Advanced search
Publication Cover
International Journal of Chronic Obstructive Pulmonary Disease Volume 18, 2023 - Issue
Submit an article Journal homepage
258
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Inhaled Corticosteroids in Patients with Chronic Obstructive Pulmonary Disease and Risk of Acquiring Streptococcus pneumoniae Infection. A Multiregional Epidemiological Study

Christian Kjer Heerfordt1 Section of Respiratory Medicine, Department of Medicine, Copenhagen University Hospital Herlev and Gentofte Hospital, Hellerup, DenmarkCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8485-3235View further author information
ORCID Icon,
Josefin Eklöf1 Section of Respiratory Medicine, Department of Medicine, Copenhagen University Hospital Herlev and Gentofte Hospital, Hellerup, DenmarkView further author information
,
Pradeesh Sivapalan1 Section of Respiratory Medicine, Department of Medicine, Copenhagen University Hospital Herlev and Gentofte Hospital, Hellerup, DenmarkView further author information
,
Truls Sylvan Ingebrigtsen1 Section of Respiratory Medicine, Department of Medicine, Copenhagen University Hospital Herlev and Gentofte Hospital, Hellerup, DenmarkView further author information
,
Tor Biering-Sørensen2 Department of Cardiology, Herlev and Gentofte Hospital, Cardiovascular Non-Invasive Imaging Research Laboratory, University of Copenhagen, Copenhagen, Denmark;3 Faculty of Biomedical Sciences, Copenhagen University, Copenhagen, Denmark;4 Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkView further author information
,
Zitta Barrella Harboe4 Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;5 Department of Respiratory Medicine and Infectious Diseases, Copenhagen University Hospital, North Zealand, DenmarkORCID Iconhttps://orcid.org/0000-0001-5552-0095View further author information
ORCID Icon,
Jesper Koefod Petersen6 Department of Respiratory Medicine, Zealand University Hospital Naestved, Naestved, Denmark;7 Department of Pulmonary Medicine, Zealand University Hospital, Roskilde, DenmarkView further author information
,
Christian Østergaard Andersen8 Department of Clinical Microbiology, Hvidovre University Hospital, Hvidovre, DenmarkView further author information
,
Jonas Bredtoft Boel9 Department of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, DenmarkORCID Iconhttps://orcid.org/0000-0003-3085-0930View further author information
ORCID Icon,
Anne Kathrine Bock10 Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, DenmarkView further author information
,
Alexander G Mathioudakis11 The North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK;12 Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UKView further author information
,
John R Hurst13 UCL Respiratory, University College London, London, UKORCID Iconhttps://orcid.org/0000-0002-7246-6040View further author information
ORCID Icon,
Shailesh Kolekar7 Department of Pulmonary Medicine, Zealand University Hospital, Roskilde, DenmarkORCID Iconhttps://orcid.org/0000-0002-7375-4618View further author information
ORCID Icon,
Sofie Lock Johansson14 Department of Respiratory Medicine, Odense University Hospital, Odense, DenmarkView further author information
,
Jette Marie Bangsborg9 Department of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, DenmarkView further author information
,
Jens Otto Jarløv9 Department of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, DenmarkView further author information
,
Ram Benny Dessau15 Department of Clinical Microbiology, Zealand University Hospital, Slagelse Hospital, Slagelse, DenmarkORCID Iconhttps://orcid.org/0000-0002-1497-6309View further author information
ORCID Icon,
Christian Borbjerg Laursen14 Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark;16 Institute for Clinical Research, University of Southern Denmark, Odense, DenmarkView further author information
,
Michael Perch4 Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;17 Department of Cardiology, Section for Lung Transplantation, Rigshospitalet, Copenhagen, DenmarkView further author information
&
Jens-Ulrik Stæhr Jensen1 Section of Respiratory Medicine, Department of Medicine, Copenhagen University Hospital Herlev and Gentofte Hospital, Hellerup, Denmark;4 Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;18 PERSIMUNE & CHIP: Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkORCID Iconhttps://orcid.org/0000-0003-4036-0521View further author information
ORCID Icon show all
Pages 373-384 | Received 08 Sep 2022, Accepted 02 Feb 2023, Published online: 21 Mar 2023

References

  • Stănescu D, Sanna A, Veriter C, et al. Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils. Thorax. 1996;51(3):267–271. doi:10.1136/thx.51.3.267
  • Calverley PM, Anderson JA, Celli B, et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med. 2007;356(8):775–789. doi:10.1056/NEJMoa063070
  • Lipson DA, Barnhart F, Brealey N, et al. Once-daily single-inhaler triple versus dual therapy in patients with COPD. N Engl J Med. 2018;378(18):1671–1680. doi:10.1056/NEJMoa1713901
  • Papi A, Vestbo J, Fabbri L, et al. Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial. Lancet. 2018;391(10125):1076–1084. doi:10.1016/S0140-6736(18)30206-X
  • Vestbo J, Anderson JA, Brook RD, et al. Fluticasone furoate and vilanterol and survival in chronic obstructive pulmonary disease with heightened cardiovascular risk (SUMMIT): a double-blind randomised controlled trial. Lancet. 2016;387(10030):1817–1826. doi:10.1016/S0140-6736(16)30069-1
  • Agusti A, Fabbri LM, Singh D, et al. Inhaled corticosteroids in COPD: friend or foe? Eur Respir J. 2018;52(6):1801219. doi:10.1183/13993003.01219-2018
  • Watz H, Tetzlaff K, Wouters EF, et al. Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the WISDOM trial. Lancet Respir Med. 2016;4(5):390–398. doi:10.1016/S2213-2600(16)00100-4
  • Kew KM, Seniukovich A. Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2014;2014(12). doi:10.1002/14651858.CD010115.pub2
  • Torres A, Blasi F, Dartois N, Akova M. Which individuals are at increased risk of pneumococcal disease and why? Impact of COPD, asthma, smoking, diabetes, and/or chronic heart disease on community-acquired pneumonia and invasive pneumococcal disease. Thorax. 2015;70(10):984–989. doi:10.1136/thoraxjnl-2015-206780
  • Welte T, Torres A, Nathwani D. Clinical and economic burden of community-acquired pneumonia among adults in Europe. Thorax. 2012;67(1):71–79. doi:10.1136/thx.2009.129502
  • WHO collaborating centre for drug statistics methodology - ATC. Available from: https://www.whocc.no/atc/structure_and_principles/. Accessed March 8, 2023.
  • Uploaded protocol. Available from: http://coptrin.dk/wp-content/uploads/2021/10/Protocol-ICS-and-Streptococcus-pneumoniae.pdf. Accessed March 8, 2023.
  • Lange P, Tøttenborg SS, Sorknæs AD, et al. Danish Register of chronic obstructive pulmonary disease. Clin Epidemiol. 2016;8:673–678. doi:10.2147/CLEP.S99489
  • Johannesdottir SA, Horváth-Puhó E, Ehrenstein V, Schmidt M, Pedersen L, Sørensen HT. Existing data sources for clinical epidemiology: the Danish National Database of Reimbursed Prescriptions. Clin Epidemiol. 2012;4:303–313. doi:10.2147/CLEP.S37587
  • Lynge E, Sandegaard JL, Rebolj M. The Danish National Patient Register. Scand J Public Health. 2011;39(7 Suppl):30–33. doi:10.1177/1403494811401482
  • Inhaled corticosteroid doses for NICE’s asthma guideline. National Institute for Health and Care Excellence; 2018 Available from: https://www.nice.org.uk/guidance/ng80/resources/inhaled-corticosteroid-doses-pdf-4731528781
  • Global strategy for prevention, diagnosis and management of COPD: 2022 report. Available from: https://goldcopd.org/2022-gold-reports-2/. Accessed March 8, 2023.
  • Biomedical statistics and informatics software packages; 2018. Available from: https://bioinformaticstools.mayo.edu/downloads/sas/gmatch.sas. Accessed March 8, 2023.
  • Singanayagam A, Glanville N, Cuthbertson L, et al. Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease. Sci Transl Med. 2019;11(507). doi:10.1126/scitranslmed.aav3879
  • Castellana G, Castellana M, Castellana C, et al. Inhaled corticosteroids and risk of tuberculosis in patients with obstructive lung diseases: a systematic review and meta-analysis of non-randomized studies. Int J Chron Obstruct Pulmon Dis. 2019;14:2219–2227. doi:10.2147/COPD.S209273
  • Eklöf J, Ingebrigtsen TS, Sørensen R, et al. Use of inhaled corticosteroids and risk of acquiring Pseudomonas aeruginosa in patients with chronic obstructive pulmonary disease. Thorax. 2021;77(6):573–580. doi:10.1136/thoraxjnl-2021-217160
  • Ni S, Fu Z, Zhao J, Liu H. Inhaled corticosteroids (ICS) and risk of mycobacterium in patients with chronic respiratory diseases: a meta-analysis. J Thorac Dis. 2014;6(7):971–978. doi:10.3978/j.issn.2072-1439.2014.07.03
  • Danish national COPD treatment guidelines. Available from: https://lungemedicin.dk/kol-vejledning/. Accessed March 8, 2023.
  • Smith EL, Wheeler I, Adler H, et al. Upper airways colonisation of Streptococcus pneumoniae in adults aged 60 years and older: a systematic review of prevalence and individual participant data meta-analysis of risk factors. J Infect. 2020;81(4):540–548. doi:10.1016/j.jinf.2020.06.028
  • Lodise TP, Li J, Gandhi HN, O’Brien G, Sethi S. Intraclass difference in pneumonia risk with fluticasone and budesonide in COPD: a systematic review of evidence from direct-comparison studies. Int J Chron Obstruct Pulmon Dis. 2020;15:2889–2900. doi:10.2147/COPD.S269637
  • Backer V, Hilberg O, Ulrik C. NLC abstracts. Eur Clin Respir J. 2022;9(sup1):14. doi:10.1080/20018525.2022.2058255

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.