eur. Respir. J.9(12), 2671–2680 (1996).
  • Zetterquist W, Pedroletti C, Lundberg JO, Alving K. Salivary contribution to exhaled nitric oxide. Eur. Respir. J.13(2), 327–333 (1999).
  • Olin AC, Aldenbratt A, Ekman A et al. Increased nitric oxide in exhaled air after intake of a nitrate-rich meal. Respir. Med.95(2), 153–158 (2001).
  • Persson MG, Zetterstrom O, Agrenius V, Ihre E, Gustafsson LE. Single-breath nitric oxide measurements in asthmatic patients and smokers. Lancet343(8890), 146–147 (1994).
  • Robbins RA, Millatmal T, Lassi K, Rennard S, Daughton D. Smoking cessation is associated with an increase in exhaled nitric oxide. Chest112(2), 313–318 (1997).
  • Kharitonov SA, Robbins RA, Yates D, Keatings V, Barnes PJ. Acute and chronic effects of cigarette smoking on exhaled nitric oxide. Am. J. Respir. Crit. Care Med.152(2), 609–612 (1995).
  • Schilling J, Holzer P, Guggenbach M, Gyurech D, Marathia K, Geroulanos S. Reduced endogenous nitric oxide in the exhaled air of smokers and hypertensives. Eur. Respir. J.7(3), 467–471 (1994).
  • Silkoff PE, Wakita S, Chatkin J et al. Exhaled nitric oxide after beta2-agonist inhalation and spirometry in asthma. Am. J. Respir. Crit. Care Med.159(3), 940–944 (1999).
  • de Gouw HW, Hendriks J, Woltman AM, Twiss IM, Sterk PJ. Exhaled nitric oxide (NO) is reduced shortly after bronchoconstriction to direct and indirect stimuli in asthma. Am. J. Respir. Crit. Care Med.158(1), 315–319 (1998).
  • Gabriele C, Pijnenburg MW, Monti F, Hop W, Bakker ME, de Jongste JC. The effect of spirometry and exercise on exhaled nitric oxide in asthmatic children. Pediatr. Allergy Immunol.16(3), 243–247 (2005).
  • Abba AA. Exhaled nitric oxide in diagnosis and management of respiratory diseases. Ann. Thorac. Med.4(4), 173–181 (2009).
  • Mattes J, Storm van’s Gravesande K, Moeller C, Moseler M, Brandis M, Kuehr J. Circadian variation of exhaled nitric oxide and urinary eosinophil protein X in asthmatic and healthy children. Pediatr. Res.51(2), 190–194 (2002).
  • Oguzulgen IK, Turktas H, Erbas D. Airway inflammation in premenstrual asthma. J. Asthma39(6), 517–522 (2002).
  • Morris NH, Sooranna SR, Steer PJ, Warren JB. The effect of the menstrual cycle on exhaled nitric oxide and urinary nitrate concentration. Eur. J. Clin. Invest.26(6), 481–484 (1996).
  • Johannesson M, Ludviksdottir D, Janson C. Lung function changes in relation to menstrual cycle in females with cystic fibrosis. Respir. Med.94(11), 1043–1046 (2000).
  • Kharitonov SA, Yates DH, Barnes PJ. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am. J. Respir. Crit. Care Med.153(1), 454–457 (1996).
  • Bisgaard H, Loland L, Oj JA. NO in exhaled air of asthmatic children is reduced by the leukotriene receptor antagonist montelukast. Am. J. Respir. Crit. Care Med.160(4), 1227–1231 (1999).
  • Kharitonov SA, Lubec G, Lubec B, Hjelm M, Barnes PJ. L-arginine increases exhaled nitric oxide in normal human subjects. Clin. Sci. (Lond.), 88(2), 135–139 (1995).
  • Mehta S, Stewart DJ, Levy RD. The hypotensive effect of L-arginine is associated with increased expired nitric oxide in humans. Chest109(6), 1550–1555 (1996).
  • Marczin N, Riedel B, Royston D, Yacoub M. Intravenous nitrate vasodilators and exhaled nitric oxide. Lancet349(9067), 1742 (1997).
  • Silkoff PE, Romero FA, Gupta N, Townley RG, Milgrom H. Exhaled nitric oxide in children with asthma receiving Xolair (omalizumab), a monoclonal anti-immunoglobulin E antibody. Pediatrics113(4), e308–e312 (2004).
  • Ashutosh K. Nitric oxide and asthma: a review. Curr. Opin. Pulm. Med.6(1), 21–25 (2000).
  • Silkoff PE, McClean PA, Slutsky AS et al. Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. Am. J. Respir. Crit. Care Med.155(1), 260–267 (1997).
  • Tsoukias NM, Tannous Z, Wilson AF, George SC. Single-exhalation profiles of NO and CO2 in humans: effect of dynamically changing flow rate. J. Appl. Physiol.85(2), 642–652 (1998).
  • Tsoukias NM, George SC. A two-compartment model of pulmonary nitric oxide exchange dynamics. J. Appl. Physiol.85(2), 653–666 (1998).
  • Jorres RA. Modelling the production of nitric oxide within the human airways. Eur. Respir. J.16(3), 555–560 (2000).
  • Shin HW, Condorelli P, George SC. Examining axial diffusion of nitric oxide in the lungs using heliox and breath hold. J. Appl. Physiol.100(2), 623–630 (2006).
  • Condorelli P, Shin HW, Aledia AS, Silkoff PE, George SC. A simple technique to characterize proximal and peripheral nitric oxide exchange using constant flow exhalations and an axial diffusion model. J. Appl. Physiol.102(1), 417–425 (2007).
  • Green RH, Brightling CE, McKenna S et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet360(9347), 1715–1721 (2002).
  • Little SA, Chalmers GW, MacLeod KJ, McSharry C, Thomson NC. Non-invasive markers of airway inflammation as predictors of oral steroid responsiveness in asthma. Thorax55(3), 232–234 (2000).
  • Jayaram L, Pizzichini MM, Cook RJ et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur. Respir. J.27(3), 483–494 (2006).
  • Petsky HL, Cates CJ, Lasserson TJ et al. A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils). Thorax doi:10.1136/thx.2010.135574 (2010) (Epub ahead of print).
  • Berry MA, Shaw DE, Green RH, Brightling CE, Wardlaw AJ, Pavord ID. The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma. Clin. Exp. Allergy35(9), 1175–1179 (2005).
  • Brown HM. Treatment of chronic asthma with prednisolone; significance of eosinophils in the sputum. Lancet2(7059), 1245–1247 (1958).
  • Massaro AF, Gaston B, Kita D, Fanta C, Stamler JS, Drazen JM. Expired nitric oxide levels during treatment of acute asthma. Am. J. Respir. Crit. Care Med.152(2), 800–803 (1995).
  • Jones SL, Kittelson J, Cowan JO et al. The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. Am. J. Respir. Crit. Care Med.164(5), 738–743 (2001).
  • Kharitonov SA, Yates DH, Chung KF, Barnes PJ. Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients. Eur. Respir. J.9(2), 196–201 (1996).
  • Green RH, Brightling CE, McKenna S et al. Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness. Eur. Respir. J.27(6), 1144–1151 (2006).
  • Gelb AF, Flynn Taylor C, Shinar CM, Gutierrez C, Zamel N. Role of spirometry and exhaled nitric oxide to predict exacerbations in treated asthmatics. Chest129(6), 1492–1499 (2006).
  • van Veen IH, Ten Brinke A, Sterk PJ et al. Exhaled nitric oxide predicts lung function decline in difficult-to-treat asthma. Eur. Respir. J.32(2), 344–349 (2008).
  • Jones SL, Herbison P, Cowan JO et al. Exhaled NO and assessment of anti-inflammatory effects of inhaled steroid: dose–response relationship. Eur. Respir. J.20(3), 601–608 (2002).
  • Ghiro L, Zanconato S, Rampon O, Piovan V, Pasquale MF, Baraldi E. Effect of montelukast added to inhaled corticosteroids on fractional exhaled nitric oxide in asthmatic children. Eur. Respir. J.20(3), 630–634 (2002).
  • Beck-Ripp J, Griese M, Arenz S, Koring C, Pasqualoni B, Bufler P. Changes of exhaled nitric oxide during steroid treatment of childhood asthma. Eur. Respir. J.19(6), 1015–1019 (2002).
  • Szefler SJ, Mitchell H, Sorkness CA et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet372(9643), 1065–1072 (2008).
  • de Jongste JC, Carraro S, Hop WC, Baraldi E. Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. Am. J. Respir. Crit. Care Med.179(2), 93–97 (2009).
  • Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N.Engl. J. Med.352(21), 2163–2173 (2005).
  • Fritsch M, Uxa S, Horak F Jr et al. Exhaled nitric oxide in the management of childhood asthma: a prospective 6-months study. Pediatr. Pulmonol.41(9), 855–862 (2006).
  • Shaw DE, Berry MA, Thomas M et al. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am. J. Respir. Crit. Care Med.176(3), 231–237 (2007).
  • Pijnenburg MW, Bakker EM, Hop WC, De Jongste JC. Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. Am. J. Respir. Crit. Care Med.172(7), 831–836 (2005).
  • Petsky HL, Cates CJ, Li A, Kynaston JA, Turner C, Chang AB. Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults. Cochrane Database Syst. Rev. (4), CD006340 (2009).
  • Gibson PG. Using fractional exhaled nitric oxide to guide asthma therapy: design and methodological issues for ASthma TReatment ALgorithm studies. Clin. Exp. Allergy39(4), 478–490 (2009).
  • Powell H, Murphy VE, Taylor DR et al. Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. Lancet378(9795), 983–990 (2011).
  • Taylor DR, Pijnenburg MW, Smith AD, De Jongste JC. Exhaled nitric oxide measurements: clinical application and interpretation. Thorax61(9), 817–827 (2006).
  • Sandrini A, Taylor DR, Thomas PS, Yates DH. Fractional exhaled nitric oxide in asthma: an update. Respirology15(1), 57–70 (2010).
  • Smith AD, Cowan JO, Taylor DR. Exhaled nitric oxide levels in asthma: personal best versus reference values. J. Allergy Clin. Immunol.124(4), 714–718 e4 (2009).
  • Pijnenburg MW, Hofhuis W, Hop WC, De Jongste JC. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax60(3), 215–218 (2005).
  • Zacharasiewicz A, Wilson N, Lex C et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am. J. Respir. Crit. Care Med.171(10), 1077–1082 (2005).
  • Pedrosa M, Cancelliere N, Barranco P, Lopez-Carrasco V, Quirce S. Usefulness of exhaled nitric oxide for diagnosing asthma. J. Asthma47(7), 817–821 (2010).
  • Dupont LJ, Demedts MG, Verleden GM. Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma. Chest123(3), 751–756 (2003).
  • Smith AD, Cowan JO, Filsell S et al. Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am. J. Respir. Crit. Care Med.169(4), 473–478 (2004).
  • Cordeiro D, Rudolphus A, Snoey E, Braunstahl GJ. Utility of nitric oxide for the diagnosis of asthma in an allergy clinic population. Allergy Asthma Proc.32(2), 119–126 (2011).
  • Malmberg LP, Pelkonen AS, Haahtela T, Turpeinen M. Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma. Thorax58(6), 494–499 (2003).
  • Prasad A, Langford B, Stradling JR, Ho LP. Exhaled nitric oxide as a screening tool for asthma in school children. Respir. Med.100(1), 167–173 (2006).
  • Thomas PS, Gibson PG, Wang H, Shah S, Henry RL. The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children. J. Asthma42(4), 291–295 (2005).
  • Sivan Y, Gadish T, Fireman E, Soferman R. The use of exhaled nitric oxide in the diagnosis of asthma in school children. J. Pediatr.155(2), 211–216 (2009).
  • D’Silva L, Cook RJ, Allen CJ, Hargreave FE, Parameswaran K. Changing pattern of sputum cell counts during successive exacerbations of airway disease. Respir. Med.101(10), 2217–2220 (2007).
  • Gibson PG, Dolovich J, Denburg J, Ramsdale EH, Hargreave FE. Chronic cough: eosinophilic bronchitis without asthma. Lancet1(8651), 1346–1348 (1989).
  • Birring SS, Berry M, Brightling CE, Pavord ID. Eosinophilic bronchitis: clinical features, management and pathogenesis. Am. J. Respir. Med.2(2), 169–173 (2003).
  • Stankiewicz JA, Chow JM. A diagnostic dilemma for chronic rhinosinusitis: definition accuracy and validity. Am. J. Rhinol.16(4), 199–202 (2002).
  • Tahamiler R, Canakcioglu S, Ogreden S, Acioglu E. The accuracy of symptom-based definition of chronic rhinosinusitis. Allergy62(9), 1029–1032 (2007).
  • Rolla G, Guida G, Heffler E et al. Diagnostic classification of persistent rhinitis and its relationship to exhaled nitric oxide and asthma: a clinical study of a consecutive series of patients. Chest131(5), 1345–1352 (2007).
  • Guida G, Rolla G, Badiu I et al. Determinants of exhaled nitric oxide in chronic rhinosinusitis. Chest137(3), 658–664 (2010).
  • Heffler E, Guida G, Marsico P et al. Exhaled nitric oxide as a diagnostic test for asthma in rhinitic patients with asthmatic symptoms. Respir. Med.100(11), 1981–1987 (2006).
  • Beg MF, Alzoghaibi MA, Abba AA, Habib SS. Exhaled nitric oxide in stable chronic obstructive pulmonary disease. Ann. Thorac. Med.4(2), 65–70 (2009).
  • Ansarin K, Chatkin JM, Ferreira IM, Gutierrez CA, Zamel N, Chapman KR. Exhaled nitric oxide in chronic obstructive pulmonary disease: relationship to pulmonary function. Eur. Respir. J.17(5), 934–938 (2001).
  • Brindicci C, Ito K, Resta O, Pride NB, Barnes PJ, Kharitonov SA. Exhaled nitric oxide from lung periphery is increased in COPD. Eur. Respir. J.26(1), 52–59 (2005).
  • Rutgers SR, van der Mark TW, Coers W et al. Markers of nitric oxide metabolism in sputum and exhaled air are not increased in chronic obstructive pulmonary disease. Thorax54(7), 576–580 (1999).
  • Robbins RA, Floreani AA, Von Essen SG et al. Measurement of exhaled nitric oxide by three different techniques. Am. J. Respir. Crit. Care Med.153(5), 1631–1635 (1996).
  • Clini E, Bianchi L, Pagani M, Ambrosino N. Endogenous nitric oxide in patients with stable COPD: correlates with severity of disease. Thorax53(10), 881–883 (1998).
  • Papi A, Romagnoli M, Baraldo S et al. Partial reversibility of airflow limitation and increased exhaled NO and sputum eosinophilia in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med.162(5), 1773–1777 (2000).
  • Kunisaki KM, Rice KL, Janoff EN, Rector TS, Niewoehner DE. Exhaled nitric oxide, systemic inflammation, and the spirometric response to inhaled fluticasone propionate in severe chronic obstructive pulmonary disease: a prospective study. Ther. Adv. Respir. Dis.2(2), 55–64 (2008).
  • Siva R, Green RH, Brightling CE et al. Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial. Eur. Respir. J.29(5), 906–913 (2007).
  • Lehouck A, Carremans C, De Bent K, Decramer M, Janssens W. Alveolar and bronchial exhaled nitric oxide in chronic obstructive pulmonary disease. Respir. Med.104(7), 1020–1026 (2010).
  • Dummer JF, Epton MJ, Cowan JO et al. Predicting corticosteroid response in chronic obstructive pulmonary disease using exhaled nitric oxide. Am. J. Respir. Crit. Care Med.180(9), 846–852 (2009).
  • Paraskakis E, Zihlif N, Bush A. Nitric oxide production in PCD: possible evidence for differential nitric oxide synthase function. Pediatr. Pulmonol.42(10), 876–880 (2007).
  • Loukides S, Kharitonov S, Wodehouse T, Cole PJ, Barnes PJ. Effect of arginine on mucociliary function in primary ciliary dyskinesia. Lancet352(9125), 371–372 (1998).
  • Karadag B, James AJ, Gultekin E, Wilson NM, Bush A. Nasal and lower airway level of nitric oxide in children with primary ciliary dyskinesia. Eur. Respir. J.13(6), 1402–1405 (1999).
  • Narang I, Ersu R, Wilson NM, Bush A. Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance. Thorax57(7), 586–589 (2002).
  • Corbelli R, Bringolf-Isler B, Amacher A, Sasse B, Spycher M, Hammer J. Nasal nitric oxide measurements to screen children for primary ciliary dyskinesia. Chest126(4), 1054–1059 (2004).
  • Baraldi E, Azzolin NM, Cracco A, Zacchello F. Reference values of exhaled nitric oxide for healthy children 6–15 years old. Pediatr. Pulmonol.27(1), 54–58 (1999).
  • Wodehouse T, Kharitonov SA, Mackay IS, Barnes PJ, Wilson R, Cole PJ. Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia. Eur. Respir. J.21(1), 43–47 (2003).
  • Marthin JK, Nielsen KG. Choice of nasal nitric oxide technique as first-line test for primary ciliary dyskinesia. Eur. Respir. J.37(3), 559–565 (2011).
  • Heresi GA, Dweik RA. Pulmonary hypertension: evaluation and management. Compr. Ther.33(3), 150–161 (2007).
  • Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature327(6122), 524–526 (1987).
  • Dweik RA. The lung in the balance: arginine, methylated arginines, and nitric oxide. Am. J. Physiol. Lung Cell Mol. Physiol.292(1), L15–L17 (2007).
  • Clini E, Cremona G, Campana M et al. Production of endogenous nitric oxide in chronic obstructive pulmonary disease and patients with cor pulmonale. Correlates with echo-Doppler assessment. Am. J. Respir. Crit. Care Med.162(2 Pt 1), 446–450 (2000).
  • Ozkan M, Dweik RA, Laskowski D, Arroliga AC, Erzurum SC. High levels of nitric oxide in individuals with pulmonary hypertension receiving epoprostenol therapy. Lung179(4), 233–243 (2001).
  • de Winter-de Groot KM, van der Ent CK. Nitric oxide in cystic fibrosis. J. Cyst. Fibros.4(Suppl. 2), 25–29 (2005).
  • Ho LP, Innes JA, Greening AP. Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide. Thorax53(8), 680–684 (1998).
  • Jones KL, Bryan TW, Jinkins PA et al. Superoxide released from neutrophils causes a reduction in nitric oxide gas. Am. J. Physiol.275(6 Pt 1), L1120–L1126 (1998).
  • Grasemann H, Kurtz F, Ratjen F. Inhaled L-arginine improves exhaled nitric oxide and pulmonary function in patients with cystic fibrosis. Am. J. Respir. Crit. Care Med.174(2), 208–212 (2006).
  • Grasemann H, Schwiertz R, Grasemann C, Vester U, Racke K, Ratjen F. Decreased systemic bioavailability of L-arginine in patients with cystic fibrosis. Respir. Res.7, 87 (2006).
  • Kelley TJ, Drumm ML. Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells. J. Clin. Invest.102(6), 1200–1207 (1998).
  • Meng QH, Springall DR, Bishop AE et al. Lack of inducible nitric oxide synthase in bronchial epithelium: a possible mechanism of susceptibility to infection in cystic fibrosis. J. Pathol.184(3), 323–331 (1998).
  • Grasemann H, Knauer N, Buscher R, Hubner K, Drazen JM, Ratjen F. Airway nitric oxide levels in cystic fibrosis patients are related to a polymorphism in the neuronal nitric oxide synthase gene. Am. J. Respir. Crit. Care Med.162(6), 2172–2176 (2000).
  • Wooldridge JL, Deutsch GH, Sontag MK et al. NO pathway in CF and non-CF children. Pediatr. Pulmonol.37(4), 338–350 (2004).
  • Antus B, Csiszer E, Czebe K, Horvath I. Pulmonary infections increase exhaled nitric oxide in lung transplant recipients: a longitudinal study. Clin. Transplant.19(3), 377–382 (2005).
  • Silkoff PE, Caramori M, Tremblay L et al. Exhaled nitric oxide in human lung transplantation. A noninvasive marker of acute rejection. Am. J. Respir. Crit. Care Med.157(6 Pt 1), 1822–1828 (1998).
  • Burton CM, Carlsen J, Mortensen J, Andersen CB, Milman N, Iversen M. Long-term survival after lung transplantation depends on development and severity of bronchiolitis obliterans syndrome. J. Heart Lung Transplant.26(7), 681–686 (2007).
  • Gabbay E, Walters EH, Orsida B et al. Post-lung transplant bronchiolitis obliterans syndrome (BOS) is characterized by increased exhaled nitric oxide levels and epithelial inducible nitric oxide synthase. Am. J. Respir. Crit. Care Med.162(6), 2182–2187 (2000).
  • Neurohr C, Huppmann P, Leuschner S et al. Usefulness of exhaled nitric oxide to guide risk stratification for bronchiolitis obliterans syndrome after lung transplantation. Am. J. Transplant.11(1), 129–137 (2011).
  • Yates DH, Krishnan A, Chow S, Thomas PS. Non-invasive assessment of exhaled biomarkers in lung transplantation. J. Breath Res.5(2), 024001 (2011).

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