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REVIEW

The Emerging Roles of Exosomal miRNAs in Breast Cancer Progression and Potential Clinical Applications

, ORCID Icon, ORCID Icon & ORCID Icon
Pages 825-840 | Received 13 Sep 2023, Accepted 08 Nov 2023, Published online: 15 Nov 2023

References

  • Loibl S, Poortmans P, Morrow M, Denkert C, Curigliano G. Breast cancer. Lancet. 2021;397(10286):1750–1769. doi:10.1016/S0140-6736(20)32381-3
  • Cao W, Chen HD, Yu YW, Li N, Chen WQ. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. Chin Med J. 2021;134(7):783–791. doi:10.1097/CM9.0000000000001474
  • Arnold M, Morgan E, Rumgay H, et al. Current and future burden of breast cancer: global statistics for 2020 and 2040. The Breast. 2022;66:15–23. doi:10.1016/j.breast.2022.08.010
  • von Arx C, De Placido P, Caltavituro A, et al. The evolving therapeutic landscape of trastuzumab-drug conjugates: future perspectives beyond HER2-positive breast cancer. Cancer Treat Rev. 2023;113:102500. doi:10.1016/j.ctrv.2022.102500
  • Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478):eaau6977. doi:10.1126/science.aau6977
  • Paskeh MDA, Entezari M, Mirzaei S, et al. Emerging role of exosomes in cancer progression and tumor microenvironment remodeling. J Hematol Oncol. 2022;15(1):83. doi:10.1186/s13045-022-01305-4
  • Yang E, Wang X, Gong Z, Yu M, Wu H, Zhang D. Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression. Signal Transduct Target Ther. 2020;5(1):242. doi:10.1038/s41392-020-00359-5
  • Fang Z, Ding Y, Xue Z, Li P, Li J, Li F. Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review. Discov Oncol. 2022;13(1):74. doi:10.1007/s12672-022-00539-5
  • Xu YX, Pu SD, Li X, et al. Exosomal ncRNAs: novel therapeutic target and biomarker for diabetic complications. Pharmacol Res. 2022;178:106135. doi:10.1016/j.phrs.2022.106135
  • Sammut SJ, Crispin-Ortuzar M, Chin SF, et al. Multi-omic machine learning predictor of breast cancer therapy response. Nature. 2022;601(7894):623–629.
  • DeVeale B, Swindlehurst-Chan J, Blelloch R. The roles of microRNAs in mouse development. Nat Rev Genet. 2021;22(5):307–323. doi:10.1038/s41576-020-00309-5
  • Mori MA, Ludwig RG, Garcia-Martin R, Brandão BB, Kahn CR. Extracellular miRNAs: from biomarkers to mediators of physiology and disease. Cell Metab. 2019;30(4):656–673. doi:10.1016/j.cmet.2019.07.011
  • Melo SA, Sugimoto H, O’Connell JT, et al. Cancer exosomes perform cell-independent microrna biogenesis and promote tumorigenesis. Cancer Cell. 2014;26(5):707–721. doi:10.1016/j.ccell.2014.09.005
  • Scognamiglio I, Cocca L, Puoti I, et al. Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer. Mol Ther Nucleic Acid. 2022;28:17–31. doi:10.1016/j.omtn.2022.02.013
  • Zhao S, Pan T, Deng J, et al. Exosomal transfer of miR-181b-5p confers senescence-mediated doxorubicin resistance via modulating BCLAF1 in breast cancer. Br J Cancer. 2023;128(4):665–677. doi:10.1038/s41416-022-02077-x
  • Sun S, Wang Z, Yao F, et al. Breast cancer cell-derived exosome-delivered microRNA-155 targets UBQLN1 in adipocytes and facilitates cancer cachexia-related fat loss. Hum Mol Genet. 2023;32(13):2219–2228. doi:10.1093/hmg/ddad055
  • Kim O, Tran P, Gal M, et al. RAS‑stimulated release of exosomal miR‑494‑3p promotes the osteolytic bone metastasis of breast cancer cells. Int J Mol Med. 2023;52(3):84. doi:10.3892/ijmm.2023.5287
  • Liu C, Li B, Lin H, et al. Multiplexed analysis of small extracellular vesicle-derived mRNAs by droplet digital PCR and machine learning improves breast cancer diagnosis. Biosens Bioelectron. 2021;194:113615. doi:10.1016/j.bios.2021.113615
  • Li X, Wang S, Mu W, et al. Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway. J Exp Clin Cancer Res. 2022;41(1):41. doi:10.1186/s13046-022-02244-1
  • Santos JC, Sarian LO, Matheu A, Ribeiro ML, Derchain SFM, Derchain SFM. Exosome-mediated breast cancer chemoresistance via miR-155 transfer. Sci Rep. 2018;8(1):829. doi:10.1038/s41598-018-19339-5
  • Kia V, Paryan M, Mortazavi Y, Biglari A, Mohammadi-Yeganeh S. Evaluation of exosomal miR-9 and miR-155 targeting PTEN and DUSP14 in highly metastatic breast cancer and their effect on low metastatic cells. J Cell Biochem. 2019;120(4):5666–5676. doi:10.1002/jcb.27850
  • Huang X, Lai S, Qu F, et al. CCL18 promotes breast cancer progression by exosomal miR-760 activation of ARF6/Src/PI3K/Akt pathway. Mol Ther Oncol. 2022;25(26):1–15. doi:10.1016/j.omto.2022.03.004
  • Yang C, Zhang G, Zhang Y, Zhang S, Li J, Liu Y. Exosome miR-134-5p restrains breast cancer progression via regulating PI3K/AKT pathway by targeting ARHGAP1. J Obstet Gynaecol Res. 2021;47(11):4037–4048. doi:10.1111/jog.14983
  • Singh R, Pochampally R, Watabe K, Lu Z, Mo YY. Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer. Mol Cancer. 2014;13(1):256. doi:10.1186/1476-4598-13-256
  • Ding J, Xu Z, Zhang Y, et al. Exosome-mediated miR-222 transferring: an insight into NF-κB-mediated breast cancer metastasis. Exp Cell Res. 2018;369(1):129–138. doi:10.1016/j.yexcr.2018.05.014
  • Wang B, Mao J, Wang B, et al. Exosomal miR-1910-3p promotes proliferation, metastasis, and autophagy of breast cancer cells by targeting MTMR3 and activating the NF-κB signaling pathway. Cancer Lett. 2020;489:87–99. doi:10.1016/j.canlet.2020.05.038
  • Wang X, Qian T, Bao S, et al. Circulating exosomal miR-363-5p inhibits lymph node metastasis by downregulating PDGFB and serves as a potential noninvasive biomarker for breast cancer. Mol Oncol. 2021;15(9):2466–2479. doi:10.1002/1878-0261.13029
  • Shen S, Song Y, Zhao B, et al. Cancer-derived exosomal miR-7641 promotes breast cancer progression and metastasis. Cell Commun Signal. 2021;19(1):20. doi:10.1186/s12964-020-00700-z
  • Liang Z, Liu L, Gao R, Che C, Yang G. Downregulation of exosomal miR-7-5p promotes breast cancer migration and invasion by targeting RYK and participating in the atypical WNT signalling pathway. Cell Mol Biol Lett. 2022;27(1):88. doi:10.1186/s11658-022-00393-x
  • AL-Abedi R, Tuncay Cagatay S, Mayah A, Brooks SA, Kadhim M. Ionising radiation promotes invasive potential of breast cancer cells: the role of exosomes in the process. Int J Mol Sci. 2021;22(21):11570. doi:10.3390/ijms222111570
  • Yang SS, Ma S, Dou H, et al. Breast cancer-derived exosomes regulate cell invasion and metastasis in breast cancer via miR-146a to activate cancer associated fibroblasts in tumor microenvironment. Exp Cell Res. 2020;391(2):111983. doi:10.1016/j.yexcr.2020.111983
  • Baroni S, Romero-Cordoba S, Plantamura I, et al. Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts. Cell Death Dis. 2016;7(7):e2312–e2312. doi:10.1038/cddis.2016.224
  • Pakravan K, Mossahebi-Mohammadi M, Ghazimoradi MH, Cho WC, Sadeghizadeh M, Babashah S. Monocytes educated by cancer-associated fibroblasts secrete exosomal miR-181a to activate AKT signaling in breast cancer cells. J Transl Med. 2022;20(1):559. doi:10.1186/s12967-022-03780-2
  • Wu Q, Li J, Li Z, et al. Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression. J Exp Clin Cancer Res. 2019;38(1):223. doi:10.1186/s13046-019-1210-3
  • Hashimoto K, Ochi H, Sunamura S, et al. Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A. Proc Natl Acad Sci. 2018;115(9):2204–2209. doi:10.1073/pnas.1717363115
  • Feng Y, Wang L, Wang T, et al. Tumor cell-secreted exosomal miR-22-3p inhibits transgelin and induces vascular abnormalization to promote tumor budding. Mol Ther. 2021;29(6):2151–2166. doi:10.1016/j.ymthe.2021.02.009
  • Zhou W, Fong MY, Min Y, et al. Cancer-Secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell. 2014;25(4):501–515. doi:10.1016/j.ccr.2014.03.007
  • Di Modica M, Regondi V, Sandri M, et al. Breast cancer-secreted miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers. Cancer Lett. 2017;384:94–100. doi:10.1016/j.canlet.2016.09.013
  • Du J, Fan JJ, Dong C, Li HT, Ma BL. Inhibition effect of exosomes-mediated Let-7a on the development and metastasis of Triple negative breast cancer by down-regulating the expression of c-Myc. Eur Rev Med Pharmacol Sci. 2019;23(12):5301–5314. doi:10.26355/eurrev_201906_18197
  • Qi M, Xia Y, Wu Y, et al. Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression. Nat Commun. 2022;13(1):897. doi:10.1038/s41467-022-28438-x
  • Fong MY, Zhou W, Liu L, et al. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol. 2015;17(2):183–194. doi:10.1038/ncb3094
  • Yan W, Wu X, Zhou W, et al. Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol. 2018;20(5):597–609. doi:10.1038/s41556-018-0083-6
  • Wang J, Zhang Q, Wang D, et al. Microenvironment-induced TIMP2 loss by cancer-secreted exosomal miR-4443 promotes liver metastasis of breast cancer. J Cell Physiol. 2020;235(7––8):5722–5735. doi:10.1002/jcp.29507
  • Wu K, Feng J, Lyu F, et al. Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer. Nat Commun. 2021;12(1):5196. doi:10.1038/s41467-021-25473-y
  • Guo L, Zhu Y, Li L, et al. Breast cancer cell-derived exosomal miR-20a-5p promotes the proliferation and differentiation of osteoclasts by targeting SRCIN1. Cancer Med. 2019;8(12):5687–5701. doi:10.1002/cam4.2454
  • Yuan X, Qian N, Ling S, et al. Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells. Theranostics. 2021;11(3):1429–1445. doi:10.7150/thno.45351
  • Wu HJ, Hao M, Yeo SK, Guan JL. FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication. Oncogene. 2020;39(12):2539–2549. doi:10.1038/s41388-020-1162-2
  • Liu Y, Yang Y, Du J, Lin D, Li F. MiR-3613-3p from carcinoma-associated fibroblasts exosomes promoted breast cancer cell proliferation and metastasis by regulating SOCS2 expression. IUBMB Life. 2020;72(8):1705–1714. doi:10.1002/iub.2292
  • Yan Z, Sheng Z, Zheng Y, et al. Cancer-associated fibroblast-derived exosomal miR-18b promotes breast cancer invasion and metastasis by regulating TCEAL7. Cell Death Dis. 2021;12(12):1120. doi:10.1038/s41419-021-04409-w
  • Chen B, Sang Y, Song X, et al. Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28. Theranostics. 2021;11(8):3932–3947. doi:10.7150/thno.53412
  • Kim JE, Kim BG, Jang Y, Kang S, Lee JH, Cho NH. The stromal loss of miR-4516 promotes the FOSL1-dependent proliferation and malignancy of triple negative breast cancer. Cancer Lett. 2020;469:256–265. doi:10.1016/j.canlet.2019.10.039
  • Pakravan K, Babashah S, Sadeghizadeh M, et al. MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells. Cell Oncol. 2017;40(5):457–470. doi:10.1007/s13402-017-0335-7
  • Lee JK, Park SR, Jung BK, et al. Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells. PLoS One. 2013;8(12):e84256. doi:10.1371/journal.pone.0084256
  • Xing L, Tang X, Wu K, Huang X, Yi Y, Huan J. LncRNA HAND2-AS1 suppressed the growth of triple negative breast cancer via reducing secretion of MSCs derived exosomal miR-106a-5p. Aging. 2021;13(1):424–436. doi:10.18632/aging.202148
  • Ono M, Kosaka N, Tominaga N, et al. Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. Sci Signal. 2014;7(332):ra63. doi:10.1126/scisignal.2005231
  • Bliss SA, Sinha G, Sandiford OA, et al. Mesenchymal stem cell-derived exosomes stimulate cycling quiescence and early breast cancer dormancy in bone marrow. Cancer Res. 2016;76(19):5832–5844. doi:10.1158/0008-5472.CAN-16-1092
  • Gernapudi R, Yao Y, Zhang Y, et al. Targeting exosomes from preadipocytes inhibits preadipocyte to cancer stem cell signaling in early-stage breast cancer. Breast Cancer Res Treat. 2015;150(3):685–695. doi:10.1007/s10549-015-3326-2
  • Chow A, Schad S, Green MD, et al. Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity. Cancer Cell. 2021;39(7):973–988.e9. doi:10.1016/j.ccell.2021.05.006
  • Moradi-Chaleshtori M, Bandehpour M, Heidari N, Mohammadi-Yeganeh S, Mahmoud Hashemi S. Exosome-mediated miR-33 transfer induces M1 polarization in mouse macrophages and exerts antitumor effect in 4T1 breast cancer cell line. Int Immunopharmacol. 2021;90:107198. doi:10.1016/j.intimp.2020.107198
  • Moradi-Chaleshtori M, Shojaei S, Mohammadi-Yeganeh S, Hashemi SM. Transfer of miRNA in tumor-derived exosomes suppresses breast tumor cell invasion and migration by inducing M1 polarization in macrophages. Life Sci. 2021;282:119800. doi:10.1016/j.lfs.2021.119800
  • Moradi-Chaleshtori M, Bandehpour M, Soudi S, Mohammadi-Yeganeh S, Hashemi SM. In vitro and in vivo evaluation of anti-tumoral effect of M1 phenotype induction in macrophages by miR-130 and miR-33 containing exosomes. Cancer Immunol Immunother. 2021;70(5):1323–1339. doi:10.1007/s00262-020-02762-x
  • Guo J, Duan Z, Zhang C, et al. Mouse 4T1 breast cancer cell–derived exosomes induce proinflammatory cytokine production in macrophages via miR-183. J Immunol. 2020;205(10):2916–2925. doi:10.4049/jimmunol.1901104
  • Chen WX, Wang DD, Zhu B, et al. Exosomal miR-222 from Adriamycin-resistant MCF-7 breast cancer cells promote macrophages M2 polarization via PTEN/Akt to induce tumor progression. Aging. 2021;13(7):10415–10430. doi:10.18632/aging.202802
  • Hao C, Sheng Z, Wang W, et al. Tumor-derived exosomal miR-148b-3p mediates M2 macrophage polarization via TSC2/mTORC1 to promote breast cancer migration and invasion. Thorac Cancer. 2023;14(16):1477–1491. doi:10.1111/1759-7714.14891
  • Xun J, Du L, Gao R, et al. Cancer-derived exosomal miR-138-5p modulates polarization of tumor-Associated macrophages through inhibition of KDM6B. Theranostics. 2021;11(14):6847–6859. doi:10.7150/thno.51864
  • Xing F, Liu Y, Wu SY, et al. Loss of XIST in breast cancer activates MSN-c-Met and reprograms microglia via exosomal miRNA to promote brain metastasis. Cancer Res. 2018;78(15):4316–4330. doi:10.1158/0008-5472.CAN-18-1102
  • Yang M, Chen J, Su F, et al. Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol Cancer. 2011;10(1):117. doi:10.1186/1476-4598-10-117
  • Yue S, Ye X, Zhou T, et al. PGRN TAMs-derived exosomes inhibit breast cancer cell invasion and migration and its mechanism exploration. Life Sci. 2021;264:118687. doi:10.1016/j.lfs.2020.118687
  • Huang S, Fan P, Zhang C, et al. Exosomal microRNA-503-3p derived from macrophages represses glycolysis and promotes mitochondrial oxidative phosphorylation in breast cancer cells by elevating DACT2. Cell Death Discov. 2021;7(1):119. doi:10.1038/s41420-021-00492-2
  • Grover A, Sanseviero E, Timosenko E, Gabrilovich DI. Myeloid-derived suppressor cells: a propitious road to clinic. Cancer Discov. 2021;11(11):2693–2706. doi:10.1158/2159-8290.CD-21-0764
  • Jiang M, Zhang W, Zhang R, et al. Cancer exosome-derived miR-9 and miR-181a promote the development of early-stage MDSCs via interfering with SOCS3 and PIAS3 respectively in breast cancer. Oncogene. 2020;39(24):4681–4694. doi:10.1038/s41388-020-1322-4
  • Deng Z, Rong Y, Teng Y, et al. Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis. Oncogene. 2017;36(5):639–651. doi:10.1038/onc.2016.229
  • Lv S, Wang Y, Xu W, Dong X. Serum exosomal miR-17-5p as a promising biomarker diagnostic biomarker for breast cancer. Clin Lab. 2020;66(9):1823–1834. doi:10.7754/Clin.Lab.2020.200127
  • Liu D, Li B, Shi X, et al. Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers. Aging. 2021;13(3):4258–4273. doi:10.18632/aging.202388
  • Kim J, Park S, Hwang D, Kim S, Lee H. Diagnostic value of circulating miR-202 in early-stage breast cancer in South Korea. Medicina. 2020;56(7):340. doi:10.3390/medicina56070340
  • Xin Y, Wang X, Meng K, Ni C, Lv Z, Guan D. Identification of exosomal miR-455-5p and miR-1255a as therapeutic targets for breast cancer. Biosci Rep. 2020;40(1):BSR20190303. doi:10.1042/BSR20190303
  • Zhang Z, Zhang L, Yu G, et al. Exosomal miR-1246 and miR-155 as predictive and prognostic biomarkers for trastuzumab-based therapy resistance in HER2-positive breast cancer. Cancer Chemother Pharmacol. 2020;86(6):761–772. doi:10.1007/s00280-020-04168-z
  • Li XJ, Ren ZJ, Tang JH, Yu Q. Exosomal MicroRNA MiR-1246 promotes cell proliferation, invasion and drug resistance by targeting CCNG2 in breast cancer. Cell Physiol Biochem. 2018;44(5):1741–1748. doi:10.1159/000485780
  • Yoshikawa M, Iinuma H, Umemoto Y, Yanagisawa T, Matsumoto A, Jinno H. Exosome-encapsulated microRNA-223-3p as a minimally invasive biomarker for the early detection of invasive breast cancer. Oncol Lett. 2018;15(6):9584–9592. doi:10.3892/ol.2018.8457
  • Asadirad A, Khodadadi A, Talaiezadeh A, Shohan M, Rashno M, Joudaki N. Evaluation of miRNA-21-5p and miRNA-10b-5p levels in serum-derived exosomes of breast cancer patients in different grades. Mol Cell Probes. 2022;64:101831. doi:10.1016/j.mcp.2022.101831
  • Curtaz CJ, Reifschläger L, Strähle L, et al. Analysis of microRNAs in exosomes of breast cancer patients in search of molecular prognostic factors in brain metastases. Int J Mol Sci. 2022;23(7):3683. doi:10.3390/ijms23073683
  • Li D, Wang J, Ma LJ, et al. Identification of serum exosomal miR-148a as a novel prognostic biomarker for breast cancer. Eur Rev Med Pharmacol Sci. 2020;24(13):7303–7309. doi:10.26355/eurrev_202007_21889
  • Liu M, Mo F, Song X, et al.. Exosomal hsa-miR-21-5p is a biomarker for breast cancer diagnosis. Peer J. 2021;9:e12147.
  • Ando W, Kikuchi K, Uematsu T, et al. Novel breast cancer screening: combined expression of miR-21 and MMP-1 in urinary exosomes detects 95% of breast cancer without metastasis. Sci Rep. 2019;9(1):13595. doi:10.1038/s41598-019-50084-5
  • Inubushi S, Kawaguchi H, Mizumoto S, et al. Oncogenic miRNAs identified in tear exosomes from metastatic breast cancer patients. Anticancer Res. 2020;40(6):3091–3096. doi:10.21873/anticanres.14290
  • Bao S, Hu T, Liu J, et al. Genomic instability-derived plasma extracellular vesicle-microRNA signature as a minimally invasive predictor of risk and unfavorable prognosis in breast cancer. J Nanobiotechnology. 2021;19(1):22. doi:10.1186/s12951-020-00767-3
  • Hannafon BN, Trigoso YD, Calloway CL, et al. Plasma exosome microRNAs are indicative of breast cancer. Breast Cancer Res. 2016;18(1):90. doi:10.1186/s13058-016-0753-x
  • Li S, Zhang M, Xu F, Wang Y, Leng D. Detection significance of miR-3662, miR-146a, and miR-1290 in serum exosomes of breast cancer patients. J Cancer Res Ther. 2021;17(3):749–755. doi:10.4103/jcrt.jcrt_280_21
  • Rodríguez-Martínez A, de Miguel-Pérez D, Ortega FG, et al. Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy. Breast Cancer Res. 2019;21(1):21. doi:10.1186/s13058-019-1109-0
  • Muluhngwi P, Klinge CM. Identification of miRNAs as biomarkers for acquired endocrine resistance in breast cancer. Mol Cell Endocrinol. 2017;456:76–86. doi:10.1016/j.mce.2017.02.004
  • Ryspayeva D, Halytskiy V, Kobyliak N, et al. Response to neoadjuvant chemotherapy in breast cancer: do microRNAs matter? Discov Oncol. 2022;13(1):43. doi:10.1007/s12672-022-00507-z
  • Guyon N, Garnier D, Briand J, et al. Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells. Cell Death Dis. 2020;11(12):1048. doi:10.1038/s41419-020-03224-z
  • Yang Q, Zhao S, Shi Z, et al. Chemotherapy-elicited exosomal miR-378a-3p and miR-378d promote breast cancer stemness and chemoresistance via the activation of EZH2/STAT3 signaling. J Exp Clin Cancer Res. 2021;40(1):120. doi:10.1186/s13046-021-01901-1
  • Li Y, Liang Y, Sang Y, et al. MiR-770 suppresses the chemo-resistance and metastasis of triple negative breast cancer via direct targeting of STMN1. Cell Death Dis. 2018;9(1):14. doi:10.1038/s41419-017-0030-7
  • Luo L, Zhang X, Rousuli Y, Aini A, Liman R. Exosome-mediated transfer of miR-3613-5Pp enhances doxorubicin resistance by suppression of pten expression in breast cancer cells. J Oncol. 2022;2022:9494910. doi:10.1155/2022/9494910
  • Andreeva OE, Sorokin DV, Mikhaevich EI, et al. Towards unravelling the role of ERα-targeting miRNAs in the exosome-mediated transferring of the hormone resistance. Molecules. 2021;26(21):6661. doi:10.3390/molecules26216661
  • Wei Y, Lai X, Yu S, et al. Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells. Breast Cancer Res Treat. 2014;147(2):423–431. doi:10.1007/s10549-014-3037-0
  • Liu J, Zhu S, Tang W, Huang Q, Mei Y, Yang H. Exosomes from tamoxifen-resistant breast cancer cells transmit drug resistance partly by delivering miR-9-5p. Cancer Cell Int. 2021;21(1):55. doi:10.1186/s12935-020-01659-0
  • Yu S, Zhou Y, Niu L, Qiao Y, Yan Y. Mesenchymal stem cell-derived exosome mir-342-3p inhibits metastasis and chemo-resistance of breast cancer through regulating ID4. Genes Genomics. 2022;44(5):539–550. doi:10.1007/s13258-021-01200-1
  • Liu Q, Zhang J, Liu Y, Peng H, Wu Y. Extracellular vesicles extracted from bone marrow mesenchymal stem cells carrying MicroRNA-342-3p inhibit the INHBA/IL13Rα2 axis to suppress the growth and metastasis of breast cancer. Transl Oncol. 2022;18:101333. doi:10.1016/j.tranon.2021.101333
  • Yang Z, Xu B, Wu S, et al. Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal stromal cells inhibits breast cancer progression via regulating TRIM31/Akt signaling. Hum Cell. 2022;35(6):1797–1812. doi:10.1007/s13577-022-00753-x
  • Jia Z, Zhu H, Sun H, et al. Adipose mesenchymal stem cell-derived exosomal microrna-1236 reduces resistance of breast cancer cells to cisplatin by suppressing slc9a1 and the wnt/β-catenin signaling. Cancer Manag Res. 2020;12:8733–8744. doi:10.2147/CMAR.S270200
  • Du L, Tao X, Shen X. Human umbilical cord mesenchymal stem cell-derived exosomes inhibit migration and invasion of breast cancer cells via miR-21-5p/ZNF367 pathway. Breast Cancer. 2021;28(4):829–837. doi:10.1007/s12282-021-01218-z
  • Khazaei-Poul Y, Shojaei S, Koochaki A, Ghanbarian H, Mohammadi-Yeganeh S. Evaluating the influence of human umbilical cord mesenchymal stem cells-derived exosomes loaded with miR-3182 on metastatic performance of triple negative breast cancer cells. Life Sci. 2021;286:120015. doi:10.1016/j.lfs.2021.120015
  • Yuan L, Liu Y, Qu Y, Liu L, Li H. Exosomes derived from MicroRNA-148b-3p-overexpressing human umbilical cord mesenchymal stem cells restrain breast cancer progression. Front Oncol. 2019;9:1076. doi:10.3389/fonc.2019.01076
  • Sheykhhasan M, Kalhor N, Sheikholeslami A, Dolati M, Amini E, Fazaeli H. Exosomes of mesenchymal stem cells as a proper vehicle for transfecting miR-145 into the breast cancer cell line and its effect on metastasis. Biomed Res Int. 2021;2021:5516078. doi:10.1155/2021/5516078
  • Zhou Y, Chen F, Xie X, et al. Tumor-derived exosome promotes metastasis via altering its phenotype and inclusions. J Cancer. 2021;12(14):4240–4246. doi:10.7150/jca.48043