732
Views
28
CrossRef citations to date
0
Altmetric
Vaccine Profile

The new ACAM2000™ vaccine and other therapies to control orthopoxvirus outbreaks and bioterror attacks

, , , &
Pages 841-850 | Published online: 09 Jan 2014

References

  • Branda JA, Ruoff K. Bioterrorism. Clinical recognition and primary management. Am. J. Clin. Pathol.117(Suppl.), S116–S123 (2002).
  • Parker S, Nuara A, Buller RM, Schultz DA. Human monkeypox: an emerging zoonotic disease. Future Microbiol.2, 17–34 (2007).
  • Henderson DA, Borio LL, Lane JM. Smallpox and vaccinia. In: Vaccines. Plotkin SA, Orenstein WA (Eds). Elsevier Inc., PA, USA, 123–153 (2004).
  • Package insert. Acambis, Inc. ACAM2000 Smallpox (Vaccinia) Vaccine, Live (2008).
  • Murphy FA, Osburn BI. Adventitious agents and smallpox vaccine in strategic national stockpile. Emerg. Infect. Dis.11(7), 1086–1089 (2005).
  • Osborne JD, Da Silva M, Frace AM et al. Genomic differences of vaccinia virus clones from Dryvax smallpox vaccine: the Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3. Vaccine25(52), 8807–8832 (2007).
  • Kutinova L, Ludvikova V, Simonova V et al. Search for optimal parent for recombinant vaccinia virus vaccines. Study of three vaccinia virus vaccinal strains and several virus lines derived from them. Vaccine13(5), 487–493 (1995).
  • Weltzin R, Liu J, Pugachev KV et al. Clonal vaccinia virus grown in cell culture as a new smallpox vaccine. Nat. Med.9(9), 1125–1130 (2003).
  • Marennikova SS, Chimishkyan KL, Maltseva NN, Shelukhina EM, Fedorov VV. Proceedings of: The Symposium on Smallpox. Yugoslavia Academy of Sciences and Arts. Zagreb, Yugoslavia, 2–3 September 1969.
  • Marennikova SS. International Symposium on Smallpox Vaccine. Bilthoven, The Netherlands, 11–13 October 1972. Karger, Basel (1973).
  • Acambis, Inc. Investigator’s brochure for ACAM2000 smallpox vaccine. Cambridge, MA, USA (2002).
  • Monath TP, Caldwell JR, Mundt W et al. ACAM2000 clonal vero cell culture vaccinia virus (New York City Board of Health strain) – a second-generation smallpox vaccine for biological defense. Int. J. Infect. Dis.8(Suppl. 2), S31–S44 (2004).
  • Greenberg RN, Kennedy JS. ACAM2000: a newly licensed cell culture-based live vaccinia smallpox vaccine. Expert Opin. Investig. Drugs17(4), 555–564 (2008).
  • Acambis, Inc. ACAM2000 prescribing information (2009).
  • Acambis, Inc. ACAM2000 smallpox vaccine: Vaccines and Related Biological Products Advisory Committee (VRBPAC). FDA, CBER (2007).
  • Marriott KA, Parkinson CV, Morefield SI, Davenport R, Nichols R, Monath TP. Clonal vaccinia virus grown in cell culture fully protects monkeys from lethal monkeypox challenge. Vaccine26(4), 581–588 (2008).
  • Frey SE, Newman FK, Kennedy JS et al. Comparison of the safety and immunogenicity of ACAM1000, ACAM2000 and Dryvax in healthy vaccinia-naive adults. Vaccine27(10), 1637–1644 (2009).
  • Downie AW, McCarthy K. The antibody response in man following infection with viruses of the pox group. III. Antibody response in smallpox. J. Hyg. (Lond.)56(4), 479–487 (1958).
  • Downie AW, Saint VL, Goldstein L, Rao AR, Kempe CH. Antibody response in non-haemorrhagic smallpox patients. J. Hyg. (Lond.)67(4), 609–618 (1969).
  • Mack TM, Noble J Jr, Thomas DB. A prospective study of serum antibody and protection against smallpox. Am. J. Trop. Med. Hyg.21(2), 214–218 (1972).
  • Sarkar JK, Mitra AC, Mukherjee MK. The minimum protective level of antibodies in smallpox. Bull. World Health Organ.52(3), 307–311 (1975).
  • Artenstein AW, Johnson C, Marbury TC et al. A novel, cell culture-derived smallpox vaccine in vaccinia-naive adults. Vaccine23(25), 3301–3309 (2005).
  • Couch RB, Winokur P, Edwards KM et al. Reducing the dose of smallpox vaccine reduces vaccine-associated morbidity without reducing vaccination success rates or immune responses. J. Infect. Dis.195(6), 826–832 (2007).
  • Rosenthal S, Merchlinsky M, Chowdhury M. VRBPAC background document: ACAM2000 (live vaccinia virus smallpox vaccine). Vaccines and Related Biological Products Advisory Committee Meeting, 17 May 2007 (2008).
  • Galasso GJ, Mattheis MJ, Cherry JD et al. Clinical and serologic study of four smallpox vaccines comparing variations of dose and route of administration. Summary. J. Infect. Dis.135(1), 183–186 (1977).
  • Polak MF, Beunders BJ, Van Der Werff AR, Sanders EW, Van Klaveren J, Brans LM. A comparative study of clinical reaction observed after application of several smallpox vaccines in primary vaccination of young adults. Bull. World Health Organ.29, 311–322 (1963).
  • Lane JM, Ruben FL, Neff JM, Millar JD. Complications of smallpox vaccination, 1968. N. Engl. J. Med.281(22), 1201–1208 (1969).
  • Lane JM, Millar JD. Risks of smallpox vaccination complications in the United States. Am. J. Epidemiol.93(4), 238–240 (1971).
  • Lane JM, Ruben FL, Neff JM, Millar JD. Complications of smallpox vaccination, 1968: results of ten statewide surveys. J. Infect. Dis.122(4), 303–309 (1970).
  • Frey SE, Newman FK, Kennedy JS et al. Clinical and immunologic responses to multiple doses of IMVAMUNE (modified vaccinia Ankara) followed by Dryvax challenge. Vaccine25(51), 8562–8573 (2007).
  • Parrino J, McCurdy LH, Larkin BD et al. Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naive and vaccinia-immune individuals. Vaccine25(8), 1513–1525 (2007).
  • Grabenstein JD, Winkenwerder W Jr. US military smallpox vaccination program experience. JAMA289(24), 3278–3282 (2003).
  • Poland GA, Grabenstein JD, Neff JM. The US smallpox vaccination program: a review of a large modern era smallpox vaccination implementation program. Vaccine23(17–18), 2078–2081 (2005).
  • Arness MK, Eckart RE, Love SS et al. Myopericarditis following smallpox vaccination. Am. J. Epidemiol.160(7), 642–651 (2004).
  • Eckart RE, Shry EA, Jones SO, Atwood JE, Grabenstein JD. Comparison of clinical presentation of acute myocarditis following smallpox vaccination to acute coronary syndromes in patients <40 years of age. Am. J. Cardiol.95(10), 1252–1255 (2005).
  • Kenner J, Cameron F, Empig C, Jobes DV, Gurwith M. LC16m8: an attenuated smallpox vaccine. Vaccine24(47–48), 7009–7022 (2006).
  • Hirayama M. Smallpox vaccination in Japan. In: International Medical Foundation of Japan. Fukumi H (Ed.). Saunders, Tokyo, Japan, 113–124 (1975).
  • Wiser I, Balicer RD, Cohen D. An update on smallpox vaccine candidates and their role in bioterrorism related vaccination strategies. Vaccine25(6), 976–984 (2007).
  • Kidokoro M, Tashiro M, Shida H. Genetically stable and fully effective smallpox vaccine strain constructed from highly attenuated vaccinia LC16m8. Proc. Natl Acad. Sci. USA102(11), 4152–4157 (2005).
  • Saito T, Fujii T, Kanatani Y et al. Clinical and immunological response to attenuated tissue-cultured smallpox vaccine LC16m8. JAMA301(10), 1025–1033 (2009).
  • Coulibaly S, Bruhl P, Mayrhofer J, Schmid K, Gerencer M, Falkner FG. The nonreplicating smallpox candidate vaccines defective vaccinia Lister (dVV-L) and modified vaccinia Ankara (MVA) elicit robust long-term protection. Virology341(1), 91–101 (2005).
  • Empig C, Higgins K, Edghill-Smith Y, Silvera P. Attenuated smallpox vaccine LC16m8 protects cynomolgus monkeys from Lethal IV monkeypox-zaire challenge, Presented at: ASM-Biodefense Meeting. Washington, DC, USA, 17 February 2006.
  • Saijo M, Ami Y, Suzaki Y et al. LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox. J. Virol.80(11), 5179–5188 (2006).
  • Kenner JK, Gurwith M, Luck A et al. Safety and immunogenicity of attenuated smallpox vaccine, LC16m8: results from a Phase 2 study [poster 206E]. In: Proceedings of the 4th Annual American Society for Microbiology Biodefense Research Meeting. Washington, DC, USA, 17 February 2006.
  • Sutter G, Moss B. Nonreplicating vaccinia vector efficiently expresses recombinant genes. Proc. Natl Acad. Sci. USA89(22), 10847–10851 (1992).
  • Meyer H, Sutter G, Mayr A. Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence. J. Gen. Virol.72(Pt 5), 1031–1038 (1991).
  • Vollmar J, Arndtz N, Eckl KM et al. Safety and immunogenicity of IMVAMUNE, a promising candidate as a third generation smallpox vaccine. Vaccine24(12), 2065–2070 (2006).
  • Earl PL, Americo JL, Wyatt LS et al. Rapid protection in a monkeypox model by a single injection of a replication-deficient vaccinia virus. Proc. Natl Acad. Sci. USA105(31), 10889–10894 (2008).
  • Meseda CA, Garcia AD, Kumar A et al. Enhanced immunogenicity and protective effect conferred by vaccination with combinations of modified vaccinia virus Ankara and licensed smallpox vaccine Dryvax in a mouse model. Virology339(2), 164–175 (2005).
  • Ferrier-Rembert A, Drillien R, Tournier JN, Garin D, Crance JM. Short- and long-term immunogenicity and protection induced by non-replicating smallpox vaccine candidates in mice and comparison with the traditional 1st generation vaccine. Vaccine26(14), 1794–1804 (2008).
  • Staib C, Suezer Y, Kisling S, Kalinke U, Sutter G. Short-term, but not post-exposure, protection against lethal orthopoxvirus challenge after immunization with modified vaccinia virus Ankara. J. Gen. Virol.87(Pt 10), 2917–2921 (2006).
  • Wyatt LS, Earl PL, Eller LA, Moss B. Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challenge. Proc. Natl Acad. Sci. USA101(13), 4590–4595 (2004).
  • Samuelsson C, Hausmann J, Lauterbach H et al. Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection. J. Clin. Invest.118(5), 1776–1784 (2008).
  • Paran N, Yasemin S, Lustig S et al. Post-exposure immunization with vaccinia virus MVA or conventional Lister vaccine provides solid protection in murine model for human smallpox. J. Infect. Dis.199(1), 39–48 (2009).
  • Pharmaceutical Technology. Third generation smallpox vaccine (2008).
  • Fogg C, Lustig S, Whitbeck JC, Eisenberg RJ, Cohen GH, Moss B. Protective immunity to vaccinia virus induced by vaccination with multiple recombinant outer membrane proteins of intracellular and extracellular virions. J. Virol.78(19), 10230–10237 (2004).
  • Galmiche MC, Goenaga J, Wittek R, Rindisbacher L. Neutralizing and protective antibodies directed against vaccinia virus envelope antigens. Virology254(1), 71–80 (1999).
  • Lai CF, Gong SC, Esteban M. The purified 14-kilodalton envelope protein of vaccinia virus produced in Escherichia coli induces virus immunity in animals. J. Virol.65(10), 5631–5635 (1991).
  • Demkowicz WE, Maa JS, Esteban M. Identification and characterization of vaccinia virus genes encoding proteins that are highly antigenic in animals and are immunodominant in vaccinated humans. J. Virol.66(1), 386–398 (1992).
  • Davies DH, McCausland MM, Valdez C et al. Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice. J. Virol.79(18), 11724–11733 (2005).
  • Bell E, Shamim M, Whitbeck JC, Sfyroera G, Lambris JD, Isaacs SN. Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin. Virology325(2), 425–431 (2004).
  • Lawrence SJ, Lottenbach KR, Newman FK et al. Antibody responses to vaccinia membrane proteins after smallpox vaccination. J. Infect. Dis.196(2), 220–229 (2007).
  • Otero M, Calarota SA, Dai A, De Groot AS, Boyer JD, Weiner DB. Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy. Vaccine24(21), 4461–4470 (2006).
  • Pulford DJ, Gates A, Bridge SH, Robinson JH, Ulaeto D. Differential efficacy of vaccinia virus envelope proteins administered by DNA immunisation in protection of BALB/c mice from a lethal intranasal poxvirus challenge. Vaccine22(25–26), 3358–3366 (2004).
  • Hooper JW, Custer DM, Thompson E. Four-gene-combination DNA vaccine protects mice against a lethal vaccinia virus challenge and elicits appropriate antibody responses in nonhuman primates. Virology306(1), 181–195 (2003).
  • Hooper JW, Golden JW, Ferro AM, King AD. Smallpox DNA vaccine delivered by novel skin electroporation device protects mice against intranasal poxvirus challenge. Vaccine25(10), 1814–1823 (2007).
  • Hooper JW, Thompson E, Wilhelmsen C et al. Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox. J. Virol.78(9), 4433–4443 (2004).
  • Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID. Smallpox and its eradication. WHO, Geneva, Switzerland (1988).
  • Arita I. Smallpox vaccine and its stockpile in 2005. Lancet Infect. Dis.5(10), 647–652 (2005).
  • Government urged to stockpile smallpox vaccine. The Daily Yomiuri, 12 June (2005).
  • News Medical Net. Canada plans to acquire MVA-based smallpox vaccine (2008).
  • Cosma A, Nagaraj R, Staib et al. Evaluation of modified vaccinia virus Ankara as an alternative vaccine against smallpox in chronically HIV type 1-infected individuals undergoing HAART. AIDS Res. Hum. Retroviruses23(6), 782–793 (2007).
  • Quenelle DC, Buller RM, Parker S et al. Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice. Antimicrob Agents Chemother.51(2), 689–695 (2007).
  • Parker S, Schriewer J, Oberle C et al. Using biomarkers to stage disease progression in a lethal mousepox model treated with CMX001. Antivir. Ther.13(7), 863–873 (2008).
  • Mortimer PP. Can postexposure vaccination against smallpox succeed? Clin. Infect. Dis.36(5), 622–629 (2003).
  • Parker S, Oberle C, Hembrador E et al. Mousepox in the C57BL/6 strain provides a new model for evaluating anti-poxvirus therapies in mammals. Virology385(1), 11–21 (2008).
  • Parker S, Handley L, Buller R. Therapeutic and prophylactic drugs to treat orthopoxvirus infections. Future Virology3(6), 595–612 (2008).
  • Chen N, Li G, Liszewski MK et al. Virulence differences between monkeypoxvirus isolates from West Africa and the Congo basin. Virology340(1), 46–63 (2005).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.