116
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

The Activation of M1 Macrophages is Associated with the JNK-m6A-p38 Axis in Chronic Obstructive Pulmonary Disease

, ORCID Icon, ORCID Icon, ORCID Icon, , ORCID Icon, , ORCID Icon & show all
Pages 2195-2206 | Received 23 May 2023, Accepted 29 Sep 2023, Published online: 06 Oct 2023

References

  • Soriano JB, Kendrick PJ, Paulson KR. Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Respir Med. 2020;8(6):585–596. doi:10.1016/S2213-2600(20)30105-3
  • Tetley TD. Macrophages and the pathogenesis of COPD. Chest. 2002;121(5 Suppl):156s–159s. doi:10.1378/chest.121.5_suppl.156S
  • Wang Y, Xu J, Meng Y, Adcock IM, Yao X. Role of inflammatory cells in airway remodeling in COPD. Int J Chron Obstruct Pulmon Dis. 2018;13:3341–3348. doi:10.2147/COPD.S176122
  • Lea SR, Reynolds SL, Kaur M, et al. The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages. Int J Chron Obstruct Pulmon Dis. 2018;13:771–780. doi:10.2147/COPD.S97071
  • Lee JW, Chun W, Lee HJ, et al. The role of macrophages in the development of acute and chronic inflammatory lung diseases. Cells. 2021;10(4):897.
  • Subhashini CPS, Dash D, Paul BN, Singh R. Intranasal curcumin ameliorates airway inflammation and obstruction by regulating MAPKinase activation (p38, Erk and JNK) and prostaglandin D2 release in murine model of asthma. Int Immunopharmacol. 2016;31:200–206. doi:10.1016/j.intimp.2015.12.025
  • Liu L, Guo H, Song A, et al. Progranulin inhibits LPS-induced macrophage M1 polarization via NF-кB and MAPK pathways. BMC Immunol. 2020;21(1):32. doi:10.1186/s12865-020-00355-y
  • Gu W, Song L, Li XM, Wang D, Guo XJ, Xu WG. Mesenchymal stem cells alleviate airway inflammation and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways. Sci Rep. 2015;5(1):8733. doi:10.1038/srep08733
  • Luo J, Xu T, Sun K. N6-methyladenosine RNA modification in inflammation: roles, mechanisms, and applications. Front Cell Dev Biol. 2021;9:670711. doi:10.3389/fcell.2021.670711
  • Zhang Y, Gu X, Li D, Cai L, Xu Q. METTL3 regulates osteoblast differentiation and inflammatory response via Smad signaling and MAPK signaling. Int J Mol Sci. 2019;21(1):199. doi:10.3390/ijms21010199
  • Fang C, He M, Li D, Xu Q. YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways. Cell Signal. 2021;85:110060. doi:10.1016/j.cellsig.2021.110060
  • Huang X, Lv D, Yang X, Li M, Zhang H. m6A RNA methylation regulators could contribute to the occurrence of chronic obstructive pulmonary disease. J Cell Mol Med. 2020;24(21):12706–12715. doi:10.1111/jcmm.15848
  • Guo X, Lin Y, Lin Y, et al. PM2.5 induces pulmonary microvascular injury in COPD via METTL16-mediated m6A modification. Environ Pollut. 2022;303:119115. doi:10.1016/j.envpol.2022.119115
  • Jiang M, Li Z, Zhang F, et al. Butyrate inhibits iILC2-mediated lung inflammation via lung-gut axis in chronic obstructive pulmonary disease (COPD). BMC Pulm Med. 2023;23(1):163. doi:10.1186/s12890-023-02438-z
  • Mustra Rakic J, Liu C, Veeramachaneni S, et al. Lycopene inhibits smoke-induced chronic obstructive pulmonary disease and lung carcinogenesis by modulating reverse cholesterol transport in Ferrets. Cancer Prev Res. 2019;12(7):421–432. doi:10.1158/1940-6207.CAPR-19-0063
  • Zhao W, Ma L, Cai C, Gong X. Caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-κB and A2aR signaling in LPS-induced THP-1 macrophages. Int J Biol Sci. 2019;15(8):1571–1581. doi:10.7150/ijbs.34211
  • Buscetta M, Di Vincenzo S, Miele M, Badami E, Pace E, Cipollina C. Cigarette smoke inhibits the NLRP3 inflammasome and leads to caspase-1 activation via the TLR4-TRIF-caspase-8 axis in human macrophages. FASEB J. 2020;34(1):1819–1832. doi:10.1096/fj.201901239R
  • Manferdini C, Saleh Y, Dolzani P, et al. Impact of isolation procedures on the development of a preclinical synovial fibroblasts/macrophages in an in vitro model of osteoarthritis. Biology. 2020;9(12):459. doi:10.3390/biology9120459
  • Xu L, Chen Y, Nagashimada M, et al. CC chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice. Metabolism. 2021;125:154914. doi:10.1016/j.metabol.2021.154914
  • Berges AJ, Ospino R, Lina IA, et al. Myeloid phenotypes in tracheostomy-associated granulation tissue. Laryngoscope. 2023;133(9):2346–2356. doi:10.1002/lary.30557
  • Xu L, Li F, Jiang M, et al. Immunosuppression by inflammation-stimulated amplification of myeloid-derived suppressor cells and changes in expression of immune checkpoint HHLA2 in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2023;18:139–153. doi:10.2147/COPD.S394327
  • Tong J, Flavell RA, Li HB. RNA m(6)A modification and its function in diseases. Front Med. 2018;12(4):481–489. doi:10.1007/s11684-018-0654-8
  • Li X, Kang J, Lv H, et al. CircPrkcsh, a circular RNA, contributes to the polarization of microglia towards the M1 phenotype induced by spinal cord injury and acts via the JNK/p38 MAPK pathway. FASEB J. 2021;35(12):e22014. doi:10.1096/fj.202100993R
  • Guan R, Wang J, Li Z, et al. Sodium Tanshinone IIA sulfonate decreases cigarette smoke-induced inflammation and oxidative stress via blocking the activation of MAPK/HIF-1α signaling pathway. Front Pharmacol. 2018;9:263. doi:10.3389/fphar.2018.00263
  • Huang Y, Gao J, Meng XM, et al. Involvement of mitogen-activated protein kinase activation in cyclooxygenase-2 and transforming growth factor-β production in alveolar macrophage from chronic bronchitis rats. Immunopharmacol Immunotoxicol. 2011;33(4):645–651. doi:10.3109/08923973.2011.557383
  • Arora S, Dev K, Agarwal B, Das P, Syed MA. Macrophages: their role, activation and polarization in pulmonary diseases. Immunobiology. 2018;223(4–5):383–396. doi:10.1016/j.imbio.2017.11.001
  • Wang C, Zhou J, Wang J, et al. Progress in the mechanism and targeted drug therapy for COPD. Signal Transduct Target Ther. 2020;5(1):248. doi:10.1038/s41392-020-00345-x
  • Zhang F, Ran Y, Tahir M, Li Z, Wang J, Chen X. Regulation of N6-methyladenosine (m6A) RNA methylation in microglia-mediated inflammation and ischemic stroke. Front Cell Neurosci. 2022;16:955222. doi:10.3389/fncel.2022.955222
  • Zhao M, Hou J, Zheng S, et al. Peucedanum praeruptorum Dunn polysaccharides regulate macrophage inflammatory response through TLR2/TLR4-mediated MAPK and NF-κB pathways. Biomed Pharmacother. 2022;152:113258. doi:10.1016/j.biopha.2022.113258
  • Cai L, Li D, Feng Z, Gu X, Xu Q, Li Q. YTHDF2 regulates macrophage polarization through NF-κB and MAPK signaling pathway inhibition or p53 degradation. Dis Markers. 2022;2022:3153362. doi:10.1155/2022/3153362
  • Jiang X, Liu B, Nie Z, et al. The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther. 2021;6(1):74. doi:10.1038/s41392-020-00450-x