A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Therapeutic Effect of Magnesium-L-Threonate Supplementation for Persistent Pain After Breast Cancer Surgery

References

• Tait RC, Zoberi K, Ferguson M, et al. Persistent post-mastectomy pain: risk factors and current approaches to treatment. J Pain. 2018;19(12):1367–1383.
   PubMed Web of Science ®Google Scholar
• Monib S, Abdelaziz MI. Epidemiology and predictive factors for persistent breast pain following breast-conserving surgery. Cureus. 2021;13(3):e14063.
   PubMed Web of Science ®Google Scholar
• Lin ZM, Li MH, Zhang F, et al. Thoracic paravertebral blockade reduces chronic postsurgical pain in breast cancer patients: a randomized controlled trial. Pain Med. 2020;21(12):3539–3547.
   PubMed Web of Science ®Google Scholar
• Wang L, Cohen JC, Devasenapathy N, et al. Prevalence and intensity of persistent post-surgical pain following breast cancer surgery: a systematic review and meta-analysis of observational studies. Br J Anaesth. 2020;125(3):346–357.
   PubMed Web of Science ®Google Scholar
• Mercado LA, Liu R, Bharadwaj KM, et al. Association of intraoperative opioid administration with postoperative pain and opioid use. JAMA Surg. 2023;e232009.
   PubMed Web of Science ®Google Scholar
• Miaskowski C, Topp K, Conley YP, et al. Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors. J Neuroimmunol. 2019;335:577019.
   PubMed Web of Science ®Google Scholar
• Inquimbert P, Moll M, Latremoliere A, et al. NMDA receptor activation underlies the loss of spinal dorsal horn neurons and the transition to persistent pain after peripheral nerve injury. Cell Rep. 2018;23(9):2678–2689.
   PubMed Web of Science ®Google Scholar
• Deng M, Chen SR, Pan HL. Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain. Cell Mol Life Sci. 2019;76(10):1889–1899.
   PubMed Web of Science ®Google Scholar
• Kirkland AE, Sarlo GL, Holton KF. The role of magnesium in neurological disorders. Nutrients. 2018;10(6):730.
   PubMed Web of Science ®Google Scholar
• Cohen SP, Mao J. Neuropathic pain: mechanisms and their clinical implications. BMJ. 2014;348:f7656.
   PubMed Web of Science ®Google Scholar
• Khoury AL, Keane H, Varghese F, et al. Trigger point injection for post-mastectomy pain: a simple intervention with high rate of long-term relief. NPJ Breast Cancer. 2021;7(1):123.
   PubMed Web of Science ®Google Scholar
• Park R, Ho AM, Pickering G, Arendt-Nielsen L, Mohiuddin M, Gilron I. Efficacy and safety of magnesium for the management of chronic pain in adults: a systematic review. Anesth Analg. 2020;131(3):764–775.
   PubMed Web of Science ®Google Scholar
• Wroolie TE, Chen K, Watson KT, et al. An 8-week open label trial of l-Threonic Acid Magnesium Salt in patients with mild to moderate dementia. Personal Med Psychiat. 2017;4(6):7–12.
   Google Scholar
• Liu J, Chang L, Song Y, Li H, Wu Y. The Role of NMDA Receptors in Alzheimer’s Disease. Front Neurosci. 2019;13:43.
   PubMed Web of Science ®Google Scholar
• Chaigne-Delalande B, Li FY, O’Connor GM, et al. Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D. Science. 2013;341(6142):186–191.
   PubMed Web of Science ®Google Scholar
• Yang X, Zhu R, Zhang J, et al. First-in-human Phase I studies of YJ001 spray applied to local skin in healthy subjects and patients with diabetic neuropathic pain. Expert Opin Investig Drugs. 2023;1–10.
   PubMed Web of Science ®Google Scholar
• Schreiber KL, Zinboonyahgoon N, Flowers KM, et al. Prediction of Persistent Pain Severity and Impact 12 Months After Breast Surgery Using Comprehensive Preoperative Assessment of Biopsychosocial Pain Modulators. Ann Surg Oncol. 2021;28(9):5015–5038.
   PubMed Web of Science ®Google Scholar
• Vilholm OJ, Cold S, Rasmussen L, Sindrup SH. The postmastectomy pain syndrome: an epidemiological study on the prevalence of chronic pain after surgery for breast cancer. Br J Cancer. 2008;99(4):604–610.
   PubMed Web of Science ®Google Scholar
• Han R, Guo G, Ni Y, et al. Clinical efficacy of short-term peripheral nerve stimulation in management of facial pain associated with herpes zoster ophthalmicus. Front Neurosci. 2020;14:574713.
   PubMed Web of Science ®Google Scholar
• Khan JS, Ladha KS, Abdallah F, Clarke H. Treating persistent pain after breast cancer surgery. Drugs. 2020;80(1):23–31.
   PubMed Web of Science ®Google Scholar
• Harris SR, Schmitz KH, Campbell KL, McNeely ML. Clinical practice guidelines for breast cancer rehabilitation: syntheses of guideline recommendations and qualitative appraisals. Cancer. 2012;118(8 Suppl):2312–2324.
   PubMed Web of Science ®Google Scholar
• Redemski T, Hamilton DG, Schuler S, Liang R, Michaleff ZA. Rehabilitation for women undergoing breast cancer surgery: a systematic review and meta-analysis of the effectiveness of early, unrestricted exercise programs on upper limb function. Clin Breast Cancer. 2022;22(7):650–665.
   PubMed Web of Science ®Google Scholar
• Fornasari D. Pharmacotherapy for neuropathic pain: a review. Pain Ther. 2017;6(Suppl 1):25–33.
   PubMed Web of Science ®Google Scholar
• Chappell AG, Yuksel S, Sasson DC, Wescott AB, Connor LM, Ellis MF. Post-mastectomy pain syndrome: an up-to-date review of treatment outcomes. JPRAS Open. 2021;30:97–109.
   PubMedGoogle Scholar
• Birkinshaw H, Friedrich CM, Cole P, et al. Antidepressants for pain management in adults with chronic pain: a network meta-analysis. Cochrane Database Syst Rev. 2023;5(5):CD014682.
   PubMedGoogle Scholar
• de Miguel-Jimeno JM, Forner-Cordero I, Zabalza-Azparren M, Matute-Tobias B. Postmastectomy pain syndrome in our region: characteristics, treatment, and experience with gabapentin. Rev Neurol. 2016;62:258–266.
   PubMed Web of Science ®Google Scholar
• Carley ME, Chaparro LE, Choinière M, et al. Pharmacotherapy for the prevention of chronic pain after surgery in adults: an updated systematic review and meta-analysis. Anesthesiology. 2021;135(2):304–325.
   PubMed Web of Science ®Google Scholar
• Chaparro LE, Smith SA, Moore RA, Wiffen PJ, Gilron I. Pharmacotherapy for the prevention of chronic pain after surgery in adults. Cochrane Database Syst Rev. 2013;2013(7):CD008307.
   PubMedGoogle Scholar
• Morel V, Pickering ME, Goubayon J, Djobo M, Macian N, Pickering G. Magnesium for pain treatment in 2021? State of the art. Nutrients. 2021;13(5):1397.
   PubMed Web of Science ®Google Scholar
• Macian N, Dualé C, Voute M, et al. Short-term magnesium therapy alleviates moderate stress in patients with fibromyalgia: a randomized double-blind clinical trial. Nutrients. 2022;14(10):2088.
   PubMed Web of Science ®Google Scholar
• Xu T, Li D, Zhou X, et al. Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-α/Nuclear Factor-κB Signaling. Anesthesiology. 2017;126(6):1151–1168.
   PubMed Web of Science ®Google Scholar
• Van Dyk K, Ganz PA. Cancer-related cognitive impairment in patients with a history of breast cancer. JAMA. 2021;326(17):1736–1737.
   PubMed Web of Science ®Google Scholar
• Pickering G, Morel V, Simen E, et al. Oral magnesium treatment in patients with neuropathic pain: a randomized clinical trial. Magnes Res. 2011;24(2):28–35.
   PubMed Web of Science ®Google Scholar
• Brill S, Sedgwick PM, Hamann W, Di Vadi PP. Efficacy of intravenous magnesium in neuropathic pain. Br J Anaesth. 2002;89(5):711–714.
   PubMed Web of Science ®Google Scholar
• Felsby S, Nielsen J, Arendt-Nielsen L, Jensen TS. NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. Pain. 1996;64(2):283–291.
   PubMed Web of Science ®Google Scholar
• Pickering G, Pereira B, Morel V, et al. Ketamine and magnesium for refractory neuropathic pain: a randomized, double-blind, crossover trial. Anesthesiology. 2020;133(1):154–164.
   PubMed Web of Science ®Google Scholar
• Yousef AA, Al-deeb AE. A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component. Anaesthesia. 2013;68(3):260–266.
   PubMed Web of Science ®Google Scholar
• Fischer SG, Collins S, Boogaard S, Loer SA, Zuurmond WW, Perez RS. Intravenous magnesium for chronic complex regional pain syndrome type 1 (CRPS-1). Pain Med. 2013;14(9):1388–1399.
   PubMed Web of Science ®Google Scholar
• van der Plas AA, Schilder JC, Marinus J, van Hilten JJ. An explanatory study evaluating the muscle relaxant effects of intramuscular magnesium sulphate for dystonia in complex regional pain syndrome. J Pain. 2013;14(11):1341–1348.
   PubMed Web of Science ®Google Scholar
• Metcalfe KA, Candib A, Giannakeas V, et al. The relationship between the predicted risk of death and psychosocial functioning among women with early-stage breast cancer. Breast Cancer Res Treat. 2021;186(1):177–189.
   PubMed Web of Science ®Google Scholar
• Boehmer U, Ozonoff A, Winter M, et al. Anxiety and depression in colorectal cancer survivors: are there differences by sexual orientation? Psychooncology. 2022;31(3):521–531.
   PubMed Web of Science ®Google Scholar
• Kim J, Cho J, Lee SK, et al. Surgical impact on anxiety of patients with breast cancer: 12-month follow-up prospective longitudinal study. Ann Surg Treat Res. 2020;98(5):215–223.
   PubMed Web of Science ®Google Scholar
• Pasi M, Sugita L, Xiong L, et al. Association of cerebral small vessel disease and cognitive decline after intracerebral hemorrhage. Neurology. 2021;96(2):e182–e192.
   PubMed Web of Science ®Google Scholar
• Carroll JE, Van Dyk K, Bower JE, et al. Cognitive performance in survivors of breast cancer and markers of biological aging. Cancer. 2019;125(2):298–306.
   PubMed Web of Science ®Google Scholar
• Lo K, Liu Q, Madsen T, et al. Relations of magnesium intake to cognitive impairment and dementia among participants in the Women’s Health Initiative Memory Study: a prospective cohort study. BMJ Open. 2019;9(11):e030052.
   PubMed Web of Science ®Google Scholar
• Shin HJ, Na HS, Do SH. Magnesium and Pain. Nutrients. 2020;12(8):2184.
   PubMed Web of Science ®Google Scholar