References
- Govindan R, Page N, Morgensztern D et al. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years, analysis of the surveillance, epidemiologic, and end results database. J. Clin. Oncol.24(28), 4539–4544 (2006).
- Felip E, Gridelli C, Baas P, Rosell R, Stahel R. Metastatic non-small-cell lung cancer, consensus on pathology and molecular tests, first-line, second-line, and third-line therapy, 1st ESMO Consensus Conference in lung cancer; Lugano 2010. Ann. Oncol.22(7), 1507–1519 (2011).
- Stahel R, Thatcher N, Früh M et al. 1st ESMO Consensus Conference in lung cancer; Lugano 2010, small-cell lung cancer. Ann. Oncol.22(9), 1973–1980 (2011).
- Sateren WB, Trimble EL, Abrams J et al. How sociodemographics, presence of oncology specialists, and hospital cancer programs affect accrual to cancer treatment trials. J. Clin. Oncol.20(8), 2109–2117 (2002).
- Shepherd FA, Dancey J, Ramlau R et al. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J. Clin. Oncol.18(10), 2085–2103 (2000).
- Fossella FV, DeVore R, Kerr RN et al. Randomized Phase 3 trial of docetaxel versus vinorelbine or ifosfamide in patients with non-small cell lung cancer previously treated with platinum-containing chemotherapy regimens. J. Clin. Oncol.18(12), 2354–2362 (2000).
- Hanna N, Shepherd FA, Fossella FV et al. Randomized Phase 3 trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J. Clin. Oncol.22, 1589–1597 (2004).
- Shepherd FA, Rodrigues Pereira J, Ciuleanu T et al. Erlotinib in previously treated non-small cell lung cancer. N. Engl. J. Med.353, 123–132 (2005).
- Thatcher N, Chang A, Parikh P et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer, results from a randomised, placebo-controlled, multicentre study (Iressa survival evaluation in lung cancer). Lancet366, 1527–1537 (2005).
- Kim ES, Hirsh V, Mok T et al. Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST), a randomised Phase 3 trial. Lancet327(9652), 1809–1818 (2008).
- Sandler A, Gray R, Perry MC et al. Paclitaxel–carboplatin alone or with bevacizumab for non-small-cell lung cancer. N. Engl. J. Med.355(24), 2542–2550 (2006).
- Reck M, von Pawel J, Zatloukal P et al. Phase 3 trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer, AVAil. J. Clin. Oncol.27(8), 1227–1234 (2009).
- Scagliotti GV, Parikh P, von Pawel J et al. Phase 3 study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J. Clin. Oncol.26(21), 3543–3551 (2008).
- Pirker R, Pereira JR, Szczesna A et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX), an open-label randomized Phase 3 trial. Lancet373(9674), 1525–1531 (2009).
- Mok TS, Wu YL, Thongprasert S et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N. Engl. J. Med.361(10), 947–957 (2009).
- Maemondo M, Inoue A, Kobayashi K et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N. Engl. J. Med.362(25), 2380–2388 (2010).
- Mitsudomi T, Morita S, Yatabe Y et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harboring mutations of the epidermal growth factor receptor (WJTOG3405), an open label, randomised Phase 3 trial. Lancet Oncol.11(2), 121–128 (2010).
- Zhou C, Wu TL, Chen G et al. Erlotinib versus chemotherapy as first-line therapy for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802), a multicentre, open-label, randomised, Phase 3 study. Lancet Oncol.12(8), 735–742 (2011).
- Rosell R, Carcereny E, Gervais R et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC), a multicentre, open-label, randomised Phase 3 trial. Lancet Oncol.13(3), 239–246 (2012).
- Ciuleanu T, Brodowicz T, Zielinski C et al. Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer, a randomised, double-blind, Phase 3 study. Lancet374(9699), 1432–1440 (2009).
- Cappuzzo F, Ciuleanu T, Stelmakh L et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer, a multicentre, randomised, placebo-controlled Phase 3 study. Lancet Oncol.11(6), 521–529 (2010).
- Paz-Ares L, de Marinis F, Dediu M et al. Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer (PARAMOUNT): a double-blind, Phase 3, randomised controlled trial. Lancet Oncol.13(3), 247–255 (2012).
- Owonikoko TK, Ragin CC, Belani CP et al. Lung cancer in elderly patients, an analysis of the surveillance, epidemiology, and end results database. J. Clin. Oncol.25(35), 5570–5577 (2007).
- Brahmer JR, Dahlberg SE, Gray RJ et al. Sex differences in outcome with bevacizumab therapy, analysis of patients with advanced-stage non-small cell lung cancer treated with or without bevacizumab in combination with paclitaxel and carboplatin in the Eastern Cooperative Oncology Group trial 4599. J. Thorac. Oncol.6(1), 103–108 (2011).
- Reck M, von Pawel J, Zatloukal P et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer, results from a randomised Phase 3 trial (AVAiL). Ann. Oncol.21(9), 1804–1809 (2010).
- Lynch TJ, Patel T, Dreisbach L et al. Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer, results of the randomized multicenter Phase 3 trial BMS099. J. Clin. Oncol.28(6), 911–917 (2010).
- Mountain JL, Cavalli-Sforza LL. Multilocus genotypes, a tree of individuals, and human evolutionary history. Am. J. Hum. Genet.61(3), 705–718 (1997).
- Goodman AH. Why genes don’t count (for racial differences in health). Am. J. Public Health90(11), 1699–1702 (2000).
- Hanna N, Bunn PA, Langer C et al. Randomized Phase 3 trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer. J. Clin. Oncol.24(13), 2038–2043 (2006).
- Beutler E, Gelbart E, Demina A. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promote; a balanced polymorphism for regulation of bilirubin metabolism? Proc. Natl Acad. Sci. USA95(14), 8170–8174 (1998).
- Font A, Sanchez JM, Taron M et al. Weekly regimen of irinotecan/docetaxel in previously treated non-small cell lung cancer patients and correlation with uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) polymorphism. Invest. New Drugs21(4), 435–443 (2003).
- Wojnowski L, Kulle B, Schirmer M et al. NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Circulation112(24), 3754–3762 (2005).
- Kelsey KT, Ross D, Traver RD et al. Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. Br. J. Cancer76(7), 852–854 (1997).
- Yancik R. Population aging and cancer, a cross-national concern. Cancer J.11(6), 437–441 (2005).
- Yancik R, Ries LA. Cancer in older persons, an international issue in an aging world. Semin. Oncol.31(2), 128–136 (2004).
- Hutchins LF, Unger JM, Crowley JJ, Coltman CA, Albain KS. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N. Engl. J. Med.341(27), 2061–2067 (1999).
- Lewis JH, Kilgore ML, Goldman DP et al. Participation of patients 65 years of age or older in cancer clinical trials. J. Clin. Oncol.21(7), 1383–1389 (2003).
- Yee KW, Pater JL, Pho L, Zee B, Siu LL. Enrolment of older patients in cancer treatment trials in Canada, why is age a barrier? J. Clin. Oncol.21(8), 1618–1623 (2003).
- Talarico L, Chen G, Pazdur R. Enrolment of elderly patients in clinical trials for cancer drug registration, a 7-year experience by the US Food and Drug Administration. J. Clin. Oncol.22(22), 4626–4631 (2004).
- Balducci L. Geriatric oncology, challenges for the new century. Eur. J. Cancer36(14), 1741–1754 (2000).
- Extermann M, Overcash J, Lyman GH, Parr J, Balducci L. Comorbidity and functional status are independent in older cancer patients. J. Clin. Oncol.16(4), 1582–1587 (1998).
- Ganz PA, Lee JJ, Siau J. Quality of life assessment. An independent prognostic variable for survival in lung cancer. Cancer67(12), 3131–3135 (1991).
- Litchman SM, Villani G. Chemotherapy in the elderly, pharmacologic considerations. Cancer Control7(6), 548–556 (2000).
- Jatoi A, Hillman S, Stella P et al. Should elderly non-small-cell lung cancer patients be offered elderly-specific trials? Results of a pooled analysis from the North Central Cancer Treatment Group. J. Clin. Oncol.23(36), 9113–9119 (2005).
- Townsley CA, Selby R, Siu LL. Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials. J. Clin. Oncol.23(13), 3112–3124 (2005).
- Basche M, Baron A, Eckhardt SG et al. Barriers to enrollment of elderly adults in early-phase cancer clinical trials. J. Oncol. Pract.4(4), 162–168 (2008).
- Langer CJ, Vangel J, Schiller DP et al. Age-specific subanalysis of ECOG 1594, fit elderly patients (70–80 yrs) with NSCLC do as well as younger patients (<70). Presented at: 39th Annual Meeting of the American Society of Clinical Oncology. Chicago, IL, USA, 31 May–3 June 2003.
- Belani CP, Fossella F. Elderly subgroup analysis of a randomized Phase 3 study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for first-line treatment of advanced nonsmall cell lung carcinoma (TAX 326). Cancer104(12), 2766–2774 (2005).
- Ramalingam S, Perry MC, La Rocca RV et al. Comparison of outcomes for elderly patients treated with weekly paclitaxel in combination with carboplatin versus the standard 3-weekly paclitaxel and carboplatin for advanced nonsmall cell lung cancer. Cancer113(3), 542–546 (2008).
- Blanchard EM, Moon J, Hesketh PJ et al. Comparison of platinum-based chemotherapy in patients older and younger than 70 years, an analysis of Southwest Oncology Group trials 9308 and 9509. J. Thorac. Oncol.6(1), 115–120 (2011).
- Rossi A. Elderly patients with advanced non-small cell lung cancer, what treatment? Open Lung Cancer J.4, 4–9 (2011).
- Kawk EL, Bang YJ, Camidge DR et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N. Engl. J. Med.363(18), 1693–1703 (2010).
Websites
- GLOBOCAN 2008 Cancer fact sheets, lung cancer. http://globocan.iarc.fr/factsheets/cancers/lung.asp (Accessed on 30 November 2011).
- National Cancer Comprehensive Center. www.nccn.org (Accessed on 30 November 2011).
- Howlader N, Noone AM, Krapcho M et al. SEER Cancer Statistics Review, 1975–2008, National Cancer Institute. Bethesda, MD, USA. http://seer.cancer.gov/csr/1975_2008 (Accessed on 30 November 2011).