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Editorial

ISCOM technology-based Matrix M™ adjuvant: success in future vaccines relies on formulation

, &
Pages 401-403 | Published online: 09 Jan 2014

References

  • Rajput ZI, Hu S, Xiao C, Arijo AG. Adjuvant effects of saponins on animal immune responses. J. Zhejiang Univ. Sci. B8(3), 153–161 (2007).
  • Waite DC, Jacobson EW, Ennis FA et al. Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21. Vaccine19, 3957–3967 (2001).
  • Morein B, Sundquist B, Höglund S, Dalsgaard K, Osterhaus A. ISCOM, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature308, 457–460 (1984).
  • Lövgren K, Morein B. The requirement of lipids for the formation of immunostimulating complexes (ISCOMs). Biotechnol. Appl. Biochem.10, 161–172 (1988).
  • Morein B, Lövgren Bengtsson K. Functional aspects of ISCOMs. Immunol. Cell. Biol.76(4), 295–299 (1998).
  • Takahashi H, Takeshita T, Morein B, Putney S, Germain RN, Berzofsky B. Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope proteins in ISCOMs. Nature344, 873–875 (1990).
  • van Binnendijk RS, van Baalen CA, Poelen MC et al. Measles virus transmembrane fusion protein synthesized de novo or presented in immunostimulating complexes is endogenously processed for HLA class I- and class II-restricted cytotoxic T cell recognition. J. Exp. Med.176(11), 119–128 (1992).
  • Heldens JG, Pouwels HG, Derks CG, Van de Zande SM, Hoeijmakers MJ. Duration of immunity induced by an equine influenza and tetanus combination vaccine formulation adjuvanted with ISCOM-Matrix. Vaccine28(43), 6989–6996 (2010).
  • McKenzie A, Watt M, Gittleson C. ISCOMATRIX™ vaccines: safety in human clinical studies. Hum. Vaccin.6(3), 237–246 (2010).
  • Madhun AS, Haaheim LR, Nilsen MV, Cox RJ. Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4+ cells and strong antibody responses in mice. Vaccine27(52), 7367–7376 (2009).
  • Cox R. H5N1 virosome vaccine development. Presented at: 6th WHO Meeting on Evaluation of Pandemic Influenza Vaccines in Clinical Trials. Geneva, Switzerland, 18–19 February 2010.

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