51
Views
7
CrossRef citations to date
0
Altmetric
Key Paper Evaluation

Malaria vaccine efficacy: overcoming the helminth hurdle

, &
Pages 707-711 | Published online: 09 Jan 2014

References

  • WHO. World Malaria Report. WHO, Geneva, Switzerland (2009).
  • Vekemans J, Ballou WR. Plasmodium falciparum malaria vaccines in development. Expert Rev. Vaccines7(2), 223–240 (2008).
  • Mlambo G, Maciel J, Kumar N. Murine model for assessment of Plasmodium falciparum transmission-blocking vaccine using transgenic Plasmodium berghei parasites expressing the target antigen Pfs25. Infect. Immun.76(5), 2018–2024 (2008).
  • Lobo CA, Dhar R, Kumar N. Immunization of mice with DNA-based Pfs25 elicits potent malaria transmission-blocking antibodies. Infect. Immun.67(4), 1688–1693 (1999).
  • Vanderberg JP. Reflections on early malaria vaccine studies, the first successful human malaria vaccination, and beyond. Vaccine27(1), 2–9 (2009).
  • Hoffman SL, Billingsley PF, James E et al. Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria. Hum. Vaccines6(1), 97–106 (2010).
  • Schofield L, Villaquiran J, Ferreira A et al. γ interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites. Nature330(6149), 664–666 (1987).
  • Mwangi TW, Bethony JM, Brooker S. Malaria and helminth interactions in humans: an epidemiological viewpoint. Ann. Trop. Med. Parasitol.100(7), 551–570 (2006).
  • Turner JD, Jackson JA, Faulkner H et al. Intensity of intestinal infection with multiple worm species is related to regulatory cytokine output and immune hyporesponsiveness. J. Infect. Dis.197(8), 1204–1212 (2008).
  • Borkow G, Bentwich Z. Chronic parasite infections cause immune changes that could affect successful vaccination. Trends Parasitol.24(6), 243–245 (2008).
  • Markus MB, Fincham JE. Helminthiasis, bystander diseases and vaccines: analysis of interaction. Trends Parasitol.23(11), 517–519 (2007).
  • Troye-Blomberg M, Berzins K. Immune interactions in malaria co-infections with other endemic infectious diseases: implications for the development of improved disease interventions. Microbes Infect.10(9), 948–952 (2008).
  • Segura M, Matte C, Thawani N, Su Z, Stevenson MM. Modulation of malaria-induced immunopathology by concurrent gastrointestinal nematode infection in mice. Int. J. Parasitol.39(14), 1525–1532 (2009).
  • Hartgers FC, Yazdanbakhsh M. Co-infection of helminths and malaria: modulation of the immune responses to malaria. Parasite Immunol.28(10), 497–506 (2006).
  • Noland GS, Chowdhury DR, Urban JF Jr, Zavala F, Kumar N. Helminth infection impairs the immunogenicity of a Plasmodium falciparum DNA vaccine, but not irradiated sporozoites, in mice. Vaccine28(17), 2917–2923 (2010).
  • Liu Z, Liu Q, Pesce J et al. Requirements for the development of IL-4-producing T cells during intestinal nematode infections: what it takes to make a Th2 cell in vivo. Immunol. Rev.201, 57–74 (2004).
  • Patel N, Kreider T, Urban JF Jr, Gause WC. Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites. Int. J. Parasitol.39(1), 13–21 (2009).
  • Su Z, Segura M, Stevenson MM. Reduced protective efficacy of a blood-stage malaria vaccine by concurrent nematode infection. Infect. Immun.74(4), 2138–2144 (2006).
  • Marshall FA, Pearce EJ. Uncoupling of induced protein processing from maturation in dendritic cells exposed to a highly antigenic preparation from a helminth parasite. J. Immunol.181(11), 7562–7570 (2008).
  • Cooper PJ, Chico M, Sandoval C et al. Human infection with Ascaris lumbricoides is associated with suppression of the interleukin-2 response to recombinant cholera toxin B subunit following vaccination with the live oral cholera vaccine CVD 103-HgR. Infect. Immun.69(3), 1574–1580 (2001).
  • Roussilhon C, Brasseur P, Agnamey P, Perignon JL, Druilhe P. Understanding human–Plasmodium falciparum immune interactions uncovers the immunological role of worms. PLoS One5(2), e9309 (2010).
  • Jackson JA, Friberg IM, Bolch L et al. Immunomodulatory parasites and Toll-like receptor-mediated tumour necrosis factor a responsiveness in wild mammals. BMC Biol.7, 16 (2009).
  • Carvalho L, Sun J, Kane C et al. Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function. Immunology126(1), 28–34 (2009).
  • Harn DA, McDonald J, Atochina O, Da’dara AA. Modulation of host immune responses by helminth glycans. Immunol. Rev.230(1), 247–257 (2009).
  • Wammes LJ, Hamid F, Wiria AE et al. Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum. Eur. J. Immunol.40(2), 437–442 (2010).
  • Finney CA, Taylor MD, Wilson MS, Maizels RM. Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection. Eur. J. Immunol.37(7), 1874–1886 (2007).
  • Metwali A, Setiawan T, Blum AM et al. Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection. Am. J. Physiol. Gastrointest. Liver Physiol.291(2), G253–G259 (2006).
  • Tetsutani K, Ishiwata K, Ishida H et al. Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4+ CD25+ Foxp3+ Treg in mice. Eur. J. Immunol.39(10), 2822–2830 (2009).
  • Eziefula AC, Brown M. Intestinal nematodes: disease burden, deworming and the potential importance of co-infection. Curr. Opin. Infect. Dis.21(5), 516–522 (2008).
  • Elias D, Wolday D, Akuffo H et al. Effect of deworming on human T cell responses to mycobacterial antigens in helminth-exposed individuals before and after bacille Calmette-Guerin (BCG) vaccination. Clin. Exp. Immunol.123(2), 219–225 (2001).
  • Da’dara AA, Harn DA. Elimination of helminth infection restores HIV-1C vaccine-specific T cell responses independent of helminth-induced IL-10. Vaccine28(5), 1310–1317 (2010).
  • Conteh S, Chattopadhyay R, Anderson C, Hoffman SL. Plasmodium yoelii-infected A. stephensi inefficiently transmit malaria compared to intravenous route. PLoS One5(1), e8947 (2010).
  • Hoffman SL, Goh LM, Luke TC et al. Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. J. Infect. Dis.185(8), 1155–1164 (2002).
  • Chattopadhyay R, Conteh S, Li M et al. The effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine. Vaccine27(27), 3675–3680 (2009).
  • Overstreet MG, Cockburn IA, Chen YC, Zavala F. Protective CD8 T cells against Plasmodium liver stages: immunobiology of an ‘unnatural’ immune response. Immunol. Rev.225, 272–283 (2008).
  • O’Neal SE, Guimaraes LH, Machado PR et al. Influence of helminth infections on the clinical course of and immune response to Leishmania braziliensis cutaneous leishmaniasis. J. Infect. Dis.195(1), 142–148 (2007).
  • Harris JB, Podolsky MJ, Bhuiyan TR et al. Immunologic responses to Vibrio cholerae in patients co-infected with intestinal parasites in Bangladesh. PLoS Negl. Trop. Dis.3(3), e403 (2009).
  • Monteiro RV, Dietz JM, Raboy B et al. Parasite community interactions: Trypanosoma cruzi and intestinal helminths infecting wild golden lion tamarins Leontopithecus rosalia and golden-headed lion tamarins L. chrysomelas (Callitrichidae, L., 1766). Parasitol. Res.101(6), 1689–1698 (2007).
  • Cruz-Chan JV, Quijano-Hernandez I, Ramirez-Sierra MJ, Dumonteil E. Dirofilaria immitis and Trypanosoma cruzi natural co-infection in dogs. Vet. J. DOI:10.1016/j.tvjl.2009.09.012 (2010) (Epub ahead of print).
  • Beadling C, Slifka MK. How do viral infections predispose patients to bacterial infections? Curr. Opin. Infect. Dis.17(3), 185–191 (2004).
  • Dauby N, Alonso-Vega C, Suarez E et al. Maternal infection with Trypanosoma cruzi and congenital Chagas disease induce a trend to a type 1 polarization of infant immune responses to vaccines. PLoS Negl. Trop. Dis.3(12), e571 (2009).
  • Elias D, Akuffo H, Pawlowski A et al.Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis. Vaccine23(11), 1326–1334 (2005).
  • Urban JF Jr, Steenhard NR, Solano-Aguilar GI et al. Infection with parasitic nematodes confounds vaccination efficacy. Vet. Parasitol.148(1), 14–20 (2007).
  • Steenhard NR, Jungersen G, Kokotovic B et al.Ascaris suum infection negatively affects the response to a Mycoplasma hyopneumoniae vaccination and subsequent challenge infection in pigs. Vaccine27(37), 5161–5169 (2009).
  • Da’Dara AA, Lautsch N, Dudek T et al. Helminth infection suppresses T-cell immune response to HIV-DNA-based vaccine in mice. Vaccine24(24), 5211–5219 (2006).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.