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REVIEW

Gastroparesis: Myths, Misconceptions, and Management

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Pages 65-78 | Received 09 Sep 2022, Accepted 29 Mar 2023, Published online: 06 Jun 2023

References

  • Camilleri M, Sanders KM. Gastroparesis. Gastroenterology. 2022;162(1):68–87 e1. doi:10.1053/j.gastro.2021.10.028
  • Camilleri M, Kuo B, Nguyen L, et al. ACG clinical guideline: gastroparesis. Am J Gastroenterol. 2022;117(8):1197–1220. doi:10.14309/ajg.0000000000001874
  • Lacy BE, Crowell MD, Cangemi DJ, et al. Diagnostic evaluation of gastric motor and sensory disorders. Am J Gastroenterol. 2021;116(12):2345–2356. doi:10.14309/ajg.0000000000001562
  • Jung HK, Choung RS, Locke GR, et al. The incidence, prevalence and outcomes of patients with gastroparesis in Olmsted County, Minnesota from 1996 to 2006. Gastroenterology. 2009;136:1225–1233. doi:10.1053/j.gastro.2008.12.047
  • Dilmaghani S, Zheng T, Camilleri M. Epidemiology and healthcare utilization in patients with gastroparesis: a systematic review. Clin Gastroenterol Hepatol. 2022. doi:10.1016/j.cgh.2022.07.011
  • Lacy BE, Crowell MD, Mathis C, et al. Gastroparesis: quality of life and health care utilization. J Clin Gastroenterol. 2018;52:20–24. doi:10.1097/MCG.0000000000000728
  • Wang YR, Fisher RS, Parkman HP. Gastroparesis-related hospitalizations in the United States: trends, characteristics, and outcomes, 1995–2004. Am J Gastroenterol. 2008;103:313–322. doi:10.1111/j.1572-0241.2007.01658.x
  • Hirsch W, Nee J, Ballou S, et al. Emergency department burden of gastroparesis in the United States, 2006 to 2013. J Clin Gastroenterol. 2019;53:109–113. doi:10.1097/MCG.0000000000000972
  • Camilleri M, Parkman HP, Shafi MA, et al. Clinical guideline: management of gastroparesis. Am J Gastroenterol. 2013;108:18–37. doi:10.1038/ajg.2012.373
  • Parkman HP, Hasler WL, Fisher RS, et al.; American Gastroenterological Association. American Gastroenterological Association medical position statement: diagnosis and treatment of gastroparesis. Gastroenterology. 127;2004:1589–1591. doi:10.1053/j.gastro.2004.09.054
  • Moshiree B, Potter M, Talley NJ. Epidemiology and pathophysiology of gastroparesis. Gastrointest Endosc Clin N Am. 2019;29(1):1–14. doi:10.1016/j.giec.2018.08.010
  • Hasler WL, May KP, Wilson L, et al. Post-infectious gastroparesis: differences in baseline clinical characteristics and evolution of symptoms and disease severity after 48 weeks versus patients without infectious prodromes. Gastroenterology. 2011;140:S707. doi:10.1016/S0016-5085(11)62936-3
  • Ye Y, Yin Y, Huh SY, et al. Epidemiology, etiology, and treatment of gastroparesis: real-world evidence from a large US national claims database. Gastroenterology. 2022;162(1):109–121 e5. doi:10.1053/j.gastro.2021.09.064
  • Camilleri M, Chedid V, Ford AC, et al. Gastroparesis. Nat Rev Dis Primers. 2018;4(1):41. doi:10.1038/s41572-018-0038-z
  • Vijayvargiya P, Jameie-Oskooei S, Camilleri M, et al. Association between delayed gastric emptying and upper gastrointestinal symptoms: a systematic review and meta-analysis. Gut. 2019;68(5):804–813. doi:10.1136/gutjnl-2018-316405
  • Silver PJ, Dadparvar S, Maurer AH, et al. Proximal and distal intragastric meal distribution during gastric emptying scintigraphy: relationships to symptoms of gastroparesis. Neurogastroenterol Motil. 2022;2022:e14436.
  • Cogliandro RF, Rizzoli G, Bellacosa L, et al. Is gastroparesis a gastric disease? Neurogastroenterol Motil. 2019;31(5):e13562. doi:10.1111/nmo.13562
  • Harberson J, Thomas RM, Harbison SP, et al. Gastric neuromuscular pathology in gastroparesis: analysis of full-thickness antral biopsies. Dig Dis Sci. 2010;55(2):359–370. doi:10.1007/s10620-009-1071-2
  • Bernard CE, Gibbons SJ, Mann IS, et al. Association of low numbers of CD206-positive cells with loss of ICC in the gastric body of patients with diabetic gastroparesis. Neurogastroenterol Motil. 2014;26(9):1275–1284. doi:10.1111/nmo.12389
  • Grover M, Farrugia G, Lurken MS, et al. Cellular changes in diabetic and idiopathic gastroparesis. Gastroenterology. 2011;140(5):1575–85 e8. doi:10.1053/j.gastro.2011.01.046
  • Grover M, Farrugia G, Stanghellini V. Gastroparesis: a turning point in understanding and treatment. Gut. 2019;68(12):2238–2250. doi:10.1136/gutjnl-2019-318712
  • Bashashati M, Moraveji S, Torabi A, et al. Pathological findings of the antral and pyloric smooth muscle in patients with gastroparesis-like syndrome compared to gastroparesis: similarities and differences. Dig Dis Sci. 2017;62(10):2828–2833. doi:10.1007/s10620-017-4629-4
  • Lacy BE. Functional dyspepsia and gastroparesis: one disease or two? Am J Gastroenterol. 2012;107(11):1615–1620. doi:10.1038/ajg.2012.104
  • Kim BJ, Kuo B. Gastroparesis and functional dyspepsia: a blurring distinction of pathophysiology and treatment. J Neurogastroenterol Motil. 2019;25(1):27–35. doi:10.5056/jnm18162
  • Cangemi DJ, Lacy BE. Gastroparesis and functional dyspepsia: different diseases or different ends of the spectrum? Curr Opin Gastroenterol. 2020;36(6):509–517. doi:10.1097/MOG.0000000000000677
  • Stanghellini V, Tack J. Gastroparesis: separate entity or just a part of dyspepsia? Gut. 2014;63(12):1972–1978. doi:10.1136/gutjnl-2013-306084
  • Stanghellini V, Chan FK, Hasler WL, et al. Gastroduodenal Disorders. Gastroenterology. 2016;150(6):1380–1392. doi:10.1053/j.gastro.2016.02.011
  • Lacy BE, Everhart K, Crowell MD. Functional dyspepsia: clinical symptoms, psychological findings, and GCSI Scores. Dig Dis Sci. 2019;64(5):1281–1287. doi:10.1007/s10620-018-5347-2
  • Pasricha PJ, Grover M, Yates KP, et al. Functional dyspepsia and gastroparesis in tertiary care are interchangeable syndromes with common clinical and pathologic features. Gastroenterology. 2021;160(6):2006–2017. doi:10.1053/j.gastro.2021.01.230
  • Karamanolis G, Caenepeel P, Arts J, et al. Determinants of symptom pattern in idiopathic severely delayed gastric emptying: gastric emptying rate or proximal stomach dysfunction? Gut. 2007;56(1):29–36. doi:10.1136/gut.2005.089508
  • Snodgrass P, Sandoval H, Calhoun VD, et al. Central nervous system mechanisms of nausea in gastroparesis: an fMRI-based case-control study. Dig Dis Sci. 2020;65(2):551–556. doi:10.1007/s10620-019-05766-5
  • Lee AA, Rao S, Nguyen LA, et al. Validation of diagnostic and performance characteristics of the wireless motility capsule in patients with suspected gastroparesis. Clin Gastroenterol Hepatol. 2019;17(9):1770–1779. doi:10.1016/j.cgh.2018.11.063
  • Brzana RJ, Koch KL, Bingaman S. Gastric myoelectrical activity in patients with gastric outlet obstruction and idiopathic gastroparesis. Am J Gastroenterol. 1998;93(10):1803–1809. doi:10.1111/j.1572-0241.1998.00524.x
  • Park S, Acosta A, Camilleri M, et al. Gastric motor dysfunction in patients with functional gastroduodenal symptoms. Am J Gastroenterol. 2017;112(11):1689–1699. doi:10.1038/ajg.2017.264
  • Cangemi DJ, Stephens L, Lacy BE. Misdiagnosis of gastroparesis is common: a retrospective review of patients referred to a tertiary gastroenterology practice. Clin Gastroenterol Hepatol. 2023;2023:S1542–3565.
  • Tougas G, Eaker EY, Abell TL, et al. Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterol. 2000;95:1456–1462. doi:10.1111/j.1572-0241.2000.02076.x
  • Wise J, Vazquez-Roque M, McKinney CJ, et al. Gastric emptying scans: poor adherence to national guidelines. Dig Dis Sci. 2021;66(9):2897–2906. doi:10.1007/s10620-020-06314-2
  • Bi D, Choi C, League J, et al. Food residue during esophagogastroduodenoscopy is commonly encountered and is not pathognomonic of delayed gastric emptying. Dig Dis Sci. 2021;66(11):3951–3959. doi:10.1007/s10620-020-06718-0
  • Lacy BE, Tack J, Gyawali CP. AGA clinical practice update on management of medically refractory gastroparesis: expert review. Clin Gastroenterol Hepatol. 2022;20(3):491–500. doi:10.1016/j.cgh.2021.10.038
  • Olausson EA, Alpsten M, Larsson A, et al. Small particle size of a solid meal increases gastric emptying and late postprandial glycaemic response in diabetic subjects with gastroparesis. Diabetes Res Clin Pract. 2008;80(2):231–237. doi:10.1016/j.diabres.2007.12.006
  • Olausson EA, Storsrud S, Grundin H, et al. A small particle size diet reduces upper gastrointestinal symptoms in patients with diabetic gastroparesis: a randomized controlled trial. Am J Gastroenterol. 2014;109(3):375–385. doi:10.1038/ajg.2013.453
  • Strijbos D, Keszthelyi D, Smets FGM, et al. Therapeutic strategies in gastroparesis: results of stepwise approach with diet and prokinetics, gastric rest, and PEG-J: a retrospective analysis. Neurogastroenterol Motil. 2019;31:e13588. doi:10.1111/nmo.13588
  • Parkman HP, Yates KP, Hasler WL, et al. Dietary intake and nutritional deficiencies in patients with diabetic or idiopathic gastroparesis. Gastroenterology. 2011;141(2):486–498. doi:10.1053/j.gastro.2011.04.045
  • Burton murray H, Jehangir A, Silvernale CJ, et al. Avoidant/restrictive food intake disorder symptoms are frequent in patients presenting for symptoms of gastroparesis. Neurogastroenterol Motil. 2020;32(12):e13931. doi:10.1111/nmo.13931
  • Benini L, Todesco T, Dalle Grave R, et al. Gastric emptying in patients with restricting and binge/purging subtypes of anorexia nervosa. Am J Gastroenterol. 2004;99(8):1448–1454. doi:10.1111/j.1572-0241.2004.30246.x
  • Perkel MS, Moore C, Hersh T, Davidson ED. Metoclopramide therapy in patients with delayed gastric emptying. Dig Dis Sci. 1979;24(9):662–666. doi:10.1007/BF01314461
  • Acosta A, Camilleri M. Prokinetics in gastroparesis. Gastroenterol Clin N Am. 2015;44(1):97–111. doi:10.1016/j.gtc.2014.11.008
  • Rao AS, Camilleri M. metoclopramide and tardive dyskinesia. Aliment Pharmacol Therapeut. 2010;31(1):11–19. doi:10.1111/j.1365-2036.2009.04189.x
  • Al-Saffar A, Lennernäs H, Hellström PM. Gastroparesis, metoclopramide, and tardive dyskinesia: risk revisited. Neurogastroenterol Motil. 2019;31(11):e13617. doi:10.1111/nmo.13617
  • Barone JA. Domperidone: a peripherally acting dopamine2-receptor antagonist. Ann Pharmacother. 1999;33(4):429–440. doi:10.1345/aph.18003
  • Drolet B, Rousseau G, Daleau P, Cardinal R, Turgeon J. Domperidone should not be considered a no-risk alternative to cisapride in the treatment of gastrointestinal motility disorders. Circulation. 2000;102(16):1883–1885. doi:10.1161/01.CIR.102.16.1883
  • Schey R, Saadi M, Midani D, Roberts AC, Parupalli R, Parkman HP. Domperidone to treat symptoms of gastroparesis: benefits and side effects from a large single-center cohort. Dig Dis Sci. 2016;61(12):3545–3551. doi:10.1007/s10620-016-4272-5
  • Hasler WL. Serotonin and the GI tract. Curr Gastroenterol Rep. 2009;11(5):383–391. doi:10.1007/s11894-009-0058-7
  • Youssef AS, Parkman HP, Nagar S. Drug‐drug interactions in pharmacologic management of gastroparesis. Neurogastroenterol Motil. 2015;27(11):1528–1541. doi:10.1111/nmo.12614
  • Navari R, Gandara D, Hesketh P, et al. Comparative clinical trial of granisetron and ondansetron in the prophylaxis of cisplatin-induced emesis. The Granisetron study group. J Clin Onc. 1995;13(5):1242–1248. doi:10.1200/JCO.1995.13.5.1242
  • Simmons K, Parkman HP. Granisetron transdermal system improves refractory nausea and vomiting in gastroparesis. Dig Dis Sci. 2014;59(6):1231–1234. doi:10.1007/s10620-014-3097-3
  • Midani D, Parkman HP. Granisetron transdermal system for treatment of symptoms of gastroparesis: a prescription registry study. J Neurogastroenterol Motil. 2016;22(4):650–655. doi:10.5056/jnm15203
  • Pasricha PJ, Yates KP, Sarosiek I, et al. Aprepitant has mixed effects on nausea and reduces other symptoms in patients with gastroparesis and related disorders. Gastroenterology. 2018;154(1):65–76. doi:10.1053/j.gastro.2017.08.033
  • Carlin JL, Lieberman R, Dahal A, et al. Efficacy and safety of tradipitant in patients with diabetic and idiopathic gastroparesis in a randomized, placebo-controlled trial. Gastroenterology. 2021;160(1):76–87. doi:10.1053/j.gastro.2020.07.029
  • Broad J, Mukherjee S, Samadi M, Martin J, Dukes G, Sanger G. Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists. Br J Pharmacol. 2012;167(4):763–774. doi:10.1111/j.1476-5381.2012.02009.x
  • Sanger GJ, Furness JB. Ghrelin and motilin receptors as drug targets for gastrointestinal disorders. Nat Rev Gastroenterol Hepatol. 2016;13(1):38–48. doi:10.1038/nrgastro.2015.163
  • Lacy BE, Weiser K. Gastric motility, gastroparesis, and gastric stimulation. Surg Clin. 2005;85(5):967–987. doi:10.1016/j.suc.2005.05.005
  • Tack J, Depoortere I, Bisschops R, et al. Influence of ghrelin on interdigestive gastrointestinal motility in humans. Gut. 2006;55(3):327–333. doi:10.1136/gut.2004.060426
  • Lembo A, Camilleri M, McCallum R, et al. Relamorelin reduces vomiting frequency and severity and accelerates gastric emptying in adults with diabetic gastroparesis. Gastroenterology. 2016;151(1):87–96. doi:10.1053/j.gastro.2016.03.038
  • Camilleri M, McCallum RW, Tack J, et al. Efficacy and safety of relamorelin in diabetics with symptoms of gastroparesis: a randomized, placebo-controlled study. Gastroenterology. 2017;153(5):1240–1250. doi:10.1053/j.gastro.2017.07.035
  • Carbone F, Ven den Houte K, Clevers E, et al. Prucalopride in gastroparesis: a randomized, placebo-controlled crossover study. Am J Gastroenterol. 2019;114(8):1265–1274. doi:10.14309/ajg.0000000000000304
  • Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, Leeprakobboon K, Leelasettagool C. The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis. Am J Obstet Gyn. 2006;194(1):95–99. doi:10.1016/j.ajog.2005.06.046
  • von Arnim U, Peitz U, Vinson B, Gundermann KJ, Malfertheiner P. STW 5, a phytopharmacon for patients with functional dyspepsia: results of a multicenter, placebo-controlled double-blind study. Am J Gastroenterol. 2007;102(6):1268–1275. doi:10.1111/j.1572-0241.2006.01183.x
  • Pilichiewicz AN, Horowitz M, Russo A, et al. Effects of Iberogast® on proximal gastric volume, antropyloroduodenal motility and gastric emptying in healthy men. Am J Gastroenterol. 2007;102(6):1276–1283. doi:10.1111/j.1572-0241.2007.01142.x
  • Braden B, Caspary W, Börner N, Vinson B, Schneider AR. Clinical effects of STW 5 (Iberogast®) are not based on acceleration of gastric emptying in patients with functional dyspepsia and gastroparesis. Neurogastroenterol Motil. 2009;21(6):632–638. doi:10.1111/j.1365-2982.2008.01249.x
  • Yang M, Li X, Liu S, et al. Meta-analysis of acupuncture for relieving non-organic dyspeptic symptoms suggestive of diabetic gastroparesis. BMC Compl Altern Med. 2013;13(1):311. doi:10.1186/1472-6882-13-311
  • Kim KH, Lee MS, Choi TY, Kim TH. Acupuncture for symptomatic gastroparesis. Cochrane Database Sys Rev. 2018;12(12):CD0096676.
  • Rhodes VA, McDaniel RW. Nausea, vomiting, and retching: complex problems in palliative care. A Cancer J Clin. 2001;51(4):232–248. doi:10.3322/canjclin.51.4.232
  • Parkman HP, Wilson LA, Hasler WL, et al. Abdominal pain in patients with gastroparesis: associations with gastroparesis symptoms, etiology of gastroparesis, gastric emptying, somatization, and quality of life. Dig Dis Sci. 2019;64(8):2242–2255. doi:10.1007/s10620-019-05522-9
  • Parkman HP, Van Natta ML, Abell TL, et al. Effect of nortriptyline on symptoms of idiopathic gastroparesis: the NORIG randomized clinical trial. JAMA. 2013;310(24):2640–2649. doi:10.1001/jama.2013.282833
  • Drossman DA, Tack J, Ford AC, Szigethy E, Tornblom H, Van Oudenhove L. Neuromodulators for functional gastrointestinal disorders (disorders of gut-brain interaction): a Rome foundation working team report. Gastroenterology. 2018;154:1140–71 e1. doi:10.1053/j.gastro.2017.11.279
  • Tack J, Ly HG, Carbone F, et al. Efficacy of mirtazapine in patients with functional dyspepsia and weight loss. Clin Gastroenterol Hepatol. 2016;14(3):385–392.e4. doi:10.1016/j.cgh.2015.09.043
  • Malamood M, Roberts A, Kataria R, Parkman HP, Schey R. Mirtazapine for symptom control in refractory gastroparesis. Drug Des Devel Ther. 2017;30:11:1035–1041.
  • Freeman R, Durso-DeCruz E, Emir B. Efficacy, safety, and tolerability of pregabalin treatment for painful diabetic peripheral neuropathy: findings from seven randomized, controlled trials across a range of doses. Diabetes Care. 2008;31(7):1448–1454. doi:10.2337/dc07-2105
  • Kotikula I, Thinrungroj N, Pinyopornpanish K, et al. Randomised clinical trial: the effects of pregabalin vs placebo on functional dyspepsia. Aliment Pharmacol Ther. 2021;54(8):1026–1032. doi:10.1111/apt.16588
  • Keefer L, Ballou SK, Drossman DA, et al. A Rome working team report on brain-gut behavior therapies for disorders of gut-brain interaction. Gastroenterology. 2022;162(1):300–315. doi:10.1053/j.gastro.2021.09.015
  • Thomas JJ, Murray HB. Cognitive-behavioral treatment of adult rumination behavior in the setting of disordered eating: a single case experimental design. Int J Eat Disord. 2016;49(10):967–972. doi:10.1002/eat.22566
  • Murray HB, Zhang F, Call CC, et al. Comprehensive cognitive-behavioral interventions augment diaphragmatic breathing for rumination syndrome: a proof-of-concept trial. Dig Dis Sci. 2021;66(10):3461–3469. doi:10.1007/s10620-020-06685-6
  • Bielefeldt K, Raza N, Zickmund SL. Different faces of gastroparesis. World J Gastroenterol. 2009;15(48):6052–6060. doi:10.3748/wjg.15.6052
  • Orive M, Barrio I, Orive VM, et al. A randomized controlled trial of a 10 week group psychotherapeutic treatment added to standard medical treatment in patients with functional dyspepsia. J Psychosom Res. 2015;78(6):563–568. doi:10.1016/j.jpsychores.2015.03.003
  • Haug TT, Wilhelmsen I, Svebak S, et al. Psychotherapy in functional dyspepsia. J Psychosom Res. 1994;38(7):735–744. doi:10.1016/0022-3999(94)90026-4
  • Calvert EL, Houghton LA, Cooper P, et al. Long-term improvement in functional dyspepsia using hypnotherapy. Gastroenterology. 2002;123(6):1778–1785. doi:10.1053/gast.2002.37071
  • Kinsinger SW, Joyce C, Venu M, et al. Pilot study of a self-administered hypnosis intervention for functional dyspepsia. Dig Dis Sci. 2022;67(7):3017–3025. doi:10.1007/s10620-021-07183-z
  • Mearin F, Camilleri M, Malagelada JR. Pyloric dysfunction in diabetics with recurrent nausea and vomiting. Gastroenterology. 1986;90(6):1919–1925. doi:10.1016/0016-5085(86)90262-3
  • Bromer MQ, Friedeberg F, Miller LS, et al. Endoscopic pyloric injection of botulinum toxin A for the treatment of refractory gastroparesis. Gastrointest Endosc. 2005;61:833–839. doi:10.1016/S0016-5107(05)00328-7
  • Arts J, van Gool S, Caenepeel P, et al. Influence of intrapyloric botulinum toxin injection on gastric emptying and meal-related symptoms in gastroparesis patients. Aliment Pharmacol Ther. 2006;24:661–667. doi:10.1111/j.1365-2036.2006.03019.x
  • Arts J, Holvoet L, Caenepeel P, et al. Clinical trial: a randomized-controlled crossover study of intrapyloric injection of botulinum toxin in gastroparesis. Aliment Pharmacol Ther. 2007;26:1251–1258. doi:10.1111/j.1365-2036.2007.03467.x
  • Friedenberg FK, Palit A, Parkman HP, Hanlon A, Nelson DB. Botulinum toxin A for the treatment of delayed gastric emptying. Am J Gastroenterol. 2008;2008:103416–103423.
  • Desprez C, Melchior C, Wuestenberghs F, et al. Pyloric distensibility measurement predicts symptomatic response to intrapyloric botulinum toxin injection. Gastrointest Endosc. 2019;90:754–60.e1. doi:10.1016/j.gie.2019.04.228
  • Abdelfatah MM, Noll A, Kapil N, et al. Long-term outcome of gastric per-oral endoscopic pyloromyotomy in treatment of gastroparesis. Clin Gastroenterol Hepatol. 2021;19:816–824. doi:10.1016/j.cgh.2020.05.039
  • Vosoughi K, Ichkhanian Y, Benias P, et al. Gastric per-oral endoscopic myotomy (G-POEM) for refractory gastroparesis: results from an international prospective trial. Gut. 2021;71(1):25–33. doi:10.1136/gutjnl-2020-322756
  • Hernández Mondragón OV, Contreras LFG, Velasco GB, et al. Gastric peroral endoscopic myotomy outcomes after 4 years of follow-up in a large cohort of patients with refractory gastroparesis (with video). Gastrointest Endosc. 2022;96(3):487–499. doi:10.1016/j.gie.2022.03.025
  • Martinek J, Hustak R, Mares J, et al. Endoscopic pyloromyotomy for the treatment of severe and refractory gastroparesis: a pilot, randomized, sham-controlled trial. Gut. 2022;71:2170–2178. doi:10.1136/gutjnl-2022-326904
  • Abell T, McCallum R, Hocking M, et al. Gastric electrical stimulation for medically refractory gastroparesis. Gastroenterology. 2003;125(2):421–428. doi:10.1016/S0016-5085(03)00878-3
  • McCallum RW, Snape W, Brody F, et al. Gastric electrical stimulation with Enterra therapy improves symptoms from diabetic gastroparesis in a prospective study. Clin Gastroenterol Hepatol. 2010;8(11):947–54;quiz e116. doi:10.1016/j.cgh.2010.05.020
  • McCallum RW, Sarosiek I, Parkman HP, et al. Gastric electrical stimulation with Enterra therapy improves symptoms of idiopathic gastroparesis. Neurogastroenterol Motil. 2013;25(10):815–e636. doi:10.1111/nmo.12185
  • Levinthal DJ, Bielefeldt K. Systematic review and meta-analysis: gastric electrical stimulation for gastroparesis. Auton Neurosci. 2021;202:45–55. doi:10.1016/j.autneu.2016.03.004
  • Ducrotte P, Coffin B, Bonaz B, et al. Gastric electrical stimulation reduces refractory vomiting in a randomized crossover trial. Gastroenterology. 2020;158(3):506–514 e2. doi:10.1053/j.gastro.2019.10.018