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ORIGINAL RESEARCH

MCM-2 Levels as a Potential Biomarker for Predicting High-Risk Breast Cancer Patients According to TAILORx Classification

ORCID Icon, , , , , , , , , , , , , , & show all
Pages 659-669 | Received 17 May 2023, Accepted 11 Aug 2023, Published online: 01 Sep 2023

References

  • Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
  • International Agency for Research on Cancer GLOBOCAN. 2020 population fact sheets 3 2021 international agency for research on cancer. GLOBOCAN; 2021. Available from: https://gco.iarc.fr/today/data/factsheets/populations/792-turkey-fact-sheets.pdf. Accessed August 24, 2023.
  • Özmen V, Özmen T, Doğru V. Breast cancer in Turkey; an analysis of 20.000 patients with breast cancer. Eur J Breast Health. 2019;15(3):141. PMID: 31312788 PMCID: PMC6619786. doi:10.5152/ejbh.2019.4890
  • Howlader N, Altekruse SF, Li CI, et al. US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status. J Natl Cancer Inst. 2014;106(5):dju055. doi:10.1093/jnci/dju055
  • Neves H, Kwok HF. In sickness and in health: the many roles of the minichromosome maintenance proteins. Biochim Biophys Acta Rev Cancer. 2017;1868(1):295–308. doi:10.1016/j.bbcan.2017.06.001
  • Wang Y, Chen H, Zhang J, et al. MCM family in gastrointestinal cancer and other malignancies: from functional characterization to clinical implication. Biochim Biophys Acta. 2020;2020:1874.
  • Maiorano D, Lutzmann M, Mechali M. MCM proteins and DNA replication. Curr Opin Cell Biol. 2006;18:130–136. doi:10.1016/j.ceb.2006.02.006
  • Pruitt SC, Bailey KJ, Freeland A. Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer. Stem Cells. 2007;25:3121–3132. doi:10.1634/stemcells.2007-0483
  • Wu W, Wang X, Shan C, Li Y, Li F. Minichromosome maintenance protein 2 correlates with the malignant status and regulates proliferation and cell cycle in lung squamous cell carcinoma. Onco Targets Ther. 2018;11:5025–5034. doi:10.2147/OTT.S169002
  • Obermann Ellen C, Went P, Zimpfer A, et al. Expression of minichromosome maintenance protein 2 as a marker for proliferation and prognosis in diffuse large B-cell lymphoma: a tissue microarray and clinico-pathological analysis. BMC Cancer. 2005;5(1):1–8. doi:10.1186/1471-2407-5-1
  • Ramnath N, Hernandez FJ, Tan DF, et al. MCM2 is an independent predictor of survival in patients with nonsmall- cell lung cancer. J Clin Oncol. 2001;19:4259–4266. doi:10.1200/JCO.2001.19.22.4259
  • Issac MSM, Yousef E, Tahir MR, Gaboury LA. MCM2, MCM4, and MCM6 in breast cancer: clinical utility in diagnosis and prognosis. Neoplasia. 2019;21:1015–1035. doi:10.1016/j.neo.2019.07.011
  • Gonzalez MA, Pinder SE, Callagy G, et al. Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer. J Clin Oncol. 2003;21:4306–4313. doi:10.1200/JCO.2003.04.121
  • Chen R, Hu B, Jiang M, et al. Bioinformatic analysis of the expression and clinical significance of the DNA replication regulator MCM complex in bladder cancer. Int J Gen Med. 2022;Volume 15:5465–5485. doi:10.2147/IJGM.S368573
  • Zhou J, Wang M, Zhou Z, et al. Expression and prognostic value of MCM family genes in osteosarcoma. Front Mol Biosci. 2021;8:668402. doi:10.3389/fmolb.2021.668402
  • Lin CY, Wu HY, Hsu YL, et al. Suppression of drug-resistant non-small-cell lung cancer with inhibitors targeting minichromosomal maintenance protein. J Med Chem. 2020;63:3172–3187. doi:10.1021/acs.jmedchem.9b01783
  • Harris LN, Ismaila N, McShane LM, et al. Use of biomarkers to guide decisions on adjuvant systemic therapy for women with early-stage invasive breast cancer: American society of clinical oncology clinical practice guideline. J Clin Oncol. 2016;34(10):1134–1150. doi:10.1200/jco.2015.65.2289
  • Gradishar WJ, Anderson BO, Balassanian R, et al. Breast cancer, version 1 2016. J Natl Compr Canc Netw. 2015;13(12):1475–1485. doi:10.6004/jnccn.2015.0176
  • Henry NL, Somerfield MR, Abramson VG, et al. Role of patient and disease factors in adjuvant systemic therapy decision making for early-stage, operable breast cancer: American society of clinical oncology endorsement of cancer care Ontario guideline recommendations. J Clin Oncol. 2016;34(19):2303–2311. doi:10.1200/jco.2015.65.8609
  • Sparano Joseph A, Gray RJ, Makower DF, et al. Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer. N Engl J Med. 2018;379(2):111–121. doi:10.1056/NEJMoa1804710
  • Updated TAILORx results confirm women with intermediate recurrence score can skip chemotherapy. Available from: https://www.breastcancer.org/research-news/updated-tailorx-results-confirm-women-with-intermediate-recurrence-score-can-skip-chemotherapy. Accessed August 24, 2023.
  • Özmen V, Çakar B, Gökmen E, et al. Cost effectiveness of gene expression profiling in patients with early-stage breast cancer in a middle-income country, Turkey: results of a prospective multicenter study. Eur J Breast Health. 2019;15(3):183.
  • Ozmen V, Atasoy A, Gokmen E, et al. Correlations between Oncotype DX Recurrence Score and classic risk factors in early breast cancer: results of a prospective multicenter study in Turkey. J Breast Health. 2016;12:107–111. doi:10.5152/tjbh.2016.2874
  • Ozmen V, Atasoy A, Gokmen E, et al. Impact of Oncotype DX Recurrence Score on treatment decisions: results of a prospective multicenter study in Turkey. Cureus. 2016;8(3):30.
  • Panousis D, Ntasiou P, Grosomanidis D, et al. Impact of Oncotype DX on chemotherapy assignment: a retrospective single-center study on female breast cancer patients. therapy. 2017;15:20.
  • Thakur SS, Li H, Chan AMY, et al. The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancer. PLoS One. 2018;13(1):e0188983. doi:10.1371/journal.pone.0188983
  • Crager M, Wijayawardana SR, Gruver AM, et al. Population-based estimate for the correlation of the Oncotype DX Breast Recurrence Score® result and Ki-67 IHC MIB-1 pharmDx in HR+, HER2−, node-positive early breast cancer. Breast Cancer Res. 2022;24:1–7. doi:10.1186/s13058-022-01571-7
  • Pilanci KN, Unal C, Ordu C, et al. Correlation between clinicopathologic factors and recurrence score according to TAILOR x risk category in patients with hormone receptor positive early-stage breast cancer. J BU ON. 2021;2021:1.
  • Piccart M, Van’t Veer LJ, Poncet C, et al. 70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the Phase 3 randomised MINDACT trial with an exploratory analysis by age. Lancet Oncol. 2021;22(4):476–488. doi:10.1016/S1470-2045(21)00007-3
  • Andre F, Ismaila N, Allison KH, et al. Biomarkers for adjuvant endocrine and chemotherapy in early-stage breast cancer: ASCO guideline update. J Clin Oncol. 2022;40:1816–1837. doi:10.1200/JCO.22.00069
  • NCCN. NCCN clinical Practice guidelines in oncology V.2. Breast Cancer; 2023. Available from: https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf. Accessed February 7, 2023.].
  • Paik S, Tang G, Shak S, et al. Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. J Clin Oncol. 2006;24:3726–3734. doi:10.1200/JCO.2005.04.7985
  • Gluz O, Nitz UA, Christgen M, et al. West German study group phase III planb trial: first prospective outcome data for the 21-gene recurrence score assay and concordance of prognostic markers by central and local pathology assessment. J Clin Oncol. 2016;34:2341–2349. doi:10.1200/JCO.2015.63.5383
  • Tang G, Shak S, Paik S, et al. Comparison of the prognostic and predictive utilities of the 21-gene recurrence score assay and adjuvant! For women with node-negative, ER-positive breast cancer: results from NSABP B-14 and NSABP B-20. Breast Cancer Res Treat. 2011;127:133–142. doi:10.1007/s10549-010-1331-z
  • Lopez F, Belloc F, Lacombe F, et al. Modalities of synthesis of Ki67 antigen during the stimulation of lymphocytes. Cytometry. 1991;12:42–49. doi:10.1002/cyto.990120107
  • Gerdes J, Lemke H, Baisch H, et al. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol. 1984;133:1710–1715. doi:10.4049/jimmunol.133.4.1710
  • Van Dierendonck JH, Keijzer R, van de Velde CJ, et al. Nuclear distribution of the Ki-67 antigen during the cell cycle: comparison with growth fraction in human breast cancer cells. Cancer Res. 1989;49:2999–3006.
  • Clark BZ, Dabbs DJ, Cooper KL, Bhargava R, Thakur SS, Li H. Impact of progesterone receptor semiquantitative immunohistochemical result on Oncotype DX recurrence score: a quality assurance study of 1074 cases. Appl Immunohistochem Mol Morphol. 2013;21(4):287–291. doi:10.1097/PAI.0b013e31826f80c9
  • Park S, Han Y, Liu Y, et al. Adjuvant chemotherapy and survival among patients 70 years of age and younger with node-negative breast cancer and the 21-gene recurrence score of 26–30. Breast Cancer Res. 2019;21(1):1–11. doi:10.1186/s13058-019-1190-4
  • Mosley JD, Keri RA. Cell cycle correlated genes dictate the prognostic power of breast cancer gene lists. BMC Med Genomics. 2008;1:11. doi:10.1186/1755-8794-1-11
  • Heidebrecht HJ, Buck F, Haas K, et al. Monoclonal antibodies Ki-S3 and Ki-S5 yield new data on the ‘Ki-67’ proteins. Cell Prolif. 1996;29:413–425. doi:10.1111/j.1365-2184.1996.tb00984.x
  • Laskey R. The Croonian Lecture 2001 hunting the antisocial cancer cell: MCM proteins and their exploitation. Philos Trans R Soc Lond B Biol Sci. 2005;360:1119–1132. doi:10.1098/rstb.2005.1656
  • Joshi S, Watkins J, Gazinska P, et al. Digital imaging in the immunohistochemical evaluation of the proliferation markers Ki67, MCM2 and Geminin, in early breast cancer, and their putative prognostic value. BMC Cancer. 2015;15:1–12. doi:10.1186/s12885-015-1531-3
  • Wojnar A, Kobierzycki C, Krolicka A, et al. Correlation of Ki-67 and MCM-2 proliferative marker expression with grade of histological malignancy (G) in ductal breast cancers. Folia Histochem Cytobiol. 2010;48(3):442–446. doi:10.2478/v10042-010-0069-0
  • Shetty A, Loddo M, Fanshawe T, et al. DNA replication licensing and cell cycle kinetics of normal and neoplastic breast. Br J Cancer. 2005;93:1295–1300. doi:10.1038/sj.bjc.6602829
  • Tőkés T, Tőkés A-M, Szentmártoni G, et al. Prognostic and clinicopathological correlations of cell cycle marker expressions before and after the primary systemic therapy of breast cancer. Pathol Oncol Res. 2020;26:1499–1510. doi:10.1007/s12253-019-00726-w
  • Yousef EM, Furrer D, Laperriere DL, et al. MCM2: an alternative to Ki-67 for measuring breast cancer cell proliferation. Mod Pathol. 2017;30(5):682–697. doi:10.1038/modpathol.2016.231
  • Sakai H, Kimura H, Otsubo K, et al. Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma. Mol Clin Oncol. 2022;14:1–7.
  • Samad A, Haque F, Nain Z, et al. Computational assessment of MCM2 transcriptional expression and identification of the prognostic biomarker for human breast cancer. Heliyon. 2020;6(10):e05087. doi:10.1016/j.heliyon.2020.e05087
  • Loddo M, Kingsbury SR, Rashid M, et al. Cell-cycle-phase progression analysis identifies unique phenotypes of major prognostic and predictive significance in breast cancer. Br J Cancer. 2009;100:959–970. doi:10.1038/sj.bjc.6604924
  • Ünal Ç, Tunçer G, Çopur B, et al. Clinical and inflammation marker features of cancer patients with COVID-19: data of Istanbul, Turkey multicenter cancer patients (2020–2022). Curr Med Res Opin. 2023;39(7):987–996. doi:10.1080/03007995.2023.2223917
  • Kalelioglu T, Karamustafalioglu N, Emul M, et al. Detecting biomarkers associated with antipsychotic-induced extrapyramidal syndromes by using machine learning techniques. J Psychiatr Res. 2023;158:300–304. doi:10.1016/j.jpsychires.2023.01.003